Renal and systemic pH imaging by contrast-enhanced MRI

Magnetic Resonance in Medicine

Volumn 49, Issue 2, 2003, Pages 249-257

  Raghunand, Natarajan ^a,d   Howison, Christine ^a   Sherry, A Dean ^b,c   Zhang, Shanrong ^b   Gillies, Robert J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

Acetazolamide; Acid base; Gadolinium; Kidney; Relaxivity

Indexed keywords

CARBONIC ANHYDRASE; GADOLINIUM; IMAGE ENHANCEMENT; MAMMALS; PHARMACOKINETICS; TISSUE;

ACETAZOLAMIDE; ACID BASE; CONTRAST AGENT; CONTRAST-ENHANCED; KIDNEY; LONGITUDINAL RELAXATION; METABOLIC ACIDOSIS; RELAXIVITY;

MAGNETIC RESONANCE IMAGING;

ACETAZOLAMIDE; CARBONATE DEHYDRATASE INHIBITOR; CONTRAST MEDIUM; GADOLINIUM; GADOLINIUM DOTP; GADOLINIUM PENTETATE; GADOTERIC ACID; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ALKALINIZATION; ANIMAL EXPERIMENT; ARTICLE; BLOOD PH; CONCENTRATION (PARAMETERS); CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE SEVERITY; DRUG STRUCTURE; FEMALE; KIDNEY; KIDNEY CALYX; KIDNEY PAPILLA; KIDNEY TUBULE ACIDOSIS; METABOLIC ACIDOSIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SURFACE CHARGE; TIME; URETER; URINE PH;

EID: 0037310125     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.10347     Document Type: Article

References (30)

1. Adrogue HE, Adrogue HJ. Acid-base physiology. Respir Care 2001;46:328-341.
2. Adrogue HJ, Wesson DE. Acid-base. Boston: Blackwell Scientific Publications; 1994.
3. 31P MRS as a method of measuring pH in rat tumours. NMR Biomed 1992;5:351-359.
4. 31P magnetic resonance spectroscopy. Biochem Pharmacol 1999;57:309-312.
5. Raghunand N, Mahoney B, Van Sluis R, Baggett B, Gillies RJ. Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone. Neoplasia 2001;3:227-235.
6. Paillard M. Na+/H+ exchanger subtypes in the renal tubule: function and regulation in physiology and disease. Exp Nephrol 1997;5:277-284.
7. Lai LW, Erickson RP, Venta PJ, Tashian RE, Lien YH. Promoter activity of carbonic anhydrase II regulatory regions in cultured renal proximal tubular cells. Life Sci 1998;63:121-126.
8. Shayakul C, Breton S, Brown D, Alper SL. Gene therapy of inherited renal tubular disease. Am J Kidney Dis 1999;34:374-379.
9. Lien YH, Lai LW. Gene therapy for renal diseases. Kidney Int Suppl 1997;61:S85-S88.
10. Ojugo AS, McSheehy PM, McIntyre DJ, McCoy C, Stubbs M, Leach MO, Judson IR, Griffiths JR. Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous 19F and 31P probes. NMR Biomed 1999;12:495-504.
11. Mason RP. Transmembrane pH gradients in vivo: measurements using fluorinated vitamin B6 derivatives. Curr Med Chem 1999;6:481-499.
12. Van Sluis R, Bhujwalla ZM, Raghunand N, Ballesteros P, Alvarez J, Cerdan S, Galons J-P, Gillies RJ. Imaging of extracellular pH using 1H MRSI. Magn Reson Med 1999;41:743-750.
13. Garcia-Martin ML, Herigault G, Remy C, Farion R, Ballesteros P, Coles JA, Cerdan S, Ziegler A. Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites. Cancer Res 2001;61:6524-6531.
14. Vermathen P, Capizzano AA, Maudsley AA. Administration and 1H MRS detection of histidine in human brain: application to in vivo pH measurement. Magn Reson Med 2000;43:665-675.
15. Mori S, Eleff SM, Pilatus U, Mori N, Van Zijl PCM. Sensitive detection of solvent-saturable resonances by proton NMR spectroscopy: a new approach to study pH effects. Magn Reson Med 1998;40:36-42.
16. Ward KM, Balaban RS. Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST). Magn Reson Med 2000;44:799-802.
17. Zhang S, Wu K, Sherry AD. A novel pH-sensitive MRI contrast agent. Angew Chem Int Ed 1999;38:3192-3194.
18. Aime S, Botta M, Crich SG, Giovenzana G, Palmisano G, Sisti M. A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications. Chem Commun 1999;16:1577-1578.
19. Mikawa M, Miwa N, Brautigam M, Akaike T, Maruyama A. Gd(3+)-loaded polyion complex for pH depiction with magnetic resonance imaging. J Biomed Mater Res 2000;49:390-395.
20. Beauregard DA, Parker D, Brindle KM. Relaxation-based mapping of tumour pH. In: Proceedings of the 6th Annual Meeting of ISMRM, Sydney, Australia, 1998. p 53.
21. Teicher BA, Liu S-H, Liu J-T, Holden SA, Herman TS. A carbonic anhydrase inhibitor as a potential modulator of cancer therapies. Anticancer Res 1993;13:1549-1556.
22. Durand-Cavagna G, Owen RA, Gordon LR, Peter CP, Boussiquet-Leroux C. Urothelial hyperplasia induced by carbonic anhydrase inhibitors (CAIs) in animals and its relationship to urinary Na and pH. Fund Appl Toxicol 1992;18:137-143.
23. Chang RL, Ueki RF, Troy JL, Deen WM, Robertson CR, Brenner BM. Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran. Biophys J 1975;15:887-906.
24. Shuter B, Tofts PS, Wang S-C, Pope JM. The relaxivity of Gd-EOB-DTPA and Gd-DTPA in liver and kidney of the Wistar rat. Magn Reson Imaging 1996;14:243-253.
25. Pedersen M, Morkenborg J, Jensen FT, Stodkilde-Jorgensen H, Djurhuus JC, Frokioer J. In vivo measurements of relaxivities in the rat kidney cortex. J Magn Reson Imaging 2000;12:289-296.
26. Landis CS, Li X, Telang FW, Coderre JA, Micca PL, Rooney WD, Latour LL, Vetek G, Palyka I, Springer Jr CS. Determination of the MRI contrast agent concentration time course in vivo following bolus injection: effect of equilibrium transcytolemmal water exchange. Magn Reson Med 2000;44:563-574.
27. Rozijn TH, Van der Sanden BP, Heerschap A, Creyghton JH, Bovee WM. Determination of in vivo rat muscle Gd-DTPA relaxivity at 6.3 T. MAGMA 1999;9:65-71.
28. 5- outersphere relaxation enhancement promoted by nitrogen bases. Magn Reson Med 1993;30:583-591.
29. Lai LW, Chan DM, Erickson RP, Hsu SJ, Lien YHH. Correction of renal tubular acidosis in carbonic anhydrase II-deficient mice with gene therapy. J Clin Invest 1998;101:1320-1325.
30. Raghunand N, Gillies RJ. pH and drug resistance in tumors. Drug Resist Updates 2000;3:39-47.