2-Nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: Reductively triggered release of the parp inhibitor 5- bromoisoquinolinone

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 2031-2036

  Parveen, Ifat ^a   Naughton, Declan P ^b   Whish, William J D ^a   Threadgill, Michael D ^a  

^a University of Bath   (United Kingdom)

^b UNIVERSITY OF BATH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 BROMO 2 [(1 METHYL 2 NITROIMIDAZOL 5 YL)METHYL]ISOQUINOLINE 1 ONE; 5 BROMOISOQUINOLINONE; 5 CHLOROMETHYL 1 METHYL 2 NITROIMIDAZOLE; ANION; ISOQUINOLINE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITROIMIDAZOLE DERIVATIVE; PRODRUG; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REDUCTION;

AMMONIUM CHLORIDE; ANOXIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; IMIDAZOLES; ISOQUINOLINES; OXIDATION-REDUCTION; PALLADIUM; POLY(ADP-RIBOSE) POLYMERASES; PRODRUGS; QUINOLONES; ZINC;

EID: 0033584157     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00306-6     Document Type: Article

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