Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

Cancer Research

Volumn 67, Issue 4, 2007, Pages 1602-1608

  Steták, Attila ^a,b,d   Veress, Réka ^b   Ovádi, Judit ^c   Csermely, Péter ^b   Kéri, György ^b   Ullrich, Axel ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLLYSYLCYSTEINYLTHREONINAMIDE 2,6 DISULFIDE; ISOENZYME; PROTEIN M2; PYRUVATE KINASE; PYRUVATE KINASE M2; SOMATOSTATIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS TRANSPLANTATION; CELL STRAIN COS7; CELL STRAIN HEK293; DRUG MECHANISM; ENZYME ACTIVITY; GLYCOLYSIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT;

ANIMALS; APOPTOSIS; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; HUMANS; PYRUVATE KINASE; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN;

EID: 33847699250     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2870     Document Type: Article

References (31)

1. Bertherat J, Bluet-Pajot MT, Epelbaum J. Neuroendocrine regulation of growth hormone. Eur J Endocrinol 1995;132:12-24.
2. Patel YC. Somatostatin and its receptor family. Front Neuroendocrinol 1999;20:348-67.
3. Lahlou H, Guillermet J, Hortala M, et al. Molecular signaling of somatostatin receptors. Ann N Y Acad Sci 2004;1014:121-31.
4. Kéri G, Erchegyi J, Horvath A, et al. A selective-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumour activity. Proc Natl Acad Sci U S A 1996;93:12513-8.
5. Stetak A, Lankenau A, Vantus T, Csermely P, Ullrich A, Keri G. The antitumor somatostatin analogue TT-232 induces cell cycle arrest through PKCδ and c-Src. Biochem Biophys Res Commun 2001;285:483-8.
6. Stetak A, Csermely P, Ullrich A, Keri G. Physical and functional interactions between protein tyrosine phosphatase α, PI 3-kinase, and PKCδ. Biochem Biophys Res Commun 2001;288:562-72.
7. Diaconu CC, Szathmari M, Keri G, Venetianer A. Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232. Br J Cancer 1999;80:1197-203.
8. Vantus T, Kéri G, Krivickiene Z, et al. The somatostatin analogue TT-232 induces apoptosis in A431 cells: sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases. Cell Signal 2001;13:717-25.
9. Kéri G, Mezö I, Horvath A, et al. Novel somatostatin analogues with tyrosine kinase inhibitory and antitumour activity. Biochem Biophys Res Commun 1993;191:681-7.
10. Kéri G, Mezö I, Vadasz Z, et al. Structure-activity relationship studies of novel somatostatin analogs with antitumour activity. J Pept Res 1993;6:281-8.
11. Tanaka T, Harano Y, Sue F, Morimura H. Crystallization, characterization, and metabolic regulation of two types of pyruvate kinase isolated from rat tissues. J Biochem (Tokyo) 1967;62:71-91.
12. Nowak T, Suelter C. Pyruvate kinase: activation by and catalytic role of the monovalent and divalent cations. Mol Cell Biochem 1981;35:65-75.
13. Ibsen K, Trippet P. Effects of amino acids on the kinetic properties of three noninterconvertible rat pyruvate kinases. Arch Biochem Biophys 1974;163:570-80.
14. Kato H, Fukuda T, Parkinson C, McPhie P, Cheng SY. Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase. Proc Natl Acad Sci U S A 1989;86:7861-5.
15. Vértessy BG, Bankfalvi D, Kovacs J, Low P, Lehotzky A, Ovadi J. Pyruvate kinase as a microtubule destabilizing factor in vivo. Biochem Biophys Res Commun 1999;254:430-5.
16. Dabrowska A, Pietkiewicz J, Dabrowska K, Czapinska E, Danielewicz R. Interaction of M1 and M2 isozymes pyruvate kinase from human tissues with phospholipids. Biochim Biophys Acta 1998;1383:123-9.
17. Takenaka M, Yamada K, Lu T, Kang R, Tanaka T, Noguchi T. Alternative splicing of the pyruvate kinase M gene in a minigene system. Eur J Biochem 1996;235:366-71.
18. Mellati A, Yucel M, Altinors N, Gunduz U. Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and L-alanine. Cancer Biochem Biophys 1992;13:33-41.
19. Guminska M, Stachurska MB, Ignacak J. Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour, Morris hepatoma 7777, and normal mouse and rat livers. Biochim Biophys Acta 1988;966:207-13.
20. Oremek GM, Teigelkamp S, Kramer W, Eigenbrodt E, Usadel K-H. The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as tumor marker for renal carcinoma. Anticancer Res 1999;19:1599-602.
21. Presek P, Reinacher M, Eigenbrodt E. Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus. FEBS Lett 1988;242:194-8.
22. Partis MD, Griffiths DG, Roberts GC, Beechey RB. Cross-linking proteins by ω-maleimido alkanoyl n-hydroxysuccinimido esters. J Protein Chem 1983;2:263-77.
23. Weernink PAO, Rijksen G, Staal GEJ. Production of a specific antibody against pyruvate kinase type M2 using a synthetic peptide. FEBS Lett 1988;236:391-5.
24. Leong SF, Lai JCK, Lim L, Clark JB. Energy-metabolising enzymes in brain regions of adult and aging rats. J Neurochem 1981;37:1548-56.
25. Valen G, Sonden A, Vaage J, Malm E, Kjellström BT. Hydrogen peroxide induces endothelial cell atypia and cytoskeleton depolymerization. Free Radic Biol Med 1999;26:1480-8.
26. Zamansky GB, Perrino BA, Chou I. Disruption of cytoplasmic microtubules by ultraviolet radiation. Exp Cell Res 1991;195:269-73.
27. Dastoor Z, Dreyer J. Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress. J Cell Sci 2001;114:1643-53.
28. Shashidharan P, Chalmers-Redman RM, Carlile GW, et al. Nuclear translocation of GAPDH-GFP fusion protein during apoptosis. Neuroreport 1999;10:1149-53.
29. Shawa A, Khan AA, Hester LD, Snyder SH. Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death. Proc Natl Acad Sci U S A 1997;94:11669-74.
30. Ronai Z. Glycolytic enzymes as DNA binding proteins. Int J Biochem 1993;25:1073-6.
31. Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441-6.