메뉴 건너뛰기




Volumn 1, Issue 3, 1999, Pages 197-207

Causes and Effects of Heterogeneous Perfusion in Tumors

Author keywords

Acid base balance; Angiogenesis; HIF 1; Hypoxia; Perfusion; VEEF

Indexed keywords

ACIDOSIS; ANIMAL; CELL HYPOXIA; HUMAN; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PERFUSION; PH; REVIEW; VASCULARIZATION;

EID: 0033170557     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.neo.7900037     Document Type: Review
Times cited : (231)

References (161)
  • 1
    • 0018853549 scopus 로고
    • Tumor pathophysiology: The perfusion model
    • Gullino PM (1980). Tumor pathophysiology: the perfusion model. Antibiot Chemother 28, 35-42.
    • (1980) Antibiot Chemother , vol.28 , pp. 35-42
    • Gullino, P.M.1
  • 2
    • 0031089415 scopus 로고    scopus 로고
    • The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors
    • Jain RK (1997). The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors. Microcirculation 4, 1-23.
    • (1997) Microcirculation , vol.4 , pp. 1-23
    • Jain, R.K.1
  • 3
    • 0025590174 scopus 로고
    • Blood flow, oxygen consumption and tissue oxygenation of human tumors
    • Vaupel P, Kallinowski F, and Okunieff P (1990). Blood flow, oxygen consumption and tissue oxygenation of human tumors. Adv Exp Med Biol 277, 895-905.
    • (1990) Adv Exp Med Biol , vol.277 , pp. 895-905
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 4
    • 0031896524 scopus 로고    scopus 로고
    • MRI of extracranial masses in children: The usefulness of gadolinium-chelate enhancement
    • Kidney DD, Dietrich RB, Goyal AK, Van K, and Bradley WG, Jr. (1998). MRI of extracranial masses in children: the usefulness of gadolinium-chelate enhancement. Pediatr Radiol 28, 322-328.
    • (1998) Pediatr Radiol , vol.28 , pp. 322-328
    • Kidney, D.D.1    Dietrich, R.B.2    Goyal, A.K.3    Van, K.4    Bradley Jr., W.G.5
  • 5
    • 0031254270 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced imaging and analysis at high spatial resolution of MCF7 human breast tumors
    • Furman-Haran E, Grobgeld D, and Degani H (1997). Dynamic contrast-enhanced imaging and analysis at high spatial resolution of MCF7 human breast tumors. J Magn Reson 128, 161-171.
    • (1997) J Magn Reson , vol.128 , pp. 161-171
    • Furman-Haran, E.1    Grobgeld, D.2    Degani, H.3
  • 6
    • 0031404162 scopus 로고    scopus 로고
    • Modeling tracer kinetics in dynamic Gd-DTPA MR imaging
    • Tofts PS (1997). Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging 7, 91-101.
    • (1997) J Magn Reson Imaging , vol.7 , pp. 91-101
    • Tofts, P.S.1
  • 9
    • 0029857166 scopus 로고    scopus 로고
    • Pharmacokinetic changes induced by vasomodulators in kidneys, livers, muscles, and implanted tumors in rats as measured by dynamic Gd-DTPA-enhanced MRI
    • Su MY, Wang Z, Roth GM, Lao X, Samoszuk MK, and Nalcioglu O (1996). Pharmacokinetic changes induced by vasomodulators in kidneys, livers, muscles, and implanted tumors in rats as measured by dynamic Gd-DTPA-enhanced MRI. Magn Reson Med 36, 868-877.
    • (1996) Magn Reson Med , vol.36 , pp. 868-877
    • Su, M.Y.1    Wang, Z.2    Roth, G.M.3    Lao, X.4    Samoszuk, M.K.5    Nalcioglu, O.6
  • 11
    • 0026011540 scopus 로고
    • Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts
    • Tofts PS, and Kermode AG (1991). Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn Reson Med 17, 357-367.
    • (1991) Magn Reson Med , vol.17 , pp. 357-367
    • Tofts, P.S.1    Kermode, A.G.2
  • 12
    • 0031421910 scopus 로고    scopus 로고
    • Water diffusion and exchange as they influence contrast enhancement
    • Donahue KM, Weisskoff RM, and Burstein D (1997). Water diffusion and exchange as they influence contrast enhancement. J Magn Reson Imaging 7, 102-110.
    • (1997) J Magn Reson Imaging , vol.7 , pp. 102-110
    • Donahue, K.M.1    Weisskoff, R.M.2    Burstein, D.3
  • 13
  • 15
    • 0345579699 scopus 로고    scopus 로고
    • Analysis of dynamic contrast enhanced MRI in tumors: Relationship of derived parameters with physiologic factors
    • He ZQ, and Evelhoch JL (1998). Analysis of dynamic contrast enhanced MRI in tumors: relationship of derived parameters with physiologic factors. Proc Int Soc Magn Reson Med 6, 1652.
    • (1998) Proc Int Soc Magn Reson Med , vol.6 , pp. 1652
    • He, Z.Q.1    Evelhoch, J.L.2
  • 16
    • 0029397899 scopus 로고
    • Dynamic contrast-enhanced MR imaging evaluation of osteosarcoma response to neoadjuvant chemotherapy
    • Reddick WE, Bhargava R, Taylor JS, Meyer WH, and Fletcher, BD (1995). Dynamic contrast-enhanced MR imaging evaluation of osteosarcoma response to neoadjuvant chemotherapy. J Magn Reson Imaging 5, 689-694.
    • (1995) J Magn Reson Imaging , vol.5 , pp. 689-694
    • Reddick, W.E.1    Bhargava, R.2    Taylor, J.S.3    Meyer, W.H.4    Fletcher, B.D.5
  • 22
    • 0026700672 scopus 로고
    • Factor analysis of dynamic magnetic resonance imaging in predicting the response of osteosarcoma to chemotherapy
    • Bonnerot V, Charpentier A, Frouin F, Kalifa C, Vanel D, and Di Paola R (1992). Factor analysis of dynamic magnetic resonance imaging in predicting the response of osteosarcoma to chemotherapy. Invest Radiol 27, 847-855.
    • (1992) Invest Radiol , vol.27 , pp. 847-855
    • Bonnerot, V.1    Charpentier, A.2    Frouin, F.3    Kalifa, C.4    Vanel, D.5    Di Paola, R.6
  • 23
    • 0012658203 scopus 로고
    • Magnetic resonance imaging in musculoskeletal primary malignant tumors
    • Vanel D, Di Paola R, and Contesso G (1987). Magnetic resonance imaging in musculoskeletal primary malignant tumors. Magnetic Resonance Annual, pp. 237-261.
    • (1987) Magnetic Resonance Annual , pp. 237-261
    • Vanel, D.1    Di Paola, R.2    Contesso, G.3
  • 26
    • 84963082140 scopus 로고
    • Transplantable tumors grown in transparent chambers in skinflaps of mice
    • Algire GH (1943). Transplantable tumors grown in transparent chambers in skinflaps of mice. J Natl Cancer Inst 4, 1-8.
    • (1943) J Natl Cancer Inst , vol.4 , pp. 1-8
    • Algire, G.H.1
  • 27
    • 0021328206 scopus 로고
    • Differential response of normal and tumor microcirculation to hyperthermia
    • Dudar TE, and Jain RK (1984). Differential response of normal and tumor microcirculation to hyperthermia. Cancer Res 44, 605-612.
    • (1984) Cancer Res , vol.44 , pp. 605-612
    • Dudar, T.E.1    Jain, R.K.2
  • 28
    • 0023635461 scopus 로고
    • Temporal effects of 5.0 Gy radiation in healing subcutaneous microvasculature of a dorsal flap window chamber
    • Dewhirst MW, Gustafson C, Gross JF, and Tso CY (1987). Temporal effects of 5.0 Gy radiation in healing subcutaneous microvasculature of a dorsal flap window chamber. Radiation Research 112, 581-591.
    • (1987) Radiation Research , vol.112 , pp. 581-591
    • Dewhirst, M.W.1    Gustafson, C.2    Gross, J.F.3    Tso, C.Y.4
  • 29
    • 0031878655 scopus 로고    scopus 로고
    • Concepts of oxygen transport at the microcirculatory level
    • Dewhirst MW (1998). Concepts of oxygen transport at the microcirculatory level. Semin Rad Oncol 8, 143-150.
    • (1998) Semin Rad Oncol , vol.8 , pp. 143-150
    • Dewhirst, M.W.1
  • 31
    • 0030476061 scopus 로고    scopus 로고
    • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
    • Kimura H, Braun RD, Ong ET, Hsu R, Secomb TW, Papahadjopoulos D, Hong, and Dewhirst MW (1996). Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res 56, 5522-5528.
    • (1996) Cancer Res , vol.56 , pp. 5522-5528
    • Kimura, H.1    Braun, R.D.2    Ong, E.T.3    Hsu, R.4    Secomb, T.W.5    Papahadjopoulos, D.6    Hong7    Dewhirst, M.W.8
  • 32
    • 0031823016 scopus 로고    scopus 로고
    • The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target
    • Blancher C, and Harris AL (1998). The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target. Cancer Metastasis Rev 17, 187-194.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 187-194
    • Blancher, C.1    Harris, A.L.2
  • 34
    • 0019129128 scopus 로고
    • Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation
    • Dewhirst MW, Ozimek EJ, Gross J, and Cetas TC (1980). Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation. Radiology 137, 811-817.
    • (1980) Radiology , vol.137 , pp. 811-817
    • Dewhirst, M.W.1    Ozimek, E.J.2    Gross, J.3    Cetas, T.C.4
  • 36
    • 0029665027 scopus 로고    scopus 로고
    • Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry
    • Halpern HJ, Yu C, Peric M, Barth ED, Karczmar GS, River, JN, Grdina DJ, and Teicher BA (1996). Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry. Radiat Res 145, 610-618.
    • (1996) Radiat Res , vol.145 , pp. 610-618
    • Halpern, H.J.1    Yu, C.2    Peric, M.3    Barth, E.D.4    Karczmar, G.S.5    River, J.N.6    Grdina, D.J.7    Teicher, B.A.8
  • 39
    • 0029658470 scopus 로고    scopus 로고
    • Hexafluorobenzene: A sensitive 19F NMR indicator of tumor oxygenation
    • Mason RP, Rodbumrung W, and Antich PP (1996). Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation. NMR Biomed 9, 125-134.
    • (1996) NMR Biomed , vol.9 , pp. 125-134
    • Mason, R.P.1    Rodbumrung, W.2    Antich, P.P.3
  • 40
    • 0032053533 scopus 로고    scopus 로고
    • Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation
    • Al-Hallaq HA, River JN, Zamora M, Oikawa H, and Karczmar GS (1998). Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation. Int J Radiat Oncol Biol Phys 41, 151-159.
    • (1998) Int J Radiat Oncol Biol Phys , vol.41 , pp. 151-159
    • Al-Hallaq, H.A.1    River, J.N.2    Zamora, M.3    Oikawa, H.4    Karczmar, G.S.5
  • 41
    • 0030834248 scopus 로고    scopus 로고
    • Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia
    • Oikawa H, Al-Hallaq HA, Lewis MZ, River JN, Kovar DA, and Karczmar GS (1997). Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia. Magn Reson Med 38, 27-32.
    • (1997) Magn Reson Med , vol.38 , pp. 27-32
    • Oikawa, H.1    Al-Hallaq, H.A.2    Lewis, M.Z.3    River, J.N.4    Kovar, D.A.5    Karczmar, G.S.6
  • 42
    • 0029802773 scopus 로고    scopus 로고
    • Pharmacokinetics of SPECT radiopharmaceuticals for imaging hypoxic tissues
    • Wiebe LI, and Stypinski D (1996). Pharmacokinetics of SPECT radiopharmaceuticals for imaging hypoxic tissues. Q J Nucl Med 40, 270-284.
    • (1996) Q J Nucl Med , vol.40 , pp. 270-284
    • Wiebe, L.I.1    Stypinski, D.2
  • 44
    • 0029870458 scopus 로고    scopus 로고
    • Comparing techniques of measuring tumor hypoxia in different murine tumors: Eppendorf pO2 Histograph, (3H)misonidazole binding and paired survival assay
    • Kavanagh MC, Sun A, Hu Q, and Hill RP (1996). Comparing techniques of measuring tumor hypoxia in different murine tumors: Eppendorf pO2 Histograph, (3H)misonidazole binding and paired survival assay. Radiat Res 145, 491-500.
    • (1996) Radiat Res , vol.145 , pp. 491-500
    • Kavanagh, M.C.1    Sun, A.2    Hu, Q.3    Hill, R.P.4
  • 45
    • 0030249455 scopus 로고    scopus 로고
    • Quantifying regional hypoxia in human tumors with positron emission tomography of (18F)fluoromisonidazole: A pretherapy study of 37 patients
    • Rasey JS, Koh WJ, Evans ML, Peterson LM, Lewellen TK, Graham MM, and Krohn KA (1996). Quantifying regional hypoxia in human tumors with positron emission tomography of (18F)fluoromisonidazole: a pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys 36, 417-428.
    • (1996) Int J Radiat Oncol Biol Phys , vol.36 , pp. 417-428
    • Rasey, J.S.1    Koh, W.J.2    Evans, M.L.3    Peterson, L.M.4    Lewellen, T.K.5    Graham, M.M.6    Krohn, K.A.7
  • 46
    • 0030926491 scopus 로고    scopus 로고
    • Cells at intermediate oxygen levels can be more important that the "hypoxic fraction" in determining tumor response to fractionated radiotherapy
    • Wouters BG, and Brown JM (1997). Cells at intermediate oxygen levels can be more important that the "hypoxic fraction" in determining tumor response to fractionated radiotherapy. Radiat Res 147, 541-550.
    • (1997) Radiat Res , vol.147 , pp. 541-550
    • Wouters, B.G.1    Brown, J.M.2
  • 47
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O (1956). On the origin of cancer cells. Science 123, 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 48
    • 0021732164 scopus 로고
    • The relevance of tumour pH to the treatment of malignant disease
    • Wike-Hooley JL, Haveman J, and Reinhold HS (1984). The relevance of tumour pH to the treatment of malignant disease. Radiother Oncol 2, 343-366.
    • (1984) Radiother Oncol , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, H.S.3
  • 49
    • 0028465482 scopus 로고
    • 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate
    • 31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate. Am J Physiol 267, C195-C203.
    • (1994) Am J Physiol , vol.267
    • Gillies, R.J.1    Liu, Z.2    Bhujwalla, Z.M.3
  • 50
    • 0028787621 scopus 로고
    • The effect of blood flow modification on ontra- And extracellular pH measured by 31P magnetic resonance spectroscopy in murine tumours
    • McCoy CL, Parkins CS, Chaplin DJ, Griffiths JR, Rodrigues LM, and Stubbs M (1995). The effect of blood flow modification on ontra-and extracellular pH measured by 31P magnetic resonance spectroscopy in murine tumours. Br J Cancer 72, 905-911.
    • (1995) Br J Cancer , vol.72 , pp. 905-911
    • McCoy, C.L.1    Parkins, C.S.2    Chaplin, D.J.3    Griffiths, J.R.4    Rodrigues, L.M.5    Stubbs, M.6
  • 52
    • 0017247945 scopus 로고
    • In vivo utilization of oxygen and glucose by neoplastic tissue
    • Gullino PM (1976). In vivo utilization of oxygen and glucose by neoplastic tissue. Adv Exp Med Biol 75, 521-536.
    • (1976) Adv Exp Med Biol , vol.75 , pp. 521-536
    • Gullino, P.M.1
  • 53
    • 0014098952 scopus 로고
    • Glucose consumption by transplanted tumors in vivo
    • Gullino PM, Grantham FH, and Courtney AH (1967). Glucose consumption by transplanted tumors in vivo. Cancer Res 27, 1031-1040.
    • (1967) Cancer Res , vol.27 , pp. 1031-1040
    • Gullino, P.M.1    Grantham, F.H.2    Courtney, A.H.3
  • 54
    • 0014095286 scopus 로고
    • Utilization of oxygen by transplanted tumors in vivo
    • Gullino PM, Grantham FH, and Courtney AH (1967). Utilization of oxygen by transplanted tumors in vivo. Cancer Res 27, 1020-1030.
    • (1967) Cancer Res , vol.27 , pp. 1020-1030
    • Gullino, P.M.1    Grantham, F.H.2    Courtney, A.H.3
  • 55
    • 0014098485 scopus 로고
    • Relationship between oxygen and glucose consumption by transplanted tumors in vivo
    • Gullino PM, Grantham FH, Courtney AH, and Losonczy I (1967). Relationship between oxygen and glucose consumption by transplanted tumors in vivo. Cancer Res 27, 1041-1052.
    • (1967) Cancer Res , vol.27 , pp. 1041-1052
    • Gullino, P.M.1    Grantham, F.H.2    Courtney, A.H.3    Losonczy, I.4
  • 56
    • 0022640859 scopus 로고
    • Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply
    • Freyer JP, and Sutherland RM (1986). Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply. Cancer Res 46, 3513-3520.
    • (1986) Cancer Res , vol.46 , pp. 3513-3520
    • Freyer, J.P.1    Sutherland, R.M.2
  • 57
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • ThomLinson RH, and Gray LH (1955). The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9, 539-549.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • ThomLinson, R.H.1    Gray, L.H.2
  • 58
    • 84944482637 scopus 로고
    • The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion
    • Krogh A (1919). The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion. J Physiol 52, 391-408.
    • (1919) J Physiol , vol.52 , pp. 391-408
    • Krogh, A.1
  • 59
    • 84911539247 scopus 로고
    • The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue
    • Krogh A (1919). The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J Physiol 52, 409-415.
    • (1919) J Physiol , vol.52 , pp. 409-415
    • Krogh, A.1
  • 60
    • 0022351061 scopus 로고
    • A reduction in the in situ of oxygen and glucose consumption of cells in EMT6/RO spheroids during growth
    • Freyer JP, and Sutherland RM (1985). A reduction in the in situ of oxygen and glucose consumption of cells in EMT6/RO spheroids during growth. J Cell Physiol 125, 516-524.
    • (1985) J Cell Physiol , vol.125 , pp. 516-524
    • Freyer, J.P.1    Sutherland, R.M.2
  • 62
    • 0026376979 scopus 로고
    • Self-diffusion of water in multicellular spheroids measured by magnetic resonance microimaging
    • Neeman M, Jarrett KA, Sillerud LO, and Freyer JP (1991). Self-diffusion of water in multicellular spheroids measured by magnetic resonance microimaging. Cancer Res 51, 4072-4079.
    • (1991) Cancer Res , vol.51 , pp. 4072-4079
    • Neeman, M.1    Jarrett, K.A.2    Sillerud, L.O.3    Freyer, J.P.4
  • 63
  • 64
    • 0030614893 scopus 로고    scopus 로고
    • 2 Gradients in Solid Tumors in vivo: High-Resolution Measurements Reveal a Lack of Correlation
    • 2 Gradients in Solid Tumors in vivo: High-Resolution Measurements Reveal a Lack of Correlation. Nature Med 3, 177-182.
    • (1997) Nature Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Jain, M.D.3    Jain, R.4
  • 67
    • 0015786426 scopus 로고
    • A posteffect of oxygen in irradiated bacteria: A submillisecond fast mixing study
    • Michael B, Adams G, Hewitt H, Jones W, and Watts M (1973). A posteffect of oxygen in irradiated bacteria: A submillisecond fast mixing study. Radiat Res 54, 239-251.
    • (1973) Radiat Res , vol.54 , pp. 239-251
    • Michael, B.1    Adams, G.2    Hewitt, H.3    Jones, W.4    Watts, M.5
  • 68
    • 0021794461 scopus 로고
    • Role of hypoxia in photodynamic therapy of tumors
    • Freitas I (1985). Role of hypoxia in photodynamic therapy of tumors. Tumori 71, 251-259.
    • (1985) Tumori , vol.71 , pp. 251-259
    • Freitas, I.1
  • 69
    • 0030865248 scopus 로고    scopus 로고
    • Predictions of mathematical models of tissue oxygenation and generation of singlet oxygen during photodynamic therapy
    • Yuan J, Mahama-Relue PA, Fournier RL, and Hampton JA (1997). Predictions of mathematical models of tissue oxygenation and generation of singlet oxygen during photodynamic therapy. Radiat Res 148, 386-394.
    • (1997) Radiat Res , vol.148 , pp. 386-394
    • Yuan, J.1    Mahama-Relue, P.A.2    Fournier, R.L.3    Hampton, J.A.4
  • 70
    • 0025771650 scopus 로고
    • Are cancer cells acidic?
    • Griffiths JR (1991). Are cancer cells acidic? Br J Cancer 64, 425-427.
    • (1991) Br J Cancer , vol.64 , pp. 425-427
    • Griffiths, J.R.1
  • 71
    • 84987463427 scopus 로고
    • Intracellular pH: Methods and applications
    • Gillies RJ, and Deamer DW (1978). Intracellular pH: Methods and applications. Curr Top Bioenergetics 9, 63-87.
    • (1978) Curr Top Bioenergetics , vol.9 , pp. 63-87
    • Gillies, R.J.1    Deamer, D.W.2
  • 72
    • 0018099461 scopus 로고
    • Weak acids, weak bases and intracellular pH
    • Roos A (1978). Weak acids, weak bases and intracellular pH. Respir Physiol 33, 27-30.
    • (1978) Respir Physiol , vol.33 , pp. 27-30
    • Roos, A.1
  • 73
    • 0345389967 scopus 로고    scopus 로고
    • pH and Drug Resistance II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs
    • Raghunand R, Martinez-Zaguilan R, Wright SH, and Gillies RJ (1999). pH and Drug Resistance II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Biochem Pharmacol 57, 1047-1058.
    • (1999) Biochem Pharmacol , vol.57 , pp. 1047-1058
    • Raghunand, R.1    Martinez-Zaguilan, R.2    Wright, S.H.3    Gillies, R.J.4
  • 74
    • 0024379967 scopus 로고
    • Acid pH in Tumors and Its Potential for Therapeutic Exploitation
    • Tannock IF, and Rotin D (1989). Acid pH in Tumors and Its Potential for Therapeutic Exploitation. Cancer Res 49, 4373-4384.
    • (1989) Cancer Res , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 75
    • 0027452387 scopus 로고
    • Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of p-glycoprotein
    • Roepe PD, Wei LY, Cruz J, and Carlson D (1993). Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of p-glycoprotein. Biochemistry 32, 11042-11056.
    • (1993) Biochemistry , vol.32 , pp. 11042-11056
    • Roepe, P.D.1    Wei, L.Y.2    Cruz, J.3    Carlson, D.4
  • 76
    • 0028128073 scopus 로고
    • Intracellular pH and the control of multidrug resistance
    • Simon S, Roy D, and Schindler M (1994). Intracellular pH and the control of multidrug resistance. Cell Biol 91, 1128-1132.
    • (1994) Cell Biol , vol.91 , pp. 1128-1132
    • Simon, S.1    Roy, D.2    Schindler, M.3
  • 77
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: Potential for exploitation for the treatment of cancer
    • Gerweck L, and Seetharaman K (1996). Cellular pH gradient in tumor versus normal tissue: Potential for exploitation for the treatment of cancer. Cancer Res 56, 1194-1198.
    • (1996) Cancer Res , vol.56 , pp. 1194-1198
    • Gerweck, L.1    Seetharaman, K.2
  • 79
    • 0025733402 scopus 로고
    • Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line
    • Taylor CW, Dalton WS, Parrish PR, Gleason MC, Bellamy WT, Thompson FH, Roe DJ, and Trent JM (1991). Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line. Br J Cancer 63, 923-929.
    • (1991) Br J Cancer , vol.63 , pp. 923-929
    • Taylor, C.W.1    Dalton, W.S.2    Parrish, P.R.3    Gleason, M.C.4    Bellamy, W.T.5    Thompson, F.H.6    Roe, D.J.7    Trent, J.M.8
  • 80
    • 0028224534 scopus 로고
    • Cell biological mechanisms of multidrug resistance in tumors
    • Simon SM, and Schindler M (1994). Cell biological mechanisms of multidrug resistance in tumors. Proc Nat Acad Sci USA 91, 3497-3504.
    • (1994) Proc Nat Acad Sci USA , vol.91 , pp. 3497-3504
    • Simon, S.M.1    Schindler, M.2
  • 81
    • 0023182776 scopus 로고
    • Enhanced morphological transformation of early passage syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH
    • LeBoeuf RA, and Kerckaert GA (1987). Enhanced morphological transformation of early passage syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH. Carcinogenesis 8, 689-697.
    • (1987) Carcinogenesis , vol.8 , pp. 689-697
    • LeBoeuf, R.A.1    Kerckaert, G.A.2
  • 82
    • 0025179536 scopus 로고
    • Enhanced morphological and neoplastic transformation of syrian hamster embryo cells cultured at pH 6.70
    • LeBoeuf RA, Kerckaert GA, Aardema MJ, Poiley JA, and Raineri R (1990). Enhanced morphological and neoplastic transformation of syrian hamster embryo cells cultured at pH 6.70. Mutat Environment D, 219-228.
    • (1990) Mutat Environment D , pp. 219-228
    • LeBoeuf, R.A.1    Kerckaert, G.A.2    Aardema, M.J.3    Poiley, J.A.4    Raineri, R.5
  • 83
    • 0024554118 scopus 로고
    • An interlaboratory comparison of enhanced morphological transformation of syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH
    • LeBoeuf RA, Kerckaert GA, Poiley JA, and Raineri R (1989). An interlaboratory comparison of enhanced morphological transformation of syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH. Mutat Res 222, 205-218.
    • (1989) Mutat Res , vol.222 , pp. 205-218
    • LeBoeuf, R.A.1    Kerckaert, G.A.2    Poiley, J.A.3    Raineri, R.4
  • 84
    • 0026623304 scopus 로고
    • Clastogenicity of low pH to various cultured mammalian cells
    • Morita T, Nagaki T, Fukuda I, and Okumura K (1992). Clastogenicity of low pH to various cultured mammalian cells. Mutat Res 268, 297-305.
    • (1992) Mutat Res , vol.268 , pp. 297-305
    • Morita, T.1    Nagaki, T.2    Fukuda, I.3    Okumura, K.4
  • 85
    • 0025019463 scopus 로고
    • Evaluation of clastogenicity of formic acid, acetic acid, and lactic acid on cultured mammalian cells
    • Morita T, Takeda K, and Okumura K (1990). Evaluation of clastogenicity of formic acid, acetic acid, and lactic acid on cultured mammalian cells. Mutat Res 240, 195-202.
    • (1990) Mutat Res , vol.240 , pp. 195-202
    • Morita, T.1    Takeda, K.2    Okumura, K.3
  • 86
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds TY, Rockwell S, and Glazer PM (1996). Genetic instability induced by the tumor microenvironment. Cancer Res 56, 5754-5757.
    • (1996) Cancer Res , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 88
    • 0025771024 scopus 로고
    • Glucose starvation and acidosis: Effect on experimental metastasic potential, DNA content and MTX resistance of murine tumour cells
    • Schlappack OK, Zimmermann A, and Hill RP (1991). Glucose starvation and acidosis: effect on experimental metastasic potential, DNA content and MTX resistance of murine tumour cells. Br J Cancer 64, 663-670.
    • (1991) Br J Cancer , vol.64 , pp. 663-670
    • Schlappack, O.K.1    Zimmermann, A.2    Hill, R.P.3
  • 89
    • 0030754527 scopus 로고    scopus 로고
    • Breast Cancer Cells Have a High Capacity to Acidify Extracellular Milieu by a Dual Mechanism
    • Montcourrier P, Silver I, Farnoud R, Bird I, and Rochefort H (1997). Breast Cancer Cells Have a High Capacity To Acidify Extracellular Milieu by a Dual Mechanism. Clin Exp Metastasis 15, 382-392.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 382-392
    • Montcourrier, P.1    Silver, I.2    Farnoud, R.3    Bird, I.4    Rochefort, H.5
  • 90
    • 0028618307 scopus 로고
    • Pericellular pH affects distribution and secretion of cathepsin B in Malignant Cells
    • Rozhin J, Sameni M, Ziegler G, and Sloane BF (1994). Pericellular pH affects distribution and secretion of cathepsin B in Malignant Cells. Cancer Res 54, 6517-6525.
    • (1994) Cancer Res , vol.54 , pp. 6517-6525
    • Rozhin, J.1    Sameni, M.2    Ziegler, G.3    Sloane, B.F.4
  • 91
    • 0031059664 scopus 로고    scopus 로고
    • Exposure to hypoxia, glucose starvation and acidosis: Effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion
    • Cuvier C, Jang A, and Hill RP (1997). Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion. Clin Exp Metastasis 15, 19-25.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 19-25
    • Cuvier, C.1    Jang, A.2    Hill, R.P.3
  • 92
    • 0030873998 scopus 로고    scopus 로고
    • An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells
    • Jang A, and Hill RP (1997). An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells. Clin Exp Metastasis 15, 469-483.
    • (1997) Clin Exp Metastasis , vol.15 , pp. 469-483
    • Jang, A.1    Hill, R.P.2
  • 93
    • 0033521864 scopus 로고    scopus 로고
    • Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression
    • Graham CH, Forsdike J, Fitzgerald CJ, and Macdonald-Goodfellow S (1999). Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. Int J Cancer 80, 617-623.
    • (1999) Int J Cancer , vol.80 , pp. 617-623
    • Graham, C.H.1    Forsdike, J.2    Fitzgerald, C.J.3    Macdonald-Goodfellow, S.4
  • 94
    • 0031797364 scopus 로고    scopus 로고
    • Stimulation of plasminogen activator inhibitor-1 expression in immortalized human trophoblast cells cultured under low levels of oxygen
    • Fitzpatrick TE, and Graham CH (1998). Stimulation of plasminogen activator inhibitor-1 expression in immortalized human trophoblast cells cultured under low levels of oxygen. Exp CellRes 245, 155-162.
    • (1998) Exp CellRes , vol.245 , pp. 155-162
    • Fitzpatrick, T.E.1    Graham, C.H.2
  • 96
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • Sundfor K, Lyng H, and Rofstad EK (1998). Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. Br J Cancer 78, 822-827.
    • (1998) Br J Cancer , vol.78 , pp. 822-827
    • Sundfor, K.1    Lyng, H.2    Rofstad, E.K.3
  • 98
    • 0031006417 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxic stress: From solid tumours to the ovarian follicle
    • Neeman M, Abramovitch R, Schiffenbauer YS, and Tempel C (1997). Regulation of angiogenesis by hypoxic stress: from solid tumours to the ovarian follicle. Int J Exp Pathol 78, 57-70.
    • (1997) Int J Exp Pathol , vol.78 , pp. 57-70
    • Neeman, M.1    Abramovitch, R.2    Schiffenbauer, Y.S.3    Tempel, C.4
  • 99
    • 0020656430 scopus 로고
    • Angiogenesis and neoplastic growth
    • Gullino PM (1983). Angiogenesis and neoplastic growth. Prog Clin Biol Res 132C, 101-107.
    • (1983) Prog Clin Biol Res , vol.132 C , pp. 101-107
    • Gullino, P.M.1
  • 100
    • 0018094041 scopus 로고
    • Angiogenesis and oncogenesis
    • Gullino PM (1978). Angiogenesis and oncogenesis. J Natl Cancer Inst 61, 639-643.
    • (1978) J Natl Cancer Inst , vol.61 , pp. 639-643
    • Gullino, P.M.1
  • 101
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, and Folkman J (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 102
    • 0020557197 scopus 로고
    • Oxygen tension regulates the expression of angiogenesis factor by macrophages
    • Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ, Werb, and Banda MJ (1983). Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science 221, 1283-1285.
    • (1983) Science , vol.221 , pp. 1283-1285
    • Knighton, D.R.1    Hunt, T.K.2    Scheuenstuhl, H.3    Halliday, B.J.4    Werb5    Banda, M.J.6
  • 103
    • 0032473399 scopus 로고    scopus 로고
    • Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines
    • Scott PA, Gleadle JM, Bicknell R, and Harris AL (1998). Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines. Int J Cancer 75, 706-712.
    • (1998) Int J Cancer , vol.75 , pp. 706-712
    • Scott, P.A.1    Gleadle, J.M.2    Bicknell, R.3    Harris, A.L.4
  • 104
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, and Keshet E (1992). Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843-845.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 105
    • 0028870050 scopus 로고
    • Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis
    • Shweiki D, Neeman M, Itin A, and Keshet E (1995). Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc Nat Acad Sci USA 92, 768-772.
    • (1995) Proc Nat Acad Sci USA , vol.92 , pp. 768-772
    • Shweiki, D.1    Neeman, M.2    Itin, A.3    Keshet, E.4
  • 106
    • 0028873333 scopus 로고
    • Vascular permeability factor expression influences tumor angiogenesis in human melanoma lines xenografted to nude mice
    • Potgens AJ, Lubsen NH, van Altena MC, Schoenmakers JG, Ruiter DJ, and de Waal RM (1995). Vascular permeability factor expression influences tumor angiogenesis in human melanoma lines xenografted to nude mice. Am J Pathol 146, 197-209.
    • (1995) Am J Pathol , vol.146 , pp. 197-209
    • Potgens, A.J.1    Lubsen, N.H.2    Van Altena, M.C.3    Schoenmakers, J.G.4    Ruiter, D.J.5    De Waal, R.M.6
  • 107
    • 0031564123 scopus 로고    scopus 로고
    • Targeting the tumor vasculature: Inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate
    • Olson TA, Mohanraj D, Roy S, and Ramakrishnan S (1997). Targeting the tumor vasculature: inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate. Int J Cancer 73, 865-870.
    • (1997) Int J Cancer , vol.73 , pp. 865-870
    • Olson, T.A.1    Mohanraj, D.2    Roy, S.3    Ramakrishnan, S.4
  • 108
    • 0030806273 scopus 로고    scopus 로고
    • Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
    • Benjamin LE, and Keshet E (1996). Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc Nat Acad Sci USA 94, 8761-8766.
    • (1996) Proc Nat Acad Sci USA , vol.94 , pp. 8761-8766
    • Benjamin, L.E.1    Keshet, E.2
  • 109
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A, Pode D, and Keshet E (1999). Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103, 159-165.
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 110
    • 0030823968 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells
    • Yu C, Harris SR, and Thorgeirsson UP (1997). Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells. Cancer Res 57, 3924-3928.
    • (1997) Cancer Res , vol.57 , pp. 3924-3928
    • Yu, C.1    Harris, S.R.2    Thorgeirsson, U.P.3
  • 111
    • 0029082384 scopus 로고
    • Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
    • Stein I, Neeman M, Shweiki D, Itin A, and Keshet E (1995). Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 15, 5363-5368.
    • (1995) Mol Cell Biol , vol.15 , pp. 5363-5368
    • Stein, I.1    Neeman, M.2    Shweiki, D.3    Itin, A.4    Keshet, E.5
  • 113
    • 0031708545 scopus 로고    scopus 로고
    • Modulation of VEGF production by pH and glucose in retinal Muller cells
    • Brooks SE, Gu X, Kaufmann PM, Marcus DM, and Caldwell RB (1998). Modulation of VEGF production by pH and glucose in retinal Muller cells. Curr Eye Res 17, 875-882.
    • (1998) Curr Eye Res , vol.17 , pp. 875-882
    • Brooks, S.E.1    Gu, X.2    Kaufmann, P.M.3    Marcus, D.M.4    Caldwell, R.B.5
  • 114
    • 0031058350 scopus 로고    scopus 로고
    • The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo
    • Griffiths L, Dachs GU, Bicknell R, Harris AL, and Stratford IJ (1997). The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo. Cancer Res 57, 570-572.
    • (1997) Cancer Res , vol.57 , pp. 570-572
    • Griffiths, L.1    Dachs, G.U.2    Bicknell, R.3    Harris, A.L.4    Stratford, I.J.5
  • 115
    • 0029034799 scopus 로고
    • Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells
    • Phillips PG, Bimby LM, and Narendran A (1995). Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells. Am J Physiol 268, L789-L800.
    • (1995) Am J Physiol , vol.268
    • Phillips, P.G.1    Bimby, L.M.2    Narendran, A.3
  • 116
    • 0029070920 scopus 로고
    • Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
    • Kuwabara K, Ogawa S, Matsumoto M, Koga S, Clauss M, Pinsky DJ, Lyn P, Leavy J, Witte L, and Joseph-Silverstein J (1995). Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Nat Acad Sci USA 92, 4606-4610.
    • (1995) Proc Nat Acad Sci USA , vol.92 , pp. 4606-4610
    • Kuwabara, K.1    Ogawa, S.2    Matsumoto, M.3    Koga, S.4    Clauss, M.5    Pinsky, D.J.6    Lyn, P.7    Leavy, J.8    Witte, L.9    Joseph-Silverstein, J.10
  • 117
    • 0032244642 scopus 로고    scopus 로고
    • Spatial and temporal expression of angiogenic molecules during tumor growth and progression
    • Kumar R, Kuniyasu H, Bucana CD, Wilson MR, and Fidler IJ (1998). Spatial and temporal expression of angiogenic molecules during tumor growth and progression. Oncol Res 10, 301-311.
    • (1998) Oncol Res , vol.10 , pp. 301-311
    • Kumar, R.1    Kuniyasu, H.2    Bucana, C.D.3    Wilson, M.R.4    Fidler, I.J.5
  • 118
    • 0032890359 scopus 로고    scopus 로고
    • The angiopoietins: Yin and Yang in angiogenesis
    • Davis S, and Yancopoulos GD (1999). The angiopoietins: Yin and Yang in angiogenesis. Curr Top Microbiol Immunol 237, 173-185.
    • (1999) Curr Top Microbiol Immunol , vol.237 , pp. 173-185
    • Davis, S.1    Yancopoulos, G.D.2
  • 120
    • 0032547764 scopus 로고    scopus 로고
    • Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
    • Mandriota SJ, and Pepper MS (1998). Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Circ Res 83, 852-859.
    • (1998) Circ Res , vol.83 , pp. 852-859
    • Mandriota, S.J.1    Pepper, M.S.2
  • 121
    • 0000073348 scopus 로고
    • Recherches expérimentales sur le mouvement des liquides dans les tubes de très petits diamètres
    • Poiseuille J (1846). Recherches expérimentales sur le mouvement des liquides dans les tubes de très petits diamètres. Mém Savant Étrangers Paris 9, 433-544.
    • (1846) Mém Savant Étrangers Paris , vol.9 , pp. 433-544
    • Poiseuille, J.1
  • 123
    • 0031090132 scopus 로고    scopus 로고
    • Geometric resistance and microvascular network architecture of human colorectal carcinoma
    • Less JR, Posner MC, Skalak TC, Wolmark N, and Jain RK (1997). Geometric resistance and microvascular network architecture of human colorectal carcinoma. Microcirculation 4, 25-33.
    • (1997) Microcirculation , vol.4 , pp. 25-33
    • Less, J.R.1    Posner, M.C.2    Skalak, T.C.3    Wolmark, N.4    Jain, R.K.5
  • 124
    • 0027242138 scopus 로고
    • Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue
    • Wu NZ, Da D, Rudoll TL, Needham D, Whorton AR, and Dewhirst, MW (1993). Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue. Cancer Res 53, 3765-3770.
    • (1993) Cancer Res , vol.53 , pp. 3765-3770
    • Wu, N.Z.1    Da, D.2    Rudoll, T.L.3    Needham, D.4    Whorton, A.R.5    Dewhirst, M.W.6
  • 125
    • 0030198988 scopus 로고    scopus 로고
    • 1995 Whitaker Lecture: Delivery of molecules, particles, and cells to solid tumors
    • Jain RK (1996). 1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors. Ann Biomed Eng 24, 457-473.
    • (1996) Ann Biomed Eng , vol.24 , pp. 457-473
    • Jain, R.K.1
  • 127
    • 0027403896 scopus 로고
    • A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model
    • Brizel DM, Klitzman B, Cook JM, Edwards J, Rosner G, and Dewhirst MW (1993). A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model. Int J Radiat Oncol Biol Phys 25, 269-276.
    • (1993) Int J Radiat Oncol Biol Phys , vol.25 , pp. 269-276
    • Brizel, D.M.1    Klitzman, B.2    Cook, J.M.3    Edwards, J.4    Rosner, G.5    Dewhirst, M.W.6
  • 129
  • 130
    • 0029127219 scopus 로고
    • Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors
    • Weidner N (1995). Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 36, 169-180.
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 169-180
    • Weidner, N.1
  • 131
    • 0029328266 scopus 로고
    • Intratumor microvessel density as a prognostic factor in cancer
    • Weidner N (1995). Intratumor microvessel density as a prognostic factor in cancer. Am J Path 147, 9-19.
    • (1995) Am J Path , vol.147 , pp. 9-19
    • Weidner, N.1
  • 132
    • 0019963220 scopus 로고
    • Angiogenesis and neoplastic progression in vitro
    • Ziche M, and Gullino PM (1982). Angiogenesis and neoplastic progression in vitro. J Natl Cancer Inst 69, 483-487.
    • (1982) J Natl Cancer Inst , vol.69 , pp. 483-487
    • Ziche, M.1    Gullino, P.M.2
  • 133
    • 0017842951 scopus 로고
    • Angiogenesis as a marker of preneoplastic lesions of the human breast
    • Brem SS, Jensen HM, and Gullino PM (1978). Angiogenesis as a marker of preneoplastic lesions of the human breast. Cancer 41, 239-244.
    • (1978) Cancer , vol.41 , pp. 239-244
    • Brem, S.S.1    Jensen, H.M.2    Gullino, P.M.3
  • 134
    • 0029689905 scopus 로고    scopus 로고
    • Tumoral vascularity as a prognostic factor in cancer
    • Weidner N, and Folkman J (1996). Tumoral vascularity as a prognostic factor in cancer. Important Adv Oncol 167-190.
    • (1996) Important Adv Oncol , pp. 167-190
    • Weidner, N.1    Folkman, J.2
  • 135
    • 0029005004 scopus 로고
    • Angiogenesis and cancer metastases: Therapeutic approaches
    • Teicher BA (1995). Angiogenesis and cancer metastases: therapeutic approaches. Crit Rev Oncol Hematol 20, 9-39.
    • (1995) Crit Rev Oncol Hematol , vol.20 , pp. 9-39
    • Teicher, B.A.1
  • 136
    • 0029035872 scopus 로고
    • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors
    • Secomb TW, Hsu R, Ong ET, Gross JF, and Dewhirst MW (1995). Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol 34, 313-316.
    • (1995) Acta Oncol , vol.34 , pp. 313-316
    • Secomb, T.W.1    Hsu, R.2    Ong, E.T.3    Gross, J.F.4    Dewhirst, M.W.5
  • 137
    • 0032415845 scopus 로고    scopus 로고
    • Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels
    • Secomb TW, Hsu R, Braun RD, Ross JR, Gross JF, and Dewhirst, MW (1998). Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. Adv Exp Med Biol 454, 629-634.
    • (1998) Adv Exp Med Biol , vol.454 , pp. 629-634
    • Secomb, T.W.1    Hsu, R.2    Braun, R.D.3    Ross, J.R.4    Gross, J.F.5    Dewhirst, M.W.6
  • 138
    • 0028968176 scopus 로고
    • Neovascularization induced growth of implanted C6 glioma multicellular spheroids: Magnetic resonance microimaging
    • Abramovitch R, Meir G, and Neeman M (1995). Neovascularization induced growth of implanted C6 glioma multicellular spheroids: magnetic resonance microimaging. Cancer Res 55, 1956-1962.
    • (1995) Cancer Res , vol.55 , pp. 1956-1962
    • Abramovitch, R.1    Meir, G.2    Neeman, M.3
  • 140
    • 0031852651 scopus 로고    scopus 로고
    • Structural adaptation and stability of microvascular networks: Theory and simulations
    • Pries AR, Secomb T, and Gaehtgens P (1998). Structural adaptation and stability of microvascular networks: theory and simulations. Am J Physiol 275, H349-H360.
    • (1998) Am J Physiol , vol.275
    • Pries, A.R.1    Secomb, T.2    Gaehtgens, P.3
  • 141
    • 0029994483 scopus 로고    scopus 로고
    • Tumor oxygenation: A matter of supply and demand
    • Gulledge CJ, and Dewhirst MW (1996). Tumor oxygenation: a matter of supply and demand. Anticancer Res 16, 741-749.
    • (1996) Anticancer Res , vol.16 , pp. 741-749
    • Gulledge, C.J.1    Dewhirst, M.W.2
  • 142
    • 0032473399 scopus 로고    scopus 로고
    • Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines
    • Scott PA, Gleadle JM, Bicknell R, and Harris AL (1998). Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines. Int J Cancer 75, 706-712.
    • (1998) Int J Cancer , vol.75 , pp. 706-712
    • Scott, P.A.1    Gleadle, J.M.2    Bicknell, R.3    Harris, A.L.4
  • 143
    • 0030445841 scopus 로고    scopus 로고
    • Erythrocyte flux in capillary networks during maturation: Implications for oxygen delivery
    • Berg BR, and Sarelius IH (1996). Erythrocyte flux in capillary networks during maturation: implications for oxygen delivery. Am J Physiol 271, H2263-H2273.
    • (1996) Am J Physiol , vol.271
    • Berg, B.R.1    Sarelius, I.H.2
  • 144
    • 0024501096 scopus 로고
    • Arteriolar control of capillary cell flow in striated muscle
    • Sweeney TE, and Sarelius IH (1989). Arteriolar control of capillary cell flow in striated muscle. Circ Res 64, 112-120.
    • (1989) Circ Res , vol.64 , pp. 112-120
    • Sweeney, T.E.1    Sarelius, I.H.2
  • 145
    • 0018588043 scopus 로고
    • Measurements of the perivascular PO2 in the vicinity of the pial vessels of the cat
    • Duling BR, Kuschinsky W, and Wahl M (1979). Measurements of the perivascular PO2 in the vicinity of the pial vessels of the cat. Pflugers Arch 383, 29-34
    • (1979) Pflugers Arch , vol.383 , pp. 29-34
    • Duling, B.R.1    Kuschinsky, W.2    Wahl, M.3
  • 147
    • 0028912233 scopus 로고
    • Functional capillary organization in striated muscle
    • Berg BR, and Sarelius IH (1995). Functional capillary organization in striated muscle. Am J Physiol 268, H1215-H1222.
    • (1995) Am J Physiol , vol.268
    • Berg, B.R.1    Sarelius, I.H.2
  • 148
    • 0027312557 scopus 로고
    • Effect of diameter variability along a microvessel segment on pressure drop
    • Kiani MF, Cokelet GR, and Sarelius IH (1993). Effect of diameter variability along a microvessel segment on pressure drop. Microvasc Res 45, 219-232.
    • (1993) Microvasc Res , vol.45 , pp. 219-232
    • Kiani, M.F.1    Cokelet, G.R.2    Sarelius, I.H.3
  • 149
    • 0028270939 scopus 로고
    • Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms
    • Kiani MF, Pries AR, Hsu LL, Sarelius IH, and Cokelet GR (1994). Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms. Am J Physiol 266, H1822-H1828.
    • (1994) Am J Physiol , vol.266
    • Kiani, M.F.1    Pries, A.R.2    Hsu, L.L.3    Sarelius, I.H.4    Cokelet, G.R.5
  • 150
    • 0025080230 scopus 로고
    • Growth regulation of the vascular system: Evidence for a metabolic hypothesis
    • Adair TH, Gay WJ, and Montani JP (1990). Growth regulation of the vascular system: evidence for a metabolic hypothesis. Am J Physiol 259, R393-R404.
    • (1990) Am J Physiol , vol.259
    • Adair, T.H.1    Gay, W.J.2    Montani, J.P.3
  • 151
    • 0013933187 scopus 로고
    • Microcirculation of Tumors Part 1: Anatomy, function and Necrosis
    • Rubin P, and Casarett G (1966). Microcirculation of Tumors Part 1: anatomy, function and Necrosis. Clin Radiol 17, 220-229.
    • (1966) Clin Radiol , vol.17 , pp. 220-229
    • Rubin, P.1    Casarett, G.2
  • 152
    • 0025264329 scopus 로고    scopus 로고
    • In vivo analysis of tumor vascularization in the rat
    • Hori K, Suzuki M, Tanda S, and Saito S (1999). In vivo analysis of tumor vascularization in the rat. Jpn J Cancer Res 81, 279-288.
    • (1999) Jpn J Cancer Res , vol.81 , pp. 279-288
    • Hori, K.1    Suzuki, M.2    Tanda, S.3    Saito, S.4
  • 153
    • 0031952212 scopus 로고    scopus 로고
    • Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models
    • Herbst RS, Takeuchi H, and Teicher BA (1998). Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models. Cancer Chemother Pharmacol 41, 497-504.
    • (1998) Cancer Chemother Pharmacol , vol.41 , pp. 497-504
    • Herbst, R.S.1    Takeuchi, H.2    Teicher, B.A.3
  • 154
    • 0031923243 scopus 로고    scopus 로고
    • Optimal scheduling of interleukin-12 and fractionated radiation therapy in the murine Lewis lung carcinoma
    • Teicher BA, Ara G, Buxton D, Leonard J, and Schaub RG (1998). Optimal scheduling of interleukin-12 and fractionated radiation therapy in the murine Lewis lung carcinoma. Radiat Oncol Invest 6, 71-80.
    • (1998) Radiat Oncol Invest , vol.6 , pp. 71-80
    • Teicher, B.A.1    Ara, G.2    Buxton, D.3    Leonard, J.4    Schaub, R.G.5
  • 155
    • 0030920374 scopus 로고    scopus 로고
    • Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents
    • Kakeji Y, and Teicher BA (1997). Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents. Invest New Drugs 15, 39-48.
    • (1997) Invest New Drugs , vol.15 , pp. 39-48
    • Kakeji, Y.1    Teicher, B.A.2
  • 156
    • 0029120875 scopus 로고
    • Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma
    • Teicher BA, Dupuis NP, Robinson MF, Emi Y, and Goff DA (1995). Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma. Oncol Res 7, 237-243.
    • (1995) Oncol Res , vol.7 , pp. 237-243
    • Teicher, B.A.1    Dupuis, N.P.2    Robinson, M.F.3    Emi, Y.4    Goff, D.A.5
  • 158
    • 18844479070 scopus 로고    scopus 로고
    • Uterine cervical carcinoma: Comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival
    • Hawighorst H, Knapstein PG, Knopp MV, Weikel W, Brix G, Zuna I, Schonberg SO, Essig M, Vaupel P, and van Kaick G (1998). Uterine cervical carcinoma: comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival. Cancer Res 58, 3598-3602.
    • (1998) Cancer Res , vol.58 , pp. 3598-3602
    • Hawighorst, H.1    Knapstein, P.G.2    Knopp, M.V.3    Weikel, W.4    Brix, G.5    Zuna, I.6    Schonberg, S.O.7    Essig, M.8    Vaupel, P.9    Van Kaick, G.10
  • 159
    • 0031969258 scopus 로고    scopus 로고
    • Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging
    • Abramovitch R, Frenkiel D, and Neeman M (1998). Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging. Magn Reson Med 39, 813-824.
    • (1998) Magn Reson Med , vol.39 , pp. 813-824
    • Abramovitch, R.1    Frenkiel, D.2    Neeman, M.3
  • 161
    • 0026920895 scopus 로고
    • Physiological properties of malignant tumours
    • Vaupel P (1992). Physiological properties of malignant tumours. NMR Biomed 5, 220-225.
    • (1992) NMR Biomed , vol.5 , pp. 220-225
    • Vaupel, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.