Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells

International Journal of Oncology

Volumn 38, Issue 2, 2011, Pages 409-417

  Xie, Jing ^a   Wang, Bing Shun ^a   Yu, De Hong ^a   Lu, Qin ^a   Ma, Jian ^a   Qi, Hong ^a   Fang, Chao ^a   Chen, Hong Zhuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cisplatin; Combination chemotherapy; Dichloroacetate; HeLa cells; Metabolism

Indexed keywords

CALCIUM ION; CHOLECYSTOKININ OCTAPEPTIDE; CISPLATIN; DICHLOROACETIC ACID; HYDROGEN PEROXIDE; POTASSIUM CHANNEL KV1.5;

ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; FEMALE; GLUCOSE OXIDATION; GLYCOLYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CELL PROLIFERATION; CELLS, CULTURED; CISPLATIN; DICHLOROACETATE; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; GLUCOSE; GLYCOLYSIS; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; KV1.5 POTASSIUM CHANNEL; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATION-REDUCTION; UMBILICAL VEINS;

EID: 78651235027     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2010.851     Document Type: Article

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