Combined uptake of [18F]FDG and [18F]FMISO correlates with radiation therapy outcome in head-and-neck cancer patients

Radiotherapy and Oncology

Volumn 80, Issue 2, 2006, Pages 151-156

  Thorwarth, Daniela ^a   Eschmann, Susanne Martina ^b   Holzner, Felix ^a   Paulsen, Frank ^c   Alber, Markus ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Radiological Clinic   (Germany)

^c Section for Biomedical Physics   (Germany)

Author keywords

FDG; FMISO; Head and neck cancer; Hypoxia; PET

Indexed keywords

1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL F 18; FLUORODEOXYGLUCOSE F 18; 1 FLUORO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE; GLUCOSE; MISONIDAZOLE; NITROIMIDAZOLE DERIVATIVE; PIMONIDAZOLE; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL EXAMINATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GLUCOSE METABOLISM; HEAD AND NECK CARCINOMA; HUMAN; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TREATMENT OUTCOME; TUMOR VOLUME; CELL HYPOXIA; HEAD AND NECK TUMOR; METABOLISM; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING;

AGED; CELL HYPOXIA; FEMALE; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; GLUCOSE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MISONIDAZOLE; NITROIMIDAZOLES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TREATMENT OUTCOME;

EID: 33748045490     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2006.07.033     Document Type: Article

References (15)

1. Avril N., Menzel M., Dose J., et al. Glucose metabolism of breast cancer assessed by 18F-FDG PET: histologic and immunohistochemical tissue analysis. J Nucl Med 42 (2001) 9-16
2. Daisne J.F., Sibomana M., Bol A., et al. Evaluation of a multimodality image (CT, MRI and PET) coregistration procedure on phantom and head and neck cancer patients: accuracy, reproducibility and consistency. Radiother Oncol 69 (2003) 237-245
3. Eschmann S.M., Paulsen F., Reimold M., et al. Prognostic impact of hypoxia imaging with 18F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy. J Nucl Med 46 (2005) 253-260
4. Fyles A., Milosevic M., Hedley D., et al. Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 20 (2002) 680-687
5. Hicks R.J., Kalff V., MacManus M.P., et al. 18F-FDG PET provides high-impact and powerful prognostic stratification in staging newly diagnosed non-small cell lung cancer. J Nucl Med 42 (2001) 1596-1604
6. Hicks R.J., Rischin D., Fisher R., Binns D., Scott A.M., and Peters L.J. Utility of FMISO PET in advanced head and neck cancer treated with chemoradiation incorporating a hypoxia-targeting chemotherapy agent. Eur J Nucl Med Mol Imag 32 (2005) 1384-1391
7. Kubota K., Tada M., Yamada S., et al. Comparison of the distribution of fluorine-18 fluoromisonidazole, deoxyglucose and methionine in tumour tissue. Eur J Nucl Med 26 (1999) 750-757
8. 18F]FDG-PET imaging in small cell lung cancer. Eur J Nucl Med Mol Imag 30 (2003) 78-84
9. Pugachev A., Ruan S., Carlin S., et al. Dependence of FDG uptake on tumour microenvironment. Int J Radiat Oncol Biol Phys 62 (2005) 545-553
10. Rajendran J.G., Mankoff D.A., O'Sullivan F., et al. Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging. Clin Cancer Res 10 (2004) 2245-2252
11. Rajendran J.G., Wilson D.C., Conrad E.U., et al. [18F]FMISO and [18F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression. Eur J Nucl Med Mol Imag 30 (2003) 695-704
12. Rasey J.S., Koh W.J., Evans M.L., et al. Quantifying regional hypoxia in human tumors with positron emission tomography of [F-18]fluoromisonidazole. Int J Radiat Oncol Biol Phys 36 (1996) 417-428
13. 2 measurements in murine tumours. Int J Radiat Oncol Biol Phys 62 (2005) 854-861
14. 18F]fluoromisonidazole pet correlates with radiation treatment outcome in head-and-neck cancer. BMC Caner 5 (2005) 152
15. Viola P., and Wells W.M. Alignment by Maximization of Mutual Information. Int J Comp Vision 24 (1997) 137-154