Dichloroacetate induces apoptosis in endometrial cancer cells

Gynecologic Oncology

Volumn 109, Issue 3, 2008, Pages 394-402

  Wong, Jason Y Y ^a   Huggins, Gordon S ^b   Debidda, Marcella ^d   Munshi, Nikhil C ^d   De Vivo, Immaculata ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; Cancer; Dichloroacetate; Endometrial; Mitochondria

Indexed keywords

CALCIUM ION; DICHLOROACETIC ACID; POTASSIUM CHANNEL KV1.5; PROTEIN P53; PUMA PROTEIN; SURVIVIN; TRANSCRIPTION FACTOR NFAT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN HEK293; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; EMBRYO; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HUMAN CELL; HYPERPOLARIZATION; INVASIVE CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; REGULATORY MECHANISM; SENSITIZATION;

ADENOCARCINOMA; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CALCIUM; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL SURVIVAL; DICHLOROACETATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; KV1.5 POTASSIUM CHANNEL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NFATC TRANSCRIPTION FACTORS; PROTO-ONCOGENE PROTEINS;

EID: 44549083746     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2008.01.038     Document Type: Article

References (42)

1. Rose P. Endometrial Carcinoma. N Engl J Med 335 9 (1996) 640-649
2. Ingram S.S., Rosenman J., Heath R., Morgan T.M., Moore D., and Varia M. The predictive value of progesterone receptor levels in endometrial cancer. Int J Radiat Oncol Biol Phys 17 1 (1989) 21-27
3. Randall M.E., Filiaci V.L., Muss H., et al. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol 24 1 (2006) 36-44
4. Bonnet S., Archer S.L., Allalunis-Turner J., et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11 1 (2007) 37-51
5. Chen Z., Lu W., Garcia-Prieto C., and Huang P. The Warburg effect and its cancer therapeutic implications. J Bioenerg Biomembr 39 3 (2007) 267-274
6. Kim J.W., and Dang C.V. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 66 18 (2006) 8927-8930
7. Chen L.B. Mitochondrial membrane potential in living cells. Annu Rev Cell Biol 4 (1988) 155-181
8. Heerdt B.G., Houston M.A., and Augenlicht L.H. The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression. Cancer Res 65 21 (2005) 9861-9867
9. Han J., Flemington C., Houghton A.B., et al. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A 98 20 (2001) 11318-11323
10. Nakano K., and Vousden K.H. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7 3 (2001) 683-694
11. Yu J., Zhang L., Hwang P.M., Kinzler K.W., and Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7 3 (2001) 673-682
12. Willis S.N., and Adams J.M. Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17 6 (2005) 617-625
13. Jeffers J.R., Parganas E., Lee Y., et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4 4 (2003) 321-328
14. Yu J., Wang Z., Kinzler K.W., Vogelstein B., and Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci U S A 100 4 (2003) 1931-1936
15. Abemayor E., Kovachich G.B., and Haugaard N. Effects of dichloroacetate on brain pyruvate dehydrogenase. J Neurochem 42 1 (1984) 38-42
16. Lopaschuk G.D., and Saddik M. The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia. Mol Cell Biochem 116 1-2 (1992) 111-116
17. Stacpoole P.W. The pharmacology of dichloroacetate. Metabolism 38 11 (1989) 1124-1144
18. Wong A., and Cortopassi G.A. High-throughput measurement of mitochondrial membrane potential in a neural cell line using a fluorescence plate reader. Biochem Biophys Res Commun 298 5 (2002) 750-754
19. Yan J., Jiang J., Lim C.A., Wu Q., Ng H.H., and Chin K.C. BLIMP1 regulates cell growth through repression of p53 transcription. Proc Natl Acad Sci U S A 104 6 (2007) 1841-1846
20. Bieche I., Parfait B., Tozlu S., Lidereau R., and Vidaud M. Quantitation of androgen receptor gene expression in sporadic breast tumors by real-time RT-PCR: evidence that MYC is an AR-regulated gene. Carcinogenesis 22 9 (2001) 1521-1526
21. Hassoun E.A., and Ray S. The induction of oxidative stress and cellular death by the drinking water disinfection by-products, dichloroacetate and trichloroacetate in J774.A1 cells. Comp Biochem Physiol Toxicol Pharmacol 135 2 (2003) 119-128
22. Di Lisa F., Silverman H.S., and Hansford R.G. Mitochondrial function and cell injury in single cardiac myocytes exposed to anoxia and reoxygenation. Transplant Proc 27 5 (1995) 2829-2830
23. Piccoli C., Scrima R., Boffoli D., and Capitanio N. Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state. Biochem J 396 3 (2006) 573-583
24. Liang Y., O'Driscoll L., McDonnell S., et al. Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer 111 4 (2004) 484-493
25. Sillem M., Prifti S., Koumouridis A., et al. Invasiveness corresponds to differentiation rather than to proteinase secretion in endometrial cancer cell lines. Eur J Gynaecol Oncol 20 5-6 (1999) 367-370
26. Dohi T., Okada K., Xia F., et al. An IAP-IAP complex inhibits apoptosis. J Biol Chem 279 33 (2004) 34087-34090
27. Ambrosini G., Adida C., and Altieri D.C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3 8 (1997) 917-921
28. Erkanli S., Bolat F., Kayaselcuk F., Demirhan B., and Kuscu E. COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. Gynecol Oncol 104 2 (2007) 320-325
29. Li F., Ambrosini G., Chu E.Y., et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396 6711 (1998) 580-584
30. Rice L.W., Stone R.L., Xu M., et al. Biologic targets for therapeutic intervention in endometrioid endometrial adenocarcinoma and malignant mixed mullerian tumors. Am J Obstet Gynecol 194 4 (2006) 1119-1126 discussion 26-8
31. Nagamani M., and Stuart C.A. Specific binding and growth-promoting activity of insulin in endometrial cancer cells in culture. Am J Obstet Gynecol 179 1 (1998) 6-12
32. Zhao Y., Yamashita T., and Ishikawa M. Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer. Oncol Rep 13 4 (2005) 721-726
33. Yaginuma Y., and Westphal H. Analysis of the p53 gene in human uterine carcinoma cell lines. Cancer Res 51 24 (1991) 6506-6509
34. Richardson G.S., Dickersin G.R., Atkins L., et al. KLE: a cell line with defective estrogen receptor derived from undifferentiated endometrial cancer. Gynecol Oncol 17 2 (1984) 213-230
35. Carter C.A., and Parham G.P. State of differentiation affects the response of endometrial adenocarcinoma cells to retinoic acid. Anticancer Res 17 3C (1997) 1973-1983
36. Yabushita H., Narumiya H., Hiratake K., et al. The association of transforming growth factor-beta 1 with myometrial invasion of endometrial carcinomas through effects on matrix metalloproteinase. J Obstet Gynaecol Res 26 3 (2000) 163-170
37. Holinka C.F., Hata H., Kuramoto H., et al. Responses to estradiol in a human endometrial adenocarcinoma cell line (Ishikawa). J Steroid Biochem 24 1 (1986) 85-89
38. Way D.L., Grosso D.S., Davis J.R., et al. Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture. In Vitro 19 3 part 1 (1983) 147-158
39. Sundareshan P., and Hendrix M.J. Growth, morphologic, and invasive characteristics of early and late passages of a human endometrial carcinoma cell line (RL95-2). In Vitro Cell Dev Biol 28A 7--8 (1992) 544-552
40. Colombatti A., Russo P., Cervi M., et al. Differential expression of IRS-1 and IRS-2 in uterine leiomyosarcomas with distinct oncogenic phenotypes: lack of correlation with downstream signaling events. Sarcoma 6 3 (2002) 89-96
41. Kuramoto H., Tamura S., and Notake Y. Establishment of a cell line of human endometrial adenocarcinoma in vitro. Am J Obstet Gynecol 114 8 (1972) 1012-1019
42. Sieuwerts A.M., Klijn J.G., and Foekens J.A. Assessment of the invasive potential of human gynecological tumor cell lines with the in vitro Boyden chamber assay: influences of the ability of cells to migrate through the filter membrane. Clin Exp Metastasis 15 1 (1997) 53-62