Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction

Journal of the American Chemical Society

Volumn 125, Issue 3, 2003, Pages 748-756

  Anderson, Robert F ^a,b   Shinde, Sujata S ^a   Hay, Michael P ^b   Gamage, Swarna A ^b   Denny, William A ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; ELECTRIC CONDUCTANCE; NEGATIVE IONS; ORGANIC COMPOUNDS; OXIDATION; PH EFFECTS; RATE CONSTANTS; REDOX REACTIONS;

UNIMOLECULAR REACTIONS;

DRUG PRODUCTS;

2 DEOXYRIBOSE; 3 AMINO 1,2,4 BENZOTRIAZINE 1 OXIDE; 3 AMINO 6 METHOXY 1,2,4 BENZOTRIAZINE 1 OXIDE; 3 AMINO 7 DIMETHYLAMINO 1,2,4 BENZOTRIAZINE 1 OXIDE; 3 AMINO 8 METHYL 1,2,4 BENZOTRIAZINE 1 OXIDE; ANTINEOPLASTIC AGENT; BENZOTRIAZOLE DERIVATIVE; DEOXYGUANOSINE PHOSPHATE; OXIDIZING AGENT; TIRAPAZAMINE; UNCLASSIFIED DRUG;

ARTICLE; CONDUCTANCE; DRUG ACTIVATION; OXIDATION; OXIDATION REDUCTION REACTION; PKA; PROTON TRANSPORT;

ANTINEOPLASTIC AGENTS; FREE RADICALS; KINETICS; OXIDANTS; OXIDATION-REDUCTION; PULSE RADIOLYSIS; SPECTRUM ANALYSIS; TRIAZINES;

EID: 0037460188     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0209363     Document Type: Article

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