Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4

Biochemical Pharmacology

Volumn 62, Issue 1, 2001, Pages 81-89

  Yu, Yue ^a   Deck, Jason A ^b   Hunsaker, Lucy A ^a   Deck, Lorraine M ^b   Royer, Robert E ^a   Goldberg, Erwin ^c   Vander Jagt, David L ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Dihydroxynaphthoic acids; Gossypol; Lactate dehydrogenase; N substituted oxamic acids

Indexed keywords

7 (2 METHYLBENZYL) 2,3 DIHYDROXY 6 METHYL 4 (1 METHYLETHYL) 1 NAPHTHOIC ACID; 7 (3 METHYLBENZYL) 2,3 DIHYDROXY 6 METHYL 4 (1 METHYLETHYL) 1 NAPHTHOIC ACID; 7 (4 CHLOROBENZYL) 2,3 DIHYDROXY 6 METHYL 4 (1 METHYLETHYL) 1 NAPHTHOIC ACID; 7 (4 METHYLBENZYL) 2,3 DIHYDROXY 6 METHYL 4 (1 METHYLETHYL) 1 NAPHTHOIC ACID; ENZYME INHIBITOR; GOSSYLIC IMINOLACTONE; GOSSYLIC LACTONE; GOSSYLIC NITRILE 1,1 DIACETATE; GOSSYPOL; GOSSYPOL DERIVATIVE; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE ISOENZYME 1; LACTATE DEHYDROGENASE ISOENZYME 5; LACTATE DEHYDROGENASE ISOENZYME X; N 1 METHYL 3 PHENYLPROPYLOXAMIC ACID; N 3 PHENYLPROPYLOXAMIC ACID; N 4 METHYLBENZYLOXAMIC ACID; N BETA METHYLPHENETHYLOXAMIC ACID; OXAMIC ACID; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME BINDING; HUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

EID: 0035400746     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00636-0     Document Type: Article

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