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Volumn 86, Issue 3, 2008, Pages 300-313

Provascular strategy: Targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment

Author keywords

Chemotherapy; Combination therapy; Endothelin; Nitric oxide; Radiotherapy; Vasodilation

Indexed keywords

AMBRISENTAN; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTINEOPLASTIC AGENT; ATRASENTAN; BEVACIZUMAB; BOSENTAN; BRADYKININ; CALCIUM ANTAGONIST; CARBOPLATIN; CYCLOPHOSPHAMIDE; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXORUBICIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; FLUNARIZINE; HYDRALAZINE; LEITARIS; LOBRADIMIL; NICOTINAMIDE; NISOLDIPINE; NITRIC OXIDE; RADIOSENSITIZING AGENT; SORAFENIB; UNCLASSIFIED DRUG; VERAPAMIL;

EID: 40249089741     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2008.01.024     Document Type: Review
Times cited : (51)

References (150)
  • 1
    • 0026439207 scopus 로고
    • Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction
    • M.A. Peinado S. Malkhosyan A. Velazquez M. Perucho Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction Proc Natl Acad Sci USA 89 1992 10065 10069
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10065-10069
    • Peinado, M.A.1    Malkhosyan, S.2    Velazquez, A.3    Perucho, M.4
  • 2
    • 0037317521 scopus 로고    scopus 로고
    • The role of p53 in determining sensitivity to radiotherapy
    • A.V. Gudkov E.A. Komarova The role of p53 in determining sensitivity to radiotherapy Nat Rev Cancer 3 2003 117 129
    • (2003) Nat Rev Cancer , vol.3 , pp. 117-129
    • Gudkov, A.V.1    Komarova, E.A.2
  • 3
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • L.H. Gray A.D. Conger M. Ebert S. Hornsey O.C. Scott The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy Br J Radiol 26 1953 638 648
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.5
  • 4
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • D. Hanahan R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • P. Carmeliet R.K. Jain Angiogenesis in cancer and other diseases Nature 407 2000 249 257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 6
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • P. Carmeliet Mechanisms of angiogenesis and arteriogenesis Nat Med 6 2000 389 395
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 7
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • R.K. Jain Molecular regulation of vessel maturation Nat Med 9 2003 685 693
    • (2003) Nat Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 8
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • G. Bergers L.E. Benjamin Tumorigenesis and the angiogenic switch Nat Rev Cancer 3 2003 401 410
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 9
    • 0001123485 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • J. Folkman Tumor angiogenesis R.C. Bast D.W. Kufe R.E. Pollock R.R. Weichselbaum J.F. Holland E. Frei Cancer medicine 5th ed. 2000 BC Decker Inc. Hamilton, Canada
    • (2000)
    • Folkman, J.1
  • 10
    • 0037805549 scopus 로고    scopus 로고
    • Basement membranes: structure, assembly and role in tumour angiogenesis
    • R. Kalluri Basement membranes: structure, assembly and role in tumour angiogenesis Nat Rev Cancer 3 2003 422 433
    • (2003) Nat Rev Cancer , vol.3 , pp. 422-433
    • Kalluri, R.1
  • 11
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • H.F. Dvorak Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing N Engl J Med 315 1986 1650 1659
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 12
    • 0023909330 scopus 로고
    • Determinants of tumor blood flow: a review
    • R.K. Jain Determinants of tumor blood flow: a review Cancer Res 48 1988 2641 2658
    • (1988) Cancer Res , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 13
    • 0034161989 scopus 로고    scopus 로고
    • Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies
    • A. Eberhard S. Kahlert V. Goede B. Hemmerlein K.H. Plate H.G. Augustin Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies Cancer Res 60 2000 1388 1393
    • (2000) Cancer Res , vol.60 , pp. 1388-1393
    • Eberhard, A.1    Kahlert, S.2    Goede, V.3    Hemmerlein, B.4    Plate, K.H.5    Augustin, H.G.6
  • 14
    • 0028478122 scopus 로고
    • Microvessel diameters of human colon adenocarcinoma during acute treatment with serotonin
    • A.S. Lubbe W. Huhnt Microvessel diameters of human colon adenocarcinoma during acute treatment with serotonin Int J Microcirc Clin Exp 14 1994 218 225
    • (1994) Int J Microcirc Clin Exp , vol.14 , pp. 218-225
    • Lubbe, A.S.1    Huhnt, W.2
  • 15
    • 0029025484 scopus 로고
    • Venules and arterioles in xenotransplanted human colon adenocarcinoma critically constrict with hyperthermia and serotonin
    • W. Huhnt A.S. Lubbe Venules and arterioles in xenotransplanted human colon adenocarcinoma critically constrict with hyperthermia and serotonin J Cancer Res Clin Oncol 121 1995 267 274
    • (1995) J Cancer Res Clin Oncol , vol.121 , pp. 267-274
    • Huhnt, W.1    Lubbe, A.S.2
  • 16
    • 0028989693 scopus 로고
    • Modulation of spatial O2 tension distribution in experimental tumors by increasing arterial O2 supply
    • O. Thews D.K. Kelleher P.W. Vaupel Modulation of spatial O2 tension distribution in experimental tumors by increasing arterial O2 supply Acta Oncol 34 1995 291 295
    • (1995) Acta Oncol , vol.34 , pp. 291-295
    • Thews, O.1    Kelleher, D.K.2    Vaupel, P.W.3
  • 17
    • 0031029637 scopus 로고    scopus 로고
    • Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte–endothelial interactions
    • D. Fukumura F. Yuan M. Endo R.K. Jain Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte–endothelial interactions Am J Pathol 150 1997 713 725
    • (1997) Am J Pathol , vol.150 , pp. 713-725
    • Fukumura, D.1    Yuan, F.2    Endo, M.3    Jain, R.K.4
  • 18
    • 0035141292 scopus 로고    scopus 로고
    • Bradykinin modulation of tumor vasculature: I. Activation of B2 receptors increases delivery of chemotherapeutic agents into solid peripheral tumors, enhancing their efficacy
    • D.F. Emerich P. Snodgrass R.L. Dean Bradykinin modulation of tumor vasculature: I. Activation of B2 receptors increases delivery of chemotherapeutic agents into solid peripheral tumors, enhancing their efficacy J Pharmacol Exp Ther 296 2001 623 631
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 623-631
    • Emerich, D.F.1    Snodgrass, P.2    Dean, R.L.3
  • 19
    • 3843124332 scopus 로고    scopus 로고
    • Assessment of vascular reactivity in rat brain glioma by measuring regional blood volume during graded hypoxic hypoxia
    • C. Julien J.F. Payen I. Tropres Assessment of vascular reactivity in rat brain glioma by measuring regional blood volume during graded hypoxic hypoxia Br J Cancer 91 2004 374 380
    • (2004) Br J Cancer , vol.91 , pp. 374-380
    • Julien, C.1    Payen, J.F.2    Tropres, I.3
  • 20
    • 22144456034 scopus 로고    scopus 로고
    • NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels
    • S. Kashiwagi Y. Izumi T. Gohongi NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels J Clin Invest 115 2005 1816 1827
    • (2005) J Clin Invest , vol.115 , pp. 1816-1827
    • Kashiwagi, S.1    Izumi, Y.2    Gohongi, T.3
  • 21
    • 32844470756 scopus 로고    scopus 로고
    • The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2∗-weighted GRE signal within tumors
    • C. Baudelet G.O. Cron R. Ansiaux The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2∗-weighted GRE signal within tumors NMR Biomed 19 2006 69 76
    • (2006) NMR Biomed , vol.19 , pp. 69-76
    • Baudelet, C.1    Cron, G.O.2    Ansiaux, R.3
  • 22
    • 0018091115 scopus 로고
    • Influence of vasoactive drugs and ischaemia on intra-tumour blood flow distribution
    • J. Mattson L. Appelgren L. Karlsson H.I. Peterson Influence of vasoactive drugs and ischaemia on intra-tumour blood flow distribution Eur J Cancer 14 1978 761 764
    • (1978) Eur J Cancer , vol.14 , pp. 761-764
    • Mattson, J.1    Appelgren, L.2    Karlsson, L.3    Peterson, H.I.4
  • 23
    • 0021205178 scopus 로고
    • Vasoactive drugs and tumor blood flow
    • H.I. Peterson J. Mattson Vasoactive drugs and tumor blood flow Biorheology 21 1984 503 508
    • (1984) Biorheology , vol.21 , pp. 503-508
    • Peterson, H.I.1    Mattson, J.2
  • 24
    • 0029948108 scopus 로고    scopus 로고
    • Microvascular studies on the origins of perfusion-limited hypoxia
    • M.W. Dewhirst H. Kimura S.W. Rehmus Microvascular studies on the origins of perfusion-limited hypoxia Br J Cancer Suppl 27 1996 S247 S251
    • (1996) Br J Cancer Suppl , vol.27 , pp. S247-S251
    • Dewhirst, M.W.1    Kimura, H.2    Rehmus, S.W.3
  • 25
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation
    • G. Helmlinger F. Yuan M. Dellian R.K. Jain Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation Nat Med 3 1997 177 182
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 26
    • 0029035872 scopus 로고
    • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors
    • T.W. Secomb R. Hsu E.T. Ong J.F. Gross M.W. Dewhirst Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors Acta Oncol 34 1995 313 316
    • (1995) Acta Oncol , vol.34 , pp. 313-316
    • Secomb, T.W.1    Hsu, R.2    Ong, E.T.3    Gross, J.F.4    Dewhirst, M.W.5
  • 27
  • 28
    • 0024232289 scopus 로고
    • Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure
    • R.K. Jain L.T. Baxter Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure Cancer Res 48 1988 7022 7032
    • (1988) Cancer Res , vol.48 , pp. 7022-7032
    • Jain, R.K.1    Baxter, L.T.2
  • 29
    • 0025334830 scopus 로고
    • Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy
    • Y. Boucher L.T. Baxter R.K. Jain Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy Cancer Res 50 1990 4478 4484
    • (1990) Cancer Res , vol.50 , pp. 4478-4484
    • Boucher, Y.1    Baxter, L.T.2    Jain, R.K.3
  • 30
    • 13044292648 scopus 로고    scopus 로고
    • Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules
    • P.A. Netti L.M. Hamberg J.W. Babich Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules Proc Natl Acad Sci USA 96 1999 3137 3142
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3137-3142
    • Netti, P.A.1    Hamberg, L.M.2    Babich, J.W.3
  • 31
    • 0033635842 scopus 로고    scopus 로고
    • Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts
    • C. Brekken M.H. Hjelstuen O.S. Bruland D.C. de Lange Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts Anticancer Res 20 2000 3513 3519
    • (2000) Anticancer Res , vol.20 , pp. 3513-3519
    • Brekken, C.1    Hjelstuen, M.H.2    Bruland, O.S.3    de Lange, D.C.4
  • 32
    • 34447103275 scopus 로고    scopus 로고
    • Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery
    • C. Bouzin O. Feron Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery Drug Resist Updat 10 2007 109 120
    • (2007) Drug Resist Updat , vol.10 , pp. 109-120
    • Bouzin, C.1    Feron, O.2
  • 33
    • 0026795032 scopus 로고
    • Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions
    • M.J. Boyer I.F. Tannock Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions Cancer Res 52 1992 4441 4447
    • (1992) Cancer Res , vol.52 , pp. 4441-4447
    • Boyer, M.J.1    Tannock, I.F.2
  • 34
    • 0042242676 scopus 로고    scopus 로고
    • The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models
    • R.A. Gatenby E.T. Gawlinski The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models Cancer Res 63 2003 3847 3854
    • (2003) Cancer Res , vol.63 , pp. 3847-3854
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 35
    • 0000912662 scopus 로고
    • Vascularization of the Brown–Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
    • A.G. Ide N.H. Baker S.L. Warren Vascularization of the Brown–Pearce rabbit epithelioma transplant as seen in the transparent ear chamber Am J Roentgenol 42 1939 891 899
    • (1939) Am J Roentgenol , vol.42 , pp. 891-899
    • Ide, A.G.1    Baker, N.H.2    Warren, S.L.3
  • 36
    • 84959830787 scopus 로고
    • Vascular reactions of normal and malignant tumors in vivo: I. Vascular reactions of mice to wounds and to normal and neoplastic transplants
    • G.H. Algire H.W. Chalkely F.Y. Legallais H. Park Vascular reactions of normal and malignant tumors in vivo: I. Vascular reactions of mice to wounds and to normal and neoplastic transplants J Natl Cancer Inst 6 1945 73 85
    • (1945) J Natl Cancer Inst , vol.6 , pp. 73-85
    • Algire, G.H.1    Chalkely, H.W.2    Legallais, F.Y.3    Park, H.4
  • 37
    • 2342513547 scopus 로고
    • Growth rate of transplanted tumors in relation to latent period and host vascular reaction
    • G.H. Algire F.Y. Legallais Growth rate of transplanted tumors in relation to latent period and host vascular reaction Cancer Res 7 1947 724
    • (1947) Cancer Res , vol.7 , pp. 724
    • Algire, G.H.1    Legallais, F.Y.2
  • 38
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • J. Folkman Tumor angiogenesis: therapeutic implications N Engl J Med 285 1971 1182 1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 39
    • 0025147371 scopus 로고
    • A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
    • D.J. Good P.J. Polverini F. Rastinejad A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin Proc Natl Acad Sci USA 87 1990 6624 6628
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6624-6628
    • Good, D.J.1    Polverini, P.J.2    Rastinejad, F.3
  • 40
    • 0027970092 scopus 로고
    • Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • M.S. O’Reilly L. Holmgren Y. Shing Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma Cell 79 1994 315 328
    • (1994) Cell , vol.79 , pp. 315-328
    • O’Reilly, M.S.1    Holmgren, L.2    Shing, Y.3
  • 41
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    • M.S. O’Reilly T. Boehm Y. Shing Endostatin: an endogenous inhibitor of angiogenesis and tumor growth Cell 88 1997 277 285
    • (1997) Cell , vol.88 , pp. 277-285
    • O’Reilly, M.S.1    Boehm, T.2    Shing, Y.3
  • 42
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • N. Ferrara VEGF and the quest for tumour angiogenesis factors Nat Rev Cancer 2 2002 795 803
    • (2002) Nat Rev Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 43
    • 33846260566 scopus 로고    scopus 로고
    • Sorafenib for the treatment of advanced renal cell carcinoma
    • R.C. Kane A.T. Farrell H. Saber Sorafenib for the treatment of advanced renal cell carcinoma Clin Cancer Res 12 2006 7271 7278
    • (2006) Clin Cancer Res , vol.12 , pp. 7271-7278
    • Kane, R.C.1    Farrell, A.T.2    Saber, H.3
  • 44
    • 33947423448 scopus 로고    scopus 로고
    • Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma
    • V.L. Goodman E.P. Rock R. Dagher Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma Clin Cancer Res 13 2007 1367 1373
    • (2007) Clin Cancer Res , vol.13 , pp. 1367-1373
    • Goodman, V.L.1    Rock, E.P.2    Dagher, R.3
  • 45
    • 34548764576 scopus 로고    scopus 로고
    • A novel tyrosine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake
    • D. Mannavola P. Coco G. Vannucchi A novel tyrosine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake J Clin Endocrinol Metab 2007
    • (2007) J Clin Endocrinol Metab
    • Mannavola, D.1    Coco, P.2    Vannucchi, G.3
  • 46
    • 34547459725 scopus 로고    scopus 로고
    • Sorafenib and sunitinib: novel targeted therapies for renal cell cancer
    • C.A. Grandinetti B.R. Goldspiel Sorafenib and sunitinib: novel targeted therapies for renal cell cancer Pharmacotherapy 27 2007 1125 1144
    • (2007) Pharmacotherapy , vol.27 , pp. 1125-1144
    • Grandinetti, C.A.1    Goldspiel, B.R.2
  • 47
    • 33645362726 scopus 로고    scopus 로고
    • Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: report of three cases
    • F. Lordick H. Geinitz J. Theisen A. Sendler M. Sarbia Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: report of three cases Int J Radiat Oncol Biol Phys 64 2006 1295 1298
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 1295-1298
    • Lordick, F.1    Geinitz, H.2    Theisen, J.3    Sendler, A.4    Sarbia, M.5
  • 48
    • 85058202206 scopus 로고    scopus 로고
    • Cardiac toxicity of trastuzumab-related regimens in HER2-overexpressing breast cancer
    • M.S. Ewer J.A. O’Shaughnessy Cardiac toxicity of trastuzumab-related regimens in HER2-overexpressing breast cancer Clin Breast Cancer 7 2007 600 607
    • (2007) Clin Breast Cancer , vol.7 , pp. 600-607
    • Ewer, M.S.1    O’Shaughnessy, J.A.2
  • 49
    • 35348984015 scopus 로고    scopus 로고
    • Hypertension secondary to anti-angiogenic therapy: experience with bevacizumab
    • A. Pande J. Lombardo E. Spangenthal M. Javle Hypertension secondary to anti-angiogenic therapy: experience with bevacizumab Anticancer Res 27 2007 3465 3470
    • (2007) Anticancer Res , vol.27 , pp. 3465-3470
    • Pande, A.1    Lombardo, J.2    Spangenthal, E.3    Javle, M.4
  • 50
    • 2342571715 scopus 로고    scopus 로고
    • Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment
    • P. Sonveaux C. Dessy P. Martinive Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment Cancer Res 64 2004 3209 3214
    • (2004) Cancer Res , vol.64 , pp. 3209-3214
    • Sonveaux, P.1    Dessy, C.2    Martinive, P.3
  • 51
    • 9144234108 scopus 로고    scopus 로고
    • Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy
    • A. Regina J. Jodoin P. Khoueir Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy J Neurosci Res 75 2004 291 299
    • (2004) J Neurosci Res , vol.75 , pp. 291-299
    • Regina, A.1    Jodoin, J.2    Khoueir, P.3
  • 52
    • 0002758481 scopus 로고    scopus 로고
    • Modification of blood flow
    • C.W. Song Modification of blood flow M. Molls P. Vaupel Blood perfusion and microenvironment of human tumors 1998 Springer-Verlag Berlin, Germany 193 208
    • (1998) , pp. 193-208
    • Song, C.W.1
  • 53
    • 0028818116 scopus 로고
    • Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation
    • R.A. Zlotecki L.T. Baxter Y. Boucher R.K. Jain Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation Microvasc Res 50 1995 429 443
    • (1995) Microvasc Res , vol.50 , pp. 429-443
    • Zlotecki, R.A.1    Baxter, L.T.2    Boucher, Y.3    Jain, R.K.4
  • 54
    • 34250731849 scopus 로고    scopus 로고
    • Life history of eNOS: partners and pathways
    • D.M. Dudzinski T. Michel Life history of eNOS: partners and pathways Cardiovasc Res 75 2007 247 260
    • (2007) Cardiovasc Res , vol.75 , pp. 247-260
    • Dudzinski, D.M.1    Michel, T.2
  • 55
    • 0029950927 scopus 로고    scopus 로고
    • Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1
    • P.J. Wood J.M. Sansom I.J. Stratford Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1 Br J Cancer Suppl 27 1996 S177 S180
    • (1996) Br J Cancer Suppl , vol.27 , pp. S177-S180
    • Wood, P.J.1    Sansom, J.M.2    Stratford, I.J.3
  • 56
    • 0034267721 scopus 로고    scopus 로고
    • Changes in tumor oxygenation/perfusion induced by the NO donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI
    • B.F. Jordan P. Misson R. Demeure C. Baudelet N. Beghein B. Gallez Changes in tumor oxygenation/perfusion induced by the NO donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI Int J Radiat Oncol Biol Phys 48 2000 565 570
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 565-570
    • Jordan, B.F.1    Misson, P.2    Demeure, R.3    Baudelet, C.4    Beghein, N.5    Gallez, B.6
  • 57
    • 0037208614 scopus 로고    scopus 로고
    • Potentiation of radiation-induced regrowth delay by isosorbide dinitrate in FSaII murine tumors
    • B.F. Jordan N. Beghein M. Aubry V. Gregoire B. Gallez Potentiation of radiation-induced regrowth delay by isosorbide dinitrate in FSaII murine tumors Int J Cancer 103 2003 138 141
    • (2003) Int J Cancer , vol.103 , pp. 138-141
    • Jordan, B.F.1    Beghein, N.2    Aubry, M.3    Gregoire, V.4    Gallez, B.5
  • 58
    • 0030811240 scopus 로고    scopus 로고
    • Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma
    • S.Q. Shan G.L. Rosner R.D. Braun J. Hahn C. Pearce M.W. Dewhirst Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma Br J Cancer 76 1997 429 437
    • (1997) Br J Cancer , vol.76 , pp. 429-437
    • Shan, S.Q.1    Rosner, G.L.2    Braun, R.D.3    Hahn, J.4    Pearce, C.5    Dewhirst, M.W.6
  • 59
    • 0035656528 scopus 로고    scopus 로고
    • No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs
    • O. Thews D.K. Kelleher P. Vaupel No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs Int J Oncol 19 2001 1243 1247
    • (2001) Int J Oncol , vol.19 , pp. 1243-1247
    • Thews, O.1    Kelleher, D.K.2    Vaupel, P.3
  • 60
    • 0029990646 scopus 로고    scopus 로고
    • Radiation sensitisation by nitric oxide releasing agents
    • J.B. Mitchell J.A. Cook M.C. Krishna Radiation sensitisation by nitric oxide releasing agents Br J Cancer Suppl 27 1996 S181 S184
    • (1996) Br J Cancer Suppl , vol.27 , pp. S181-S184
    • Mitchell, J.B.1    Cook, J.A.2    Krishna, M.C.3
  • 62
    • 1642542351 scopus 로고    scopus 로고
    • Nitric oxide as a radiosensitizer: evidence for an intrinsic role in addition to its effect on oxygen delivery and consumption
    • B.F. Jordan P. Sonveaux O. Feron Nitric oxide as a radiosensitizer: evidence for an intrinsic role in addition to its effect on oxygen delivery and consumption Int J Cancer 109 2004 768 773
    • (2004) Int J Cancer , vol.109 , pp. 768-773
    • Jordan, B.F.1    Sonveaux, P.2    Feron, O.3
  • 64
    • 4544333732 scopus 로고    scopus 로고
    • Targeting the tumor vascular compartment to improve conventional cancer therapy
    • O. Feron Targeting the tumor vascular compartment to improve conventional cancer therapy Trends Pharmacol Sci 25 2004 536 542
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 536-542
    • Feron, O.1
  • 65
    • 0036884118 scopus 로고    scopus 로고
    • Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery
    • P. Sonveaux C. Dessy A. Brouet Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery FASEB J 16 2002 1979 1981
    • (2002) FASEB J , vol.16 , pp. 1979-1981
    • Sonveaux, P.1    Dessy, C.2    Brouet, A.3
  • 66
    • 0344844473 scopus 로고    scopus 로고
    • Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response
    • J. Tan D.E. Hallahan Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response Cancer Res 63 2003 7663 7667
    • (2003) Cancer Res , vol.63 , pp. 7663-7667
    • Tan, J.1    Hallahan, D.E.2
  • 67
    • 0035980110 scopus 로고    scopus 로고
    • Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells
    • 2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells J Biol Chem 276 2001 32663 32669
    • (2001) J Biol Chem , vol.276 , pp. 32663-32669
    • Brouet, A.1    Sonveaux, P.2    Dessy, C.3    Balligand, J.L.4    Feron, O.5
  • 68
    • 0037373834 scopus 로고    scopus 로고
    • Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy
    • P. Sonveaux A. Brouet X. Havaux Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy Cancer Res 63 2003 1012 1019
    • (2003) Cancer Res , vol.63 , pp. 1012-1019
    • Sonveaux, P.1    Brouet, A.2    Havaux, X.3
  • 69
    • 33847291365 scopus 로고    scopus 로고
    • Irradiation promotes Akt-targeting therapeutic gene delivery to the tumor vasculature
    • P. Sonveaux F. Frerart C. Bouzin Irradiation promotes Akt-targeting therapeutic gene delivery to the tumor vasculature Int J Radiat Oncol Biol Phys 67 2007 1155 1162
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 1155-1162
    • Sonveaux, P.1    Frerart, F.2    Bouzin, C.3
  • 70
    • 0033564974 scopus 로고    scopus 로고
    • Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • D.H. Gorski M.A. Beckett N.T. Jaskowiak Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation Cancer Res 59 1999 3374 3378
    • (1999) Cancer Res , vol.59 , pp. 3374-3378
    • Gorski, D.H.1    Beckett, M.A.2    Jaskowiak, N.T.3
  • 71
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
    • B.J. Moeller Y. Cao C.Y. Li M.W. Dewhirst Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules Cancer Cell 5 2004 429 441
    • (2004) Cancer Cell , vol.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 72
    • 34047272690 scopus 로고    scopus 로고
    • Regulation of HIF-1alpha stability through S-nitrosylation
    • F. Li P. Sonveaux Z.N. Rabbani Regulation of HIF-1alpha stability through S-nitrosylation Mol Cell 26 2007 63 74
    • (2007) Mol Cell , vol.26 , pp. 63-74
    • Li, F.1    Sonveaux, P.2    Rabbani, Z.N.3
  • 73
    • 0029875840 scopus 로고    scopus 로고
    • S-Nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
    • L. Jia C. Bonaventura J. Bonaventura J.S. Stamler S -Nitrosohaemoglobin: a dynamic activity of blood involved in vascular control Nature 380 1996 221 226
    • (1996) Nature , vol.380 , pp. 221-226
    • Jia, L.1    Bonaventura, C.2    Bonaventura, J.3    Stamler, J.S.4
  • 74
    • 34247221499 scopus 로고    scopus 로고
    • Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery
    • P. Sonveaux I.I. Lobysheva O. Feron T.J. McMahon Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery Physiology 22 2007 97 112
    • (2007) Physiology , vol.22 , pp. 97-112
    • Sonveaux, P.1    Lobysheva, I.I.2    Feron, O.3    McMahon, T.J.4
  • 75
    • 0029131674 scopus 로고
    • Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions
    • R. Lee K. Neya T.A. Svizzero G.J. Vlahakes Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions J Appl Physiol 79 1995 236 242
    • (1995) J Appl Physiol , vol.79 , pp. 236-242
    • Lee, R.1    Neya, K.2    Svizzero, T.A.3    Vlahakes, G.J.4
  • 76
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • L.J. Ignarro G.M. Buga K.S. Wood R.E. Byrns G. Chaudhuri Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide Proc Natl Acad Sci USA 84 1987 9265 9269
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 77
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • R.M. Palmer A.G. Ferrige S. Moncada Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Nature 327 1987 524 526
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 78
    • 20344384288 scopus 로고    scopus 로고
    • Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide
    • P. Sonveaux A.M. Kaz S.A. Snyder Oxygen regulation of tumor perfusion by S -nitrosohemoglobin reveals a pressor activity of nitric oxide Circ Res 96 2005 1119 1126
    • (2005) Circ Res , vol.96 , pp. 1119-1126
    • Sonveaux, P.1    Kaz, A.M.2    Snyder, S.A.3
  • 79
    • 1242353138 scopus 로고    scopus 로고
    • Oxygen therapeutics: can we tame haemoglobin?
    • A.I. Alayash Oxygen therapeutics: can we tame haemoglobin? Nat Rev Drug Discov 3 2004 152 159
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 152-159
    • Alayash, A.I.1
  • 80
    • 0035826803 scopus 로고    scopus 로고
    • S-Nitrosothiol repletion by an inhaled gas regulates pulmonary function
    • M.P. Moya A.J. Gow T.J. McMahon S -Nitrosothiol repletion by an inhaled gas regulates pulmonary function Proc Natl Acad Sci USA 98 2001 5792 5797
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5792-5797
    • Moya, M.P.1    Gow, A.J.2    McMahon, T.J.3
  • 81
    • 0037072098 scopus 로고    scopus 로고
    • Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn
    • M.P. Moya A.J. Gow R.M. Califf R.N. Goldberg J.S. Stamler Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn Lancet 360 2002 141 143
    • (2002) Lancet , vol.360 , pp. 141-143
    • Moya, M.P.1    Gow, A.J.2    Califf, R.M.3    Goldberg, R.N.4    Stamler, J.S.5
  • 82
    • 26844439856 scopus 로고    scopus 로고
    • A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension
    • T.J. McMahon G.S. Ahearn M.P. Moya A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S -nitrosohemoglobin in pulmonary hypertension Proc Natl Acad Sci USA 102 2005 14801 14806
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14801-14806
    • McMahon, T.J.1    Ahearn, G.S.2    Moya, M.P.3
  • 83
    • 10644270846 scopus 로고    scopus 로고
    • Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response
    • P. Vaupel L. Harrison Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response Oncologist 9 2004 4 9
    • (2004) Oncologist , vol.9 , pp. 4-9
    • Vaupel, P.1    Harrison, L.2
  • 84
    • 0037096740 scopus 로고    scopus 로고
    • Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption
    • B.F. Jordan V. Gregoire R.J. Demeure Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption Cancer Res 62 2002 3555 3561
    • (2002) Cancer Res , vol.62 , pp. 3555-3561
    • Jordan, B.F.1    Gregoire, V.2    Demeure, R.J.3
  • 86
    • 0242586076 scopus 로고    scopus 로고
    • Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses
    • B.F. Jordan P. Sonveaux O. Feron V. Gregoire N. Beghein B. Gallez Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses Int J Radiat Oncol Biol Phys 55 2003 1066 1073
    • (2003) Int J Radiat Oncol Biol Phys , vol.55 , pp. 1066-1073
    • Jordan, B.F.1    Sonveaux, P.2    Feron, O.3    Gregoire, V.4    Beghein, N.5    Gallez, B.6
  • 87
    • 33644783745 scopus 로고    scopus 로고
    • Botulinum toxin potentiates cancer radiotherapy and chemotherapy
    • R. Ansiaux C. Baudelet G.O. Cron Botulinum toxin potentiates cancer radiotherapy and chemotherapy Clin Cancer Res 12 2006 1276 1283
    • (2006) Clin Cancer Res , vol.12 , pp. 1276-1283
    • Ansiaux, R.1    Baudelet, C.2    Cron, G.O.3
  • 88
    • 40249092194 scopus 로고    scopus 로고
    • Nitric oxide and tumor biology
    • P. Sonveaux O. Feron Nitric oxide and tumor biology S. Lamas E. Cadenas Nitric oxide, cell signaling, and gene expression 2005 CRC Press Boca Raton, USA 393 418
    • (2005) , pp. 393-418
    • Sonveaux, P.1    Feron, O.2
  • 89
    • 0027983753 scopus 로고
    • Contribution of endogenous generation of endothelin-1 to basal vascular tone
    • W.G. Haynes D.J. Webb Contribution of endogenous generation of endothelin-1 to basal vascular tone Lancet 344 1994 852 854
    • (1994) Lancet , vol.344 , pp. 852-854
    • Haynes, W.G.1    Webb, D.J.2
  • 90
    • 0028989389 scopus 로고
    • ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro
    • J.J. Maguire A.P. Davenport ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro Br J Pharmacol 115 1995 191 197
    • (1995) Br J Pharmacol , vol.115 , pp. 191-197
    • Maguire, J.J.1    Davenport, A.P.2
  • 93
    • 0032435594 scopus 로고    scopus 로고
    • Pharmacological reactivity of neoplastic and non-neoplastic associated neovasculature to vasoconstrictors
    • S.P. Andrade W.T. Beraldo Pharmacological reactivity of neoplastic and non-neoplastic associated neovasculature to vasoconstrictors Int J Exp Pathol 79 1998 425 432
    • (1998) Int J Exp Pathol , vol.79 , pp. 425-432
    • Andrade, S.P.1    Beraldo, W.T.2
  • 94
    • 0029740269 scopus 로고    scopus 로고
    • A comparative study of tumour blood flow modification in two rat tumour systems using endothelin-1 and angiotensin II: influence of tumour size on angiotensin II response
    • K.M. Bell V.E. Prise K.M. Shaffi D.J. Chaplin G.M. Tozer A comparative study of tumour blood flow modification in two rat tumour systems using endothelin-1 and angiotensin II: influence of tumour size on angiotensin II response Int J Cancer 67 1996 730 738
    • (1996) Int J Cancer , vol.67 , pp. 730-738
    • Bell, K.M.1    Prise, V.E.2    Shaffi, K.M.3    Chaplin, D.J.4    Tozer, G.M.5
  • 95
    • 0030823733 scopus 로고    scopus 로고
    • Vascular response of tumour and normal tissues to endothelin-1 following antagonism of ET(A) and ET(B) receptors in anaesthetised rats
    • K.M. Bell V.E. Prise D.J. Chaplin S. Wordsworth G.M. Tozer Vascular response of tumour and normal tissues to endothelin-1 following antagonism of ET(A) and ET(B) receptors in anaesthetised rats Int J Cancer 73 1997 283 289
    • (1997) Int J Cancer , vol.73 , pp. 283-289
    • Bell, K.M.1    Prise, V.E.2    Chaplin, D.J.3    Wordsworth, S.4    Tozer, G.M.5
  • 96
    • 0037222445 scopus 로고    scopus 로고
    • Evidence for the involvement of ET(B) receptors in ET-1-induced changes in blood flow to the rat breast tumor
    • A. Rai A. Gulati Evidence for the involvement of ET(B) receptors in ET-1-induced changes in blood flow to the rat breast tumor Cancer Chemother Pharmacol 51 2003 21 28
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 21-28
    • Rai, A.1    Gulati, A.2
  • 97
    • 0036367123 scopus 로고    scopus 로고
    • Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium
    • G. Aliev M.A. Smith D. Seyidova Increased expression of NOS and ET-1 immunoreactivity in human colorectal metastatic liver tumours is associated with selective depression of constitutive NOS immunoreactivity in vessel endothelium J Submicrosc Cytol Pathol 34 2002 37 50
    • (2002) J Submicrosc Cytol Pathol , vol.34 , pp. 37-50
    • Aliev, G.1    Smith, M.A.2    Seyidova, D.3
  • 98
    • 33746086723 scopus 로고    scopus 로고
    • Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery
    • P. Martinive J. De Wever C. Bouzin Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery Mol Cancer Ther 5 2006 1620 1627
    • (2006) Mol Cancer Ther , vol.5 , pp. 1620-1627
    • Martinive, P.1    De Wever, J.2    Bouzin, C.3
  • 99
    • 0029150245 scopus 로고
    • Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size
    • F. Yuan M. Dellian D. Fukumura Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size Cancer Res 55 1995 3752 3756
    • (1995) Cancer Res , vol.55 , pp. 3752-3756
    • Yuan, F.1    Dellian, M.2    Fukumura, D.3
  • 100
    • 0037843596 scopus 로고    scopus 로고
    • Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma
    • L. Rosano F. Spinella D. Salani Therapeutic targeting of the endothelin a receptor in human ovarian carcinoma Cancer Res 63 2003 2447 2453
    • (2003) Cancer Res , vol.63 , pp. 2447-2453
    • Rosano, L.1    Spinella, F.2    Salani, D.3
  • 102
    • 33645542495 scopus 로고    scopus 로고
    • Endothelin receptor antagonists: rationale, clinical development, and role in prostate cancer therapeutics
    • S.G. Thakkar T.K. Choueiri J.A. Garcia Endothelin receptor antagonists: rationale, clinical development, and role in prostate cancer therapeutics Curr Oncol Rep 8 2006 108 113
    • (2006) Curr Oncol Rep , vol.8 , pp. 108-113
    • Thakkar, S.G.1    Choueiri, T.K.2    Garcia, J.A.3
  • 103
    • 34248667859 scopus 로고    scopus 로고
    • A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma
    • R. Kefford J.M. Beith G.A. Van Hazel A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma Invest New Drugs 25 2007 247 252
    • (2007) Invest New Drugs , vol.25 , pp. 247-252
    • Kefford, R.1    Beith, J.M.2    Van Hazel, G.A.3
  • 104
    • 34547441506 scopus 로고    scopus 로고
    • New drug approved for pulmonary arterial hypertension
    • D. Young New drug approved for pulmonary arterial hypertension Am J Health Syst Pharm 64 2007 1562
    • (2007) Am J Health Syst Pharm , vol.64 , pp. 1562
    • Young, D.1
  • 105
    • 0025737554 scopus 로고
    • Effect of angiotensin II on intermittent tumour blood flow and acute hypoxia in the murine SCCVII carcinoma
    • M.J. Trotter D.J. Chaplin P.L. Olive Effect of angiotensin II on intermittent tumour blood flow and acute hypoxia in the murine SCCVII carcinoma Eur J Cancer 27 1991 887 893
    • (1991) Eur J Cancer , vol.27 , pp. 887-893
    • Trotter, M.J.1    Chaplin, D.J.2    Olive, P.L.3
  • 106
    • 0019478990 scopus 로고
    • A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II
    • M. Suzuki K. Hori I. Abe S. Saito H. Sato A new approach to cancer chemotherapy: selective enhancement of tumor blood flow with angiotensin II J Natl Cancer Inst 67 1981 663 669
    • (1981) J Natl Cancer Inst , vol.67 , pp. 663-669
    • Suzuki, M.1    Hori, K.2    Abe, I.3    Saito, S.4    Sato, H.5
  • 107
    • 0034125262 scopus 로고    scopus 로고
    • Disparate responses of tumour vessels to angiotensin II: tumour volume-dependent effects on perfusion and oxygenation
    • O. Thews D.K. Kelleher P. Vaupel Disparate responses of tumour vessels to angiotensin II: tumour volume-dependent effects on perfusion and oxygenation Br J Cancer 83 2000 225 231
    • (2000) Br J Cancer , vol.83 , pp. 225-231
    • Thews, O.1    Kelleher, D.K.2    Vaupel, P.3
  • 108
    • 0027326726 scopus 로고
    • New modality of radiation therapy under increased tumor oxygen tension with angiotensin II: a pilot study
    • T. Kato Y. Murakami Y. Saito New modality of radiation therapy under increased tumor oxygen tension with angiotensin II: a pilot study Radiat Med 11 1993 86 90
    • (1993) Radiat Med , vol.11 , pp. 86-90
    • Kato, T.1    Murakami, Y.2    Saito, Y.3
  • 109
    • 1542544500 scopus 로고    scopus 로고
    • Intra-arterial infusion chemotherapy with angiotensin-II for locally advanced and nonresectable pancreatic adenocarcinoma: further evaluation and prognostic implications
    • H. Ohigashi O. Ishikawa S. Yokayama Intra-arterial infusion chemotherapy with angiotensin-II for locally advanced and nonresectable pancreatic adenocarcinoma: further evaluation and prognostic implications Ann Surg Oncol 10 2003 927 934
    • (2003) Ann Surg Oncol , vol.10 , pp. 927-934
    • Ohigashi, H.1    Ishikawa, O.2    Yokayama, S.3
  • 110
    • 34447279668 scopus 로고    scopus 로고
    • Angiotensin-II administration is useful for the detection of liver metastasis from pancreatic cancer during pharmacoangiographic computed tomography
    • T. Ishikawa T. Ushiki H. Kamimura Angiotensin-II administration is useful for the detection of liver metastasis from pancreatic cancer during pharmacoangiographic computed tomography World J Gastroenterol 13 2007 3080 3083
    • (2007) World J Gastroenterol , vol.13 , pp. 3080-3083
    • Ishikawa, T.1    Ushiki, T.2    Kamimura, H.3
  • 111
    • 33644778610 scopus 로고    scopus 로고
    • Manipulating the angiotensin system – new approaches to the treatment of solid tumours
    • K. Ino K. Shibata H. Kajiyama A. Nawa S. Nomura F. Kikkawa Manipulating the angiotensin system – new approaches to the treatment of solid tumours Expert Opin Biol Ther 6 2006 243 255
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 243-255
    • Ino, K.1    Shibata, K.2    Kajiyama, H.3    Nawa, A.4    Nomura, S.5    Kikkawa, F.6
  • 112
    • 0024427505 scopus 로고
    • Modification of tumour response by calcium antagonists in the SCVII/St tumour implanted at two different sites
    • P.J. Wood D.G. Hirst Modification of tumour response by calcium antagonists in the SCVII/St tumour implanted at two different sites Int J Radiat Biol 56 1989 355 367
    • (1989) Int J Radiat Biol , vol.56 , pp. 355-367
    • Wood, P.J.1    Hirst, D.G.2
  • 113
    • 0012257052 scopus 로고
    • Effects of various calcium antagonists on blood flow and red blood cell flux in malignant tumors
    • P. Vaupel H. Menke Effects of various calcium antagonists on blood flow and red blood cell flux in malignant tumors Prog Appl Microcirc 14 1989 88 103
    • (1989) Prog Appl Microcirc , vol.14 , pp. 88-103
    • Vaupel, P.1    Menke, H.2
  • 114
    • 0026482591 scopus 로고
    • Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature
    • M.W. Dewhirst E.T. Ong D. Madwed Effects of the calcium channel blocker flunarizine on the hemodynamics and oxygenation of tumor microvasculature Radiat Res 132 1992 61 68
    • (1992) Radiat Res , vol.132 , pp. 61-68
    • Dewhirst, M.W.1    Ong, E.T.2    Madwed, D.3
  • 115
    • 0027536635 scopus 로고
    • The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment
    • B.D. Kavanagh B.E. Coffey D. Needham R.M. Hochmuth M.W. Dewhirst The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment Br J Cancer 67 1993 734 741
    • (1993) Br J Cancer , vol.67 , pp. 734-741
    • Kavanagh, B.D.1    Coffey, B.E.2    Needham, D.3    Hochmuth, R.M.4    Dewhirst, M.W.5
  • 116
    • 0023895209 scopus 로고
    • Chemical modification of tumour blood flow
    • R.L. Jirtle Chemical modification of tumour blood flow Int J Hyperthermia 4 1988 355 371
    • (1988) Int J Hyperthermia , vol.4 , pp. 355-371
    • Jirtle, R.L.1
  • 117
    • 0023691409 scopus 로고
    • Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage
    • W.T. Bellamy W.S. Dalton J.M. Kailey Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage Cancer Res 48 1988 6365 6370
    • (1988) Cancer Res , vol.48 , pp. 6365-6370
    • Bellamy, W.T.1    Dalton, W.S.2    Kailey, J.M.3
  • 118
    • 0023237840 scopus 로고
    • Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients
    • R.F. Ozols R.E. Cunnion R.W. Klecker Jr Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients J Clin Oncol 5 1987 641 647
    • (1987) J Clin Oncol , vol.5 , pp. 641-647
    • Ozols, R.F.1    Cunnion, R.E.2    Klecker, R.W.3
  • 119
    • 33745736603 scopus 로고    scopus 로고
    • Multidrug resistance: retrospect and prospects in anti-cancer drug treatment
    • R. Perez-Tomas Multidrug resistance: retrospect and prospects in anti-cancer drug treatment Curr Med Chem 13 2006 1859 1876
    • (2006) Curr Med Chem , vol.13 , pp. 1859-1876
    • Perez-Tomas, R.1
  • 120
    • 0024458140 scopus 로고
    • Histological evidence for nonperfused vasculature in a murine tumor following hydralazine administration
    • M.J. Trotter B.D. Acker D.J. Chaplin Histological evidence for nonperfused vasculature in a murine tumor following hydralazine administration Int J Radiat Oncol Biol Phys 17 1989 785 789
    • (1989) Int J Radiat Oncol Biol Phys , vol.17 , pp. 785-789
    • Trotter, M.J.1    Acker, B.D.2    Chaplin, D.J.3
  • 121
    • 0025165266 scopus 로고
    • Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors
    • J. Kalmus P. Okunieff P. Vaupel Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors Cancer Res 50 1990 15 19
    • (1990) Cancer Res , vol.50 , pp. 15-19
    • Kalmus, J.1    Okunieff, P.2    Vaupel, P.3
  • 122
    • 0028291964 scopus 로고
    • Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI
    • C.A. Belfi C.R. Paul S. Shan F.Q. Ngo Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI Int J Radiat Oncol Biol Phys 29 1994 473 479
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 473-479
    • Belfi, C.A.1    Paul, C.R.2    Shan, S.3    Ngo, F.Q.4
  • 123
    • 0025819143 scopus 로고
    • Effect of hydralazine on the blood flow in tumors and normal tissues in rats
    • T. Hasegawa C.W. Song Effect of hydralazine on the blood flow in tumors and normal tissues in rats Int J Radiat Oncol Biol Phys 20 1991 1001 1007
    • (1991) Int J Radiat Oncol Biol Phys , vol.20 , pp. 1001-1007
    • Hasegawa, T.1    Song, C.W.2
  • 124
    • 0025343704 scopus 로고
    • Bioreductive drugs and the selective induction of tumour hypoxia
    • J.C. Bremner I.J. Stratford J. Bowler G.E. Adams Bioreductive drugs and the selective induction of tumour hypoxia Br J Cancer 61 1990 717 721
    • (1990) Br J Cancer , vol.61 , pp. 717-721
    • Bremner, J.C.1    Stratford, I.J.2    Bowler, J.3    Adams, G.E.4
  • 125
    • 0034029002 scopus 로고    scopus 로고
    • Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent
    • L.H. Patterson S.R. McKeown K. Ruparelia Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent Br J Cancer 82 2000 1984 1990
    • (2000) Br J Cancer , vol.82 , pp. 1984-1990
    • Patterson, L.H.1    McKeown, S.R.2    Ruparelia, K.3
  • 126
    • 0024531650 scopus 로고
    • Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo
    • M.R. Horsman K.L. Christensen J. Overgaard Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo Int J Hyperthermia 5 1989 123 136
    • (1989) Int J Hyperthermia , vol.5 , pp. 123-136
    • Horsman, M.R.1    Christensen, K.L.2    Overgaard, J.3
  • 127
    • 0026742089 scopus 로고
    • The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours
    • P.K. Quinn M.C. Bibby J.A. Cox S.M. Crawford The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours Br J Cancer 66 1992 323 330
    • (1992) Br J Cancer , vol.66 , pp. 323-330
    • Quinn, P.K.1    Bibby, M.C.2    Cox, J.A.3    Crawford, S.M.4
  • 128
    • 0026089368 scopus 로고
    • The effect of hydralazine on blood flow and misonidazole toxicity in human tumour xenografts
    • M. Guichard F. Lespinasse M. Trotter R. Durand D. Chaplin The effect of hydralazine on blood flow and misonidazole toxicity in human tumour xenografts Radiother Oncol 20 1991 117 123
    • (1991) Radiother Oncol , vol.20 , pp. 117-123
    • Guichard, M.1    Lespinasse, F.2    Trotter, M.3    Durand, R.4    Chaplin, D.5
  • 130
    • 0026565240 scopus 로고
    • Pharmacological modification of tumor blood flow: lack of correlation between alteration of mean arterial blood pressure and changes in tumor perfusion
    • H.B. Stone A.I. Minchinton M. Lemmon D. Menke J.M. Brown Pharmacological modification of tumor blood flow: lack of correlation between alteration of mean arterial blood pressure and changes in tumor perfusion Int J Radiat Oncol Biol Phys 22 1992 79 86
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 79-86
    • Stone, H.B.1    Minchinton, A.I.2    Lemmon, M.3    Menke, D.4    Brown, J.M.5
  • 131
    • 0026715808 scopus 로고
    • Comparative effects of hydralazine on perfusion of KHT tumor, kidney and liver and on renal function in mice
    • D.J. Honess N.M. Bleehen Comparative effects of hydralazine on perfusion of KHT tumor, kidney and liver and on renal function in mice Int J Radiat Oncol Biol Phys 22 1992 953 961
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 953-961
    • Honess, D.J.1    Bleehen, N.M.2
  • 132
    • 0025130936 scopus 로고
    • The use of hydralazine to manipulate tumour temperatures during hyperthermia
    • M.W. Dewhirst D.M. Prescott S. Clegg The use of hydralazine to manipulate tumour temperatures during hyperthermia Int J Hyperthermia 6 1990 971 983
    • (1990) Int J Hyperthermia , vol.6 , pp. 971-983
    • Dewhirst, M.W.1    Prescott, D.M.2    Clegg, S.3
  • 133
    • 0025148030 scopus 로고
    • The effects of single dose oral hydralazine on blood flow through human lung tumours
    • N.P. Rowell M.A. Flower V.R. McCready B. Cronin A. Horwich The effects of single dose oral hydralazine on blood flow through human lung tumours Radiother Oncol 18 1990 283 292
    • (1990) Radiother Oncol , vol.18 , pp. 283-292
    • Rowell, N.P.1    Flower, M.A.2    McCready, V.R.3    Cronin, B.4    Horwich, A.5
  • 135
  • 136
    • 0029894851 scopus 로고    scopus 로고
    • Tumour oxygenation is increased by hyperthermia at mild temperatures
    • C.W. Song A. Shakil J.L. Osborn K. Iwata Tumour oxygenation is increased by hyperthermia at mild temperatures Int J Hyperthermia 12 1996 367 373
    • (1996) Int J Hyperthermia , vol.12 , pp. 367-373
    • Song, C.W.1    Shakil, A.2    Osborn, J.L.3    Iwata, K.4
  • 137
    • 0033832478 scopus 로고    scopus 로고
    • Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters
    • B. Rau P. Wust W. Tilly Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters Int J Radiat Oncol Biol Phys 48 2000 381 391
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 381-391
    • Rau, B.1    Wust, P.2    Tilly, W.3
  • 138
    • 85047696164 scopus 로고
    • Tissue NAD levels and the response to irradiation of cytotoxic drugs
    • G. Calcutt S.M. Ting A.V. Preece Tissue NAD levels and the response to irradiation of cytotoxic drugs Br J Cancer 24 1970 380 388
    • (1970) Br J Cancer , vol.24 , pp. 380-388
    • Calcutt, G.1    Ting, S.M.2    Preece, A.V.3
  • 139
    • 0028113930 scopus 로고
    • Enhancement of chemosensitivity of quiescent cell populations in murine solid tumors using nicotinamide
    • S. Masunaga K. Ono K. Akuta Enhancement of chemosensitivity of quiescent cell populations in murine solid tumors using nicotinamide Chemotherapy 40 1994 418 426
    • (1994) Chemotherapy , vol.40 , pp. 418-426
    • Masunaga, S.1    Ono, K.2    Akuta, K.3
  • 140
    • 0027935569 scopus 로고
    • Possible mechanisms involved in tumor radiosensitization following nicotinamide administration
    • D.K. Kelleher P.W. Vaupel Possible mechanisms involved in tumor radiosensitization following nicotinamide administration Radiother Oncol 32 1994 47 53
    • (1994) Radiother Oncol , vol.32 , pp. 47-53
    • Kelleher, D.K.1    Vaupel, P.W.2
  • 141
    • 0031047791 scopus 로고    scopus 로고
    • Nicotinamide reduces tumour interstitial fluid pressure in a dose- and time-dependent manner
    • C.E. Peters D.J. Chaplin D.G. Hirst Nicotinamide reduces tumour interstitial fluid pressure in a dose- and time-dependent manner Br J Radiol 70 1997 160 167
    • (1997) Br J Radiol , vol.70 , pp. 160-167
    • Peters, C.E.1    Chaplin, D.J.2    Hirst, D.G.3
  • 142
    • 0034979156 scopus 로고    scopus 로고
    • Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
    • R.D. Braun J.L. Lanzen S.A. Snyder M.W. Dewhirst Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents Am J Physiol Heart Circ Physiol 280 2001 H2533 H2544
    • (2001) Am J Physiol Heart Circ Physiol , vol.280 , pp. H2533-H2544
    • Braun, R.D.1    Lanzen, J.L.2    Snyder, S.A.3    Dewhirst, M.W.4
  • 144
    • 33744492332 scopus 로고    scopus 로고
    • Phase II trial of intravenous lobradimil and carboplatin in childhood brain tumors: a report from the Children’s Oncology Group
    • K. Warren R. Jakacki B. Widemann Phase II trial of intravenous lobradimil and carboplatin in childhood brain tumors: a report from the Children’s Oncology Group Cancer Chemother Pharmacol 58 2006 343 347
    • (2006) Cancer Chemother Pharmacol , vol.58 , pp. 343-347
    • Warren, K.1    Jakacki, R.2    Widemann, B.3
  • 145
    • 0035146475 scopus 로고    scopus 로고
    • Bradykinin modulation of tumor vasculature: II. Activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors
    • D.F. Emerich R.L. Dean P. Snodgrass Bradykinin modulation of tumor vasculature: II. Activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors J Pharmacol Exp Ther 296 2001 632 641
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 632-641
    • Emerich, D.F.1    Dean, R.L.2    Snodgrass, P.3
  • 146
    • 0018103794 scopus 로고
    • Effects of several vasoactive drugs on the vascular resistance of MT-W9B tumors in W/Fu rats
    • R. Jirtle K.H. Clifton J.H. Rankin Effects of several vasoactive drugs on the vascular resistance of MT-W9B tumors in W/Fu rats Cancer Res 38 1978 2385 2390
    • (1978) Cancer Res , vol.38 , pp. 2385-2390
    • Jirtle, R.1    Clifton, K.H.2    Rankin, J.H.3
  • 147
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize
    • D. Fukumura R.K. Jain Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize J Cell Biochem 101 2007 937 949
    • (2007) J Cell Biochem , vol.101 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 149
    • 3142552508 scopus 로고    scopus 로고
    • Measurement of tumor hypoxia using single-cell methods
    • P.L. Olive C. Aquino-Parsons Measurement of tumor hypoxia using single-cell methods Semin Radiat Oncol 14 2004 241 248
    • (2004) Semin Radiat Oncol , vol.14 , pp. 241-248
    • Olive, P.L.1    Aquino-Parsons, C.2
  • 150
    • 78650639672 scopus 로고    scopus 로고
    • Post-treatment changes in tumor microenvironment: dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging
    • B.F. Jordan J.P. Galon R.J. Gillies Post-treatment changes in tumor microenvironment: dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging M.A. Hayat Cancer imaging: instrumentation and applications 2008 Academic Press Burlington, USA 235 248
    • (2008) , pp. 235-248
    • Jordan, B.F.1    Galon, J.P.2    Gillies, R.J.3


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