-
2
-
-
7144227930
-
Recombinant human interleukin-2, recombinant human interferon alpha-2a, or both in metastatic renal-cell carcinoma
-
Negrier S, Escudier B, Lasset C, et al. Recombinant human interleukin-2, recombinant human interferon alpha-2a, or both in metastatic renal-cell carcinoma. N Engl J Med 1998;338:1272-8.
-
(1998)
N Engl J Med
, vol.338
, pp. 1272-1278
-
-
Negrier, S.1
Escudier, B.2
Lasset, C.3
-
3
-
-
0028929682
-
Results of treatment of 255 patients with metastatic renal cell carcinoma who recieved high-dose recombinant interleukin-2 therapy
-
Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC. Results of treatment of 255 patients with metastatic renal cell carcinoma who recieved high-dose recombinant interleukin-2 therapy. J Clin Oncol 1995;13:688-96.
-
(1995)
J Clin Oncol
, vol.13
, pp. 688-696
-
-
Fyfe, G.1
Fisher, R.I.2
Rosenberg, S.A.3
Sznol, M.4
Parkinson, D.R.5
Louie, A.C.6
-
4
-
-
16644401873
-
-
McDermott DF, Regan MM, Clark JI, et al. Randomized phase III trial of highdose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 2005;23:133-41. [Erratum, J Clin Oncol 2005;23:2877.]
-
McDermott DF, Regan MM, Clark JI, et al. Randomized phase III trial of highdose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 2005;23:133-41. [Erratum, J Clin Oncol 2005;23:2877.]
-
-
-
-
5
-
-
0033902999
-
Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma
-
Motzer RJ, Murphy BA, Bacik J, et al. Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma. J Clin Oncol 2000;18:2972-80.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2972-2980
-
-
Motzer, R.J.1
Murphy, B.A.2
Bacik, J.3
-
6
-
-
23044461230
-
Randomized phase II/III trial of interferon alfa-2a with and without 13-cisretinoic acid in patients with progressive metastatic renal cell carcinoma: The European Organization for Research and Treat-ment of Cancer Genito-Urinary Tract Cancer Group (EORTC 30951)
-
Aass N, De Mulder HM, Mickisch GHJ, et al. Randomized phase II/III trial of interferon alfa-2a with and without 13-cisretinoic acid in patients with progressive metastatic renal cell carcinoma: the European Organization for Research and Treat-ment of Cancer Genito-Urinary Tract Cancer Group (EORTC 30951). J Clin Oncol 2005;23:4172-8.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4172-4178
-
-
Aass, N.1
De Mulder, H.M.2
Mickisch, G.H.J.3
-
7
-
-
0036138580
-
Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002;20:289-96.
-
(2002)
J Clin Oncol
, vol.20
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
Russo, P.4
Mazumdar, M.5
-
8
-
-
0036739439
-
Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: A report from the Groupe Français d'Immunotherapie
-
Negrier S, Escudier B, Gomez F, et al. Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Français d'Immunotherapie. Ann Oncol 2002;13:1460-8.
-
(2002)
Ann Oncol
, vol.13
, pp. 1460-1468
-
-
Negrier, S.1
Escudier, B.2
Gomez, F.3
-
9
-
-
14144252047
-
Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma
-
Mekhail TM, Abou-Jawde RM, Boumerhi G, et al. Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol 2005;23:832-41.
-
(2005)
J Clin Oncol
, vol.23
, pp. 832-841
-
-
Mekhail, T.M.1
Abou-Jawde, R.M.2
Boumerhi, G.3
-
10
-
-
0034644525
-
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253-62.
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253-62.
-
-
-
-
11
-
-
0345732640
-
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation factor 4E
-
Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation factor 4E. Mol Cell Biol 2004;24:200-16.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 200-216
-
-
Fingar, D.C.1
Richardson, C.J.2
Tee, A.R.3
Cheatham, L.4
Tsou, C.5
Blenis, J.6
-
12
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
-
Hudson CC, Liu M, Chiang GG, et al. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002;22:7004-14.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
-
13
-
-
85030518184
-
-
Skotnicki JS, Leone CL, Smith AL, et al. Design, synthesis and biological evaluation of C-42 hydroxyesters of rapamycin: the identification of CCI-779. Clin Cancer Res 2001;7:Suppl:3749S-3750S. abstract.
-
Skotnicki JS, Leone CL, Smith AL, et al. Design, synthesis and biological evaluation of C-42 hydroxyesters of rapamycin: the identification of CCI-779. Clin Cancer Res 2001;7:Suppl:3749S-3750S. abstract.
-
-
-
-
14
-
-
0042025119
-
Immunophilins, mTOR, and pharmacodynamic strategies for a targeted cancer therapy
-
Harding MW. Immunophilins, mTOR, and pharmacodynamic strategies for a targeted cancer therapy. Clin Cancer Res 2003;9:2882-6.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2882-2886
-
-
Harding, M.W.1
-
15
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004;18:1926-45.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
16
-
-
0034790016
-
mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
Yu K, Toral-Barza L, Discafani C, et al. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 2001;8:249-58.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 249-258
-
-
Yu, K.1
Toral-Barza, L.2
Discafani, C.3
-
17
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
Thomas GV, Tran C, Mellinghoff IK, et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006;12:122-7.
-
(2006)
Nat Med
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
-
18
-
-
33745242315
-
Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
-
Del Bufalo D, Ciuffreda L, Trisciuoglio D, et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 2006;66:5549-54.
-
(2006)
Cancer Res
, vol.66
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
-
19
-
-
0142219359
-
Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway
-
Pantuck AJ, Zeng G, Belldegrun AS, Figlin RA. Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway. Clin Cancer Res 2003;9:4641-52.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4641-4652
-
-
Pantuck, A.J.1
Zeng, G.2
Belldegrun, A.S.3
Figlin, R.A.4
-
20
-
-
2942735384
-
Safety and pharmacokinetics of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond E, Alexandre J, Faivre S, et al. Safety and pharmacokinetics of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004;22:2336-47.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
-
21
-
-
33750321673
-
A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer
-
Hidalgo M, Buckner JC, Erlichman C, et al. A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer. Clin Cancer Res 2006;12:5755-63.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5755-5763
-
-
Hidalgo, M.1
Buckner, J.C.2
Erlichman, C.3
-
22
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM, et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004;22:909-18.
-
(2004)
J Clin Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
-
23
-
-
85030503290
-
Phase 1/2 study of intravenous CCI-779 given in combination with interferon-α to patients with advanced renal cell carcinoma
-
abstract
-
Smith II JW, Ko Y, Dutcher J, et al. Phase 1/2 study of intravenous CCI-779 given in combination with interferon-α to patients with advanced renal cell carcinoma. Proc Am Soc Clin Oncol 2004;22:Suppl:14S. abstract.
-
Proc Am Soc Clin Oncol 2004;22:Suppl:14S
-
-
Smith II, J.W.1
Ko, Y.2
Dutcher, J.3
-
24
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors
-
Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000;92:205-16.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
25
-
-
0018687930
-
A multiple testing procedure for clinical trials
-
O'Brien PC, Fleming TR. A multiple testing procedure for clinical trials. Biometrics 1979;5:549-56.
-
(1979)
Biometrics
, vol.5
, pp. 549-556
-
-
O'Brien, P.C.1
Fleming, T.R.2
-
26
-
-
0027462554
-
Randomized phase II trial of high-dose interleukin-2 either alone or in combination with interferon alfa-2b in advanced renal cell carcinoma
-
Atkins MB, Sparano J, Fisher RI, et al. Randomized phase II trial of high-dose interleukin-2 either alone or in combination with interferon alfa-2b in advanced renal cell carcinoma. J Clin Oncol 1993;11:661-70.
-
(1993)
J Clin Oncol
, vol.11
, pp. 661-670
-
-
Atkins, M.B.1
Sparano, J.2
Fisher, R.I.3
-
27
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115-24.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
28
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356:125-34.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
29
-
-
4644268358
-
Prognostic factors in patients with advanced renal cell carcinoma: Development of an international kidney cancer working group
-
Bukowski RM, Negrier S, Elson P. Prognostic factors in patients with advanced renal cell carcinoma: development of an international kidney cancer working group. Clin Cancer Res 2004;10:6310S-6314S.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Bukowski, R.M.1
Negrier, S.2
Elson, P.3
|