The effects of vasodilating drugs on pH in tumors

Oncology Research

Volumn 11, Issue 4, 1999, Pages 179-185

  Adachi, Eisuke ^a   Tannock, Ian F ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

pH; Tumor physiology; Vasodilating drugs

Indexed keywords

VASODILATOR AGENT;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C3H MOUSE; CELL CULTURE; CELL DIVISION; CELL SURVIVAL; DRUG EFFECT; EXPERIMENTAL NEOPLASM; FEMALE; METABOLISM; MOUSE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PH;

ANIMALS; CELL DIVISION; CELL SURVIVAL; FEMALE; HYDROGEN-ION CONCENTRATION; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; TUMOR CELLS, CULTURED; VASODILATOR AGENTS;

EID: 0033257375     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Tannock, I. F.; Rotin, D. Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res. 49:4373-4384; 1989.
2. Vaupel, P.; Kallinowski, F.; Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res. 49:6449-6456; 1989.
3. Wike-Hooley, J. L.; Haveman, J.; Reinhold, J. S. The relevance of tumour pH to the treatment of malignant disease. Radiother. Oncol. 2:343-366; 1984.
4. Jahde, E.; Glusenkamp, K. H.; Klunder, I.; Hulser, D. F.; Tietze, L. F.; Rajewsky, M. F. Hydrogen ion-mediated enhancement of cytotoxicity of bis-chlorethylating drugs in rat mammary carcinoma cells in vitro. Cancer Res. 49:2965-2972; 1989.
5. Kovin, S. V.; Gerwick, L. E. Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: Role of the transmembrane pH gradient. Br. J. Cancer 77:1580-1585; 1998.
6. Lee, A. H.; Tannock, I. F. Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Res. 58:1901-1908; 1998.
7. Owen, C. S.; Wahl, M. L.; Pooler, P. M.; Coss, R. A.; Leeper, D. B. Temporal association between alterations in proton extrusion and low pH adaptation. Int. J. Hyperthermia 14:227-232; 1998.
8. Jahde, E.; Volk, T.; Atema, A.; Smets, L. A.; Glusenkamp, K. H.; Rajewsky, M. F. pH in human tumor xenografts and transplanted rat tumors: Effect of insulin, inorganic phosphate and m-iodobenzylguanidine. Cancer Res. 52:6209-6215; 1992.
9. Volk, T.; Jahde, E.; Fortmeyer, H. P.; Glusenkamp, K. H.; Rajewsky, M. F. pH in human tumour xenografts: Effect of intravenous administration of glucose. Br. J. Cancer 68:492-500; 1993.
10. Leeper, D. B.; Engin, K.; Thistlethwaite, A. J.; Hitchon, H. D.; Dover, J. D.; Li, D. J.; Tupchong, L. Human tumor extracellular pH as a function of blood glucose concentration. Int. J. Radial. Oncol. Biol. Phys. 28:935-943; 1994.
11. Warren, B. A. The vascular morphology of tumors. In: Peterson, H-I., ed. Tumor blood circulation. Boca Raton: CRC Press; 1979: 1-47.
12. Peterson, H-I. Modification of tumour blood flow - a review. Int. J. Radiat. Biol. 60:201-210; 1991.
13. Babbs, C. F.; DeWitt, D. P.; Voorhees, W. D.; McCaw, J. S.; Chan, R. C. Theoretical feasibility of vasodilator-enhanced local tumor heating. Eur. J. Cancer Clin. Oncol. 18:1137-1146; 1982.
14. Jain, R. K. Transport of molecules in the interstitium: A review. Cancer Res. 47:3039-3051; 1987.
15. Kalmus, J.; Okunieff, P.; Vaupel, P. Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine Fsall tumors. Cancer Res. 50:15-19; 1990.
16. Okunieff, P.; Kallinowski, F.; Vaupel, P.; Neuringer, J. Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P-nuclear magnetic resonance spectroscopy. J. Natl. Cancer Inst. 80:745-750; 1988.
17. Zlotecki, R. A.; Baxter, L. T.; Boucher, Y.; Jain, R. K. Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: Network analysis and mechanistic interpretation. Microvasc. Res. 50:429-143; 1995.
18. Burney, I. A.; Maxwell, R. J.; Griffiths, J. R.; Field, S. B. The potential for prazosin and calcitonin gene-related peptide (CGRP) in causing hypoxia in tumors. Br. J. Cancer 64:683-688; 1991.
19. Hasuda, K.; Lee, C.; Tannock, I. F. Antitumor activity of nigericin and 5-(N-ethyl-N-isopropyl) amiloride: An approach to therapy based on cellular acidification and inhibition of regulation of intracellular pH. Oncol. Res. 6:259-268; 1994.
20. Yamagata, M.; Tannock, I. F. The chronic administration of drugs that inhibit the regulation of intracellular pH: In vitro and antitumor effects. Br. J. Cancer 73:1328-1334; 1996.
21. 2) on the in vivo radiation response of a murine sarcoma. Int. J. Radiat. Oncol. Biol. Phys. 2:903-911; 1999.
22. Volpert, O. V.; Ward, W. F.; Lingen, M. W.; Chesler, L.; Solt, D. B.; Johnson, M. D.; Molteni, A.; Polverini, P. J.; Bouck, N. P. Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats. J. Clin. Invest. 98:671-679; 1996.
23. Hii, S. I.; Nicol, D. L.; Gotley, D. C.; Thompson, L. C.; Green, M. K.; Jonsson, J. R. Captopril inhibits tumor growth in a xenograft model of human renal cell carcinoma. Br. J. Cancer 77:880-883; 1998.
24. Engin, K.; Leeper, D. B.; Thistlethwaite, A. J.; Tupchong, L.; McFarlane, J. D. Tumor extracellular pH as a prognostic factor in thermoradiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 29:125-132; 1994.