메뉴 건너뛰기




Volumn 76, Issue 5, 2000, Pages 589-605

Microenvironment-induced cancer metastasis

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUCOSE; LACTIC ACID; OXYGEN;

EID: 0034037286     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530000138259     Document Type: Review
Times cited : (309)

References (205)
  • 1
    • 0028137580 scopus 로고
    • Mechanism and meaning of cellular oxygen sensing in the organism
    • ACKER, H., 1994, Mechanism and meaning of cellular oxygen sensing in the organism. Respiratory Physiology, 95, 1-10.
    • (1994) Respiratory Physiology , vol.95 , pp. 1-10
    • Acker, H.1
  • 2
    • 0030744115 scopus 로고    scopus 로고
    • Radiation, hypoxia and genetic stimulation: Implications for future therapies
    • ADAMS, G. E., HASAN, N. M. and JOINER, M. C., 1997, Radiation, hypoxia and genetic stimulation: implications for future therapies. Radiotherapy and Oncology, 44, 101-109.
    • (1997) Radiotherapy and Oncology , vol.44 , pp. 101-109
    • Adams, G.E.1    Hasan, N.M.2    Joiner, M.C.3
  • 6
    • 0030716233 scopus 로고    scopus 로고
    • Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype
    • BARSKY, S. H., STERNLICHT, M. D., SAFARIANS, S., NGUYEN, M., CHIN, K., STEWART, S. D., HITI, A. L. and GRAY, J. W., 1997, Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype. Oncogene, 15, 2077-2091.
    • (1997) Oncogene , vol.15 , pp. 2077-2091
    • Barsky, S.H.1    Sternlicht, M.D.2    Safarians, S.3    Nguyen, M.4    Chin, K.5    Stewart, S.D.6    Hiti, A.L.7    Gray, J.W.8
  • 7
    • 0027172514 scopus 로고
    • Characterization of hypoxia-responsive enhancer in the human erythropsoietin gene shows presence of hypoxia-inducible 120-kD nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells
    • BECK, I., WEINMANN, R. and CARO, J., 1993, Characterization of hypoxia-responsive enhancer in the human erythropoietin gene shows presence of hypoxia-inducible 120-kD nuclear DNA-binding protein in erythropoietin-producing and nonproducing cells. Blood, 82, 704-711.
    • (1993) Blood , vol.82 , pp. 704-711
    • Beck, I.1    Weinmann, R.2    Caro, J.3
  • 8
    • 0025836802 scopus 로고
    • Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations
    • BEDFORD, J. S., 1991, Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations. International Journal of Radiation Oncology, Biology, Physics, 21, 1457-1469.
    • (1991) International Journal of Radiation Oncology, Biology, Physics , vol.21 , pp. 1457-1469
    • Bedford, J.S.1
  • 9
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
    • BERGERS, G., JAVAHERIAN, K., LO, K.-M., FOLKMAN, J. and HANAHAN, D., 1999, Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science, 284, 808-812.
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Lo, K.-M.3    Folkman, J.4    Hanahan, D.5
  • 10
    • 0029961624 scopus 로고    scopus 로고
    • Mechanisms and therapeutic implications of angiogenesis
    • BICKNELL, R. and HARRIS, A. L., 1996, Mechanisms and therapeutic implications of angiogenesis. Current Opinion in Oncology, 8, 60-65.
    • (1996) Current Opinion in Oncology , vol.8 , pp. 60-65
    • Bicknell, R.1    Harris, A.L.2
  • 11
    • 0031823016 scopus 로고    scopus 로고
    • The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target
    • BLANCHER, C. and HARRIS, A. L., 1998, The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target. Cancer and Metastasis Reviews, 17, 187-194.
    • (1998) Cancer and Metastasis Reviews , vol.17 , pp. 187-194
    • Blancher, C.1    Harris, A.L.2
  • 12
    • 0025286753 scopus 로고
    • Tumor interactions with the vasculature: Angiogenesis and tumor metastasis
    • BLOOD, C. H. and ZETTER, B. R., 1990, Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochimica and Biophysica Acta, 1032, 89-118.
    • (1990) Biochimica and Biophysica Acta , vol.1032 , pp. 89-118
    • Blood, C.H.1    Zetter, B.R.2
  • 13
    • 0024361530 scopus 로고
    • Identification and characterization of X-ray-induced proteins in human cells
    • BOOTHMAN, D. A., BOUVARD, I. and HUGHES, E. N., 1989, Identification and characterization of X-ray-induced proteins in human cells. Cancer Research, 49, 2871-2879.
    • (1989) Cancer Research , vol.49 , pp. 2871-2879
    • Boothman, D.A.1    Bouvard, I.2    Hughes, E.N.3
  • 18
    • 0018760476 scopus 로고
    • Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
    • BROWN, J. M., 1979, Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. British Journal of Radiology, 52, 650-656.
    • (1979) British Journal of Radiology , vol.52 , pp. 650-656
    • Brown, J.M.1
  • 19
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
    • BROWN, J. M. and GIACCIA, A. J., 1998, The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Research, 58, 1408-1416.
    • (1998) Cancer Research , vol.58 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 20
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • BUNN, H. F. and POYTON, R. O., 1996, Oxygen sensing and molecular adaptation to hypoxia. Physiological Reviews, 76, 839-885.
    • (1996) Physiological Reviews , vol.76 , pp. 839-885
    • Bunn, H.F.1    Poyton, R.O.2
  • 22
    • 0027531680 scopus 로고
    • Role of tyrosine phosphorylation in radiation-induced activation of c-jun protooncogene in human lympho-hematopoietic precursor cells
    • CHAE, H. P., JARVIS, L. J. and UCKUN, F. M., 1993, Role of tyrosine phosphorylation in radiation-induced activation of c-jun protooncogene in human lympho-hematopoietic precursor cells. Cancer Research, 53, 447-451.
    • (1993) Cancer Research , vol.53 , pp. 447-451
    • Chae, H.P.1    Jarvis, L.J.2    Uckun, F.M.3
  • 23
    • 0344791650 scopus 로고    scopus 로고
    • Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma
    • CHALMERS, I. J., HOFLER, H. and ATKINSON, M. J., 1999, Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. Genomics, 57, 160-163.
    • (1999) Genomics , vol.57 , pp. 160-163
    • Chalmers, I.J.1    Hofler, H.2    Atkinson, M.J.3
  • 24
    • 0026592966 scopus 로고
    • 8-Hydroxy-guanine, an abundant form of oxidative DNA damage, causes G-T and A C substitutions
    • CHENG, K. C., CAHILL, D. S., KASAI, H., NISHIMURA, S. and LOEB, L. A., 1992, 8-hydroxy-guanine, an abundant form of oxidative DNA damage, causes G-T and A C substitutions. Journal of Biological Chemistry, 267, 166-172.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 166-172
    • Cheng, K.C.1    Cahill, D.S.2    Kasai, H.3    Nishimura, S.4    Loeb, L.A.5
  • 25
    • 0027354561 scopus 로고
    • Genomic instability and tumor progression: Mechanistic considerations
    • CHENG, K. C. and LOEB, L. A., 1993, Genomic instability and tumor progression: mechanistic considerations. Advances in Cancer Research, 60, 121-156.
    • (1993) Advances in Cancer Research , vol.60 , pp. 121-156
    • Cheng, K.C.1    Loeb, L.A.2
  • 26
    • 0027428950 scopus 로고
    • Beneficial liaisons: Radiobiology meets cellular and molecular biology
    • COLEMAN, C. N., 1993, Beneficial liaisons: radiobiology meets cellular and molecular biology. Radiotherapy and Oncology, 28, 1-15.
    • (1993) Radiotherapy and Oncology , vol.28 , pp. 1-15
    • Coleman, C.N.1
  • 29
    • 0031059664 scopus 로고    scopus 로고
    • Exposure to hypoxia, glucose starvation and acidosis: Effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion
    • CUVIER, C., JANG, A. and HILL, R. P., 1997, Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion. Clinical and Experimental Metastasis, 15, 19-25.
    • (1997) Clinical and Experimental Metastasis , vol.15 , pp. 19-25
    • Cuvier, C.1    Jang, A.2    Hill, R.P.3
  • 31
    • 0029976685 scopus 로고    scopus 로고
    • The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy
    • DACHS, G. U. and STRATFORD, I. J., 1996, The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy. British Journal of Cancer, 74 (Suppl XXVII), s126-s132.
    • (1996) British Journal of Cancer , vol.74 , Issue.SUPPL. XXVII
    • Dachs, G.U.1    Stratford, I.J.2
  • 36
    • 0033580218 scopus 로고    scopus 로고
    • Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma
    • DESBAILLETS, I., DISERENS, A.-C., DE TRIBOLET, N., HAMOU, M.-F. and VAN MEIR, E. G., 1999, Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma. Oncogene, 18, 1447-1456.
    • (1999) Oncogene , vol.18 , pp. 1447-1456
    • Desbaillets, I.1    Diserens, A.-C.2    De Tribolet, N.3    Hamou, M.-F.4    Van Meir, E.G.5
  • 37
    • 0032476059 scopus 로고    scopus 로고
    • Hypoxia regulates β-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
    • DISCHER, D. J., BISHOPRIC, N. H., WU, X., PETERSON, C. A. and WEBSTER, K. A., 1998, Hypoxia regulates β-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. Journal of Biological Chemisty, 273, 26087-26093.
    • (1998) Journal of Biological Chemisty , vol.273 , pp. 26087-26093
    • Discher, D.J.1    Bishopric, N.H.2    Wu, X.3    Peterson, C.A.4    Webster, K.A.5
  • 38
    • 0022891340 scopus 로고
    • Tumours: Wounds that do not heal. Similarity between tumor stroma generation and wound healing
    • DVORAK, H. F., 1986, Tumours: wounds that do not heal. Similarity between tumor stroma generation and wound healing. New England Journal of Medicine, 315, 1650-1658.
    • (1986) New England Journal of Medicine , vol.315 , pp. 1650-1658
    • Dvorak, H.F.1
  • 40
    • 0014975237 scopus 로고
    • Stereology: Applications to biomedical research
    • ELIAS, H., HENNING, A. and SCHWARZ, D. E., 1971, Stereology: applications to biomedical research. Histology Reviews, 51, 158-200.
    • (1971) Histology Reviews , vol.51 , pp. 158-200
    • Elias, H.1    Henning, A.2    Schwarz, D.E.3
  • 42
    • 0030500444 scopus 로고    scopus 로고
    • Vascular endothelial growth factor
    • FERRARA, N., 1996, Vascular endothelial growth factor. European Journal of Cancer, 32A, 2413-2422.
    • (1996) European Journal of Cancer , vol.32 A , pp. 2413-2422
    • Ferrara, N.1
  • 43
    • 0025083071 scopus 로고
    • Critical factors in the biology of human cancer metastasis: Twenty-eighth G. H. A. clowes memorial award lecture
    • FIDLER, I. J., 1990, Critical factors in the biology of human cancer metastasis: twenty-eighth G. H. A. Clowes memorial award lecture. Cancer Research, 50, 6130-6138.
    • (1990) Cancer Research , vol.50 , pp. 6130-6138
    • Fidler, I.J.1
  • 44
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis
    • FIDLER, I. J. and ELLIS, L. M., 1994, The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell, 79, 185-188.
    • (1994) Cell , vol.79 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 47
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • FOLKMAN, J., 1990, What is the evidence that tumors are angiogenesis dependent? Journal of the National Cancer Institute, 82, 4-6.
    • (1990) Journal of the National Cancer Institute , vol.82 , pp. 4-6
    • Folkman, J.1
  • 48
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • FOLKMAN, J., 1995, Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine, 1, 27-31.
    • (1995) Nature Medicine , vol.1 , pp. 27-31
    • Folkman, J.1
  • 53
    • 0030067856 scopus 로고    scopus 로고
    • Hypoxic stress proteins: Survival of the fittest
    • GIACCIA, A. J., 1996, Hypoxic stress proteins: survival of the fittest. Seminars in Radiation Oncology, 6, 46-58.
    • (1996) Seminars in Radiation Oncology , vol.6 , pp. 46-58
    • Giaccia, A.J.1
  • 54
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • GOLDBERG, M. A., DUNNING, S. P. and BUNN, H. F., 1988, Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science, 242, 1412-1415.
    • (1988) Science , vol.242 , pp. 1412-1415
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 55
    • 0029133608 scopus 로고
    • The acid deoxyribo-nuclease of neutrophils: A possible participant in apoptosis-associated genome destruction
    • GOTTLIEB, R. A., GIESING, H. A., ENGLER, R. L. and BABIOR, B. M., 1995, The acid deoxyribo-nuclease of neutrophils: a possible participant in apoptosis-associated genome destruction. Blood, 86, 2414-2418.
    • (1995) Blood , vol.86 , pp. 2414-2418
    • Gottlieb, R.A.1    Giesing, H.A.2    Engler, R.L.3    Babior, B.M.4
  • 56
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediatcd selection of cells with diminished apoptotic potential in solid tumours
    • GRAEBER, T. G., OSMANIAN, C., JACKS, T., HOUSMAN, D. E., KOCH, C. J., LOWE, S. W. and GIACCIA, A. J., 1996, Hypoxia-mediatcd selection of cells with diminished apoptotic potential in solid tumours. Nature, 379, 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 58
    • 0033521864 scopus 로고    scopus 로고
    • Hypoxia-mediatcd stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression
    • GRAHAM, C. H., FORSDIKE, J., FITZGERALD, C. J. and MACDONALD-GOODFELLOW, S., 1999, Hypoxia-mediatcd stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. International Journal of Cancer, 80, 617-623.
    • (1999) International Journal of Cancer , vol.80 , pp. 617-623
    • Graham, C.H.1    Forsdike, J.2    Fitzgerald, C.J.3    MacDonald-Goodfellow, S.4
  • 59
    • 0031058350 scopus 로고    scopus 로고
    • The influence of oxygen tension and ph on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown m vitro and in vivo
    • GRIFFITHS, L., DACHS, G. U., BICKNELL, R., HARRIS, A. L. and STRATFORD, I. J., 1997, The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown m vitro and in vivo. Cancer Research, 57, 570-572.
    • (1997) Cancer Research , vol.57 , pp. 570-572
    • Griffiths, L.1    Dachs, G.U.2    Bicknell, R.3    Harris, A.L.4    Stratford, I.J.5
  • 60
    • 0030963616 scopus 로고    scopus 로고
    • The hypoxic response: Huffing and HIFing
    • GUILLEMIN, K. and KRASNOW, M. A., 1997, The hypoxic response: huffing and HIFing. Cell, 89, 9-12.
    • (1997) Cell , vol.89 , pp. 9-12
    • Guillemin, K.1    Krasnow, M.A.2
  • 61
    • 0029994483 scopus 로고    scopus 로고
    • Tumor oxygenation: A matter of supply and demand
    • GULLEDGE, C. J. and DEWHIRST, M. W., 1996, Tumor oxygenation: a matter of supply and demand. Anticancer Research, 16, 741-750.
    • (1996) Anticancer Research , vol.16 , pp. 741-750
    • Gulledge, C.J.1    Dewhirst, M.W.2
  • 62
    • 0001496579 scopus 로고
    • Extracellular compartments of solid tumors
    • edited by F. F. Becker (New York: Plenum Press)
    • GULLINO, P. M., 1975, Extracellular compartments of solid tumors. In Cancer, Vol. 3, edited by F. F. Becker (New York: Plenum Press), pp. 327-354.
    • (1975) Cancer , vol.3 , pp. 327-354
    • Gullino, P.M.1
  • 63
    • 0026005817 scopus 로고
    • Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation
    • HALLAHAN, D. R., VIRUDACHALAM, S., SHERMAN, M. L., HUBERMAN, E., KUFE, D. W. and WEICHSELBAUM, R. R., 1991, Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation. Cancer Research, 51, 4565-4569.
    • (1991) Cancer Research , vol.51 , pp. 4565-4569
    • Hallahan, D.R.1    Virudachalam, S.2    Sherman, M.L.3    Huberman, E.4    Kufe, D.W.5    Weichselbaum, R.R.6
  • 65
    • 0023612009 scopus 로고
    • The significance of local control in the primary treatment of breast cancer
    • HAYWARD, J. and CALEFFI, M., 1987, The significance of local control in the primary treatment of breast cancer. Archives of Surgery, 122, 1244-1247.
    • (1987) Archives of Surgery , vol.122 , pp. 1244-1247
    • Hayward, J.1    Caleffi, M.2
  • 66
    • 0025025779 scopus 로고
    • Tumor progression: Potential role of unstable genomic changes
    • HILL, R. P., 1990, Tumor progression: potential role of unstable genomic changes. Cancer Metastasis Reviews, 9, 137-147.
    • (1990) Cancer Metastasis Reviews , vol.9 , pp. 137-147
    • Hill, R.P.1
  • 67
    • 85037959100 scopus 로고    scopus 로고
    • Hypoxia and metastasis
    • University of Ulster at Jordanstown, Newtownabbey, Northern Ireland, 15-17 July 1999, Abstract 3.3
    • HILL, R. P., BRAIL, L. H., JANG, A. and DE JAEGER, K., 1999, Hypoxia and metastasis. International Workshop: The Tumour Microenvironment, University of Ulster at Jordanstown, Newtownabbey, Northern Ireland, 15-17 July 1999, Abstract 3.3.
    • (1999) International Workshop: The Tumour Microenvironment
    • Hill, R.P.1    Brail, L.H.2    Jang, A.3    De Jaeger, K.4
  • 69
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • HÖCKEL, M., SCHLENGER, K., ARAL, B., MITZE, M., SCHÄFFER, U. and VAUPEL, P., 1996, Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Research, 56, 4509-4515.
    • (1996) Cancer Research , vol.56 , pp. 4509-4515
    • Höckel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schäffer, U.5    Vaupel, P.6
  • 71
    • 0037480606 scopus 로고    scopus 로고
    • Hypoxic cervical cancers with low apoptotic index are highly aggressive
    • HÖCKEL, M., SCHLENGER, K., HÖCKEL, S. and VAUPEL, P., 1999, Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Research, 59, 4525-4528.
    • (1999) Cancer Research , vol.59 , pp. 4525-4528
    • Höckel, M.1    Schlenger, K.2    Höckel, S.3    Vaupel, P.4
  • 73
    • 0027730121 scopus 로고
    • Tumor oxygenation: A new predictive parameter in locally advanced cancer of the uterine cervix
    • HÖCKEL, M., VORNDRAN, B., SCHLENGER, K., BAUSSMANN, E. and KNAPSTEIN, P. G., 1993b, Tumor oxygenation: a new predictive parameter in locally advanced cancer of the uterine cervix. Gynecologic Oncology, 51, 141-149.
    • (1993) Gynecologic Oncology , vol.51 , pp. 141-149
    • Höckel, M.1    Vorndran, B.2    Schlenger, K.3    Baussmann, E.4    Knapstein, P.G.5
  • 74
    • 0029123236 scopus 로고
    • Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours
    • HORSMAN, M. R., 1995, Nicotinamide and other benzamide analogs as agents for overcoming hypoxic cell radiation resistance in tumours. Acta Oncologica, 34, 571-587.
    • (1995) Acta Oncologica , vol.34 , pp. 571-587
    • Horsman, M.R.1
  • 75
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit
    • HUANG, L. E., ARANY, Z., LIVINGSTON, D. M. and BUNN, H. F., 1996, Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit. Journal of Biological Chemistry, 271, 32253-32259.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 76
    • 0030873998 scopus 로고    scopus 로고
    • An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells
    • JANG, A. and HILL, R. P., 1997, An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells. Clinical and Experimental Metastasis, 15, 469-483.
    • (1997) Clinical and Experimental Metastasis , vol.15 , pp. 469-483
    • Jang, A.1    Hill, R.P.2
  • 78
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • JIANG, B.-H., AGANI, F., PASSANITI, A. and SEMENZA, G. L., 1997, V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Research, 57, 5328-5335.
    • (1997) Cancer Research , vol.57 , pp. 5328-5335
    • Jiang, B.-H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 81
    • 0015412531 scopus 로고
    • The phenomenon of reoxygenation and its implications for fractionated radiotherapy
    • KALLMAN, R. F., 1972, The phenomenon of reoxygenation and its implications for fractionated radiotherapy. Radiology, 105, 135-142.
    • (1972) Radiology , vol.105 , pp. 135-142
    • Kallman, R.F.1
  • 82
    • 0026667311 scopus 로고
    • Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines
    • KATO, Y., NAKAYAMA, Y., UMEDA, M. and MIYAZAKI, K., 1992, Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines. Journal of Biological Chemistry, 267, 11424-11430.
    • (1992) Journal of Biological Chemistry , vol.267 , pp. 11424-11430
    • Kato, Y.1    Nakayama, Y.2    Umeda, M.3    Miyazaki, K.4
  • 83
    • 0024252321 scopus 로고
    • Clonal dominance of primary tumours by metastatic cells: Genetic analysis and biological implications
    • KERBEL, R. S., WAGHORNE, C., KORCZAK, B., LAGARDE, A. and BREITMAN, M. L., 1988, Clonal dominance of primary tumours by metastatic cells: genetic analysis and biological implications. Cancer Surveys, 7, 597-629.
    • (1988) Cancer Surveys , vol.7 , pp. 597-629
    • Kerbel, R.S.1    Waghorne, C.2    Korczak, B.3    Lagarde, A.4    Breitman, M.L.5
  • 85
    • 0030592517 scopus 로고    scopus 로고
    • Lessons form hereditary colorectal cancer
    • KINZLER, K. W. and VOGELSTEIN, B., 1996a, Lessons form hereditary colorectal cancer. Cell, 87, 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 86
    • 0030025772 scopus 로고    scopus 로고
    • Life (and death) in a malignant tumour
    • KANZLER, K. W. and VOGELSTEIN, B., 1996b, Life (and death) in a malignant tumour. Nature, 379, 19-20.
    • (1996) Nature , vol.379 , pp. 19-20
    • Kanzler, K.W.1    Vogelstein, B.2
  • 89
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor κB through phosphorylation of IκBα on tyrosine residues
    • KOONG, A. C., CHEN, E. Y. and GIACCIA, A. J., 1994, Hypoxia causes the activation of nuclear factor κB through phosphorylation of IκBα on tyrosine residues. Cancer Research, 54, 1425-1430.
    • (1994) Cancer Research , vol.54 , pp. 1425-1430
    • Koong, A.C.1    Chen, E.Y.2    Giaccia, A.J.3
  • 90
    • 0031955521 scopus 로고    scopus 로고
    • Angiogenic molecules and cancer metastasis
    • KUMAR, R. and FIDLER, I. J., 1998, Angiogenic molecules and cancer metastasis. In Vivo, 12, 27-34.
    • (1998) In Vivo , vol.12 , pp. 27-34
    • Kumar, R.1    Fidler, I.J.2
  • 91
    • 0026758210 scopus 로고
    • Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen
    • LADEROUTE, K. R., GRANT, T. D., MURPHY, B. J. and SUTHERLAND, R. M., 1992, Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen. International Journal of Cancer, 52, 428-432.
    • (1992) International Journal of Cancer , vol.52 , pp. 428-432
    • Laderoute, K.R.1    Grant, T.D.2    Murphy, B.J.3    Sutherland, R.M.4
  • 92
    • 0025302535 scopus 로고
    • Multistage neoplastic transformation of Syrian hamster embryo eells cultured at pH 6.7
    • LEBOEUF, R. A., KERCKAERT, G. A., AARDEMA, M. J. and GIBSON, D. P., 1990, Multistage neoplastic transformation of Syrian hamster embryo eells cultured at pH 6.7. Cancer Research, 50, 3722-3729.
    • (1990) Cancer Research , vol.50 , pp. 3722-3729
    • Leboeuf, R.A.1    Kerckaert, G.A.2    Aardema, M.J.3    Gibson, D.P.4
  • 93
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • LENGAUER, C., KINZLER, K. W. and VOGELSTEIN, B., 1998, Genetic instabilities in human cancers. Nature, 396, 643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 95
    • 0029795584 scopus 로고    scopus 로고
    • Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein
    • LEVY, A. P., LEVY, N. S. and GOLDBERG, M. A., 1996, Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein. Journal of Biological Chemistry, 271, 25492-25497.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 25492-25497
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 96
    • 0023893386 scopus 로고
    • Gene products which play a role in cancer invasion and metastasis
    • LIOTTA, L. A., 1988, Gene products which play a role in cancer invasion and metastasis. Breast Cancer Research and Treatment, 11, 113-124.
    • (1988) Breast Cancer Research and Treatment , vol.11 , pp. 113-124
    • Liotta, L.A.1
  • 97
    • 0026536653 scopus 로고
    • Cancer cell invasion and metastasis
    • LIOTTA, L. A., 1992, Cancer cell invasion and metastasis. Scientific American, 266, 34-41.
    • (1992) Scientific American , vol.266 , pp. 34-41
    • Liotta, L.A.1
  • 98
    • 0026425631 scopus 로고
    • Tumor invasion and metastasis: An imbalance of positive and negative regulation
    • LIOTTA, L. A. and STETLER-STEVENSON, W. G., 1991, Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Research, 51, 5054s-5059s.
    • (1991) Cancer Research , vol.51
    • Liotta, L.A.1    Stetler-Stevenson, W.G.2
  • 99
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • LU, X. and LANE, D. P., 1993, Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell, 75, 765-778.
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 100
    • 0031753290 scopus 로고    scopus 로고
    • Molecular changes in human melanoma metastasis
    • LUCA, M. R. and BAR-ELI, M., 1998, Molecular changes in human melanoma metastasis. Histology and Histopathology, 13, 1225-1231.
    • (1998) Histology and Histopathology , vol.13 , pp. 1225-1231
    • Luca, M.R.1    Bar-Eli, M.2
  • 103
    • 0025255214 scopus 로고
    • Metastasis and angiogenesis
    • MAHADEVAN, V. and HART, I. R., 1990, Metastasis and angiogenesis. Acta Oncologica, 29, 97-103.
    • (1990) Acta Oncologica , vol.29 , pp. 97-103
    • Mahadevan, V.1    Hart, I.R.2
  • 104
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • MALTEPE, E., SCHMIDT, J. V., BAUNOCH, D., BRADFIELD, C. A. and SIMON, M. C., 1997, Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature, 386, 403-407.
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3    Bradfield, C.A.4    Simon, M.C.5
  • 109
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression
    • MAZURE, N. M., CHEN, E. Y., YEH, P., LADEROUTE, K. R. and GIACCIA, A. J., 1996, Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Research, 56, 3436-3440.
    • (1996) Cancer Research , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3    Laderoute, K.R.4    Giaccia, A.J.5
  • 110
    • 0029867951 scopus 로고    scopus 로고
    • Metastasis suppressed, but tumorigenicity and local invasiveness unaffected, in the human melanoma cell line MelJuSo after introduction of human chromosomes 1 or 6
    • MIELE, M. E., ROBERTSON, G., LEE, J. H., COLEMAN, A., MCGARY, C. T., FISHER, P. B., LUGO, T. G. and WELCH, D. R., 1996, Metastasis suppressed, but tumorigenicity and local invasiveness unaffected, in the human melanoma cell line MelJuSo after introduction of human chromosomes 1 or 6. Molecular Carcinogenesis, 15, 284-299.
    • (1996) Molecular Carcinogenesis , vol.15 , pp. 284-299
    • Miele, M.E.1    Robertson, G.2    Lee, J.H.3    Coleman, A.4    McGary, C.T.5    Fisher, P.B.6    Lugo, T.G.7    Welch, D.R.8
  • 111
    • 0029897419 scopus 로고    scopus 로고
    • The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis
    • MORANA, S. J., WOLF, C. M., LI, J., REYNOLDS, J. E., BROWN, M. K. and EASTMAN, A., 1996, The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis. Journal of Biological Chemistry, 271, 18263-18271.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 18263-18271
    • Morana, S.J.1    Wolf, C.M.2    Li, J.3    Reynolds, J.E.4    Brown, M.K.5    Eastman, A.6
  • 112
  • 116
    • 0023922762 scopus 로고
    • Role of oncogenes in metastases
    • MUSCHEL, R. and LIOTTA, L. A., 1988, Role of oncogenes in metastases. Carcinogenesis, 9, 705-710.
    • (1988) Carcinogenesis , vol.9 , pp. 705-710
    • Muschel, R.1    Liotta, L.A.2
  • 117
    • 0028834106 scopus 로고
    • Pathogenesis of ascites tumor growth. Vascular permeability factor, vascular hyperpermeability and ascites fluid accumulation
    • NAGY, J. A., MASSE, E. M., HERZBERG, K. T., MEYERS, M. S., YEO, K. T., YEO, T. K., SIOUSSAT, T. M. and DVORAK, H. F., 1995, Pathogenesis of ascites tumor growth. Vascular permeability factor, vascular hyperpermeability and ascites fluid accumulation. Cancer Research, 55, 360-368.
    • (1995) Cancer Research , vol.55 , pp. 360-368
    • Nagy, J.A.1    Masse, E.M.2    Herzberg, K.T.3    Meyers, M.S.4    Yeo, K.T.5    Yeo, T.K.6    Sioussat, T.M.7    Dvorak, H.F.8
  • 118
    • 0023095251 scopus 로고
    • Tumor cell instability, diversification, and progression to the metastatic phenotype: From oncogene to oncofetal expression
    • NICOLSON, G. L., 1987, Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression. Cancer Research, 47, 1473-1487.
    • (1987) Cancer Research , vol.47 , pp. 1473-1487
    • Nicolson, G.L.1
  • 119
    • 0027318445 scopus 로고
    • Cancer progression and growth: Relationship of paracrine and autocrine growth mechanisms to organ preference of metastasis
    • NICOLSON, G. L., 1993, Cancer progression and growth: relationship of paracrine and autocrine growth mechanisms to organ preference of metastasis. Experimental Cell Research, 204, 171-180.
    • (1993) Experimental Cell Research , vol.204 , pp. 171-180
    • Nicolson, G.L.1
  • 121
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • NORDSMARK, M., OVERGAARD, M. and OVERGAARD, J., 1996, Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiotherapy and Oncology, 41, 31-39.
    • (1996) Radiotherapy and Oncology , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 122
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • NOWELL, P. C., 1976, The clonal evolution of tumor cell populations. Science, 194, 23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 123
    • 0022600767 scopus 로고
    • Mechanisms of tumor progression
    • NOWELL, P. C., 1986, Mechanisms of tumor progression. Cancer Research, 46, 2203-2207.
    • (1986) Cancer Research , vol.46 , pp. 2203-2207
    • Nowell, P.C.1
  • 124
    • 0024328273 scopus 로고
    • Chromosomal and molecular clues to tumor progression
    • NOWELL, P. C., 1989, Chromosomal and molecular clues to tumor progression. Seminars in Oncology, 16, 116-127.
    • (1989) Seminars in Oncology , vol.16 , pp. 116-127
    • Nowell, P.C.1
  • 125
    • 0026717548 scopus 로고
    • Radiation-induced increased expression of the αII/β3 integrin in melanoma cells: Effects on metastatic potential
    • ONODA, J. M., PIECHOKI, M. P. and HONN, H. V., 1992, Radiation-induced increased expression of the αII/β3 integrin in melanoma cells: effects on metastatic potential. Radiation Research, 130, 281-288.
    • (1992) Radiation Research , vol.130 , pp. 281-288
    • Onoda, J.M.1    Piechoki, M.P.2    Honn, H.V.3
  • 126
    • 0024539516 scopus 로고
    • Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells
    • OTTO, E., MCCORD, S. and TLSTY, T. D., 1989, Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells. Journal of Biological Chemistry, 264, 3390-3396.
    • (1989) Journal of Biological Chemistry , vol.264 , pp. 3390-3396
    • Otto, E.1    McCord, S.2    Tlsty, T.D.3
  • 127
    • 0030200651 scopus 로고    scopus 로고
    • Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry
    • PIGOTT, K. H., HILL, S. A., CHAPLIN, D. J. and SAUNDERS, M. I., 1996, Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry. Radiotherapy and Oncology, 40, 45-50.
    • (1996) Radiotherapy and Oncology , vol.40 , pp. 45-50
    • Pigott, K.H.1    Hill, S.A.2    Chaplin, D.J.3    Saunders, M.I.4
  • 128
    • 0024816246 scopus 로고
    • Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells
    • PLOUET, J., SCHILLING, J. and GOSPODAROWICZ, D., 1989, Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells. EMBO Journal, 8, 3801-3806.
    • (1989) EMBO Journal , vol.8 , pp. 3801-3806
    • Plouet, J.1    Schilling, J.2    Gospodarowicz, D.3
  • 129
    • 0017665008 scopus 로고
    • Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation
    • POUYSSÉGUR, J., SHIU, R. P. C. and PASTAN, I., 1977, Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation. Cell, 11, 941-947.
    • (1977) Cell , vol.11 , pp. 941-947
    • Pouysségur, J.1    Shiu, R.P.C.2    Pastan, I.3
  • 130
    • 0028822834 scopus 로고
    • Mutant ras oncogenes up-regulate VEGF/VPF expression - Implications for induction and inhibition of tumor angiogenesis
    • RAK, J., MITSUHASHI, Y., BAYKO, L., FILMUS, J., SHIRASAWA, S., SASAZUKI, T. and KERBEL, R. S., 1995, Mutant ras oncogenes up-regulate VEGF/VPF expression - implications for induction and inhibition of tumor angiogenesis. Cancer Research, 55, 4575-4580.
    • (1995) Cancer Research , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3    Filmus, J.4    Shirasawa, S.5    Sasazuki, T.6    Kerbel, R.S.7
  • 131
    • 0026576030 scopus 로고
    • Differential expression of proteins in radioresistant and radiosensitive human squamous carcinoma cells
    • RAMSAMOOJ, P., KASID, U. and DRITSCHILO, A., 1992, Differential expression of proteins in radioresistant and radiosensitive human squamous carcinoma cells. Journal of the National Cancer Institute, 84, 622-628.
    • (1992) Journal of the National Cancer Institute , vol.84 , pp. 622-628
    • Ramsamooj, P.1    Kasid, U.2    Dritschilo, A.3
  • 132
    • 0023753661 scopus 로고
    • Experimental studies of the incidence of metastases after failure of radiation treatment and the effect of salvage surgery
    • RAMSAY, J., SUIT, H. D. and SEDLACEK, R., 1988, Experimental studies of the incidence of metastases after failure of radiation treatment and the effect of salvage surgery. International Journal of Radiation Oncology, Biology, Physics, 14, 1165-1168.
    • (1988) International Journal of Radiation Oncology, Biology, Physics , vol.14 , pp. 1165-1168
    • Ramsay, J.1    Suit, H.D.2    Sedlacek, R.3
  • 133
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • REYNOLDS, T. Y., ROCKWELL, S. and GLAZER, P. M., 1996, Genetic instability induced by the tumor microenvironment. Cancer Research, 56, 5754-5757.
    • (1996) Cancer Research , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 136
    • 0031936861 scopus 로고    scopus 로고
    • Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma
    • ROFSTAD, E. K. and DANIELSEN, T., 1998, Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma. British Journal of Cancer, 77, 897-902.
    • (1998) British Journal of Cancer , vol.77 , pp. 897-902
    • Rofstad, E.K.1    Danielsen, T.2
  • 137
    • 0032774194 scopus 로고    scopus 로고
    • Hypoxia-induced metastasis of human melanoma cells: Involvement of vascular endothelial growth factor-mediated angiogenesis
    • ROFSTAD, E. K. and DANIELSEN, T., 1999, Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis. British Journal of Cancer, 80, 1697-1707.
    • (1999) British Journal of Cancer , vol.80 , pp. 1697-1707
    • Rofstad, E.K.1    Danielsen, T.2
  • 139
    • 0028618307 scopus 로고
    • Pericellular pH affects distribution and secretion of cathepsin B in malignant cells
    • ROZHIN J., SAMENI, M., SIEGLER, G. and SLOANE, B. F., 1994, Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Cancer Research, 54, 6517-6525.
    • (1994) Cancer Research , vol.54 , pp. 6517-6525
    • Rozhin, J.1    Sameni, M.2    Siegler, G.3    Sloane, B.F.4
  • 141
    • 0024852986 scopus 로고
    • Tumor suppressor genes: The puzzle and the promise
    • SAGER, R., 1989, Tumor suppressor genes: the puzzle and the promise. Science, 246, 1406-1412.
    • (1989) Science , vol.246 , pp. 1406-1412
    • Sager, R.1
  • 142
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor I alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions - Its stabilization by hypoxia depends on redox-induced changes
    • SALCEDA, S. and CARO, J., 1997, Hypoxia-inducible factor I alpha (HIF-1 alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions - its stabilization by hypoxia depends on redox-induced changes. Journal of Biological Chemistry, 272, 22642-22647.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 143
    • 13844320300 scopus 로고
    • Gene amplification: What are we learning?
    • SCHIMKE, R. T., 1992, Gene amplification: what are we learning? Mutation Research, 276, 145-149.
    • (1992) Mutation Research , vol.276 , pp. 145-149
    • Schimke, R.T.1
  • 144
    • 0023621716 scopus 로고
    • Amplification of genes in somatic mammalian cells
    • SCHIMKE, R. T., ROOS, D. S. and BROWN, P. C., 1987, Amplification of genes in somatic mammalian cells. Methods in Enzymology, 151, 85-104.
    • (1987) Methods in Enzymology , vol.151 , pp. 85-104
    • Schimke, R.T.1    Roos, D.S.2    Brown, P.C.3
  • 145
    • 0021941053 scopus 로고
    • Cancer metastasis: Experimental approaches, theoretical concepts, and impacts for treatment strategies
    • SCHIRRMACHER, V., 1985, Cancer metastasis: experimental approaches, theoretical concepts, and impacts for treatment strategies. Advances in Cancer Research, 43, 1-73.
    • (1985) Advances in Cancer Research , vol.43 , pp. 1-73
    • Schirrmacher, V.1
  • 146
    • 0025771024 scopus 로고
    • Glucose starvation and acidosis: Effect on experimental metastalic potential, DNA content and MTX resistance of murine tumour cells
    • SCHLAPPAK, O. K., ZIMMERMANN, A. and HILL, R. P., 1991, Glucose starvation and acidosis: effect on experimental metastalic potential, DNA content and MTX resistance of murine tumour cells. British Journal of Cancer, 64, 663-670.
    • (1991) British Journal of Cancer , vol.64 , pp. 663-670
    • Schlappak, O.K.1    Zimmermann, A.2    Hill, R.P.3
  • 147
    • 0028784650 scopus 로고
    • Correlation of high lactate levels in human cervical cancer with incidence of metastasis
    • SCHWICKERT, G., WALENTA, S., SUNDFØR, K., ROFSTAD, E. K. and MUELLER-KLIESER, W., 1995, Correlation of high lactate levels in human cervical cancer with incidence of metastasis. Cancer Research, 55, 4757-4759.
    • (1995) Cancer Research , vol.55 , pp. 4757-4759
    • Schwickert, G.1    Walenta, S.2    Sundfør, K.3    Rofstad, E.K.4    Mueller-Klieser, W.5
  • 148
    • 0021075626 scopus 로고
    • The effects of glucose on protein synthesis and thermosensitivity in Chinese hamster ovary cells
    • SCIANDRA, J. J. and SUBJECK, J. R., 1983, The effects of glucose on protein synthesis and thermosensitivity in Chinese hamster ovary cells. Journal of Biological Chemistry, 258, 12091-12093.
    • (1983) Journal of Biological Chemistry , vol.258 , pp. 12091-12093
    • Sciandra, J.J.1    Subjeck, J.R.2
  • 149
    • 0032473399 scopus 로고    scopus 로고
    • Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines
    • SCOTT, P. A. E., GLEADLE, J. M., BICKNELL, R. and HARRIS, A. L., 1998, Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines. International Journal of Cancer, 75, 706-712.
    • (1998) International Journal of Cancer , vol.75 , pp. 706-712
    • Scott, P.A.E.1    Gleadle, J.M.2    Bicknell, R.3    Harris, A.L.4
  • 150
    • 0033529656 scopus 로고    scopus 로고
    • Perspectives on oxygen sensing
    • SEMENZA, G. L., 1999, Perspectives on oxygen sensing. Cell, 98, 281-284.
    • (1999) Cell , vol.98 , pp. 281-284
    • Semenza, G.L.1
  • 151
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • SENGER, D. R., GALLI, S. J., DVORAK, A. M., PERUZZI, C. A., HARVEY, V. S. and DVORAK, H. F., 1983, Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science, 219, 983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Peruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 152
    • 0028123571 scopus 로고
    • The propensity for gene amplification: A comparison of protocols, cell lines and selection agents
    • SHARMA, R. C. and SCHIMKE, R. T., 1994, The propensity for gene amplification: a comparison of protocols, cell lines and selection agents. Mutation Research, 304, 243-260.
    • (1994) Mutation Research , vol.304 , pp. 243-260
    • Sharma, R.C.1    Schimke, R.T.2
  • 153
    • 0016290179 scopus 로고
    • The incidence of lung metastases in C3H mice after treatment of implanted solid tumours with x-rays or surgery
    • SHELDON, P. W., BEGG, A. C., FOWLER, J. F. and LANSLEY, I. F., 1974, The incidence of lung metastases in C3H mice after treatment of implanted solid tumours with x-rays or surgery. British Journal of Cancer, 30, 342-348.
    • (1974) British Journal of Cancer , vol.30 , pp. 342-348
    • Sheldon, P.W.1    Begg, A.C.2    Fowler, J.F.3    Lansley, I.F.4
  • 154
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • SHWEIKI, D., ITIN, A., SOFFER, D. and KESHET, E., 1992, Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature, 359, 843-845.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 155
    • 0028870050 scopus 로고
    • Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis
    • SHWEIKI, D., NEEMAN, M., ITIN, A. and KESHET, E., 1995, Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 92, 768-772.
    • (1995) Proceedings of the National Academy of Sciences of the United States of America , vol.92 , pp. 768-772
    • Shweiki, D.1    Neeman, M.2    Itin, A.3    Keshet, E.4
  • 158
    • 0031696089 scopus 로고    scopus 로고
    • Changes in tumor oxygenation during combined treatment with split-course radiotherapy and chemotherapy in patients with head and neck cancer
    • STADLER, P., FELDMANN, H. J., CREIGHTON, C., KAU, R. and MOLLS, M., 1998, Changes in tumor oxygenation during combined treatment with split-course radiotherapy and chemotherapy in patients with head and neck cancer. Radiotherapy and Oncology, 48, 157-164.
    • (1998) Radiotherapy and Oncology , vol.48 , pp. 157-164
    • Stadler, P.1    Feldmann, H.J.2    Creighton, C.3    Kau, R.4    Molls, M.5
  • 159
    • 0022839051 scopus 로고
    • DNA amplification in drug resistant cells and in tumours
    • STARK, G. R., 1986, DNA amplification in drug resistant cells and in tumours. Cancer Surveys, 5, 1-23.
    • (1986) Cancer Surveys , vol.5 , pp. 1-23
    • Stark, G.R.1
  • 160
    • 0029082384 scopus 로고
    • Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
    • STEIN, I., NEEMAN, M., SHWEIKI, D., ITIN, A. and KESHET, E., 1995, Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Molecular and Cellular Biology, 15, 5363-5368.
    • (1995) Molecular and Cellular Biology , vol.15 , pp. 5363-5368
    • Stein, I.1    Neeman, M.2    Shweiki, D.3    Itin, A.4    Keshet, E.5
  • 161
    • 0026787669 scopus 로고
    • Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells
    • STOLER, D. L., ANDERSON, G. R., RUSSO, C. A., SPINA, A. M. and BEERMAN, T. A., 1992, Anoxia-inducible endonuclease activity as a potential basis of the genomic instability of cancer cells. Cancer Research, 52, 4372-4378.
    • (1992) Cancer Research , vol.52 , pp. 4372-4378
    • Stoler, D.L.1    Anderson, G.R.2    Russo, C.A.3    Spina, A.M.4    Beerman, T.A.5
  • 162
    • 0019985516 scopus 로고
    • Potential for improving survival rates for the cancer patient by increasing the efficacy of treatment of the primary lesion
    • SUIT, H. D., 1982, Potential for improving survival rates for the cancer patient by increasing the efficacy of treatment of the primary lesion. Cancer, 50, 1227-1234.
    • (1982) Cancer , vol.50 , pp. 1227-1234
    • Suit, H.D.1
  • 165
    • 0031688165 scopus 로고    scopus 로고
    • Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    • SUNDFØR, K., LYNG, H. and ROFSTAD, E. K., 1998, Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix. British Journal of Cancer, 78, 822-827.
    • (1998) British Journal of Cancer , vol.78 , pp. 822-827
    • Sundfør, K.1    Lyng, H.2    Rofstad, E.K.3
  • 166
    • 0031735450 scopus 로고    scopus 로고
    • Tumor hypoxia and gene expression
    • SUTHERLAND, R. M., 1998, Tumor hypoxia and gene expression. Acta Oncologica, 37, 567-574.
    • (1998) Acta Oncologica , vol.37 , pp. 567-574
    • Sutherland, R.M.1
  • 168
    • 0028852057 scopus 로고
    • Metabolic imaging in tumours by means of bioluminescence
    • TAMULEVICIUS, P. and STREFFER, C., 1995, Metabolic imaging in tumours by means of bioluminescence. British Journal of Cancer, 72, 1102-1112.
    • (1995) British Journal of Cancer , vol.72 , pp. 1102-1112
    • Tamulevicius, P.1    Streffer, C.2
  • 169
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • THOMLINSON, R. H. and GRAY, L. H., 1955, The histological structure of some human lung cancers and the possible implications for radiotherapy. British Journal of Cancer, 9, 539-549.
    • (1955) British Journal of Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 170
    • 0032774407 scopus 로고    scopus 로고
    • Metastasis-related genes in prostate cancer: The role of caveolin-1
    • THOMPSON, T. C., 1999, Metastasis-related genes in prostate cancer: the role of caveolin-1. Cancer and Metastasis Reviews, 17, 439-442.
    • (1999) Cancer and Metastasis Reviews , vol.17 , pp. 439-442
    • Thompson, T.C.1
  • 171
    • 0024357990 scopus 로고
    • Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis
    • TLSTY, T. D., MARGOLIN, B. and LUM, K., 1989, Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis. Proceedings of the National Academy of Sciences of the United States of America, 86, 9441-9445.
    • (1989) Proceedings of the National Academy of Sciences of the United States of America , vol.86 , pp. 9441-9445
    • Tlsty, T.D.1    Margolin, B.2    Lum, K.3
  • 172
    • 0018590846 scopus 로고
    • Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis
    • TURNER, G. A., 1979, Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis. Experentia, 35, 1657-1658.
    • (1979) Experentia , vol.35 , pp. 1657-1658
    • Turner, G.A.1
  • 173
    • 0026446859 scopus 로고
    • Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
    • UNEMORI, E. N., FERRARA, N., BAUER, E. A. and AMENTO, A. P., 1992, Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. Journal of Cellular Physiology, 153, 557-562.
    • (1992) Journal of Cellular Physiology , vol.153 , pp. 557-562
    • Unemori, E.N.1    Ferrara, N.2    Bauer, E.A.3    Amento, A.P.4
  • 175
    • 0029840367 scopus 로고    scopus 로고
    • Activation of cathepsin B secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D
    • VAN DER STAPPEN, J. W., WILLIAMS, A. C., MACIEWICZ, R. A. and PARASKEVA, C., 1996, Activation of cathepsin B secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D. International Journal of Cancer, 67, 547-554.
    • (1996) International Journal of Cancer , vol.67 , pp. 547-554
    • Van Der Stappen, J.W.1    Williams, A.C.2    Maciewicz, R.A.3    Paraskeva, C.4
  • 176
  • 177
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • VAUPEL, P., KALLINOWSKI, F. and OKUNIEFF, P., 1989, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Research, 49, 6449-6465.
    • (1989) Cancer Research , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 180
    • 0023678834 scopus 로고
    • Genetic instability of cancer: Why a metastatic tumor is unstable and a benign tumor is stable
    • VOLPE, J. P. G., 1988, Genetic instability of cancer: why a metastatic tumor is unstable and a benign tumor is stable. Cancer Genetics and Cytogenetics, 34, 125-134.
    • (1988) Cancer Genetics and Cytogenetics , vol.34 , pp. 125-134
    • Volpe, J.P.G.1
  • 182
    • 0023790913 scopus 로고
    • Genetic evidence for progressive selection and overgrowth of primary tumors by metastatic cell subpopulations
    • WAGHORNE, C., THOMAS, M., LAGARDE, A., KERBEL, R. S. and BREITMAN, M. L., 1988, Genetic evidence for progressive selection and overgrowth of primary tumors by metastatic cell subpopulations. Cancer Research, 48, 6109-6114.
    • (1988) Cancer Research , vol.48 , pp. 6109-6114
    • Waghorne, C.1    Thomas, M.2    Lagarde, A.3    Kerbel, R.S.4    Breitman, M.L.5
  • 183
    • 0027062852 scopus 로고
    • Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours
    • WALENTA, S., DELLIAN, M., GOETZ, A. E., KUHNLE, G. E. H. and MUELLER-KLIESER, W., 1992, Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours. British Journal of Cancer, 66, 1099-1102.
    • (1992) British Journal of Cancer , vol.66 , pp. 1099-1102
    • Walenta, S.1    Dellian, M.2    Goetz, A.E.3    Kuhnle, G.E.H.4    Mueller-Klieser, W.5
  • 188
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor-I
    • WANG, G. L. and SEMENZA, G. L., 1995, Purification and characterization of hypoxia-inducible factor-I. Journal of Biological Chemistry, 270, 1230-1237.
    • (1995) Journal of Biological Chemistry , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 190
    • 0027732212 scopus 로고
    • Tumor angiogenesis: Review of current applications in tumor prognostication
    • WEIDNER, N., 1993, Tumor angiogenesis: review of current applications in tumor prognostication. Seminars in Diagnostic Pathology, 10, 302-313.
    • (1993) Seminars in Diagnostic Pathology , vol.10 , pp. 302-313
    • Weidner, N.1
  • 191
    • 0029328266 scopus 로고
    • Intratumor microvessel density as a prognostic factor in cancer
    • WEIDNER, N., 1995, Intratumor microvessel density as a prognostic factor in cancer. American Journal of Pathology, 147, 9-19.
    • (1995) American Journal of Pathology , vol.147 , pp. 9-19
    • Weidner, N.1
  • 192
  • 193
    • 0022352547 scopus 로고
    • Differential induction of glucose-regulated and heat shock proteins: Effects of pH and sulfhydryl-reducing agents on chicken embryo cells
    • WHELAN, S. A. and HIGHTOWER, L. E., 1985, Differential induction of glucose-regulated and heat shock proteins: effects of pH and sulfhydryl-reducing agents on chicken embryo cells. Journal of Cellular Physiology, 125, 251-258.
    • (1985) Journal of Cellular Physiology , vol.125 , pp. 251-258
    • Whelan, S.A.1    Hightower, L.E.2
  • 194
  • 195
  • 196
    • 0033609365 scopus 로고    scopus 로고
    • An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: Implications for clonal selection during colorectal carcinogenesis
    • WILLIAMS, A. C., COLLARD, T. J. and PARASKEVA, C., 1999, An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene, 18, 3199-3204.
    • (1999) Oncogene , vol.18 , pp. 3199-3204
    • Williams, A.C.1    Collard, T.J.2    Paraskeva, C.3
  • 197
    • 0024315240 scopus 로고
    • Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia
    • WILSON, R. E., KENG, P. C. and SUTHERLAND, R. M., 1989, Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia. Journal of the National Cancer Institute, 81, 1235-1240.
    • (1989) Journal of the National Cancer Institute , vol.81 , pp. 1235-1240
    • Wilson, R.E.1    Keng, P.C.2    Sutherland, R.M.3
  • 198
    • 0026018901 scopus 로고
    • A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration
    • WINDLE, B. E., DRAPER, B. W., YIN, Y., O'GORMAN, S. and WAHL, G. M., 1991, A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes and Development, 5, 160-174.
    • (1991) Genes and Development , vol.5 , pp. 160-174
    • Windle, B.E.1    Draper, B.W.2    Yin, Y.3    O'Gorman, S.4    Wahl, G.M.5
  • 199
    • 0242672936 scopus 로고
    • Molecular dissection of mammalian gene amplification: New mechanistic insights revealed by analyses of very early events
    • WINDLE, B. E. and WAHL, G. M., 1992, Molecular dissection of mammalian gene amplification: new mechanistic insights revealed by analyses of very early events. Mutation Research, 276, 199-224.
    • (1992) Mutation Research , vol.276 , pp. 199-224
    • Windle, B.E.1    Wahl, G.M.2
  • 200
  • 201
    • 0027936404 scopus 로고
    • Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia
    • YAO, K.-S., XANTHOUDAKIS, S., CURRAN, T. and O'DWYER, P. J., 1994, Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Molecular and Cellular Biology, 14, 5997-6003.
    • (1994) Molecular and Cellular Biology , vol.14 , pp. 5997-6003
    • Yao, K.-S.1    Xanthoudakis, S.2    Curran, T.3    O'Dwyer, P.J.4
  • 202
    • 0025253789 scopus 로고
    • Effects of reoxygenation on cells from hypoxic regions of solid tumors: Anticancer drug sensitivity and metastatic potential
    • YOUNG, S. D. and HILL, R. P., 1990, Effects of reoxygenation on cells from hypoxic regions of solid tumors: anticancer drug sensitivity and metastatic potential. Journal of the National Cancer Institute, 82, 371-380.
    • (1990) Journal of the National Cancer Institute , vol.82 , pp. 371-380
    • Young, S.D.1    Hill, R.P.2
  • 204
    • 0030755044 scopus 로고    scopus 로고
    • Matrix metalloproteinases. Novel targets for directed cancer therapy
    • YU, A. E., HEWITT, R. E., CONNOR, E. W. and STETLER-STEVENSON, W. G., 1997, Matrix metalloproteinases. Novel targets for directed cancer therapy. Drugs and Aging, 11, 229-244.
    • (1997) Drugs and Aging , vol.11 , pp. 229-244
    • Yu, A.E.1    Hewitt, R.E.2    Connor, E.W.3    Stetler-Stevenson, W.G.4
  • 205
    • 0026337286 scopus 로고
    • The influence of local control on metastatic dissemination of prostate cancer treated by external beam megavoltage radiation therapy
    • ZAGARS, G. K., VON ESCHENBACH, A. C., AYALA, A. G., SCHULTHEISS, T. E. and SHERMAN, N. E., 1991, The influence of local control on metastatic dissemination of prostate cancer treated by external beam megavoltage radiation therapy. Cancer, 68, 2370-2377.
    • (1991) Cancer , vol.68 , pp. 2370-2377
    • Zagars, G.K.1    Von Eschenbach, A.C.2    Ayala, A.G.3    Schultheiss, T.E.4    Sherman, N.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.