Glucose catabolism in the rabbit VX2 tumor model for liver cancer: Characterization and targeting hexokinase

Cancer Letters

Volumn 173, Issue 1, 2001, Pages 83-91

  Ko, Young Hee ^a   Pedersen, Peter L ^a   Geschwind, J F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 Deoxy Glucose; 3 Bromo Pyruvate; Drug targeting; Hexokinase; Liver cancer; Tumor metabolism

Indexed keywords

BROMOPYRUVIC ACID; DEOXYGLUCOSE; GLUCOSE; GLYCOLYTIC ENZYME; HEXOKINASE; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME GLYCOSYLATION; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME PHOSPHORYLATION; FEMALE; GLYCOLYSIS; HEPATOMA CELL; LIVER CELL CARCINOMA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RABBIT; RAT;

ANIMALS; ANTIMETABOLITES; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DEOXYGLUCOSE; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; GLUCOSE; GLYCOLYSIS; HEXOKINASE; KINETICS; LACTIC ACID; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; PHENOTYPE; PYRUVATES; RABBITS;

EID: 0035829074     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00667-X     Document Type: Article

References (19)

1. Hepatic tumors and cysts
2. Experiments on the cause of the rabbit carcinomas derived from virus-induced papillomas. II. Loss by the VX2 carcinomas of the power to immunize hosts against the papilloma virus
3. Evaluation of efficient chemoembolization mixtures by MR imaging therapy monitoring: An experimental study on the VX2 tumor in the rabbit liver
4. Chemoembolization of liver tumor in a rabbit model: Assessment of tumor cell death with diffusion-weighted MR imaging and histological analysis
5. Transcatheter chemoembolization effective for treating hepatocellular carcinoma: A histopathologic study
6. Chemoembolization of hepatic malignancies
7. Glycolysis, respiration, and anomalous gene expression in experimental hepatomas. G.H.A. Clowes Memorial Lecture
8. Tumor mitochondria and the bioenergetics of cancer cells
9. Energy metabolism of tumor cells: Requirement for a form of hexokinase with a propensity for mitochondrial binding
10. Intracellular localization and properties of particulate hexokinase in the Novikoff ascites tumor
11. Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130
12. Glucose catabolism in cancer cells: Amplification of the gene encoding type II hexokinase
13. Glucose catabolism in cancer cells: Isolation, sequence, and activity of the promoter for type II hexokinase
14. Glucokinase: Structural analysis of a protein involved in susceptibility to diabetes
15. Carbohydrate metabolism I: Major metabolic pathways and their control
16. Functional significance of mitochondrial bound hexokinase in tumor cell metabolism: Evidence for preferential phosphorylation of glucose by intra-mitochondrially generated ATP
17. Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production
18. Glucose catabolism in cancer cells: Role and regulation of hexokinase
19. Evaluation of experimental liver tumors using fluorine-18-2-fluoro-2-deoxy-D-glucose PET