메뉴 건너뛰기




Volumn 136, Issue 1, 2012, Pages 106-130

Drug transport by Organic Anion Transporters (OATs)

Author keywords

lactam antibiotics; Drug drug interaction; Kidney; Nonsteroidal anti inflammatory drugs; Renal excretion; Sex differences; SLC22 family

Indexed keywords

ACETAZOLAMIDE; ACICLOVIR; BENZBROMARONE; BUMETANIDE; CANDESARTAN; CAPTOPRIL; CEFTIBUTEN; DICLOFENAC; FLUINDOSTATIN; LOSARTAN; MESSENGER RNA; METHOTREXATE; NICOTINIC ACID; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 10; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 4; ORGANIC ANION TRANSPORTER 5; ORGANIC ANION TRANSPORTER 6; ORGANIC ANION TRANSPORTER 7; ORGANIC ANION TRANSPORTER 8; ORGANIC ANION TRANSPORTER 9; ORGANIC ANION TRANSPORTER URAT1; PENICILLIN G; PRATOSARTAN; QUINAPRIL; UNCLASSIFIED DRUG; UNINDEXED DRUG; URATE;

EID: 84865578333     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.07.010     Document Type: Review
Times cited : (294)

References (248)
  • 1
    • 0017900464 scopus 로고
    • The interaction between methotrexate and probenecid in man
    • G.W. Aherne, V. Marks, G.P. Mould, E. Piall, and W.F. White The interaction between methotrexate and probenecid in man Br J Pharmacol 63 1978 369P (Pubitemid 8390421)
    • (1978) British Journal of Pharmacology , vol.63 , Issue.2
    • Aherne, G.W.1    Marks, V.2    Mould, G.P.3
  • 2
    • 71449118407 scopus 로고    scopus 로고
    • Interaction of organic cations with organic anion transporters
    • S.-Y. Ahn, S.A. Eraly, I. Tsigelny, and S.K. Nigam Interaction of organic cations with organic anion transporters J Biol Chem 284 2009 31422 31430
    • (2009) J Biol Chem , vol.284 , pp. 31422-31430
    • Ahn, S.-Y.1    Eraly, S.A.2    Tsigelny, I.3    Nigam, S.K.4
  • 4
    • 49849086125 scopus 로고    scopus 로고
    • Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment
    • L.M. Aleksunes, L.M. Augustine, G.L. Scheffer, N.J. Cherrington, and J.E. Manautou Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment Toxicology 250 2008 82 88
    • (2008) Toxicology , vol.250 , pp. 82-88
    • Aleksunes, L.M.1    Augustine, L.M.2    Scheffer, G.L.3    Cherrington, N.J.4    Manautou, J.E.5
  • 7
    • 0032931612 scopus 로고    scopus 로고
    • Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes
    • N. Apiwattanakul, T. Sekine, A. Chairoungdua, Y. Kanai, N. Nakajima, and S. Sophasan Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes Mol Pharmacol 55 1999 847 854 (Pubitemid 29214604)
    • (1999) Molecular Pharmacology , vol.55 , Issue.5 , pp. 847-854
    • Apiwattanakul, N.1    Sekine, T.2    Chairoungdua, A.3    Kanai, Y.4    Nakajima, N.5    Sophasan, S.6    Endou, H.7
  • 13
    • 47749112096 scopus 로고    scopus 로고
    • Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
    • A. Bahn, Y. Hagos, S. Reuter, D. Balen, H. Brzica, and W. Krick Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13) J Biol Chem 283 2008 16332 16341
    • (2008) J Biol Chem , vol.283 , pp. 16332-16341
    • Bahn, A.1    Hagos, Y.2    Reuter, S.3    Balen, D.4    Brzica, H.5    Krick, W.6
  • 15
    • 26844476662 scopus 로고    scopus 로고
    • Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites
    • A. Bahn, M. Ljubojevic, H. Lorenz, C. Schultz, E. Ghebremedhin, and B. Ugele Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites Am J Physiol Cell Physiol 289 2005 C1075 C1084
    • (2005) Am J Physiol Cell Physiol , vol.289
    • Bahn, A.1    Ljubojevic, M.2    Lorenz, H.3    Schultz, C.4    Ghebremedhin, E.5    Ugele, B.6
  • 16
    • 0034726674 scopus 로고    scopus 로고
    • Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene
    • A. Bahn, D. Prawitt, D. Butler, G. Reid, T. Enklaar, and N.A. Wolff Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene Biochem Biophys Res Commun 275 2000 623 630
    • (2000) Biochem Biophys Res Commun , vol.275 , pp. 623-630
    • Bahn, A.1    Prawitt, D.2    Butler, D.3    Reid, G.4    Enklaar, T.5    Wolff, N.A.6
  • 17
    • 0242290366 scopus 로고    scopus 로고
    • Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux
    • DOI 10.1159/000074539
    • N. Bakhiya, A. Bahn, G. Burckhardt, and N.A. Wolff Human organic anion transporter 3 (hOAT3) can operate as an exchanger accepting urate as a substrate Cell Physiol Biochem 13 2003 249 256 (Pubitemid 37356730)
    • (2003) Cellular Physiology and Biochemistry , vol.13 , Issue.5 , pp. 249-256
    • Bakhiya, N.1    Bahn, A.2    Burckhardt, G.3    Wolff, N.A.4
  • 18
    • 59149087698 scopus 로고    scopus 로고
    • Activation of protein kinase Cζ increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport
    • S.A. Barros, C. Srimaroeng, J.L. Perry, R. Walden, N. Dembla-Rajpal, and D.H. Sweet Activation of protein kinase Cζ increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport J Biol Chem 284 2009 2672 2679
    • (2009) J Biol Chem , vol.284 , pp. 2672-2679
    • Barros, S.A.1    Srimaroeng, C.2    Perry, J.L.3    Walden, R.4    Dembla-Rajpal, N.5    Sweet, D.H.6
  • 23
    • 33746808149 scopus 로고    scopus 로고
    • Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3
    • DOI 10.1016/j.bbadis.2006.05.011, PII S0925443906000974
    • A. Brandoni, N. Anzai, Y. Kanai, H. Endou, and A.M. Torres Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3 Biochim Biophys Acta 1762 2006 673 682 (Pubitemid 44175825)
    • (2006) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1762 , Issue.7 , pp. 673-682
    • Brandoni, A.1    Anzai, N.2    Kanai, Y.3    Endou, H.4    Torres, A.M.5
  • 24
    • 0037266213 scopus 로고    scopus 로고
    • Compensation increase in organic anion excretion in rats with acute biliary obstruction: Role of the renal organic anion transporter 1
    • DOI 10.1159/000069529
    • A. Brandoni, N.B. Quaglia, and A.M. Torres Compensation increase in organic anion excretion in rats with acute biliary obstruction: role of the renal organic anion transporter 1 Pharmacology 68 2003 57 63 (Pubitemid 36469851)
    • (2003) Pharmacology , vol.68 , Issue.2 , pp. 57-63
    • Brandoni, A.1    Quaglia, N.B.2    Torres, A.M.3
  • 25
    • 33646567499 scopus 로고    scopus 로고
    • Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction
    • DOI 10.1002/hep.21142
    • A. Brandoni, S.R. Villar, J.C. Picena, N. Anzai, H. Endou, and A.M. Torres Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction Hepatology 43 2006 1092 1100 (Pubitemid 43724633)
    • (2006) Hepatology , vol.43 , Issue.5 , pp. 1092-1100
    • Brandoni, A.1    Villar, S.R.2    Picena, J.C.3    Anzai, N.4    Endou, H.5    Torres, A.M.6
  • 28
    • 2442700344 scopus 로고    scopus 로고
    • Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels
    • DOI 10.1124/dmd.32.6.620
    • S.C.N. Buist, and C.D. Klaassen Rat and mouse differences in gender-predominant expression of organic anion transporter (OAT1-3, SLC22A6-8) mRNA levels Drug Metab Dispos 32 2004 620 625 (Pubitemid 38668154)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.6 , pp. 620-625
    • Buist, S.C.N.1    Klaassen, C.D.2
  • 30
    • 0038728565 scopus 로고    scopus 로고
    • Transport of organic anions across the basolateral membrane of proximal tubule cells
    • B.C. Burckhardt, and G. Burckhardt Transport of organic anions across the basolateral membrane of proximal tubule cells Rev Physiol Biochem Pharmacol 146 2003 95 158
    • (2003) Rev Physiol Biochem Pharmacol , vol.146 , pp. 95-158
    • Burckhardt, B.C.1    Burckhardt, G.2
  • 31
    • 78649665012 scopus 로고    scopus 로고
    • In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy
    • G. Burckhardt, and B.C. Burckhardt In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy M.F. Fromm, R.B. Kim, Drug Transporters 2011 Springer-Verlag Heidelberg 29 104
    • (2011) Drug Transporters , pp. 29-104
    • Burckhardt, G.1    Burckhardt, B.C.2
  • 32
    • 0035039326 scopus 로고    scopus 로고
    • Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
    • S.H. Cha, T. Sekine, J.-I. Fukushima, Y. Kanai, Y. Kobayashi, and T. Goya Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney Mol Pharmacol 59 2001 1277 1286 (Pubitemid 32385197)
    • (2001) Molecular Pharmacology , vol.59 , Issue.5 , pp. 1277-1286
    • Cha, S.H.1    Sekine, T.2    Fukushima, J.-I.3    Kanai, Y.4    Kobayashi, Y.5    Goya, T.6    Endou, H.7
  • 35
    • 84857395758 scopus 로고    scopus 로고
    • Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs
    • Y. Cheng, A. Vapurcuyan, M. Shadidullah, L.M. Aleksunes, and R.M. Pelis Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs Drug Metab Dispos 40 2012 618 624
    • (2012) Drug Metab Dispos , vol.40 , pp. 618-624
    • Cheng, Y.1    Vapurcuyan, A.2    Shadidullah, M.3    Aleksunes, L.M.4    Pelis, R.M.5
  • 38
    • 0034662273 scopus 로고    scopus 로고
    • Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter
    • DOI 10.1006/abio.2000.4633
    • T. Cihlar, and E.S. Ho Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1 Anal Biochem 283 2000 49 55 (Pubitemid 30469749)
    • (2000) Analytical Biochemistry , vol.283 , Issue.1 , pp. 49-55
    • Cihlar, T.1    Ho, E.S.2
  • 39
    • 0032856603 scopus 로고    scopus 로고
    • The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
    • T. Cihlar, D.C. Lin, J.B. Pritchard, M.D. Fuller, D.B. Mendel, and D.H. Sweet The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1 Mol Pharmacol 56 1999 570 580 (Pubitemid 29406884)
    • (1999) Molecular Pharmacology , vol.56 , Issue.3 , pp. 570-580
    • Cihlar, T.1    Lin, D.C.2    Pritchard, J.B.3    Fuller, M.D.4    Mendel, D.B.5    Sweet, D.H.6
  • 43
    • 0347362498 scopus 로고    scopus 로고
    • Characterization of uremic toxin transport by organic anion transporters in the kidney
    • DOI 10.1111/j.1523-1755.2004.00354.x
    • T. Deguchi, H. Kusuhara, A. Takadate, H. Endou, M. Otagiri, and Y. Sugiyama Characterization of uremic toxin transport by organic anion transporters in the kidney Kidney Int 65 2004 162 174 (Pubitemid 38037501)
    • (2004) Kidney International , vol.65 , Issue.1 , pp. 162-174
    • Deguchi, T.1    Kusuhara, H.2    Takadate, A.3    Endou, H.4    Otagiri, M.5    Sugiyama, Y.6
  • 44
    • 38749117869 scopus 로고    scopus 로고
    • Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: Role of basolateral plasma membrane transporters and cortical renal blood flow
    • DOI 10.1159/000110555
    • G. Di Giusto, N. Anzai, H. Endou, and A.M. Torres Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: role of basolateral plasma transporters and cortical renal blood flow Pharmacology 81 2008 127 136 (Pubitemid 351182687)
    • (2008) Pharmacology , vol.81 , Issue.2 , pp. 127-136
    • Di Giusto, G.1    Anzai, N.2    Endou, H.3    Torres, A.M.4
  • 45
    • 58149095489 scopus 로고    scopus 로고
    • Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury
    • G. Di Giusto, N. Anzai, H. Endou, and A.M. Torres Oat5 and NaDC1 protein abundance in kidney and urine after renal ischemic reperfusion injury J Histochem Cytochem 57 2009 17 27
    • (2009) J Histochem Cytochem , vol.57 , pp. 17-27
    • Di Giusto, G.1    Anzai, N.2    Endou, H.3    Torres, A.M.4
  • 48
    • 26244449838 scopus 로고    scopus 로고
    • Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
    • DOI 10.1007/s10157-005-0368-5
    • A. Enomoto, and H. Endou Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human diseases Clin Exp Nephrol 9 2005 195 205 (Pubitemid 41414118)
    • (2005) Clinical and Experimental Nephrology , vol.9 , Issue.3 , pp. 195-205
    • Enomoto, A.1    Endou, H.2
  • 54
    • 0037427506 scopus 로고    scopus 로고
    • Organic anion and cation transporters occur in pairs of similar and similarly expressed genes
    • DOI 10.1016/S0006-291X(02)02853-X, PII S0006291X0202853X
    • S.A. Eraly, B.A. Hamilton, and S.K. Nigam Organic anion and cation transporters occur in pairs of similar and similarly expressed genes Biochem Biophys Res Commun 300 2003 333 342 (Pubitemid 38379656)
    • (2003) Biochemical and Biophysical Research Communications , vol.300 , Issue.2 , pp. 333-342
    • Eraly, S.A.1    Hamilton, B.A.2    Nigam, S.K.3
  • 55
    • 0036401507 scopus 로고    scopus 로고
    • Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters
    • DOI 10.1016/S0006-291X(02)02343-4, PII S0006291X02023434
    • S.A. Eraly, and S.K. Nigam Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters Biochem Biophys Res Commun 297 2002 1159 1166 (Pubitemid 35216369)
    • (2002) Biochemical and Biophysical Research Communications , vol.297 , Issue.5 , pp. 1159-1166
    • Eraly, S.A.1    Nigam, S.K.2
  • 58
    • 0035826582 scopus 로고    scopus 로고
    • Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3
    • DOI 10.1021/bi002841o
    • B. Feng, M.J. Dresser, Y. Shu, S.J. Johns, and K.M. Giacomini Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3 Biochemistry 40 2001 5511 5520 (Pubitemid 32458253)
    • (2001) Biochemistry , vol.40 , Issue.18 , pp. 5511-5520
    • Feng, B.1    Dresser, M.J.2    Shu, Y.3    Johns, S.J.4    Giacomini, K.M.5
  • 59
    • 0037118701 scopus 로고    scopus 로고
    • Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition
    • DOI 10.1021/bi0200615
    • B. Feng, Y. Shu, and K.M. Giacomini Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition Biochemistry 41 2002 8941 8947 (Pubitemid 34774407)
    • (2002) Biochemistry , vol.41 , Issue.28 , pp. 8941-8947
    • Feng, B.1    Shu, Y.2    Giacomini, K.M.3
  • 61
    • 0026570125 scopus 로고
    • Methotrexate and non-steroidal antiinflammatory drug interactions
    • M.L. Frenia, and K.S. Long Methotrexate and non-steroidal antiinflammatory drug interactions Ann Pharmacother 26 1992 234 237
    • (1992) Ann Pharmacother , vol.26 , pp. 234-237
    • Frenia, M.L.1    Long, K.S.2
  • 64
    • 31144465910 scopus 로고    scopus 로고
    • Sex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubules
    • DOI 10.1124/jpet.105.094979
    • C.E. Groves, W.B. Suhre, N.J. Cherrington, and S.H. Wright Sex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubules J Pharmacol Exp Ther 316 2006 743 752 (Pubitemid 43131002)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.316 , Issue.2 , pp. 743-752
    • Groves, C.E.1    Suhre, W.B.2    Cherrington, N.J.3    Wright, S.H.4
  • 65
    • 14644430364 scopus 로고    scopus 로고
    • Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney
    • DOI 10.1016/j.bcp.2004.12.004
    • Y. Habu, I. Yano, M. Okuda, A. Fukatsu, and K.-I. Inui Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney Biochem Pharmacol 69 2005 993 999 (Pubitemid 40312716)
    • (2005) Biochemical Pharmacology , vol.69 , Issue.6 , pp. 993-999
    • Habu, Y.1    Yano, I.2    Okuda, M.3    Fukatsu, A.4    Inui, K.-I.5
  • 66
    • 0036963238 scopus 로고    scopus 로고
    • Cloning of the pig renal organic anion transporter 1 (pOAT1)
    • PII S0300908402000226
    • Y. Hagos, A. Bahn, A.R. Asif, W. Krick, M. Sendler, and G. Burckhardt Cloning of the pig renal organic anion transporter 1 (pOAT1) Biochimie 84 2002 1221 1224 (Pubitemid 36372170)
    • (2002) Biochimie , vol.84 , Issue.12 , pp. 1221-1224
    • Hagos, Y.1    Bahn, A.2    Asif, A.R.3    Krick, W.4    Sendler, M.5    Burckhardt, G.6
  • 68
    • 16844379360 scopus 로고    scopus 로고
    • Functional expression of pig renal organic anion transporter 3 (pOAT3)
    • DOI 10.1016/j.biochi.2005.01.006
    • Y. Hagos, I.M. Braun, W. Krick, G. Burckhardt, and A. Bahn Functional expression of pig renal organic anion transporter 3 (pOAT3) Biochimie 87 2005 421 424 (Pubitemid 40488370)
    • (2005) Biochimie , vol.87 , Issue.5 , pp. 421-424
    • Hagos, Y.1    Braun, I.M.2    Krick, W.3    Burckhardt, G.4    Bahn, A.5
  • 71
    • 0038137530 scopus 로고    scopus 로고
    • Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat
    • DOI 10.1124/jpet.102.046847
    • M. Hasegawa, H. Kusuhara, H. Endou, and Y. Sugiyama Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat J Pharmacol Exp Ther 305 2003 1087 1097 (Pubitemid 36617987)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.305 , Issue.3 , pp. 1087-1097
    • Hasegawa, M.1    Kusuhara, H.2    Endou, H.3    Sugiyama, Y.4
  • 73
    • 4644333578 scopus 로고    scopus 로고
    • Characterization of the renal tubular transport of zonampanel, a novel α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters
    • T. Hashimoto, S. Narikawa, X.-L. Huang, T. Minematsu, T. Usui, and H. Kamimura Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters Drug Metab Dispos 32 2004 1096 1102 (Pubitemid 39287583)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.10 , pp. 1096-1102
    • Hashimoto, T.1    Narikawa, S.2    Huang, X.-L.3    Minematsu, T.4    Usui, T.5    Kamimura, H.6    Endou, H.7
  • 74
  • 75
    • 34547169521 scopus 로고    scopus 로고
    • Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
    • DOI 10.1124/dmd.107.014902
    • C. Hilgendorf, G. Ahlin, A. Seithel, P. Artursson, A.-L. Ungell, and J. Karlsson Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines Drug Metab Dispos 35 2007 1333 1340 (Pubitemid 47121774)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.8 , pp. 1333-1340
    • Hilgendorf, C.1    Ahlin, G.2    Seithel, A.3    Artursson, P.4    Ungell, A.-L.5    Karlsson, J.6
  • 76
    • 0034008388 scopus 로고    scopus 로고
    • Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1
    • E.S. Ho, D.C. Lin, D.B. Mendel, and T. Cihlar Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1 J Am Soc Nephrol 11 2000 383 393 (Pubitemid 30115068)
    • (2000) Journal of the American Society of Nephrology , vol.11 , Issue.3 , pp. 383-393
    • Ho, E.S.1    Lin, D.C.2    Mendel, D.B.3    Cihlar, T.4
  • 77
    • 59149084250 scopus 로고    scopus 로고
    • COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the renal cortex
    • K. Höcherl, C. Schmidt, and M. Bucher COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the renal cortex Kidney Int 75 2009 373 380
    • (2009) Kidney Int , vol.75 , pp. 373-380
    • Höcherl, K.1    Schmidt, C.2    Bucher, M.3
  • 78
    • 0017757983 scopus 로고
    • Influence of probenecid and spironolacton on furosemide clearance and dynamics in man
    • M. Homeida, C. Roberts, and R.A. Branch Influence of probenecid and spironolacton on furosemide clearance and dynamics in man Clin Pharmacol Ther 22 1977 402 408
    • (1977) Clin Pharmacol Ther , vol.22 , pp. 402-408
    • Homeida, M.1    Roberts, C.2    Branch, R.A.3
  • 81
    • 0032919287 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
    • M. Hosoyamada, T. Sekine, Y. Kanai, and H. Endou Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney Am J Physiol Renal Physiol 276 1999 F122 F128
    • (1999) Am J Physiol Renal Physiol , vol.276
    • Hosoyamada, M.1    Sekine, T.2    Kanai, Y.3    Endou, H.4
  • 84
    • 0346734163 scopus 로고    scopus 로고
    • Clinical and Molecular Analysis of Patients with Renal Hypouricemia in Japan-Influence of URAT1 Gene on Urinary Urate Excretion
    • DOI 10.1097/01.ASN.0000105320.04395.D0
    • K. Ichida, M. Hosoyamada, I. Hisatome, A. Enomoto, M. Hikita, and H. Endou Clinical and molecular analysis of patients with renal hypouricemia in Japan - influence of URAT1 gene on urinary urate excretion J Am Soc Nephrol 15 2004 164 173 (Pubitemid 38020708)
    • (2004) Journal of the American Society of Nephrology , vol.15 , Issue.1 , pp. 164-173
    • Ichida, K.1    Hosoyamada, M.2    Hisatome, I.3    Enomoto, A.4    Hikita, M.5    Endou, H.6    Hosoya, T.7
  • 87
    • 28144462450 scopus 로고    scopus 로고
    • Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone
    • DOI 10.1124/dmd.105.006056
    • T. Iwanaga, D. Kobayashi, M. Hirayama, T. Maeda, and I. Tamai Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone Drug Metab Dispos 33 2005 1791 1795 (Pubitemid 41697263)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.12 , pp. 1791-1795
    • Iwanaga, T.1    Kobayashi, D.2    Hirayama, M.3    Maeda, T.4    Tamai, I.5
  • 88
    • 33845887252 scopus 로고    scopus 로고
    • Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter
    • DOI 10.1124/jpet.106.112755
    • T. Iwanaga, M. Sato, T. Maeda, T. Ogihara, and I. Tamai Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter J Pharmacol Exp Ther 320 2007 211 217 (Pubitemid 46025736)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.320 , Issue.1 , pp. 211-217
    • Iwanaga, T.1    Sato, M.2    Maeda, T.3    Ogihara, T.4    Tamai, I.5
  • 89
    • 35548966750 scopus 로고    scopus 로고
    • Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family
    • DOI 10.1016/j.ygeno.2007.03.017, PII S0888754307000754
    • J.A. Jacobsson, T. Haitina, J. Lindblom, and R. Fredriksson Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family Genomics 90 2007 595 609 (Pubitemid 350016717)
    • (2007) Genomics , vol.90 , Issue.5 , pp. 595-609
    • Jacobsson, J.A.1    Haitina, T.2    Lindblom, J.3    Fredriksson, R.4
  • 91
    • 0035991421 scopus 로고    scopus 로고
    • Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy
    • DOI 10.1046/j.1523-1755.2002.00464.x
    • L. Ji, S. Masuda, H. Saito, and K.-I. Inui Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy Kidney Int 62 2002 514 524 (Pubitemid 34779762)
    • (2002) Kidney International , vol.62 , Issue.2 , pp. 514-524
    • Ji, L.1    Masuda, S.2    Saito, H.3    Inui, K.-I.4
  • 92
    • 33748894676 scopus 로고    scopus 로고
    • Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
    • DOI 10.1124/dmd.106.010033
    • E. Jigorel, M. Le Vee, C. Boursier-Neyret, Y. Parmentier, and O. Fardel Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes Drug Metab Dispos 34 2006 1756 1763 (Pubitemid 44427479)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1756-1763
    • Jigorel, E.1    Le Vee, M.2    Boursier-Neyret, C.3    Parmentier, Y.4    Fardel, O.5
  • 95
    • 78049387680 scopus 로고    scopus 로고
    • Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate
    • P. Jutabha, N. Anzai, K. Kitamura, A. Taniguchi, S. Kaneko, and K. Yan Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate J Biol Chem 285 2010 35123 35132
    • (2010) J Biol Chem , vol.285 , pp. 35123-35132
    • Jutabha, P.1    Anzai, N.2    Kitamura, K.3    Taniguchi, A.4    Kaneko, S.5    Yan, K.6
  • 96
    • 34547196949 scopus 로고    scopus 로고
    • Structural variation governs substrate specificity for Organic Anion Transporter (OAT) homologs: Potential remote sensing by OAT family members
    • DOI 10.1074/jbc.M703467200
    • G. Kaler, D.M. Truong, A. Khandelwal, M. Nagle, S.A. Eraly, and P.W. Swaan Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members J Biol Chem 282 2007 23841 23853 (Pubitemid 47328029)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.33 , pp. 23841-23853
    • Kaler, G.1    Truong, D.M.2    Khandelwal, A.3    Nagle, M.4    Eraly, S.A.5    Swaan, P.W.6    Nigam, S.K.7
  • 99
    • 6344251595 scopus 로고    scopus 로고
    • Screening of the interaction between xenobiotic transporters and PDZ proteins
    • DOI 10.1023/B:PHAM.0000045244.83999.43
    • Y. Kato, K. Yoshida, C. Watanabe, Y. Sai, and A. Tsuji Screening of the interaction between xenobiotic transporters and PDZ proteins Pharm Res 21 2004 1886 1894 (Pubitemid 39390102)
    • (2004) Pharmaceutical Research , vol.21 , Issue.10 , pp. 1886-1894
    • Kato, Y.1    Yoshida, K.2    Watanabe, C.3    Sai, Y.4    Tsuji, A.5
  • 100
    • 80055066801 scopus 로고    scopus 로고
    • Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3
    • M. Kaufhold, K. Schulz, D. Breljak, S. Gupta, M. Henjakovic, and W. Krick Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3 Am J Physiol Renal Physiol 301 2011 F1026 F1034
    • (2011) Am J Physiol Renal Physiol , vol.301
    • Kaufhold, M.1    Schulz, K.2    Breljak, D.3    Gupta, S.4    Henjakovic, M.5    Krick, W.6
  • 104
    • 36348965458 scopus 로고    scopus 로고
    • Regulation of the tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1α/β and DNA methylation
    • R. Kikuchi, H. Kusuhara, N. Hattori, I. Kim, K. Shiota, and F.J. Gonzales Regulation of the tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1α/β and DNA methylation Mol Pharmacol 72 2007 619 625
    • (2007) Mol Pharmacol , vol.72 , pp. 619-625
    • Kikuchi, R.1    Kusuhara, H.2    Hattori, N.3    Kim, I.4    Shiota, K.5    Gonzales, F.J.6
  • 105
    • 33747606242 scopus 로고    scopus 로고
    • Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1α/β and DNA methylation
    • DOI 10.1124/mol.106.025494
    • R. Kikuchi, H. Kusuhara, N. Hattori, K. Shiota, I. Kim, and F.J. Gonzales Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1α/β and DNA methylation Mol Pharmacol 70 2006 887 896 (Pubitemid 44268446)
    • (2006) Molecular Pharmacology , vol.70 , Issue.3 , pp. 887-896
    • Kikuchi, R.1    Kusuhara, H.2    Hattori, N.3    Shiota, K.4    Kim, I.5    Gonzalez, F.J.6    Sugiyama, Y.7
  • 106
    • 0038274495 scopus 로고    scopus 로고
    • Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier
    • DOI 10.1124/jpet.103.049197
    • R. Kikuchi, H. Kusuhara, D. Sugiyama, and Y. Sugiyama Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier J Pharmacol Exp Ther 306 2003 51 58 (Pubitemid 36734356)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.306 , Issue.1 , pp. 51-58
    • Kikuchi, R.1    Kusuhara, H.2    Sugiyama, D.3    Sugiyama, Y.4
  • 107
    • 0042665566 scopus 로고    scopus 로고
    • Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney
    • DOI 10.1093/ndt/gfg186
    • G.-H. Kim, K.Y. Na, S.-Y. Kim, K.W. Joo, Y.K. Oh, and S.-W. Chae Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney Nephrol Dial Transplant 18 2003 1505 1511 (Pubitemid 36939621)
    • (2003) Nephrology Dialysis Transplantation , vol.18 , Issue.8 , pp. 1505-1511
    • Kim, G.-H.1    Na, K.Y.2    Kim, S.-Y.3    Joo, K.W.4    Oh, Y.K.5    Chae, S.-W.6    Endou, H.7    Han, J.S.8
  • 108
    • 33644664085 scopus 로고    scopus 로고
    • Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1
    • N. Kimura, S. Masuda, Y. Tanihara, H. Ueo, M. Okuda, and T. Katsura Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1 Drug Metab Pharmacokinet 20 2005 379 386
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 379-386
    • Kimura, N.1    Masuda, S.2    Tanihara, Y.3    Ueo, H.4    Okuda, M.5    Katsura, T.6
  • 111
    • 78649949040 scopus 로고    scopus 로고
    • The human organic anion transporter genes OAT5 and OAT7 are trans-activated by hepatocyte nuclear factor-1α (HNF-1α)
    • K. Klein, C. Jüngst, J. Mwinyi, B. Stieger, F. Krempler, and W. Patsch The human organic anion transporter genes OAT5 and OAT7 are trans-activated by hepatocyte nuclear factor-1α (HNF-1α) Mol Pharmacol 78 2010 1079 1087
    • (2010) Mol Pharmacol , vol.78 , pp. 1079-1087
    • Klein, K.1    Jüngst, C.2    Mwinyi, J.3    Stieger, B.4    Krempler, F.5    Patsch, W.6
  • 112
    • 27744585891 scopus 로고    scopus 로고
    • Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediates the renal transport of bumetanide
    • DOI 10.1016/j.ejphar.2005.09.054, PII S0014299905010113
    • Y. Kobayashi, M. Ohbayashi, N. Kohyama, and T. Yamamoto Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8]) mediated the renal transport of bumetanide Eur J Pharmacol 524 2005 44 48 (Pubitemid 41606811)
    • (2005) European Journal of Pharmacology , vol.524 , Issue.1-3 , pp. 44-48
    • Kobayashi, Y.1    Ohbayashi, M.2    Kohyama, N.3    Yamamoto, T.4
  • 113
  • 115
    • 2042542061 scopus 로고    scopus 로고
    • Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): Further substrate specificity of mOat3
    • DOI 10.1124/dmd.32.5.479
    • Y. Kobayashi, N. Ohshiro, A. Tsuchiya, N. Kohyama, M. Ohbayashi, and T. Yamamoto Renal transport of organic compounds mediated by mouse organic anion transporter 3 (MOAT3): further substrate specificity of MOAT3 Drug Metab Dispos 32 2004 479 483 (Pubitemid 38535024)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.5 , pp. 479-483
    • Kobayashi, Y.1    Ohshiro, N.2    Tsuchiya, A.3    Kohyama, N.4    Ohbayashi, M.5    Yamamoto, T.6
  • 116
    • 17844378450 scopus 로고    scopus 로고
    • Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver
    • DOI 10.1124/dmd.104.003301
    • Y. Kobayashi, R. Sakai, N. Ohshiro, M. Ohbayashi, N. Kohyama, and T. Yamamoto Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver Drug Metab Dispos 33 2005 619 622 (Pubitemid 40593874)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.5 , pp. 619-622
    • Kobayashi, Y.1    Sakai, R.2    Ohshiro, N.3    Ohbayashi, M.4    Kohyama, N.5    Yamamoto, T.6
  • 117
    • 1242295185 scopus 로고    scopus 로고
    • The SLC22 drug transporter family
    • DOI 10.1007/s00424-003-1089-9, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • H. Koepsell, and H. Endou The SLC22 drug transporter family Pflügers Arch. - Eur J Physiol 447 2004 666 676 (Pubitemid 38241452)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 666-676
    • Koepsell, H.1    Endou, H.2
  • 120
    • 0033532065 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
    • H. Kusuhara, T. Sekine, N. Utsunomiya-Tate, M. Tsuda, R. Kojima, and S.H. Cha Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain J Biol Chem 274 1999 13675 13680
    • (1999) J Biol Chem , vol.274 , pp. 13675-13680
    • Kusuhara, H.1    Sekine, T.2    Utsunomiya-Tate, N.3    Tsuda, M.4    Kojima, R.5    Cha, S.H.6
  • 121
    • 0033555578 scopus 로고    scopus 로고
    • Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells
    • K. Kuze, P. Graves, A. Leahy, P. Wilson, H. Stuhlmann, and G. You Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells J Biol Chem 274 1999 1519 1524
    • (1999) J Biol Chem , vol.274 , pp. 1519-1524
    • Kuze, K.1    Graves, P.2    Leahy, A.3    Wilson, P.4    Stuhlmann, H.5    You, G.6
  • 123
    • 33747834042 scopus 로고    scopus 로고
    • Drug-drug interactions involving membrane transporters in the human kidney
    • DOI 10.1517/17425255.2.4.505
    • M. Li, G.D. Anderson, and J. Wang Drug-drug interactions involving membrane transporters in the human kidney Expert Opin Drug Metab Toxicol 2 2006 505 532 (Pubitemid 46127070)
    • (2006) Expert Opinion on Drug Metabolism and Toxicology , vol.2 , Issue.4 , pp. 505-532
    • Li, M.1    Anderson, G.D.2    Wang, J.3
  • 125
  • 126
    • 2942675119 scopus 로고    scopus 로고
    • Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition
    • M. Ljubojevic, C.M. Herak-Kramberger, Y. Hagos, A. Bahn, H. Endou, and G. Burckhardt Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition Am J Physiol Renal Physiol 287 2004 F124 F138
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Ljubojevic, M.1    Herak-Kramberger, C.M.2    Hagos, Y.3    Bahn, A.4    Endou, H.5    Burckhardt, G.6
  • 127
    • 0030940999 scopus 로고    scopus 로고
    • Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
    • DOI 10.1074/jbc.272.10.6471
    • C.E. Lopez-Nieto, G.F. You, K.T. Bush, E.J.G. Barros, D.R. Beier, and S.K. Nigam Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney J Biol Chem 272 1997 6471 6478 (Pubitemid 27118127)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.10 , pp. 6471-6478
    • Lopez-Nieto, C.E.1    You, G.2    Bush, K.T.3    Barros, E.J.G.4    Beier, D.R.5    Nigam, S.K.6
  • 128
    • 0032995116 scopus 로고    scopus 로고
    • Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C
    • R. Lu, B.S. Chan, and V.L. Schuster Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C Am J Physiol Renal Physiol 276 1999 F295 F303
    • (1999) Am J Physiol Renal Physiol , vol.276
    • Lu, R.1    Chan, B.S.2    Schuster, V.L.3
  • 129
    • 33745952758 scopus 로고    scopus 로고
    • Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1α
    • DOI 10.1016/j.bcp.2006.03.016, PII S0006295206001882
    • J.M. Maher, A.L. Slitt, T.N. Callaghan, X. Cheng, X. Cheung, and F.J. Gonzales Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1α Biochem Pharmacol 72 2006 512 522 (Pubitemid 44061742)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.4 , pp. 512-522
    • Maher, J.M.1    Slitt, A.L.2    Callaghan, T.N.3    Cheng, X.4    Cheung, C.5    Gonzalez, F.J.6    Klaassen, C.D.7
  • 131
    • 77951091171 scopus 로고    scopus 로고
    • Therapeutic implications of renal anionic drug transporters
    • R. Masereeuw, and F.G.M. Russel Therapeutic implications of renal anionic drug transporters Pharmacol Ther 126 2010 200 216
    • (2010) Pharmacol Ther , vol.126 , pp. 200-216
    • Masereeuw, R.1    Russel, F.G.M.2
  • 132
    • 34548103253 scopus 로고    scopus 로고
    • Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy- camptothecin hydrochloride]
    • DOI 10.1124/jpet.107.123323
    • S. Matsumoto, K. Yoshida, N. Ishiguro, T. Maeda, and I. Tamai Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride] J Pharmacol Exp Ther 322 2007 1246 1252 (Pubitemid 47295802)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.322 , Issue.3 , pp. 1246-1252
    • Matsumoto, S.-I.1    Yoshida, K.2    Ishiguro, N.3    Maeda, T.4    Tamai, I.5
  • 134
    • 47949121279 scopus 로고    scopus 로고
    • Role of the organic anion transporters in the pharmacokinetics of Zonampanel, and α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, in rats
    • T. Minematsu, T. Hashimoto, T. Aoki, T. Usui, and H. Kamimura Role of the organic anion transporters in the pharmacokinetics of Zonampanel, and α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, in rats Drug Metab Dispos 36 2008 1496 1504
    • (2008) Drug Metab Dispos , vol.36 , pp. 1496-1504
    • Minematsu, T.1    Hashimoto, T.2    Aoki, T.3    Usui, T.4    Kamimura, H.5
  • 136
    • 0042468096 scopus 로고    scopus 로고
    • Impact of drug transporter studies on drug discovery and development
    • DOI 10.1124/pr.55.3.1
    • N. Mizuno, T. Niwa, Y. Yotsumoto, and Y. Sugiyama Impact of drug transporter studies on drug discovery and development Pharmacol Rev 55 2003 425 461 (Pubitemid 37013212)
    • (2003) Pharmacological Reviews , vol.55 , Issue.3 , pp. 425-461
    • Mizuno, N.1    Niwa, T.2    Yotsumoto, Y.3    Sugiyama, Y.4
  • 137
    • 34547174404 scopus 로고    scopus 로고
    • Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate
    • DOI 10.1124/dmd.106.013912
    • N. Mizuno, T. Takahashi, Y. Iwase, H. Kusuhara, T. Niwa, and Y. Sugiyama Human organic anion transporter 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate Drug Metab Dispos 35 2007 1429 1434 (Pubitemid 47121785)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.8 , pp. 1429-1434
    • Mizuno, N.1    Takahashi, T.2    Iwase, Y.3    Kusuhara, H.4    Niwa, T.5    Sugiyama, Y.6
  • 138
    • 4544322271 scopus 로고    scopus 로고
    • Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa
    • DOI 10.1016/j.bbrc.2004.08.112, PII S0006291X04018200
    • J.C. Monte, M.A. Nagle, S.A. Eraly, and S.K. Nigam Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa Biochem Biophys Res Commun 323 2004 429 436 (Pubitemid 39221116)
    • (2004) Biochemical and Biophysical Research Communications , vol.323 , Issue.2 , pp. 429-436
    • Monte, J.C.1    Nagle, M.A.2    Eraly, S.A.3    Nigam, S.K.4
  • 140
    • 4143113395 scopus 로고    scopus 로고
    • Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs
    • DOI 10.1111/j.1471-4159.2004.02552.x
    • S. Mori, S. Ohtsuki, H. Takanaga, T. Kikkawa, Y.-S. Kang, and T. Terasaki Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs J Neurochem 90 2004 931 941 (Pubitemid 39099975)
    • (2004) Journal of Neurochemistry , vol.90 , Issue.4 , pp. 931-941
    • Mori, S.1    Ohtsuki, S.2    Takanaga, H.3    Kikkawa, T.4    Kang, Y.-S.5    Terasaki, T.6
  • 141
    • 0037383621 scopus 로고    scopus 로고
    • Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells
    • S. Mori, H. Takanaga, S. Ohtsuki, T. Deguchi, Y.-S. Kang, and K.-I. Hosoya Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells J Cereb Blood Flow Metab 23 2003 432 440 (Pubitemid 36403025)
    • (2003) Journal of Cerebral Blood Flow and Metabolism , vol.23 , Issue.4 , pp. 432-440
    • Mori, S.1    Takanaga, H.2    Ohtsuki, S.3    Deguchi, T.4    Kang, Y.-S.5    Hosoya, K.-I.6    Terasaki, T.7
  • 144
    • 7444254904 scopus 로고    scopus 로고
    • Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)
    • DOI 10.1016/j.ejphar.2004.09.032, PII S0014299904010933
    • H. Motohashi, Y. Uwai, K. Hiramoto, M. Okuda, and K.-I. Inui Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A) Eur J Pharmacol 503 2004 25 30 (Pubitemid 39445936)
    • (2004) European Journal of Pharmacology , vol.503 , Issue.1-3 , pp. 25-30
    • Motohashi, H.1    Uwai, Y.2    Hiramoto, K.3    Okuda, M.4    Inui, K.-I.5
  • 145
    • 0036179812 scopus 로고    scopus 로고
    • Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake
    • M. Motojima, A. Hosokawa, H. Yamato, T. Muraki, and T. Yoshioka Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake Br J Pharmacol 135 2002 555 563 (Pubitemid 34151188)
    • (2002) British Journal of Pharmacology , vol.135 , Issue.2 , pp. 555-563
    • Motojima, M.1    Hosokawa, A.2    Yamato, H.3    Muraki, T.4    Yoshioka, T.5
  • 146
    • 0033815816 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1
    • A.S. Mulato, E.S. Ho, and T. Cihlar Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1 J Pharmacol Exp Ther 295 2000 10 15
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 10-15
    • Mulato, A.S.1    Ho, E.S.2    Cihlar, T.3
  • 147
    • 0036235889 scopus 로고    scopus 로고
    • Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus
    • DOI 10.1124/mol.61.5.982
    • Y. Nagata, H. Kusuhara, H. Endou, and Y. Sugiyama Expression and functional characterization of rat organic anion transporter 3 (rOAT3) in the choroid plexus Mol Pharmacol 61 2002 982 988 (Pubitemid 34441762)
    • (2002) Molecular Pharmacology , vol.61 , Issue.5 , pp. 982-988
    • Nagata, Y.1    Kusuhara, H.2    Endou, H.3    Sugiyama, Y.4
  • 149
    • 33644854071 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies
    • M. Nishimura, and S. Naito Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies Drug Metab Pharmacokinet 20 2005 452 477
    • (2005) Drug Metab Pharmacokinet , vol.20 , pp. 452-477
    • Nishimura, M.1    Naito, S.2
  • 151
    • 84862601826 scopus 로고    scopus 로고
    • Developmental expression of renal organic anion transporters in rat kidney and its effect on renal secretion of phenolsulfonphthalein
    • M. Nomura, H. Motohashi, H. Sekine, T. Katsura, and K. Inui Developmental expression of renal organic anion transporters in rat kidney and its effect on renal secretion of phenolsulfonphthalein Am J Physiol Renal Physiol 302 2012 F1640 F1649
    • (2012) Am J Physiol Renal Physiol , vol.302
    • Nomura, M.1    Motohashi, H.2    Sekine, H.3    Katsura, T.4    Inui, K.5
  • 152
    • 1642388976 scopus 로고    scopus 로고
    • Quantitative Evaluation of the Drug-Drug Interactions between Methotrexate and Nonsteroidal Anti-Inflammatory Drugs in the Renal Uptake Process Based on the Contribution of Organic Anion Transporters and Reduced Folate Carrier
    • DOI 10.1124/jpet.103.061812
    • Y. Nozaki, H. Kusuhara, H. Endou, and Y. Sugiyama Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporter and reduced folate transporter J Pharmacol Exp Ther 309 2004 226 234 (Pubitemid 38393134)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.309 , Issue.1 , pp. 226-234
    • Nozaki, Y.1    Kusuhara, H.2    Endou, H.3    Sugiyama, Y.4
  • 153
    • 34548103547 scopus 로고    scopus 로고
    • Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices
    • Y. Nozaki, H. Kusuhara, T. Kondo, M. Iwaki, Y. Shiroyanagi, and H. Nakayama Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices J Pharmacol Exp Ther 322 2007 1162 1170
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1162-1170
    • Nozaki, Y.1    Kusuhara, H.2    Kondo, T.3    Iwaki, M.4    Shiroyanagi, Y.5    Nakayama, H.6
  • 155
    • 34447634890 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4α regulates the human organic anion transporter 1 gene in the kidney
    • K. Ogasawara, T. Terada, J.-I. Asaka, T. Katsura, and K.-I. Inui Hepatocyte nuclear factor-4α regulates the human organic anion transporter 1 gene in the kidney Am J Physiol Renal Physiol 292 2007 F1819 F1826
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Ogasawara, K.1    Terada, T.2    Asaka, J.-I.3    Katsura, T.4    Inui, K.-I.5
  • 156
    • 46149091944 scopus 로고    scopus 로고
    • Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney
    • K. Ogasawara, T. Terada, H. Motohashi, J.-I. Asaka, M. Aoki, and T. Katsura Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney J Hum Genet 53 2008 607 614
    • (2008) J Hum Genet , vol.53 , pp. 607-614
    • Ogasawara, K.1    Terada, T.2    Motohashi, H.3    Asaka, J.-I.4    Aoki, M.5    Katsura, T.6
  • 157
    • 2442720194 scopus 로고    scopus 로고
    • Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier
    • DOI 10.1124/jpet.103.063370
    • S. Ohtsuki, T. Kikkawa, S. Mori, S. Hori, H. Takanaga, and M. Otagiri Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier J Pharmacol Exp Ther 309 2004 1273 1281 (Pubitemid 38669719)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.309 , Issue.3 , pp. 1273-1281
    • Ohtsuki, S.1    Kikkawa, T.2    Mori, S.3    Hori, S.4    Takanaga, H.5    Otagiri, M.6    Terasaki, T.7
  • 158
    • 0023900303 scopus 로고
    • The effect of probenecid on the renal tubular excretion of benzylpenicillin
    • D. Overbosch, C. Van Gulpen, J. Hermans, and H. Mattie The effect of probenecid on the renal tubular excretion of benzylpenicillin Br J Clin Pharmacol 25 1988 51 58
    • (1988) Br J Clin Pharmacol , vol.25 , pp. 51-58
    • Overbosch, D.1    Van Gulpen, C.2    Hermans, J.3    Mattie, H.4
  • 159
    • 29944444676 scopus 로고    scopus 로고
    • Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters
    • DOI 10.1007/s00424-005-1487-2
    • A.M. Pajor Molecular properties of the SCL13 family of dicarboxylate and sulfate transporters Pflügers Arch Eur J Physiol 451 2006 597 605 (Pubitemid 43042171)
    • (2006) Pflugers Archiv European Journal of Physiology , vol.451 , Issue.5 , pp. 597-605
    • Pajor, A.M.1
  • 160
    • 33846010171 scopus 로고    scopus 로고
    • A three-dimensional model of human organic anion transporter 1: Aromatic amino acids required for substrate transport
    • DOI 10.1074/jbc.M608834200
    • J.L. Perry, N. Dembla-Rajpal, L.A. Hall, and J.B. Pritchard A three-dimensional model of human organic anion transporter 1. Aromatic amino acids required for substrate transport J Biol Chem 281 2006 38071 38079 (Pubitemid 46042110)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.49 , pp. 38071-38079
    • Perry, J.L.1    Dembla-Rajpal, N.2    Hall, L.A.3    Pritchard, J.B.4
  • 161
    • 17844385785 scopus 로고    scopus 로고
    • The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4α and suppressed by bile acids
    • DOI 10.1124/mol.104.010223
    • K. Popowski, J.J. Eloranta, M. Saborowski, M. Fried, P.J. Meier, and G.A. Kullak-Ublick The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4α and suppressed by bile acids Mol Pharmacol 67 2005 1629 1638 (Pubitemid 40594162)
    • (2005) Molecular Pharmacology , vol.67 , Issue.5 , pp. 1629-1638
    • Popowski, K.1    Eloranta, J.J.2    Saborowski, M.3    Fried, M.4    Meier, P.J.5    Kullak-Ublick, G.A.6
  • 164
    • 0033574034 scopus 로고    scopus 로고
    • Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
    • DOI 10.1006/bbrc.1998.9978
    • J.E. Race, S.M. Grassl, W.J. Williams, and E.J. Holtzman Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3) Biochem Biophys Res Commun 255 1999 508 514 (Pubitemid 29292290)
    • (1999) Biochemical and Biophysical Research Communications , vol.255 , Issue.2 , pp. 508-514
    • Race, J.E.1    Grassl, S.M.2    Williams, W.J.3    Holtzman, E.J.4
  • 166
    • 33847139479 scopus 로고    scopus 로고
    • Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
    • DOI 10.1007/s11095-006-9181-4
    • A.N. Rizwan, and G. Burckhardt Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles Pharm Res 24 2007 450 470 (Pubitemid 46295167)
    • (2007) Pharmaceutical Research , vol.24 , Issue.3 , pp. 450-470
    • Rizwan, A.N.1    Burckhardt, G.2
  • 170
    • 40549090278 scopus 로고    scopus 로고
    • Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers
    • DOI 10.1007/s11095-007-9401-6
    • M. Sato, T. Iwanaga, H. Mamada, T. Ogihara, H. Yabuuchi, and T. Maeda Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers Pharm Res 25 2008 639 646 (Pubitemid 351357726)
    • (2008) Pharmaceutical Research , vol.25 , Issue.3 , pp. 639-646
    • Sato, M.1    Iwanaga, T.2    Mamada, H.3    Ogihara, T.4    Yabuuchi, H.5    Maeda, T.6    Tamai, I.7
  • 171
    • 77649212118 scopus 로고    scopus 로고
    • Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human
    • M. Sato, H. Mamada, N. Anzai, Y. Shirasaka, T. Nakanishi, and I. Tamai Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human Biol Pharm Bull 33 2010 498 503
    • (2010) Biol Pharm Bull , vol.33 , pp. 498-503
    • Sato, M.1    Mamada, H.2    Anzai, N.3    Shirasaka, Y.4    Nakanishi, T.5    Tamai, I.6
  • 175
    • 33645457811 scopus 로고    scopus 로고
    • 2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3
    • 2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3 J Am Soc Nephrol 17 2006 46 53
    • (2006) J Am Soc Nephrol , vol.17 , pp. 46-53
    • Sauvant, C.1    Holzinger, H.2    Gekle, M.3
  • 176
    • 77956237495 scopus 로고    scopus 로고
    • Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles
    • G.W. Schnabolk, B. Gupta, A. Mulgaonkar, M. Kulkarni, and D.H. Sweet Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles J Pharmacol Exp Ther 334 2010 927 935
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 927-935
    • Schnabolk, G.W.1    Gupta, B.2    Mulgaonkar, A.3    Kulkarni, M.4    Sweet, D.H.5
  • 177
    • 33746657602 scopus 로고    scopus 로고
    • Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20)
    • G.W. Schnabolk, G.L. Youngblood, and D.H. Sweet Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20) Am J Physiol Renal Physiol 291 2006 F314 F321
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Schnabolk, G.W.1    Youngblood, G.L.2    Sweet, D.H.3
  • 178
    • 34247885858 scopus 로고    scopus 로고
    • Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats
    • R. Schneider, C. Sauvant, B. Betz, M. Otremba, D. Fischer, and H. Holzinger Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats Am J Physiol Renal Physiol 292 2007 F1599 F1605
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Schneider, R.1    Sauvant, C.2    Betz, B.3    Otremba, M.4    Fischer, D.5    Holzinger, H.6
  • 179
    • 17144449057 scopus 로고    scopus 로고
    • Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
    • DOI 10.1016/S0014-5793(98)00585-7, PII S0014579398005857
    • T. Sekine, S.H. Cha, M. Tsuda, N. Apiwattanakul, N. Nakajima, and Y. Kanai Identification of multispecific organic anion transporter 2 expressed predominantly in the liver FEBS Lett 429 1998 179 182 (Pubitemid 28288205)
    • (1998) FEBS Letters , vol.429 , Issue.2 , pp. 179-182
    • Sekine, T.1    Cha, S.H.2    Tsuda, M.3    Apiwattanakul, N.4    Nakajima, N.5    Kanai, Y.6    Endou, H.7
  • 180
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • DOI 10.1074/jbc.272.30.18526
    • T. Sekine, N. Watanabe, M. Hosoyamada, Y. Kanai, and H. Endou Expression cloning and characterization of a novel multispecific organic anion transporter J Biol Chem 272 1997 18526 18529 (Pubitemid 27318187)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.30 , pp. 18526-18529
    • Sekine, T.1    Watanabe, N.2    Hosoyamada, M.3    Kanai, Y.4    Endou, H.5
  • 181
    • 33748942990 scopus 로고    scopus 로고
    • Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats
    • DOI 10.1111/j.1349-7006.2006.00304.x
    • Y. Shibayama, K. Ushinohama, R. Ikeda, Y. Yoshikawa, T. Motoya, and Y. Takeda Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats Cancer Sci 97 2006 1260 1266 (Pubitemid 44430654)
    • (2006) Cancer Science , vol.97 , Issue.11 , pp. 1260-1266
    • Shibayama, Y.1    Ushinohama, K.2    Ikeda, R.3    Yoshikawa, Y.4    Motoya, T.5    Takeda, Y.6    Yamada, K.7
  • 182
    • 34247400616 scopus 로고    scopus 로고
    • Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate
    • DOI 10.1002/hep.21596
    • H.J. Shin, N. Anzai, A. Enomoto, D.K. Kim, H. Endou, and Y. Kanai Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate Hepatology 45 2007 1046 1055 (Pubitemid 46631573)
    • (2007) Hepatology , vol.45 , Issue.4 , pp. 1046-1055
    • Ho, J.S.1    Anzai, N.2    Enomoto, A.3    He, X.4    Do, K.K.5    Endou, H.6    Kanai, Y.7
  • 183
    • 13844314148 scopus 로고    scopus 로고
    • Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs
    • DOI 10.1146/annurev.pharmtox.44.101802.121444
    • Y. Shitara, H. Sato, and Y. Sugiyama Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs Annu Rev Pharmacol Toxicol 45 2005 689 723 (Pubitemid 40261822)
    • (2005) Annual Review of Pharmacology and Toxicology , vol.45 , pp. 689-723
    • Shitara, Y.1    Sato, H.2    Sugiyama, Y.3
  • 184
    • 0028285029 scopus 로고
    • Molecular cloning and characterization of a novel liver-specific transport protein
    • G.D. Simonson, A.C. Vincent, K.J. Roberg, Y. Huang, and V. Iwanij Molecular cloning and characterization of a novel liver-specific transport protein J Cell Sci 107 1994 1065 1072
    • (1994) J Cell Sci , vol.107 , pp. 1065-1072
    • Simonson, G.D.1    Vincent, A.C.2    Roberg, K.J.3    Huang, Y.4    Iwanij, V.5
  • 186
    • 26844436872 scopus 로고    scopus 로고
    • Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules
    • S. Soodvilai, S.H. Wright, W.H. Dantzler, and V. Chatsudthipong Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules Am J Physiol Renal Physiol 289 2005 F1057 F1064
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Soodvilai, S.1    Wright, S.H.2    Dantzler, W.H.3    Chatsudthipong, V.4
  • 187
    • 48749084010 scopus 로고    scopus 로고
    • Physiology, structure, and regulation of the cloned organic anion transporters
    • C. Srimaroeng, J.L. Perry, and J.B. Pritchard Physiology, structure, and regulation of the cloned organic anion transporters Xenobiotica 38 2008 889 935
    • (2008) Xenobiotica , vol.38 , pp. 889-935
    • Srimaroeng, C.1    Perry, J.L.2    Pritchard, J.B.3
  • 188
    • 23644457833 scopus 로고    scopus 로고
    • Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites
    • DOI 10.1016/j.bbamem.2005.06.006, PII S000527360500180X
    • M. Sugawara, T. Mochizuki, Y. Takekuma, and K. Miyazaki Structure-activity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites Biochim Biophys Acta 1714 2005 85 92 (Pubitemid 41133610)
    • (2005) Biochimica et Biophysica Acta - Biomembranes , vol.1714 , Issue.2 , pp. 85-92
    • Sugawara, M.1    Mochizuki, T.2    Takekuma, Y.3    Miyazaki, K.4
  • 190
    • 17444420647 scopus 로고    scopus 로고
    • Organic anion transporter (Slc22a) family members as mediators of toxicity
    • DOI 10.1016/j.taap.2004.10.016, Membrane Transporters in Toxicology
    • D.H. Sweet Organic anion transporter (Slc22a) family members as mediators of toxicity Toxicol Appl Pharmacol 204 2005 198 215 (Pubitemid 40545228)
    • (2005) Toxicology and Applied Pharmacology , vol.204 , Issue.3 , pp. 198-215
    • Sweet, D.H.1
  • 192
    • 0037178852 scopus 로고    scopus 로고
    • Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice
    • DOI 10.1074/jbc.M203803200
    • D.H. Sweet, D.S. Miller, J.B. Pritchard, Y. Fujiwara, D.R. Beier, and S.K. Nigam Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice J Biol Chem 277 2002 26934 26943 (Pubitemid 34951703)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.30 , pp. 26934-26943
    • Sweet, D.H.1    Miller, D.S.2    Pritchard, J.B.3    Fujiwara, Y.4    Beier, D.R.5    Nigam, S.K.6
  • 193
    • 0030781076 scopus 로고    scopus 로고
    • Expression cloning and characterization of ROAT1
    • D.H. Sweet, N.A. Wolff, and J.B. Pritchard Expression cloning and characterization of ROAT1 J Biol Chem 272 1997 30088 30095
    • (1997) J Biol Chem , vol.272 , pp. 30088-30095
    • Sweet, D.H.1    Wolff, N.A.2    Pritchard, J.B.3
  • 194
    • 1942535147 scopus 로고    scopus 로고
    • Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice
    • D. Sykes, D.H. Sweet, S. Lowes, S.K. Nigam, J.B. Pritchard, and D.S. Miller Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice Am J Physiol Renal Physiol 286 2004 F972 F978
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Sykes, D.1    Sweet, D.H.2    Lowes, S.3    Nigam, S.K.4    Pritchard, J.B.5    Miller, D.S.6
  • 195
    • 33644749355 scopus 로고    scopus 로고
    • Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists
    • DOI 10.1124/jpet.105.094052
    • H. Tahara, H. Kusuhara, M. Chida, E. Fuse, and Y. Sugiyama Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists J Pharmacol Exp Ther 316 2006 1187 1194 (Pubitemid 43345293)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.316 , Issue.3 , pp. 1187-1194
    • Tahara, H.1    Kusuhara, H.2    Chida, M.3    Fuse, E.4    Sugiyama, Y.5
  • 198
    • 0037119021 scopus 로고    scopus 로고
    • Corrigendum to "interaction of human organic anion transporters with various cephalosporin antibiotics"
    • M. Takeda, E. Babu, S. Narikawa, and H. Endou Corrigendum to "Interaction of human organic anion transporters with various cephalosporin antibiotics" Eur J Pharmacol 450 2002 111
    • (2002) Eur J Pharmacol , vol.450 , pp. 111
    • Takeda, M.1    Babu, E.2    Narikawa, S.3    Endou, H.4
  • 199
    • 0037040390 scopus 로고    scopus 로고
    • Interaction of human organic anion transporters with various cephalosporin antibiotics
    • DOI 10.1016/S0014-2999(02)01306-7, PII S0014299902013067
    • M. Takeda, E. Babu, S. Narikawa, and H. Endou Interaction of human organic anion transporters with various cephalosporin antibiotics Eur J Pharmacol 438 2002 137 142 (Pubitemid 34241501)
    • (2002) European Journal of Pharmacology , vol.438 , Issue.3 , pp. 137-142
    • Takeda, M.1    Babu, E.2    Narikawa, S.3    Endou, H.4
  • 200
    • 0036076780 scopus 로고    scopus 로고
    • Characterization of methotrexate transport and its drug interactions with human organic anion transporters
    • DOI 10.1124/jpet.102.034330
    • M. Takeda, S. Khamdang, S. Narikawa, H. Kimura, M. Hosoyamada, and S.H. Cha Characterization of methotrexate transport and its drug interactions with human organic anion transporters J Pharmacol Exp Ther 302 2002 666 671 (Pubitemid 34787234)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.302 , Issue.2 , pp. 666-671
    • Takeda, M.1    Khamdang, S.2    Narikawa, S.3    Kimura, H.4    Coceani, F.5
  • 203
    • 0033458777 scopus 로고    scopus 로고
    • Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)- induced nephrotoxicity
    • DOI 10.1046/j.1523-1755.1999.00789.x
    • M. Takeda, A. Tojo, T. Sekine, M. Hosoyamada, Y. Kanai, and H. Endou Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity Kidney Int 56 1999 2128 2136 (Pubitemid 30004741)
    • (1999) Kidney International , vol.56 , Issue.6 , pp. 2128-2136
    • Takeda, M.1    Tojo, A.2    Sekine, T.3    Hosoyamada, M.4    Kanai, Y.5    Endou, H.6
  • 204
    • 2442479788 scopus 로고    scopus 로고
    • Role of Glycosylation in the Organic Anion Transporter OAT1
    • DOI 10.1074/jbc.M400197200
    • K. Tanaka, W. Xu, F. Zhou, and G. You Role of glycosylation in the organic anion transporter OAT1 J Biol Chem 279 2004 14961 14966 (Pubitemid 38618888)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.15 , pp. 14961-14966
    • Tanaka, K.1    Xu, W.2    Zhou, F.3    You, G.4
  • 205
    • 80052544306 scopus 로고    scopus 로고
    • Angiotensin receptor blockers: Pharmacology, efficacy, and safety
    • A.A. Taylor, H. Siragy, and S. Nesbitt Angiotensin receptor blockers: pharmacology, efficacy, and safety J Clin Hypertens 13 2011 677 686
    • (2011) J Clin Hypertens , vol.13 , pp. 677-686
    • Taylor, A.A.1    Siragy, H.2    Nesbitt, S.3
  • 206
    • 0022613399 scopus 로고
    • Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen
    • A. Thyss, G. Milano, J. Kubar, M. Namer, and M. Schneider Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen Lancet 1 8475 1986 256 258 (Pubitemid 16132863)
    • (1986) Lancet , vol.1 , Issue.8475 , pp. 256-258
    • Thyss, A.1    Milano, G.2    Kubar, J.3
  • 208
    • 79960666822 scopus 로고    scopus 로고
    • Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
    • A.M. Torres, A.V. Dnyanmote, K.T. Bush, W. Wu, and S.K. Nigam Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury J Biol Chem 286 2011 26391 26395
    • (2011) J Biol Chem , vol.286 , pp. 26391-26395
    • Torres, A.M.1    Dnyanmote, A.V.2    Bush, K.T.3    Wu, W.4    Nigam, S.K.5
  • 209
    • 43749115381 scopus 로고    scopus 로고
    • Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
    • D.M. Truong, G. Kaler, A. Khandelwal, P.W. Swaan, and S.K. Nigam Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination J Biol Chem 283 2008 8654 8663
    • (2008) J Biol Chem , vol.283 , pp. 8654-8663
    • Truong, D.M.1    Kaler, G.2    Khandelwal, A.3    Swaan, P.W.4    Nigam, S.K.5
  • 210
    • 77949922736 scopus 로고    scopus 로고
    • Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney
    • H. Tsuchida, N. Anzai, H.J. Shin, M.F. Wempe, P. Jutabha, and A. Enomoto Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney Cell Physiol Biochem 25 2010 511 522
    • (2010) Cell Physiol Biochem , vol.25 , pp. 511-522
    • Tsuchida, H.1    Anzai, N.2    Shin, H.J.3    Wempe, M.F.4    Jutabha, P.5    Enomoto, A.6
  • 211
    • 34548022843 scopus 로고    scopus 로고
    • Cl-dependent up-regulation of human organic anion transporters: Different effects on transport kinetics between hOAT1 and hOAT3
    • H. Ueo, H. Motohashi, and K.-I. Inui Cl-dependent up-regulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3 Am J Physiol Renal Physiol 293 2007 F391 F397
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Ueo, H.1    Motohashi, H.2    Inui, K.-I.3
  • 212
    • 24344461838 scopus 로고    scopus 로고
    • Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1
    • DOI 10.1016/j.bcp.2005.06.024, PII S0006295205004533
    • H. Ueo, H. Motohashi, T. Katsura, and K.-I. Inui Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1 Biochem Pharmacol 70 2005 1104 1113 (Pubitemid 41262086)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.7 , pp. 1104-1113
    • Ueo, H.1    Motohashi, H.2    Katsura, T.3    Inui, K.-I.4
  • 215
    • 33947138325 scopus 로고    scopus 로고
    • Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2)
    • DOI 10.1007/s11095-006-9196-x
    • Y. Uwai, H. Ida, Y. Tsuji, T. Katsura, and K. Inui Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2) Pharm Res 24 2007 811 815 (Pubitemid 46411965)
    • (2007) Pharmaceutical Research , vol.24 , Issue.4 , pp. 811-815
    • Uwai, Y.1    Ida, H.2    Tsuji, Y.3    Katsura, T.4    Inui, K.-I.5
  • 216
    • 34249014286 scopus 로고    scopus 로고
    • Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3
    • DOI 10.1016/j.bcp.2007.03.024, PII S000629520700192X
    • Y. Uwai, H. Motohashi, Y. Tsuji, H. Ueo, T. Katsura, and K.-I. Inui Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3 Biochem Pharmacol 74 2007 161 168 (Pubitemid 46802493)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.1 , pp. 161-168
    • Uwai, Y.1    Motohashi, H.2    Tsuji, Y.3    Ueo, H.4    Katsura, T.5    Inui, K.-i.6
  • 217
    • 0034674381 scopus 로고    scopus 로고
    • Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1
    • DOI 10.1016/S0014-2999(00)00324-1, PII S0014299900003241
    • Y. Uwai, H. Saito, Y. Hashimoto, and K. Inui Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1 Eur J Pharmacol 398 2000 193 197 (Pubitemid 30333345)
    • (2000) European Journal of Pharmacology , vol.398 , Issue.2 , pp. 193-197
    • Uwai, Y.1    Saito, H.2    Hashimoto, Y.3    Inui, K.-I.4
  • 218
    • 0033803165 scopus 로고    scopus 로고
    • Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1
    • Y. Uwai, H. Saito, Y. Hashimoto, and K.-I. Inui Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1 J Pharmacol Exp Ther 295 2000 261 265
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 261-265
    • Uwai, Y.1    Saito, H.2    Hashimoto, Y.3    Inui, K.-I.4
  • 219
    • 85013794678 scopus 로고    scopus 로고
    • Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone
    • Y. Uwai, H. Saito, and K. Inui Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone Drug Metab Pharmacokinet 17 2002 125 129
    • (2002) Drug Metab Pharmacokinet , vol.17 , pp. 125-129
    • Uwai, Y.1    Saito, H.2    Inui, K.3
  • 220
    • 16644373437 scopus 로고    scopus 로고
    • Methotrexate-loxoprofen interaction: Involvement of human organic anion transporters hOAT1 and hOAT3
    • Y. Uwai, R. Taniguchi, H. Motohashi, H. Saito, M. Okuda, and K.-I. Inui Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3 Drug Metab Dispos 19 2004 369 374
    • (2004) Drug Metab Dispos , vol.19 , pp. 369-374
    • Uwai, Y.1    Taniguchi, R.2    Motohashi, H.3    Saito, H.4    Okuda, M.5    Inui, K.-I.6
  • 222
    • 44949088665 scopus 로고    scopus 로고
    • Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics
    • V. Vallon, T. Rieg, S.Y. Ahn, W. Wu, S.A. Eraly, and S.K. Nigam Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics Am J Physiol Renal Physiol 294 2008 F867 F873
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Vallon, V.1    Rieg, T.2    Ahn, S.Y.3    Wu, W.4    Eraly, S.A.5    Nigam, S.K.6
  • 223
    • 35348889668 scopus 로고    scopus 로고
    • Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G
    • A.L. Van Wert, R.M. Bailey, and D.H. Sweet Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G Am J Physiol Renal Physiol 293 2007 F1332 F1341
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Van Wert, A.L.1    Bailey, R.M.2    Sweet, D.H.3
  • 224
    • 75349105185 scopus 로고    scopus 로고
    • Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology
    • A.L. Van Wert, M.R. Gionfriddo, and D.H. Sweet Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology Biopharm Drug Dispos 31 2010 1 71
    • (2010) Biopharm Drug Dispos , vol.31 , pp. 1-71
    • Van Wert, A.L.1    Gionfriddo, M.R.2    Sweet, D.H.3
  • 225
    • 45749158039 scopus 로고    scopus 로고
    • Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin
    • DOI 10.1124/mol.107.042853
    • A.L. Van Wert, C. Srimaroeng, and D.H. Sweet Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin Mol Pharmacol 74 2008 122 131 (Pubitemid 351872164)
    • (2008) Molecular Pharmacology , vol.74 , Issue.1 , pp. 122-131
    • VanWert, A.L.1    Srimaroeng, C.2    Sweet, D.H.3
  • 226
    • 39149106149 scopus 로고    scopus 로고
    • Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: A gender specific impact of reduced folates
    • DOI 10.1007/s11095-007-9407-0
    • A.L. Van Wert, and D.H. Sweet Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact on reduced folates Pharm Res 25 2008 453 462 (Pubitemid 351257979)
    • (2008) Pharmaceutical Research , vol.25 , Issue.2 , pp. 453-462
    • VanWert, A.L.1    Sweet, D.H.2
  • 228
    • 32844454648 scopus 로고    scopus 로고
    • Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction
    • DOI 10.1111/j.1523-1755.2005.00741.x, PII 4495614
    • S.R. Villar, A. Brandoni, N. Anzai, H. Endou, and A.M. Torres Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction Kidney Int 68 2005 2704 2713 (Pubitemid 43251015)
    • (2005) Kidney International , vol.68 , Issue.6 , pp. 2704-2713
    • Villar, S.R.1    Brandoni, A.2    Anzai, N.3    Endou, H.4    Torres, A.M.5
  • 229
    • 54449102183 scopus 로고    scopus 로고
    • Time course of organic anion excretion in rats with bilateral ureteral obstruction: Role of organic anion transporters (Oat1 and Oat3)
    • S.R. Villar, A. Brandoni, and A.M. Torres Time course of organic anion excretion in rats with bilateral ureteral obstruction: role of organic anion transporters (Oat1 and Oat3) Nephron Physiol 110 2008 45 56
    • (2008) Nephron Physiol , vol.110 , pp. 45-56
    • Villar, S.R.1    Brandoni, A.2    Torres, A.M.3
  • 232
    • 84859970418 scopus 로고    scopus 로고
    • Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6
    • W. Wegner, B.C. Burckhardt, G. Burckhardt, and M. Henjakovic Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6 PLoS One 7 2012 e35556
    • (2012) PLoS One , vol.7 , pp. 35556
    • Wegner, W.1    Burckhardt, B.C.2    Burckhardt, G.3    Henjakovic, M.4
  • 233
    • 34548060345 scopus 로고    scopus 로고
    • The contribution of Organic Anion Transporters OAT1 and OAT3 to the renal uptake of rosuvastatin
    • DOI 10.1124/jpet.107.125831
    • A.S. Windass, S. Lowes, Y. Wang, and C.D.A. Brown The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin J Pharmacol Exp Ther 322 2007 1221 1227 (Pubitemid 47295808)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.322 , Issue.3 , pp. 1221-1227
    • Windass, A.S.1    Lowes, S.2    Wang, Y.3    Brown, C.D.A.4
  • 234
    • 34548414188 scopus 로고    scopus 로고
    • Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney
    • DOI 10.1093/ndt/gfm219
    • N.A. Wolff, B.C. Burckhardt, G. Burckhardt, M. Oellerich, and V.W. Armstrong Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of human kidney Nephrol Dial Transplant 22 2007 2497 2503 (Pubitemid 47365512)
    • (2007) Nephrology Dialysis Transplantation , vol.22 , Issue.9 , pp. 2497-2503
    • Wolff, N.A.1    Burckhardt, B.C.2    Burckhardt, G.3    Oellerich, M.4    Armstrong, V.W.5
  • 235
    • 0042844712 scopus 로고    scopus 로고
    • Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization
    • DOI 10.1097/01.ASN.0000079040.55124.25
    • N.A. Wolff, K. Thies, N. Kuhnke, G. Reid, B. Friedrich, and F. Lang Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization J Am Soc Nephrol 14 2003 1959 1968 (Pubitemid 36909903)
    • (2003) Journal of the American Society of Nephrology , vol.14 , Issue.8 , pp. 1959-1968
    • Wolff, N.A.1    Thies, K.2    Kuhnke, N.3    Reid, G.4    Friedrich, B.5    Lang, F.6    Burckhardt, G.7
  • 236
    • 3042542425 scopus 로고    scopus 로고
    • Molecular and cellular physiology of renal organic cation and anion transport
    • DOI 10.1152/physrev.00040.2003
    • S.H. Wright, and W.H. Dantzler Molecular and cellular physiology of renal organic cation and anion transport Physiol Rev 84 2004 987 1049 (Pubitemid 38823772)
    • (2004) Physiological Reviews , vol.84 , Issue.3 , pp. 987-1049
    • Wright, S.H.1    Dantzler, W.H.2
  • 237
    • 31644434086 scopus 로고    scopus 로고
    • Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]: Rapid communication
    • DOI 10.1111/j.1523-1755.2005.00612.x, PII 4494752
    • G. Xu, V. Bhatnagar, G. Wen, B.A. Hamilton, S.A. Eraly, and S.K. Nigam Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT1 (RST)] Kidney Int 68 2005 1491 1499 (Pubitemid 43169896)
    • (2005) Kidney International , vol.68 , Issue.4 , pp. 1491-1499
    • Xu, G.1    Bhatnagar, V.2    Wen, G.3    Hamilton, B.A.4    Eraly, S.A.5    Nigam, S.K.6
  • 241
    • 3242707822 scopus 로고    scopus 로고
    • Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney
    • G.L. Youngblood, and D.H. Sweet Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney Am J Physiol Renal Physiol 287 2004 F236 F244
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Youngblood, G.L.1    Sweet, D.H.2
  • 242
    • 67649886935 scopus 로고    scopus 로고
    • Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril
    • H. Yuan, B. Feng, Y. Yu, J. Chupka, J.Y. Zheng, and T.G. Heath Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril J Pharmacol Exp Ther 330 2009 191 197
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 191-197
    • Yuan, H.1    Feng, B.2    Yu, Y.3    Chupka, J.4    Zheng, J.Y.5    Heath, T.G.6
  • 243
    • 6344240973 scopus 로고    scopus 로고
    • Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule
    • X. Zhang, C.E. Groves, A. Bahn, W.M. Barendt, M.D. Prado, and M. Rödiger Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule Am J Physiol Renal Physiol 287 2004 F999 F1010
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Zhang, X.1    Groves, C.E.2    Bahn, A.3    Barendt, W.M.4    Prado, M.D.5    Rödiger, M.6
  • 244
    • 57749119509 scopus 로고    scopus 로고
    • Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway
    • Q. Zhang, M. Hong, P. Duan, Z. Pan, J. Ma, and G. You Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway J Biol Chem 283 2008 32570 32579
    • (2008) J Biol Chem , vol.283 , pp. 32570-32579
    • Zhang, Q.1    Hong, M.2    Duan, P.3    Pan, Z.4    Ma, J.5    You, G.6
  • 245
    • 51149108117 scopus 로고    scopus 로고
    • Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury
    • R. Zhang, X. Yang, J. Li, J. Wu, W.-X. Peng, and X.-Q. Dong Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury Am J Nephrol 28 2008 772 783
    • (2008) Am J Nephrol , vol.28 , pp. 772-783
    • Zhang, R.1    Yang, X.2    Li, J.3    Wu, J.4    Peng, W.-X.5    Dong, X.-Q.6
  • 246
    • 14944353459 scopus 로고    scopus 로고
    • The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4
    • DOI 10.1124/mol.104.007583
    • F. Zhou, W. Xu, M. Hong, Z. Pan, P.J. Sinko, and J. Ma The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter OAT4 Mol Pharmacol 67 2005 868 876 (Pubitemid 40365334)
    • (2005) Molecular Pharmacology , vol.67 , Issue.3 , pp. 868-876
    • Zhou, F.1    Xu, W.2    Hong, M.3    Pan, Z.4    Sinko, P.J.5    Ma, J.6    You, G.7
  • 247
    • 39149097829 scopus 로고    scopus 로고
    • Comparison of the interaction of human organic anion transporter hOAT4 with PDZ proteins between kidney cells and placental cells
    • F. Zhou, W. Xu, K. Tanaka, and G. You Comparison of the interaction of human organic anion transporter hOAT4 with PDZ proteins between kidney cells and placental cells Pharm Res 25 2007 475 480
    • (2007) Pharm Res , vol.25 , pp. 475-480
    • Zhou, F.1    Xu, W.2    Tanaka, K.3    You, G.4
  • 248
    • 69049119083 scopus 로고    scopus 로고
    • Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex
    • V. Zlender, D. Breljak, M. Ljubojevic, D. Flajs, D. Balen, and H. Brzica Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex Toxicol Appl Pharmacol 239 2009 284 296
    • (2009) Toxicol Appl Pharmacol , vol.239 , pp. 284-296
    • Zlender, V.1    Breljak, D.2    Ljubojevic, M.3    Flajs, D.4    Balen, D.5    Brzica, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.