메뉴 건너뛰기




Volumn 45, Issue , 2005, Pages 689-723

Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

Author keywords

Pharmacokinetics; Quantitative prediction of drug drug interaction; Transporter

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTIBIOTIC AGENT; ATORVASTATIN; CEFACLOR; CEFALEXIN; CEFAZOLIN; CEFMETAZOLE; CEFOXITIN; CEFRADINE; CEPHALOSPORIN DERIVATIVE; CERIVASTATIN; CYCLOSPORIN A; DIGOXIN; FLUINDOSTATIN; GEMFIBROZIL; GLYCOPROTEIN P; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC ANION TRANSPORTER; PEPTIDE TRANSPORTER 1; PITAVASTATIN; PRAVASTATIN; PROBENECID; QUINIDINE; QUININE; RIFAMPICIN; ROSUVASTATIN; SIMVASTATIN; UNINDEXED DRUG;

EID: 13844314148     PISSN: 03621642     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pharmtox.44.101802.121444     Document Type: Review
Times cited : (311)

References (200)
  • 1
    • 0028052723 scopus 로고
    • Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport
    • Petzinger E. 1994. Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport. Rev. Physiol. Biochem. Pharmacol. 123:47-211
    • (1994) Rev. Physiol. Biochem. Pharmacol. , vol.123 , pp. 47-211
    • Petzinger, E.1
  • 3
    • 0029926676 scopus 로고    scopus 로고
    • Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics
    • Yamazaki M, Suzuki H, Sugiyama Y. 1996. Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics. Pharm. Res. 13:497-513
    • (1996) Pharm. Res. , vol.13 , pp. 497-513
    • Yamazaki, M.1    Suzuki, H.2    Sugiyama, Y.3
  • 4
    • 0029686478 scopus 로고    scopus 로고
    • Use of an isolated perfused kidney to assess renal clearance of drugs: Information obtained in steady-state and non-steady-state experimental systems
    • ed RT Borchard, PL Smith, G Wilson. New York: Plenum Press
    • Okudaira N, Sugiyama Y. 1996. Use of an isolated perfused kidney to assess renal clearance of drugs: information obtained in steady-state and non-steady-state experimental systems. In Models for Assessing Drug Absorption and Metabolism, ed RT Borchard, PL Smith, G Wilson, pp. 211-38. New York: Plenum Press
    • (1996) Models for Assessing Drug Absorption and Metabolism , pp. 211-238
    • Okudaira, N.1    Sugiyama, Y.2
  • 5
    • 0024063121 scopus 로고
    • Renal transport of drugs: An overview of methodology with application to cimetidine
    • Giacomini KM, Hsyu PH, Gisclon JG. 1988. Renal transport of drugs: an overview of methodology with application to cimetidine. Pharm. Res. 5:465-71
    • (1988) Pharm. Res. , vol.5 , pp. 465-471
    • Giacomini, K.M.1    Hsyu, P.H.2    Gisclon, J.G.3
  • 7
    • 0037122743 scopus 로고    scopus 로고
    • Role of transporters in the tissue-selective distribution and elimination of drugs: Transporters in the liver, small intestine, brain and kidney
    • Kusuhara H, Sugiyama Y. 2002. Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J. Control. Release 78:43-54
    • (2002) J. Control. Release , vol.78 , pp. 43-54
    • Kusuhara, H.1    Sugiyama, Y.2
  • 8
    • 0031691234 scopus 로고    scopus 로고
    • The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs
    • Kusuhara H, Suzuki H, Sugiyama Y. 1998. The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs. J. Pharm. Sci. 87:1025-40
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1025-1040
    • Kusuhara, H.1    Suzuki, H.2    Sugiyama, Y.3
  • 9
    • 0033736560 scopus 로고    scopus 로고
    • Transport of drugs across the hepatic sinusoidal membrane: Sinusoidal drug influx and efflux in the liver
    • Suzuki H, Sugiyama Y. 2000. Transport of drugs across the hepatic sinusoidal membrane: sinusoidal drug influx and efflux in the liver. Semin. Liver Dis. 20:251-63
    • (2000) Semin. Liver Dis. , vol.20 , pp. 251-263
    • Suzuki, H.1    Sugiyama, Y.2
  • 10
    • 0033849976 scopus 로고    scopus 로고
    • Cellular and molecular aspects of drug transport in the kidney
    • Inui K, Masuda S, Saito H. 2000. Cellular and molecular aspects of drug transport in the kidney. Kidney Int. 58:944-58
    • (2000) Kidney Int. , vol.58 , pp. 944-958
    • Inui, K.1    Masuda, S.2    Saito, H.3
  • 11
    • 0035066252 scopus 로고    scopus 로고
    • Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
    • Dresser MJ, Leabman MK, Giacomini KM. 2001. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J. Pharm. Sci. 90:397-421
    • (2001) J. Pharm. Sci. , vol.90 , pp. 397-421
    • Dresser, M.J.1    Leabman, M.K.2    Giacomini, K.M.3
  • 12
    • 0034880349 scopus 로고    scopus 로고
    • The organic anion transporter family: From physiology to ontogeny and the clinic
    • Sweet DH, Bush KT, Nigam SK. 2001. The organic anion transporter family: from physiology to ontogeny and the clinic. Am. J. Physiol. Renal Physiol. 281: F197-205
    • (2001) Am. J. Physiol. Renal Physiol. , vol.281
    • Sweet, D.H.1    Bush, K.T.2    Nigam, S.K.3
  • 13
    • 0033938669 scopus 로고    scopus 로고
    • The multispecific organic anion transporter (OAT) family
    • Sekine T, Cha SH, Endou H. 2000. The multispecific organic anion transporter (OAT) family. Pflugers Arch. 440:337-50
    • (2000) Pflugers Arch. , vol.440 , pp. 337-350
    • Sekine, T.1    Cha, S.H.2    Endou, H.3
  • 14
    • 0032942525 scopus 로고    scopus 로고
    • Molecular pharmacology of organic cation transporters in the kidney
    • Koepsell H, Gorboulev V, Arndt P. 1999. Molecular pharmacology of organic cation transporters in the kidney. J. Membr. Biol. 167:103-17
    • (1999) J. Membr. Biol. , vol.167 , pp. 103-117
    • Koepsell, H.1    Gorboulev, V.2    Arndt, P.3
  • 15
    • 0002674396 scopus 로고    scopus 로고
    • Drugtransporters: Their roles and importance in the selection and development of new drugs
    • Mizuno N, Sugiyama Y. 2002. Drugtransporters: their roles and importance in the selection and development of new drugs. Drug Metab. Pharmacokin. 17:93-108
    • (2002) Drug Metab. Pharmacokin. , vol.17 , pp. 93-108
    • Mizuno, N.1    Sugiyama, Y.2
  • 16
    • 0030725999 scopus 로고    scopus 로고
    • Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
    • Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B. 1997. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 26:1667-77
    • (1997) Hepatology , vol.26 , pp. 1667-1677
    • Meier, P.J.1    Eckhardt, U.2    Schroeder, A.3    Hagenbuch, B.4    Stieger, B.5
  • 17
    • 0017603437 scopus 로고
    • Hepatic clearance of drugs I: Theoretical considerations of a "well-stirred" model and a "parallel-tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance
    • Pang KS, Rowland M. 1977. Hepatic clearance of drugs I: theoretical considerations of a "well-stirred" model and a "parallel- tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance. J. Pharmacokin. Biopharm. 5:625-53
    • (1977) J. Pharmacokin. Biopharm. , vol.5 , pp. 625-653
    • Pang, K.S.1    Rowland, M.2
  • 18
    • 0018121698 scopus 로고
    • Kinetics of metabolite formation and elimination in the perfused rat liver preparation: Difference between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin
    • Pang KS, Gillette R. 1978. Kinetics of metabolite formation and elimination in the perfused rat liver preparation: difference between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin. J. Pharmacol. Exp. Ther. 207:178-94
    • (1978) J. Pharmacol. Exp. Ther. , vol.207 , pp. 178-194
    • Pang, K.S.1    Gillette, R.2
  • 19
    • 0023184551 scopus 로고
    • Kinetics of hepatic transport of 4-methylumbel-liferone in rats: Analysis by multiple indicator dilution method
    • Miyauchi S, Sugiyama Y, Sawada Y, Morita K, Iga T, et al. 1987. Kinetics of hepatic transport of 4-methylumbel-liferone in rats: analysis by multiple indicator dilution method. J. Pharmacokin. Biopharm. 15:25-38
    • (1987) J. Pharmacokin. Biopharm. , vol.15 , pp. 25-38
    • Miyauchi, S.1    Sugiyama, Y.2    Sawada, Y.3    Morita, K.4    Iga, T.5
  • 20
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H. 1997. Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272:18526-29
    • (1997) J. Biol. Chem. , vol.272 , pp. 18526-18529
    • Sekine, T.1    Watanabe, N.2    Hosoyamada, M.3    Kanai, Y.4    Endou, H.5
  • 21
    • 0032919287 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
    • Hosoyamada M, Sekine T, Kanai Y, Endou H. 1999. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am. J. Physiol. Renal Physiol. 276:F122-28
    • (1999) Am. J. Physiol. Renal Physiol. , vol.276
    • Hosoyamada, M.1    Sekine, T.2    Kanai, Y.3    Endou, H.4
  • 22
    • 0034817065 scopus 로고    scopus 로고
    • Isolation of a family of organic anion transporters from human liver and kidney
    • Sun W, Wu RR, van Poelje PD, Erion MD. 2001. Isolation of a family of organic anion transporters from human liver and kidney. Biochem. Biophys. Res. Comm. 283:417-22
    • (2001) Biochem. Biophys. Res. Comm. , vol.283 , pp. 417-422
    • Sun, W.1    Wu, R.R.2    Van Poelje, P.D.3    Erion, M.D.4
  • 23
    • 0033574034 scopus 로고    scopus 로고
    • Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
    • Race JE, Grassl SM, Williams WJ, Holtzman EJ. 1999. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem. Biophys. Res. Commun. 255:508-14
    • (1999) Biochem. Biophys. Res. Commun. , vol.255 , pp. 508-514
    • Race, J.E.1    Grassl, S.M.2    Williams, W.J.3    Holtzman, E.J.4
  • 24
    • 0000518648 scopus 로고    scopus 로고
    • Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    • Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, et al. 2000. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem. 275:4507-12
    • (2000) J. Biol. Chem. , vol.275 , pp. 4507-4512
    • Cha, S.H.1    Sekine, T.2    Kusuhara, H.3    Yu, E.4    Kim, J.Y.5
  • 25
    • 0035039326 scopus 로고    scopus 로고
    • Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
    • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, et al. 2001. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol. 59:1277-86
    • (2001) Mol. Pharmacol. , vol.59 , pp. 1277-1286
    • Cha, S.H.1    Sekine, T.2    Fukushima, J.I.3    Kanai, Y.4    Kobayashi, Y.5
  • 26
    • 0036076780 scopus 로고    scopus 로고
    • Characterization of methotrexate transport and its drug interactions with human organic anion transporters
    • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, et al. 2002. Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J. Pharmacol. Exp. Ther. 302:666-71
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 666-671
    • Takeda, M.1    Khamdang, S.2    Narikawa, S.3    Kimura, H.4    Hosoyamada, M.5
  • 27
    • 0036175142 scopus 로고    scopus 로고
    • Human organic anion transporters and human organic cation transporters mediate renal antiviral transport
    • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, et al. 2002. Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J. Pharmacol. Exp. Ther. 300:918-24
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 918-924
    • Takeda, M.1    Khamdang, S.2    Narikawa, S.3    Kimura, H.4    Kobayashi, Y.5
  • 28
    • 0035929163 scopus 로고    scopus 로고
    • Characterization of ochratoxin A transport by human organic anion transporters
    • Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, et al. 2001. Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 69:2123-35
    • (2001) Life Sci. , vol.69 , pp. 2123-2135
    • Jung, K.Y.1    Takeda, M.2    Kim, D.K.3    Tojo, A.4    Narikawa, S.5
  • 29
    • 0033989134 scopus 로고    scopus 로고
    • Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein
    • Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, et al. 2000. Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol. Pharmacol. 57:24-35
    • (2000) Mol. Pharmacol. , vol.57 , pp. 24-35
    • Lecureur, V.1    Sun, D.2    Hargrove, P.3    Schuetz, E.G.4    Kim, R.B.5
  • 30
    • 0035119989 scopus 로고    scopus 로고
    • In vitro substrate identification studies for p-glycoprotein-mediated transport: Species difference and predictability of in vivo results
    • Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, et al. 2001. In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results. J. Pharmacol. Exp. Ther. 296:723-35
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 723-735
    • Yamazaki, M.1    Neway, W.E.2    Ohe, T.3    Chen, I.4    Rowe, J.F.5
  • 31
    • 0026662530 scopus 로고
    • Partial purification and reconstitution of the human multidrug-resistance pump: Characterization of the drug-stimulatable ATP hydrolysis
    • Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, et al. 1992. Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc. Natl. Acad. Sci. USA 89:8472-76
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8472-8476
    • Ambudkar, S.V.1    Lelong, I.H.2    Zhang, J.3    Cardarelli, C.O.4    Gottesman, M.M.5
  • 32
    • 0035668339 scopus 로고    scopus 로고
    • Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein
    • Adachi Y, Suzuki H, Sugiyama Y. 2001. Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm. Res. 18:1660-68
    • (2001) Pharm. Res. , vol.18 , pp. 1660-1668
    • Adachi, Y.1    Suzuki, H.2    Sugiyama, Y.3
  • 33
    • 0036206470 scopus 로고    scopus 로고
    • Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT)
    • Guo A, Marinaro W, Hu P, Sinko PJ. 2002. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab. Dispos. 30:457-63
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 457-463
    • Guo, A.1    Marinaro, W.2    Hu, P.3    Sinko, P.J.4
  • 34
    • 0031941789 scopus 로고    scopus 로고
    • Taxol transport by human intestinal epithelial Caco-2 cells
    • Walle UK, Walle T. 1998. Taxol transport by human intestinal epithelial Caco-2 cells. Drug Metab. Dispos. 26:343-46
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 343-346
    • Walle, U.K.1    Walle, T.2
  • 35
    • 0026459449 scopus 로고
    • Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1)
    • Tanigawara Y, Okamura N, Hirai M, Yasuhara M, Ueda K, et al. 1992. Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J. Pharmacol. Exp. Ther. 263:840-45
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 840-845
    • Tanigawara, Y.1    Okamura, N.2    Hirai, M.3    Yasuhara, M.4    Ueda, K.5
  • 36
    • 0026487058 scopus 로고
    • Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone
    • Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, et al. 1992. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J. Biol Chem. 267:24248-52
    • (1992) J. Biol Chem. , vol.267 , pp. 24248-24252
    • Ueda, K.1    Okamura, N.2    Hirai, M.3    Tanigawara, Y.4    Saeki, T.5
  • 37
    • 0028826927 scopus 로고
    • Differential recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2
    • Ganapathy ME, Brandsch M, Prasad PD, Ganapathy V, Leibach FH. 1995. Differential recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J. Biol. Chem. 270:25672-77
    • (1995) J. Biol. Chem. , vol.270 , pp. 25672-25677
    • Ganapathy, M.E.1    Brandsch, M.2    Prasad, P.D.3    Ganapathy, V.4    Leibach, F.H.5
  • 38
    • 0031713192 scopus 로고    scopus 로고
    • Tubular localization and tissue distribution of peptide transporters in rat kidney
    • Smith DE, Pavlova A, Berger UV, Hediger MA, Yang T, et al. 1998. Tubular localization and tissue distribution of peptide transporters in rat kidney. Pharm. Res. 15:1244-49
    • (1998) Pharm. Res. , vol.15 , pp. 1244-1249
    • Smith, D.E.1    Pavlova, A.2    Berger, U.V.3    Hediger, M.A.4    Yang, T.5
  • 39
    • 0032967296 scopus 로고    scopus 로고
    • Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney
    • Shen H, Smith DE, Yang T, Huang YG, Schnermann JB, et al. 1999. Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney. Am. J. Physiol. Renal Physiol. 276:F658-65
    • (1999) Am. J. Physiol. Renal Physiol. , vol.276
    • Shen, H.1    Smith, D.E.2    Yang, T.3    Huang, Y.G.4    Schnermann, J.B.5
  • 40
    • 0042391834 scopus 로고    scopus 로고
    • Transporter-mediated drug interactions
    • Tsuji A. 2002. Transporter-mediated drug interactions. Drug. Metabol. Pharmacokin. 17:253-74
    • (2002) Drug. Metabol. Pharmacokin. , vol.17 , pp. 253-274
    • Tsuji, A.1
  • 41
    • 0344572686 scopus 로고    scopus 로고
    • CHO/hPEPT1 cells over-expressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs
    • Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, et al. 1999. CHO/hPEPT1 cells over-expressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J. Pharm. Sci. 88:347-50
    • (1999) J. Pharm. Sci. , vol.88 , pp. 347-350
    • Han, H.K.1    Rhie, J.K.2    Oh, D.M.3    Saito, G.4    Hsu, C.P.5
  • 43
    • 0031846917 scopus 로고    scopus 로고
    • Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)
    • Zhang L, Schaner ME, Giacomini KM. 1998. Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J. Pharmacol. Exp. Ther. 286:354-61
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 354-361
    • Zhang, L.1    Schaner, M.E.2    Giacomini, K.M.3
  • 44
    • 0033811707 scopus 로고    scopus 로고
    • The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK1 cell monolayers
    • Dudley AJ, Bleasby K, Brown CD. 2000. The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK1 cell monolayers. Br. J. Pharmacol. 131:71-79
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 71-79
    • Dudley, A.J.1    Bleasby, K.2    Brown, C.D.3
  • 45
    • 0031824347 scopus 로고    scopus 로고
    • Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine
    • Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, et al. 1998. Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol. Pharmacol. 54:342-52
    • (1998) Mol. Pharmacol. , vol.54 , pp. 342-352
    • Busch, A.E.1    Karbach, U.2    Miska, D.3    Gorboulev, V.4    Akhoundova, A.5
  • 46
    • 0036294807 scopus 로고    scopus 로고
    • cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney
    • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K. 2002. cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J. Am. Soc. Nephrol. 13:1703-10
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 1703-1710
    • Urakami, Y.1    Akazawa, M.2    Saito, H.3    Okuda, M.4    Inui, K.5
  • 47
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, et al. 1997. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett. 419:107-11
    • (1997) FEBS Lett. , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.3    Sai, Y.4    Oku, A.5
  • 48
    • 0032935034 scopus 로고    scopus 로고
    • Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations
    • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, et al. 1999. Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J. Pharmacol. Exp. Ther. 289:768-73
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 768-773
    • Yabuuchi, H.1    Tamai, I.2    Nezu, J.3    Sakamoto, K.4    Oku, A.5
  • 49
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, et al. 1998. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem. 273:20378-82
    • (1998) J. Biol. Chem. , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3    Yabuuchi, H.4    Oku, A.5
  • 50
    • 0032767691 scopus 로고    scopus 로고
    • Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
    • Wu X, Huang W, Prasad PD, Seth P, Rajan DP, et al. 1999. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol. Exp. Ther. 290:1482-92
    • (1999) J Pharmacol. Exp. Ther. , vol.290 , pp. 1482-1492
    • Wu, X.1    Huang, W.2    Prasad, P.D.3    Seth, P.4    Rajan, D.P.5
  • 51
    • 0032953645 scopus 로고    scopus 로고
    • Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
    • Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, et al. 1999. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat. Genet 21:91-94
    • (1999) Nat. Genet. , vol.21 , pp. 91-94
    • Nezu, J.1    Tamai, I.2    Oku, A.3    Ohashi, R.4    Yabuuchi, H.5
  • 52
    • 0032696186 scopus 로고    scopus 로고
    • +-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
    • +-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J. Pharmacol. Exp. Ther. 291:778-84
    • (1999) J. Pharmacol. Exp. Ther. , vol.291 , pp. 778-784
    • Ohashi, R.1    Tamai, I.2    Yabuuchi, H.3    Nezu, J.I.4    Oku, A.5
  • 53
    • 0034695673 scopus 로고    scopus 로고
    • β-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter
    • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, et al. 2000. β-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J. Biol. Chem. 275:1699-707
    • (2000) J. Biol. Chem. , vol.275 , pp. 1699-1707
    • Ganapathy, M.E.1    Huang, W.2    Rajan, D.P.3    Carter, A.L.4    Sugawara, M.5
  • 54
    • 0034709561 scopus 로고    scopus 로고
    • Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, et al. 2000. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. 273:251-60
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 251-260
    • Tamai, I.1    Nezu, J.2    Uchino, H.3    Sai, Y.4    Oku, A.5
  • 55
    • 0033601257 scopus 로고    scopus 로고
    • A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
    • Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, et al. 1999. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J. Biol. Chem. 274:37161-68
    • (1999) J. Biol. Chem. , vol.274 , pp. 37161-37168
    • Hsiang, B.1    Zhu, Y.2    Wang, Z.3    Wu, Y.4    Sasseville, V.5
  • 56
    • 0035012075 scopus 로고    scopus 로고
    • Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes
    • Nakai D, Nakagomi R, Furuta Y, Tokui T, Abe T, et al. 2001. Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J. Pharmacol. Exp. Ther. 297:861-67
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 861-867
    • Nakai, D.1    Nakagomi, R.2    Furuta, Y.3    Tokui, T.4    Abe, T.5
  • 57
    • 0037733365 scopus 로고    scopus 로고
    • A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
    • König J, Cui Y, Nies AT, Keppler D. 2000. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 278:G156-64
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.278
    • König, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 58
    • 0034725617 scopus 로고    scopus 로고
    • Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
    • König J, Cui Y, Nies AT, Keppler D. 2000. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J. Biol. Chem. 275:23161-68
    • (2000) J. Biol. Chem. , vol.275 , pp. 23161-23168
    • König, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 60
    • 0030886124 scopus 로고    scopus 로고
    • Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain
    • Noé B, Hagenbuch B, Stieger B, Meier PJ. 1997. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc. Natl. Acad. Sci. USA 94:10346-50
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10346-10350
    • Noé, B.1    Hagenbuch, B.2    Stieger, B.3    Meier, P.J.4
  • 61
    • 0034595593 scopus 로고    scopus 로고
    • Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver
    • Carton V, Hagenbuch B, Hagenbuch N, Stieger B, Ha R, et al. 2000. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver. FEBS Lett. 474:242-45
    • (2000) FEBS Lett. , vol.474 , pp. 242-245
    • Carton, V.1    Hagenbuch, B.2    Hagenbuch, N.3    Stieger, B.4    Ha, R.5
  • 62
    • 0037310871 scopus 로고    scopus 로고
    • Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A
    • Shitara Y, Itoh T, Sato H, Li AP, Sugiyama Y. 2003. Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A. J. Pharmacol. Exp. Ther. 304:610-16
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 610-616
    • Shitara, Y.1    Itoh, T.2    Sato, H.3    Li, A.P.4    Sugiyama, Y.5
  • 63
    • 17344364101 scopus 로고    scopus 로고
    • The modified dipeptide enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein
    • Pang KS, Wang PJ, Chung AYK, Wolkoff AW. 1998. The modified dipeptide enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology 28:1341-46
    • (1998) Hepatology , vol.28 , pp. 1341-1346
    • Pang, K.S.1    Wang, P.J.2    Chung, A.Y.K.3    Wolkoff, A.W.4
  • 64
    • 0032455502 scopus 로고    scopus 로고
    • Transport of temocaprilat into rat hepatocytes: Role of organic anion transporting polypeptide
    • Ishizuka H, Konno K, Naganuma H, Nishimura K, Kouzuki H, et al. 1998. Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide. J. Pharmacol. Exp. Ther. 287:37-42
    • (1998) J. Pharmacol. Exp. Ther. , vol.287 , pp. 37-42
    • Ishizuka, H.1    Konno, K.2    Naganuma, H.3    Nishimura, K.4    Kouzuki, H.5
  • 65
    • 0035125407 scopus 로고    scopus 로고
    • Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver
    • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, et al. 2001. Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120:525-33
    • (2001) Gastroenterology , vol.120 , pp. 525-533
    • Kullak-Ublick, G.A.1    Ismair, M.G.2    Stieger, B.3    Landmann, L.4    Huber, R.5
  • 66
    • 0021804301 scopus 로고
    • Hereditary chronic conjugated hyperbilirunemia in mutant rats caused by defective hepatic anion transport
    • Jansen PL, Peters WH, Lamers WH. 1985. Hereditary chronic conjugated hyperbilirunemia in mutant rats caused by defective hepatic anion transport. Hepatology 5:573-79
    • (1985) Hepatology , vol.5 , pp. 573-579
    • Jansen, P.L.1    Peters, W.H.2    Lamers, W.H.3
  • 67
    • 0026519238 scopus 로고
    • A new rat mutant with chronic conjugated hyperbilirunemia and renal glomerular lesions
    • Hosokawa S, Tagaya O, Mikami T, Nozaki Y, Kawaguchi Y, et al. 1992. A new rat mutant with chronic conjugated hyperbilirunemia and renal glomerular lesions. Lab. Animal Sci. 42:27-34
    • (1992) Lab. Animal Sci. , vol.42 , pp. 27-34
    • Hosokawa, S.1    Tagaya, O.2    Mikami, T.3    Nozaki, Y.4    Kawaguchi, Y.5
  • 70
    • 0032145320 scopus 로고    scopus 로고
    • Bile acid and xenobiotic transporters in liver
    • Stieger B, Meier PJ. 1998. Bile acid and xenobiotic transporters in liver. Curr. Opin. Cell. Biol. 10:462-67
    • (1998) Curr. Opin. Cell. Biol. , vol.10 , pp. 462-467
    • Stieger, B.1    Meier, P.J.2
  • 71
    • 0032434272 scopus 로고    scopus 로고
    • Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2
    • Suzuki H, Sugiyama Y. 1998. Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. Semin. Liver Dis. 18:359-76
    • (1998) Semin. Liver Dis. , vol.18 , pp. 359-376
    • Suzuki, H.1    Sugiyama, Y.2
  • 72
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • König J, Nies AT, Cui Y, Leier I, Keppler D. 1999. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim. Biophys. Acta 1461:377-94
    • (1999) Biochim. Biophys. Acta , vol.1461 , pp. 377-394
    • König, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 73
    • 0029981430 scopus 로고    scopus 로고
    • Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
    • Paulusma CC, Bosma PJ, Zaman GJ, Bakker CT, Otter M, et al. 1996. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 271:1126-28
    • (1996) Science , vol.271 , pp. 1126-1128
    • Paulusma, C.C.1    Bosma, P.J.2    Zaman, G.J.3    Bakker, C.T.4    Otter, M.5
  • 75
    • 0040761368 scopus 로고    scopus 로고
    • cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • Buchler M, König J, Brom M, Kartenbeck J, Spring H, et al. 1996. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem. 271:15091-98
    • (1996) J. Biol. Chem. , vol.271 , pp. 15091-15098
    • Buchler, M.1    König, J.2    Brom, M.3    Kartenbeck, J.4    Spring, H.5
  • 76
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, et al. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 56:4124-29
    • Cancer Res , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3    Nakamura, T.4    Kawabe, T.5
  • 78
    • 0344258381 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein subfamily transporters and drug resistance
    • Kuwano M, Toh S, Uchiumi T, Takano H, Kohno K, Wada M. 1999. Multidrug resistance-associated protein subfamily transporters and drug resistance. Anticancer Drug Des. 14:123-31
    • (1999) Anticancer Drug Des. , vol.14 , pp. 123-131
    • Kuwano, M.1    Toh, S.2    Uchiumi, T.3    Takano, H.4    Kohno, K.5    Wada, M.6
  • 79
    • 0030668526 scopus 로고    scopus 로고
    • ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
    • Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B, et al. 1997. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem. J. 327:305-10
    • (1997) Biochem. J. , vol.327 , pp. 305-310
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Hummel-Eisenbeiss, J.4    Burchell, B.5
  • 81
    • 0345299165 scopus 로고    scopus 로고
    • Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
    • Cui Y, Konig J, Buchholz JK, Spring H, Leier I, et al. 1999. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol. Pharmacol. 55:929-37
    • (1999) Mol. Pharmacol. , vol.55 , pp. 929-937
    • Cui, Y.1    Konig, J.2    Buchholz, J.K.3    Spring, H.4    Leier, I.5
  • 83
    • 0033104810 scopus 로고    scopus 로고
    • Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
    • Paulusma CC, van Geer MA, Evers R, Heijn M, Ottenhoff R, et al. 1999. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem. J. 338:393-401
    • (1999) Biochem. J. , vol.338 , pp. 393-401
    • Paulusma, C.C.1    Van Geer, M.A.2    Evers, R.3    Heijn, M.4    Ottenhoff, R.5
  • 84
    • 0034671544 scopus 로고    scopus 로고
    • Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2
    • Ryu S, Kawabe T, Nada S, Yamaguchi A. 2000. Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2. J. Biol. Chem. 275:39617-24
    • (2000) J. Biol. Chem. , vol.275 , pp. 39617-39624
    • Ryu, S.1    Kawabe, T.2    Nada, S.3    Yamaguchi, A.4
  • 85
    • 0037155204 scopus 로고    scopus 로고
    • Transcellular transport of organic aidons across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
    • Sasaki M, Suzuki H, Ito K, Abe T, Sugiyama Y. 2002. Transcellular transport of organic aidons across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2). J. Biol. Chem. 277:6497-503
    • (2002) J. Biol. Chem. , vol.277 , pp. 6497-6503
    • Sasaki, M.1    Suzuki, H.2    Ito, K.3    Abe, T.4    Sugiyama, Y.5
  • 86
    • 0033152212 scopus 로고    scopus 로고
    • Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
    • Hooijberg JH, Broxterman HJ, Kool M, Assaraf YG, Peters GJ, et al. 1999. Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. 59:2532-35
    • (1999) Cancer Res. , vol.59 , pp. 2532-2535
    • Hooijberg, J.H.1    Broxterman, H.J.2    Kool, M.3    Assaraf, Y.G.4    Peters, G.J.5
  • 87
    • 0036298317 scopus 로고    scopus 로고
    • Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
    • Tang F, Horie K, Borchardt RT. 2002. Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm. Res. 19:773-79
    • (2002) Pharm. Res. , vol.19 , pp. 773-779
    • Tang, F.1    Horie, K.2    Borchardt, R.T.3
  • 88
    • 0032753749 scopus 로고    scopus 로고
    • Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter
    • Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, et al. 1999. Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol Pharmacol. 56:1219-28
    • (1999) Mol Pharmacol. , vol.56 , pp. 1219-1228
    • Chen, Z.S.1    Kawabe, T.2    Ono, M.3    Aoki, S.4    Sumizawa, T.5
  • 89
    • 0036149075 scopus 로고    scopus 로고
    • Transport activity of human MRP3 expressed in Sf9 cells: Comparative studies with rat MRP3
    • Akita H, Suzuki H, Hirohashi T, Takikawa H, Sugiyama Y. 2002. Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharm. Res. 19:34-41
    • (2002) Pharm. Res. , vol.19 , pp. 34-41
    • Akita, H.1    Suzuki, H.2    Hirohashi, T.3    Takikawa, H.4    Sugiyama, Y.5
  • 90
    • 0034282991 scopus 로고    scopus 로고
    • Transport of amphipathic anions by human multidrug resistance protein 3
    • Zeng H, Liu G, Rea PA, Kruh GD. 2000. Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res. 60:4779-84
    • (2000) Cancer Res. , vol.60 , pp. 4779-4784
    • Zeng, H.1    Liu, G.2    Rea, P.A.3    Kruh, G.D.4
  • 92
    • 0032404092 scopus 로고    scopus 로고
    • A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
    • Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V, Dean M. 1998. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res. 58:5337-39
    • (1998) Cancer Res. , vol.58 , pp. 5337-5339
    • Allikmets, R.1    Schriml, L.M.2    Hutchinson, A.3    Romano-Spica, V.4    Dean, M.5
  • 93
    • 0032895533 scopus 로고    scopus 로고
    • Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells
    • Miyake K, Mickley L, Litman T, Zhan Z, Robey R, et al. 1999. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells. Cancer Res. 59:8-13
    • (1999) Cancer Res. , vol.59 , pp. 8-13
    • Miyake, K.1    Mickley, L.2    Litman, T.3    Zhan, Z.4    Robey, R.5
  • 94
    • 0035870289 scopus 로고    scopus 로고
    • Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
    • Maliepaard M, Scheffer GL, Faneyte BF, van Gastelen MA, Pijnenborg ACLM, et al. 2001. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res. 61:3458-64
    • (2001) Cancer Res. , vol.61 , pp. 3458-3464
    • Maliepaard, M.1    Scheffer, G.L.2    Faneyte, B.F.3    Van Gastelen, M.A.4    Pijnenborg, A.C.L.M.5
  • 95
    • 0038265441 scopus 로고    scopus 로고
    • ABCG2 transports sulfated conjugates of steroids and xenobiotics
    • Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y. 2003. ABCG2 transports sulfated conjugates of steroids and xenobiotics. J. Biol. Chem. 278:22644-49
    • (2003) J. Biol. Chem. , vol.278 , pp. 22644-22649
    • Suzuki, M.1    Suzuki, H.2    Sugimoto, Y.3    Sugiyama, Y.4
  • 96
    • 0032717266 scopus 로고    scopus 로고
    • Gender differences in expression of organic cation transporter OCT2 in rat kidney
    • Urakami Y, Nakamura N, Takahashi K, Okuda M, Saito H, et al. 1999. Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett. 461:339-42
    • (1999) FEBS Lett. , vol.461 , pp. 339-342
    • Urakami, Y.1    Nakamura, N.2    Takahashi, K.3    Okuda, M.4    Saito, H.5
  • 97
    • 0036175127 scopus 로고    scopus 로고
    • Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions
    • Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, et al. 2002. Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J. Pharmacol. Exp. Ther. 300:746-53
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 746-753
    • Hasegawa, M.1    Kusuhara, H.2    Sugiyama, D.3    Ito, K.4    Ueda, S.5
  • 98
    • 0019977139 scopus 로고
    • The interaction of cephalosporin antibiotics with renal cortex of rats: Accumulation to cortical slices and binding to purified plasma membranes
    • Hori R, Ishikawa Y, Takano M, Okano T, Kitazawa S, et al. 1982. The interaction of cephalosporin antibiotics with renal cortex of rats: accumulation to cortical slices and binding to purified plasma membranes. Biochem. Pharmacol. 31:2267-72
    • (1982) Biochem. Pharmacol. , vol.31 , pp. 2267-2272
    • Hori, R.1    Ishikawa, Y.2    Takano, M.3    Okano, T.4    Kitazawa, S.5
  • 101
    • 0029608831 scopus 로고
    • Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes
    • Ishigami M, Tokui T, Komai T, Tsukahara K, Yamazaki M, et al. 1995. Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes. Pharm. Res. 12:1741-45
    • (1995) Pharm. Res. , vol.12 , pp. 1741-1745
    • Ishigami, M.1    Tokui, T.2    Komai, T.3    Tsukahara, K.4    Yamazaki, M.5
  • 102
  • 103
    • 0030726508 scopus 로고    scopus 로고
    • Preclinical evaluation of drug-drug interaction potential: Present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction
    • Li AP, Maurel P, Gomez-Lechon MJ, Cheng LC, Jurima-Romet M. 1997. Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction. Chem. Biol. Interact. 107:5-16
    • (1997) Chem. Biol. Interact. , vol.107 , pp. 5-16
    • Li, A.P.1    Maurel, P.2    Gomez-Lechon, M.J.3    Cheng, L.C.4    Jurima-Romet, M.5
  • 104
    • 0032968777 scopus 로고    scopus 로고
    • Cryopreserved human hepatocytes: Characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential
    • Li AP, Lu C, Brent JA, Pham C, Fackett A, et al. 1999. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. Chem. Biol. Interact. 121:17-35
    • (1999) Chem. Biol. Interact. , vol.121 , pp. 17-35
    • Li, A.P.1    Lu, C.2    Brent, J.A.3    Pham, C.4    Fackett, A.5
  • 105
    • 0033008799 scopus 로고    scopus 로고
    • Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: Consensus of an international expert panel
    • Li AP, Gorycki PD, Hengstler JG, Kedderis GL, Koebe HG, et al. 1999. Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel. Chem. Biol. Interact. 121:117-23
    • (1999) Chem. Biol. Interact. , vol.121 , pp. 117-123
    • Li, A.P.1    Gorycki, P.D.2    Hengstler, J.G.3    Kedderis, G.L.4    Koebe, H.G.5
  • 106
    • 85024471761 scopus 로고    scopus 로고
    • Function of uptake transporters for taurocholate and estradiol 17β- D-glucuronide in cryopreserved human hepatocytes
    • Shitara Y, Li AP, Kato Y, Lu C, Ito K, et al. 2003. Function of uptake transporters for taurocholate and estradiol 17β- D-glucuronide in cryopreserved human hepatocytes. Drug Metab. Pharmacokin. 18:33-41
    • (2003) Drug Metab. Pharmacokin. , vol.18 , pp. 33-41
    • Shitara, Y.1    Li, A.P.2    Kato, Y.3    Lu, C.4    Ito, K.5
  • 107
    • 0034897346 scopus 로고    scopus 로고
    • The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake
    • Olinga P, Hof IH, Merema MT, Smit M, de Jager MH, et al. 2001. The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake. J. Pharmacol. Toxicol. Methods 45:55-63
    • (2001) J. Pharmacol. Toxicol. Methods , vol.45 , pp. 55-63
    • Olinga, P.1    Hof, I.H.2    Merema, M.T.3    Smit, M.4    De Jager, M.H.5
  • 108
    • 0033805001 scopus 로고    scopus 로고
    • Viability of liver slices exhibiting absorption, metabolism, and elimination of substrates in culture medium
    • Shigematsu A, Motoji N, Momose Y, Iida A, Higashi N. 2000. Viability of liver slices exhibiting absorption, metabolism, and elimination of substrates in culture medium. Exp. Mol. Pathol. 69:119-43
    • (2000) Exp. Mol. Pathol. , vol.69 , pp. 119-143
    • Shigematsu, A.1    Motoji, N.2    Momose, Y.3    Iida, A.4    Higashi, N.5
  • 109
    • 0027133590 scopus 로고
    • Mechanisms mediating renal secretion of organic anions and cations
    • Pritchard JB, Miller DS. 1993. Mechanisms mediating renal secretion of organic anions and cations. Physiol. Rev. 73:765-96
    • (1993) Physiol. Rev. , vol.73 , pp. 765-796
    • Pritchard, J.B.1    Miller, D.S.2
  • 110
    • 0024348932 scopus 로고
    • Transport studies with renal proximal tubular and small intestinal brush border and basolateral membrane vesicles: Vesicle heterogeneity, coexistence of transport system
    • Murer H, Gmaj P, Steiger B, Hagenbuch B. 1989. Transport studies with renal proximal tubular and small intestinal brush border and basolateral membrane vesicles: vesicle heterogeneity, coexistence of transport system. Methods Enzymol. 172:346-64
    • (1989) Methods Enzymol. , vol.172 , pp. 346-364
    • Murer, H.1    Gmaj, P.2    Steiger, B.3    Hagenbuch, B.4
  • 111
    • 0025684803 scopus 로고
    • Characterizing mechanisms of hepatic bile acid transport utilizing isolated membrane vesicles
    • Boyer JL, Meier PJ. 1990. Characterizing mechanisms of hepatic bile acid transport utilizing isolated membrane vesicles. Methods Enzymol. 192:517-33
    • (1990) Methods Enzymol. , vol.192 , pp. 517-533
    • Boyer, J.L.1    Meier, P.J.2
  • 112
    • 0025613205 scopus 로고    scopus 로고
    • Isolation of luminal and cotralumenal plasma membrane vesicles from kidney
    • Kinne-Saffran E, Kinne RK. Isolation of luminal and cotralumenal plasma membrane vesicles from kidney. Methods Enzymol. 191:450-69
    • Methods Enzymol , vol.191 , pp. 450-469
    • Kinne-Saffran, E.1    Kinne, R.K.2
  • 113
    • 0025606834 scopus 로고
    • Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes
    • Meier PJ, Boyer JL. 1990. Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes. Methods Enzymol. 192:534-45
    • (1990) Methods Enzymol. , vol.192 , pp. 534-545
    • Meier, P.J.1    Boyer, J.L.2
  • 114
    • 0021250574 scopus 로고
    • Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier
    • Meier PJ, St Meier-Abt A, Barrett C, Boyer JL. 1984. Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. Evidence for an electrogenic canalicular organic anion carrier. J. Biol. Chem. 259:10614-22
    • (1984) J. Biol. Chem. , vol.259 , pp. 10614-10622
    • Meier, P.J.1    St. Meier-Abt, A.2    Barrett, C.3    Boyer, J.L.4
  • 115
    • 0034753042 scopus 로고    scopus 로고
    • Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
    • Cui Y, Konig J, Keppler D. 2001. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol. Pharmacol. 60:934-43
    • (2001) Mol. Pharmacol. , vol.60 , pp. 934-943
    • Cui, Y.1    Konig, J.2    Keppler, D.3
  • 116
    • 4243801613 scopus 로고    scopus 로고
    • Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
    • Schinkel AH, Mayer U, Wagenaar E, Mol CA, van Deemter L, et al. 1997. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc. Natl. Acad. Sci. USA 94:4028-33
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4028-4033
    • Schinkel, A.H.1    Mayer, U.2    Wagenaar, E.3    Mol, C.A.4    Van Deemter, L.5
  • 117
    • 0029822980 scopus 로고    scopus 로고
    • Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes
    • Hagenbuch B, Scharschmidt BF, Meier PJ. 1996. Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem. J. 316:901-4
    • (1996) Biochem. J. , vol.316 , pp. 901-904
    • Hagenbuch, B.1    Scharschmidt, B.F.2    Meier, P.J.3
  • 118
    • 15144346706 scopus 로고    scopus 로고
    • The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine
    • Tamai I, Nakanishi T, Hayashi K, Terao T, Sai Y, et al. 1997. The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine. J. Pharm. Pharmacol. 49:796-801
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 796-801
    • Tamai, I.1    Nakanishi, T.2    Hayashi, K.3    Terao, T.4    Sai, Y.5
  • 119
    • 0032422456 scopus 로고    scopus 로고
    • Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes
    • Kouzuki H, Suzuki H, Ito K, Ohashi R, Sugiyama Y. 1998. Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes. J. Pharmacol. Exp. Ther. 286:1043-50
    • (1998) J. Pharmacol. Exp. Ther. , vol.286 , pp. 1043-1050
    • Kouzuki, H.1    Suzuki, H.2    Ito, K.3    Ohashi, R.4    Sugiyama, Y.5
  • 120
    • 0033063815 scopus 로고    scopus 로고
    • Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes
    • Kouzuki H, Suzuki H, Ito K, Ohashi R, Sugiyama Y. 1999. Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes. J. Pharmacol. Exp. Ther. 288:627-34
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 627-634
    • Kouzuki, H.1    Suzuki, H.2    Ito, K.3    Ohashi, R.4    Sugiyama, Y.5
  • 121
    • 4644364576 scopus 로고    scopus 로고
    • Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
    • Hirano M, Maeda K, Shitara Y, Sugiyama Y. 2004. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J. Pharmacol. Exp. Ther. 311:139-46
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , pp. 139-146
    • Hirano, M.1    Maeda, K.2    Shitara, Y.3    Sugiyama, Y.4
  • 122
    • 0036175452 scopus 로고    scopus 로고
    • Comparative inhibitory effects of different compounds on rat oatp1 (Slc21a1)- and Oatp2 (Slc21a5)-mediated transport
    • Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T. 2002. Comparative inhibitory effects of different compounds on rat oatp1 (Slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm. Res. 19:147-53
    • (2002) Pharm. Res. , vol.19 , pp. 147-153
    • Shitara, Y.1    Sugiyama, D.2    Kusuhara, H.3    Kato, Y.4    Abe, T.5
  • 123
    • 0031723235 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic alterations caused by drug-drug interactions: Metabolic interaction in the liver
    • Ito K, Iwatsubo T, Kanamitsu S, Ueda K, Suzuki H, et al. 1998. Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Pharmacol. Rev. 50:387-412
    • (1998) Pharmacol. Rev. , vol.50 , pp. 387-412
    • Ito, K.1    Iwatsubo, T.2    Kanamitsu, S.3    Ueda, K.4    Suzuki, H.5
  • 124
    • 0031777718 scopus 로고    scopus 로고
    • Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport
    • Ito K, Iwatsubo T, Kanamitsu S, Nakajima Y, Sugiyama Y. 1998. Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport. Annu. Rev. Pharmacol. Toxicol. 38:461-99
    • (1998) Annu. Rev. Pharmacol. Toxicol. , vol.38 , pp. 461-499
    • Ito, K.1    Iwatsubo, T.2    Kanamitsu, S.3    Nakajima, Y.4    Sugiyama, Y.5
  • 125
    • 0035012079 scopus 로고    scopus 로고
    • Inhibition of biliary excretion of methotrexate by probenecid in rats: Quantitative prediction of interaction from in vitro data
    • Ueda K, Kato Y, Komatsu K, Sugiyama Y. 2001. Inhibition of biliary excretion of methotrexate by probenecid in rats: quantitative prediction of interaction from in vitro data. J. Pharmacol. Exp. Ther. 297:1036-43
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 1036-1043
    • Ueda, K.1    Kato, Y.2    Komatsu, K.3    Sugiyama, Y.4
  • 126
    • 0029786681 scopus 로고    scopus 로고
    • Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney
    • Saito H, Masuda S, Inui K. 1996. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J. Biol. Chem. 271:20719-25
    • (1996) J. Biol. Chem. , vol.271 , pp. 20719-20725
    • Saito, H.1    Masuda, S.2    Inui, K.3
  • 127
    • 0031459990 scopus 로고    scopus 로고
    • Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1
    • Masuda S, Saito H, Inui K. 1997. Interactions of nonsteroidal anti-inflammatory drugs with rat renal organic anion transporter, OAT-K1. J. Pharmacol. Exp. Ther. 283:1039-42
    • (1997) J. Pharmacol. Exp. Ther. , vol.283 , pp. 1039-1042
    • Masuda, S.1    Saito, H.2    Inui, K.3
  • 128
    • 0032859176 scopus 로고    scopus 로고
    • Functional analysis of rat renal organic anion transporter OAT-K1: Bidirectional methotrexate transport in apical membrane
    • Masuda S, Takeuchi A, Saito H, Hashimoto Y, Inui K. 1999. Functional analysis of rat renal organic anion transporter OAT-K1: bidirectional methotrexate transport in apical membrane. FEBS Lett. 459:128-32
    • (1999) FEBS Lett. , vol.459 , pp. 128-132
    • Masuda, S.1    Takeuchi, A.2    Saito, H.3    Hashimoto, Y.4    Inui, K.5
  • 129
    • 0032943652 scopus 로고    scopus 로고
    • Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney
    • Masuda S, Ibaramoto K, Takeuchi A, Saito H, Hashimoto Y, et al. 1999. Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Mol. Pharmacol. 55:743-52
    • (1999) Mol. Pharmacol. , vol.55 , pp. 743-752
    • Masuda, S.1    Ibaramoto, K.2    Takeuchi, A.3    Saito, H.4    Hashimoto, Y.5
  • 130
    • 0034812634 scopus 로고    scopus 로고
    • Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2
    • Takeuchi A, Masuda S, Saito H, Abe T, Inui K. 2001. Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2. J. Pharmacol. Exp. Ther. 299:261-67
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 261-267
    • Takeuchi, A.1    Masuda, S.2    Saito, H.3    Abe, T.4    Inui, K.5
  • 132
    • 0029846754 scopus 로고    scopus 로고
    • Tissue-selective uptake of pravastatin in rats: Contribution of a specific carrier-mediated uptake system
    • Yamazaki M, Tokui T, Ishigami M, Sugiyama Y. 1996. Tissue-selective uptake of pravastatin in rats: contribution of a specific carrier-mediated uptake system. Biopharm. Drug Dispos. 17:775-89
    • (1996) Biopharm. Drug Dispos. , vol.17 , pp. 775-789
    • Yamazaki, M.1    Tokui, T.2    Ishigami, M.3    Sugiyama, Y.4
  • 133
    • 0025092259 scopus 로고
    • Interactions in the renal and biliary elimination of digoxin: Stereoselective difference between quinine and quinidine
    • Hedman A, Angelin B, Arvidsson A, Dahlqvist R, Nilsson B. 1990. Interactions in the renal and biliary elimination of digoxin: stereoselective difference between quinine and quinidine. Clin. Pharmacol. Ther. 47:20-26
    • (1990) Clin. Pharmacol. Ther. , vol.47 , pp. 20-26
    • Hedman, A.1    Angelin, B.2    Arvidsson, A.3    Dahlqvist, R.4    Nilsson, B.5
  • 135
    • 0028136603 scopus 로고
    • Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells
    • Versantvoort CH, Broxterman HJ, Lankelma J, Feller N, Pinedo HM. 1994. Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells. Biochem. Pharmacol 48:1129-36
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1129-1136
    • Versantvoort, C.H.1    Broxterman, H.J.2    Lankelma, J.3    Feller, N.4    Pinedo, H.M.5
  • 136
    • 0030959378 scopus 로고    scopus 로고
    • Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats
    • Chu XY, Kato Y, Niinuma K, Sudo KI, Hakusui H, et al. 1997. Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats. J. Pharmacol. Exp. Ther. 281:304-14
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 304-314
    • Chu, X.Y.1    Kato, Y.2    Niinuma, K.3    Sudo, K.I.4    Hakusui, H.5
  • 137
    • 0027242140 scopus 로고
    • Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11
    • Araki E, Ishikawa M, Iigo M, Koide T, Itabashi M, et al. 1993. Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11. Jpn. J. Cancer Res. 84:697-702
    • (1993) Jpn. J. Cancer Res. , vol.84 , pp. 697-702
    • Araki, E.1    Ishikawa, M.2    Iigo, M.3    Koide, T.4    Itabashi, M.5
  • 138
    • 0028022585 scopus 로고
    • Metabolic fate of irinotecan in humans: Correlation of glucuronidation with diarrhea
    • Gupta E, Lestingi TM, Mick R, Ramirez J, Yokes EE, et al. 1994. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea. Cancer Res. 54:3723-25
    • (1994) Cancer Res. , vol.54 , pp. 3723-3725
    • Gupta, E.1    Lestingi, T.M.2    Mick, R.3    Ramirez, J.4    Yokes, E.E.5
  • 139
    • 0037613131 scopus 로고    scopus 로고
    • The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: Probenecid as a candidate inhibitor of the bibiary excretion of irinotecan metabolites
    • Horikawa M, Kato Y, Tyson CA, Sugiyama Y. 2002. The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the bibiary excretion of irinotecan metabolites. Drug Metab. Pharmacokin. 17:23-33
    • (2002) Drug Metab. Pharmacokin. , vol.17 , pp. 23-33
    • Horikawa, M.1    Kato, Y.2    Tyson, C.A.3    Sugiyama, Y.4
  • 140
    • 0036744875 scopus 로고    scopus 로고
    • Reduced gastrointestinal toxicity following inhibition of the biliary excretion of irinotecan and its metabolites by probenecid in rats
    • Horikawa M, Kato Y, Sugiyama Y. 2002. Reduced gastrointestinal toxicity following inhibition of the biliary excretion of irinotecan and its metabolites by probenecid in rats. Pharm. Res. 19:1345-53
    • (2002) Pharm. Res. , vol.19 , pp. 1345-1353
    • Horikawa, M.1    Kato, Y.2    Sugiyama, Y.3
  • 141
    • 0033831429 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of cerivastatin
    • Mück W. 2000. Clinical pharmacokinetics of cerivastatin. Clin. Pharmacokinet. 39:99-116
    • (2000) Clin. Pharmacokinet. , vol.39 , pp. 99-116
    • Mück, W.1
  • 142
    • 0033064071 scopus 로고    scopus 로고
    • Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporin-treated kidney transplant recipients
    • Mück W, Mai I, Pritsche L, Ochmann K, Rohde G, et al. 1999. Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporin-treated kidney transplant recipients. Clin. Pharmacol Ther. 65:251-61
    • (1999) Clin. Pharmacol Ther. , vol.65 , pp. 251-261
    • Mück, W.1    Mai, I.2    Pritsche, L.3    Ochmann, K.4    Rohde, G.5
  • 143
    • 0027327029 scopus 로고
    • Altered disposition of pravastatin following concomitant drug therapy with cyclosporin A in transplant recipients
    • Regazzi MB, Campana IC, Raddato V, Lesi C, Perani G, et al. 1993. Altered disposition of pravastatin following concomitant drug therapy with cyclosporin A in transplant recipients. Transplant. Proc. 25:2732-34
    • (1993) Transplant. Proc. , vol.25 , pp. 2732-2734
    • Regazzi, M.B.1    Campana, I.C.2    Raddato, V.3    Lesi, C.4    Perani, G.5
  • 144
    • 3242789902 scopus 로고    scopus 로고
    • The drug-drug interactions of pitavstatm (NK-104), a novel HMG-CoA reductase inhibitor and cyclosporine
    • Hasunuma T, Nakamura M, Yachi T, Arisawa N, Fukushima K, et al. 2003. The drug-drug interactions of pitavstatm (NK-104), a novel HMG-CoA reductase inhibitor and cyclosporine. J. Clin. Ther. Med. 19:381-89
    • (2003) J. Clin. Ther. Med. , vol.19 , pp. 381-389
    • Hasunuma, T.1    Nakamura, M.2    Yachi, T.3    Arisawa, N.4    Fukushima, K.5
  • 145
    • 0035502455 scopus 로고    scopus 로고
    • Bilateral pharmacokinetic interaction between cyclosporine A and atorvastatin in renal transplant recipients
    • Asberg A, Hartmann A, Fjeldsa E, Bergan S, Holdaas H. 2001. Bilateral pharmacokinetic interaction between cyclosporine A and atorvastatin in renal transplant recipients. Am. J. Transplant. 1: 382-86
    • (2001) Am. J. Transplant. , vol.1 , pp. 382-386
    • Asberg, A.1    Hartmann, A.2    Fjeldsa, E.3    Bergan, S.4    Holdaas, H.5
  • 146
    • 0242383181 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of atorvastatin
    • Lennernas H. 2003. Clinical pharmacokinetics of atorvastatin. Clin. Pharmacokinet. 42:1141-60
    • (2003) Clin. Pharmacokinet. , vol.42 , pp. 1141-1160
    • Lennernas, H.1
  • 148
    • 0003246629 scopus 로고    scopus 로고
    • Gemfibrozil/cerivastatin interaction
    • Abstr.
    • Mueck W, Frey R, Boix O, Voith B. 2001. Gemfibrozil/cerivastatin interaction. AAPS PharmSci. 3(Suppl.):3566 (Abstr.)
    • (2001) AAPS PharmSci. , vol.3 , Issue.SUPPL. , pp. 3566
    • Mueck, W.1    Frey, R.2    Boix, O.3    Voith, B.4
  • 150
    • 4644301418 scopus 로고    scopus 로고
    • Gemflbrozil and its glucuronide inhibit the OATP2(OATP1B1:SLC21A6)- mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin-analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
    • Shitara Y, Hirano M, Sato H, Sugiyama Y. 2004. Gemflbrozil and its glucuronide inhibit the OATP2(OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin-analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J. Pharmacol. Exp. Ther. 311:228-36
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , pp. 228-236
    • Shitara, Y.1    Hirano, M.2    Sato, H.3    Sugiyama, Y.4
  • 152
  • 153
    • 0032987802 scopus 로고    scopus 로고
    • Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil β-D-glucuronide: Effects of dibromosulfophthalein on membrane transport and aglycone formation
    • Sabordo L, Sallutio BC, Evans AM, Nation RL, 1998. Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil β-D-glucuronide: effects of dibromosulfophthalein on membrane transport and aglycone formation. J. Pharmacol. Exp. Ther. 288:414-20
    • (1998) J. Pharmacol. Exp. Ther. , vol.288 , pp. 414-420
    • Sabordo, L.1    Sallutio, B.C.2    Evans, A.M.3    Nation, R.L.4
  • 154
    • 0033815555 scopus 로고    scopus 로고
    • Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil-β-D- glucuronide: Effects of clofibric acid, acetaminophen, and acetaminophen glucuronide
    • Sabordo L, Sallustio BC, Evans AM, Nation RL. 2000. Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil-β-D-glucuronide: effects of clofibric acid, acetaminophen, and acetaminophen glucuronide. J. Pharmacol Exp. Ther. 295: 44-50
    • (2000) J. Pharmacol Exp. Ther. , vol.295 , pp. 44-50
    • Sabordo, L.1    Sallustio, B.C.2    Evans, A.M.3    Nation, R.L.4
  • 155
    • 0031926050 scopus 로고    scopus 로고
    • Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes
    • Hedman A, Meijer DK. 1998. Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes. J. Pharm. Sci. 87:457-61
    • (1998) J. Pharm. Sci. , vol.87 , pp. 457-461
    • Hedman, A.1    Meijer, D.K.2
  • 156
    • 0031836110 scopus 로고    scopus 로고
    • Characterization of the uptake of rocuronium and digoxin in human hepatocytes: Carrier specificity and comparison with in vivo data
    • Olinga P, Merema M, Hof IH, Slooff MJ, Proost JH, et al. 1998. Characterization of the uptake of rocuronium and digoxin in human hepatocytes: carrier specificity and comparison with in vivo data. J. Pharmacol. Exp. Ther. 285:506-10
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , pp. 506-510
    • Olinga, P.1    Merema, M.2    Hof, I.H.3    Slooff, M.J.4    Proost, J.H.5
  • 157
    • 0027417835 scopus 로고
    • Cephalosporin-probenecid drug interactions
    • Brown GR. 1993. Cephalosporin-probenecid drug interactions. Clin. Pharmacokinet. 24:289-300
    • (1993) Clin. Pharmacokinet. , vol.24 , pp. 289-300
    • Brown, G.R.1
  • 161
    • 84960561529 scopus 로고
    • Practical clinical pharmacology and drug interactions of low-dose methotrexate therapy in rheumatoid arthritis
    • Furst DE. 1995. Practical clinical pharmacology and drug interactions of low-dose methotrexate therapy in rheumatoid arthritis. Br. J. Rheumatol. 34(Suppl. 2):20-25
    • (1995) Br. J. Rheumatol. , vol.34 , Issue.SUPPL. 2 , pp. 20-25
    • Furst, D.E.1
  • 162
    • 0026502732 scopus 로고
    • The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis
    • Tracy TS, Krohn K, Jones DR, Bradley JD, Hall SD, et al. 1992. The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis. Eur. J. Clin. Pharmacol. 42:121-25
    • (1992) Eur. J. Clin. Pharmacol. , vol.42 , pp. 121-125
    • Tracy, T.S.1    Krohn, K.2    Jones, D.R.3    Bradley, J.D.4    Hall, S.D.5
  • 163
    • 0028792273 scopus 로고
    • The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: Impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg
    • Kremer JM, Hamilton RA. 1995. The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg. J. Rheumatol. 22:2072-77
    • (1995) J. Rheumatol. , vol.22 , pp. 2072-2077
    • Kremer, J.M.1    Hamilton, R.A.2
  • 164
    • 0026570125 scopus 로고
    • Methotrexate and nonsteroidal antiinflammatory drug interactions
    • Frenia ML, Long KS. 1992. Methotrexate and nonsteroidal antiinflammatory drug interactions. Ann. Pharmacother. 26:234-37
    • (1992) Ann. Pharmacother. , vol.26 , pp. 234-237
    • Frenia, M.L.1    Long, K.S.2
  • 165
    • 1642388976 scopus 로고    scopus 로고
    • Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier
    • Nozaki Y, Kusuhara H, Endou H, Sugiyama Y. 2004. Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporters and reduced folate carrier. J. Pharmacol. Exp. Ther. 309: 226-34
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , pp. 226-234
    • Nozaki, Y.1    Kusuhara, H.2    Endou, H.3    Sugiyama, Y.4
  • 166
    • 0032931612 scopus 로고    scopus 로고
    • Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes
    • Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, et al. 1999. Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol. Pharmacol. 55:847-54
    • (1999) Mol. Pharmacol. , vol.55 , pp. 847-854
    • Apiwattanakul, N.1    Sekine, T.2    Chairoungdua, A.3    Kanai, Y.4    Nakajima, N.5
  • 167
    • 0034560136 scopus 로고    scopus 로고
    • Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter
    • Uwai Y, Saito H, Inui K. 2000. Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur. J. Pharmacol. 409:31-36
    • (2000) Eur. J. Pharmacol. , vol.409 , pp. 31-36
    • Uwai, Y.1    Saito, H.2    Inui, K.3
  • 168
    • 0032995116 scopus 로고    scopus 로고
    • Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C
    • Lu R, Chan BS, Schuster VL. 1999. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am. J. Physiol. Renal Physiol. 276:F295-303
    • (1999) Am. J. Physiol. Renal Physiol. , vol.276
    • Lu, R.1    Chan, B.S.2    Schuster, V.L.3
  • 169
    • 0036788234 scopus 로고    scopus 로고
    • Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: Its involvement in neurotransmitter metabolite clearance from the brain
    • Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, et al. 2002. Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J. Neurochem. 83:57-66
    • (2002) J. Neurochem. , vol.83 , pp. 57-66
    • Ohtsuki, S.1    Asaba, H.2    Takanaga, H.3    Deguchi, T.4    Hosoya, K.5
  • 170
    • 17144449057 scopus 로고    scopus 로고
    • Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
    • Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, et al. 1998. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 429:179-82
    • (1998) FEBS Lett. , vol.429 , pp. 179-182
    • Sekine, T.1    Cha, S.H.2    Tsuda, M.3    Apiwattanakul, N.4    Nakajima, N.5
  • 171
  • 172
    • 0033532065 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
    • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, et al. 1999. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 274:13675-80
    • (1999) J. Biol. Chem. , vol.274 , pp. 13675-13680
    • Kusuhara, H.1    Sekine, T.2    Utsunomiya-Tate, N.3    Tsuda, M.4    Kojima, R.5
  • 173
    • 0032780906 scopus 로고    scopus 로고
    • The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
    • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, et al. 1999. The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J. Pharmacol. Exp. Ther. 290:672-77
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 672-677
    • Jariyawat, S.1    Sekine, T.2    Takeda, M.3    Apiwattanakul, N.4    Kanai, Y.5
  • 174
    • 0037040390 scopus 로고    scopus 로고
    • Interaction of human organic anion transporters with various cephalosporin antibiotics
    • Takeda M, Babu E, Narikawa S, Endou H. 2002. Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur. J. Pharmacol. 438:137-42
    • (2002) Eur. J. Pharmacol. , vol.438 , pp. 137-142
    • Takeda, M.1    Babu, E.2    Narikawa, S.3    Endou, H.4
  • 175
    • 18344371636 scopus 로고    scopus 로고
    • Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: In comparison with rOAT1
    • Jung KY, Takeda M, Shimoda M, Narikawa S, Tojo A, et al. 2002. Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 70:1861-74
    • (2002) Life Sci. , vol.70 , pp. 1861-1874
    • Jung, K.Y.1    Takeda, M.2    Shimoda, M.3    Narikawa, S.4    Tojo, A.5
  • 176
    • 85013794678 scopus 로고    scopus 로고
    • Rat renal organic anion transporter rOAT1 mediated transport of urinary-excreted cephalosporins, but not of biliary excreted cefoperazone
    • Uwai Y, Saito H, Inui K. 2002. Rat renal organic anion transporter rOAT1 mediated transport of urinary-excreted cephalosporins, but not of biliary excreted cefoperazone. Drug Metab. Pharmacokin. 17:125-29
    • (2002) Drug Metab. Pharmacokin. , vol.17 , pp. 125-129
    • Uwai, Y.1    Saito, H.2    Inui, K.3
  • 179
    • 0033803165 scopus 로고    scopus 로고
    • Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1
    • Uwai Y, Saito H, Hashimoto Y, Inui K. 2000. Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J. Pharmacol Exp. Ther. 295:261-65
    • (2000) J. Pharmacol Exp. Ther. , vol.295 , pp. 261-265
    • Uwai, Y.1    Saito, H.2    Hashimoto, Y.3    Inui, K.4
  • 180
    • 0034674381 scopus 로고    scopus 로고
    • Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1
    • Uwai Y, Saito H, Hashimoto Y, Inui K. 2000. Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1. Eur. J. Pharmacol. 398:193-97
    • (2000) Eur. J. Pharmacol. , vol.398 , pp. 193-197
    • Uwai, Y.1    Saito, H.2    Hashimoto, Y.3    Inui, K.4
  • 181
    • 0036235889 scopus 로고    scopus 로고
    • Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus
    • Nagata Y, Kusuhara H, Endou H, Sugiyama Y. 2002. Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Mol. Pharmacol. 61:982-88
    • (2002) Mol. Pharmacol. , vol.61 , pp. 982-988
    • Nagata, Y.1    Kusuhara, H.2    Endou, H.3    Sugiyama, Y.4
  • 182
    • 0035843770 scopus 로고    scopus 로고
    • Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters
    • Takeda M, Narikawa S, Hosoyamada M, Cha SH, Sekine T, et al. 2001. Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur. J. Pharmacol. 419:113-20
    • (2001) Eur. J. Pharmacol. , vol.419 , pp. 113-120
    • Takeda, M.1    Narikawa, S.2    Hosoyamada, M.3    Cha, S.H.4    Sekine, T.5
  • 183
    • 0036260663 scopus 로고    scopus 로고
    • Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
    • Enomoto A, Takeda M, Shimoda M, Narikawa S, Kobayashi Y, et al. 2002. Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J. Pharmacol. Exp. Ther. 301:797-802
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 797-802
    • Enomoto, A.1    Takeda, M.2    Shimoda, M.3    Narikawa, S.4    Kobayashi, Y.5
  • 184
    • 0032793959 scopus 로고    scopus 로고
    • OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
    • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB. 1999. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab. Dispos. 27:866-71
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 866-871
    • Cvetkovic, M.1    Leake, B.2    Fromm, M.F.3    Wilkinson, G.R.4    Kim, R.B.5
  • 185
    • 0033058448 scopus 로고    scopus 로고
    • Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2
    • Tokui T, Nakai D, Nakagomi R, Yawo H, Abe T, et al. 1999. Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2. Pharm. Res. 16:904-8
    • (1999) Pharm. Res. , vol.16 , pp. 904-908
    • Tokui, T.1    Nakai, D.2    Nakagomi, R.3    Yawo, H.4    Abe, T.5
  • 186
    • 0032513049 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfate (DHEAS): Identification of a carrier protein in human liver and brain
    • Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, et al. 1998. Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett. 424:173-76
    • (1998) FEBS Lett. , vol.424 , pp. 173-176
    • Kullak-Ublick, G.A.1    Fisch, T.2    Oswald, M.3    Hagenbuch, B.4    Meier, P.J.5
  • 187
    • 0030098277 scopus 로고    scopus 로고
    • Poly specific drug and steroid clearance by an organic anion transporter of mammalian liver
    • Bossuyt X, Muller M, Hagenbuch B, Meier PJ. 1996. Poly specific drug and steroid clearance by an organic anion transporter of mammalian liver. J. Pharmacol. Exp. Ther. 276:891-96
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 891-896
    • Bossuyt, X.1    Muller, M.2    Hagenbuch, B.3    Meier, P.J.4
  • 188
    • 0034978374 scopus 로고    scopus 로고
    • Characterization of the efflux transport of 17β-estradiol-D- glucuronide from the brain across the blood-brain barrier
    • Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, et al. 2001. Characterization of the efflux transport of 17β-estradiol-D-glucuronide from the brain across the blood-brain barrier. J Pharmacol. Exp.
    • (2001) J Pharmacol. Exp.
    • Sugiyama, D.1    Kusuhara, H.2    Shitara, Y.3    Abe, T.4    Meier, P.J.5
  • 189
    • 0036146641 scopus 로고    scopus 로고
    • Effect of 17β-estradiol-D-17β-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates
    • Sugiyama D, Kusuhara H, Shitara Y, Abe T, Sugiyama Y. 2002. Effect of 17β-estradiol-D-17β-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates. Drug Metab. Dispos. 30:220-23
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 220-223
    • Sugiyama, D.1    Kusuhara, H.2    Shitara, Y.3    Abe, T.4    Sugiyama, Y.5
  • 190
    • 0035006408 scopus 로고    scopus 로고
    • LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
    • Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, et al. 2001. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 120:1689-99
    • (2001) Gastroenterology , vol.120 , pp. 1689-1699
    • Abe, T.1    Unno, M.2    Onogawa, T.3    Tokui, T.4    Kondo, T.N.5
  • 191
    • 0036293982 scopus 로고    scopus 로고
    • Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
    • Vavricka SR, van Montfoort J, Ha HR, Meier PJ, Fat tinger K. 2002. Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology 36:164-72
    • (2002) Hepatology , vol.36 , pp. 164-172
    • Vavricka, S.R.1    Van Montfoort, J.2    Ha, H.R.3    Meier, P.J.4    Fat Tinger, K.5
  • 192
    • 0034235341 scopus 로고    scopus 로고
    • Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp
    • Fattinger K, Cattori V, Hagenbuch B, Meier PJ, Stieger B. 2000. Rifamycin SV and rifampicin exhibit differential inhibition of the hepatic rat organic anion transporting polypeptides, Oatp1 and Oatp2. Hepatology 32:82-86
    • (2000) Hepatology , vol.32 , pp. 82-86
    • Fattinger, K.1    Cattori, V.2    Hagenbuch, B.3    Meier, P.J.4    Stieger, B.5
  • 193
    • 0034808667 scopus 로고    scopus 로고
    • Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus
    • Ichimaru N, Takahara S, Kokado Y, Wang J-D, Hatori M, et al. 2001. Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus. Atherosclerosis 158:471-23
    • (2001) Atherosclerosis , vol.158 , pp. 471-423
    • Ichimaru, N.1    Takahara, S.2    Kokado, Y.3    Wang, J.-D.4    Hatori, M.5
  • 194
    • 0027377733 scopus 로고
    • Plasma concentration profiles of simvastatin 3-hydroxy-3-methyl-glutaryl- coenzyme A reductase inhibitory activity in kidney transplant recipients with and without cyclosporin
    • Amadottir M, Eriksson LO, Thysell H, Karkas JD. 1993. Plasma concentration profiles of simvastatin 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitory activity in kidney transplant recipients with and without cyclosporin. Nephron 65:410-13
    • (1993) Nephron , vol.65 , pp. 410-413
    • Amadottir, M.1    Eriksson, L.O.2    Thysell, H.3    Karkas, J.D.4
  • 195
    • 0030463459 scopus 로고    scopus 로고
    • Evaluation of fluvastatin in the treatment of hypercholesterolemia in renal transplant recipients taking cyclosporine
    • Goldberg R, Roth D. 1996. Evaluation of fluvastatin in the treatment of hypercholesterolemia in renal transplant recipients taking cyclosporine. Transplantation 62:1559-34
    • (1996) Transplantation , vol.62 , pp. 1559-1534
    • Goldberg, R.1    Roth, D.2
  • 196
    • 0035337643 scopus 로고    scopus 로고
    • Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate
    • Kyrklund C, Backman JT, Kivistö KT, Neuvonen M, Latila J, et al. 2001. Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate. Clin. Pharmacol. Ther. 69:340-45
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 340-345
    • Kyrklund, C.1    Backman, J.T.2    Kivistö, K.T.3    Neuvonen, M.4    Latila, J.5
  • 198
    • 0037534010 scopus 로고    scopus 로고
    • Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
    • Kyrklund C, Backman JT, Neuvonen M, Neuvonen PJ. 2003. Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance. Clin. Pharmacol. Ther. 73:538-44
    • (2003) Clin. Pharmacol. Ther. , vol.73 , pp. 538-544
    • Kyrklund, C.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 200
    • 4644272415 scopus 로고    scopus 로고
    • An open-label study on the pharmacokinetics (PK) of pitavastatin (NK-104) when administered concomitantly with fenofibrate or gemfibrozil in healthy volunteers
    • Mathew P, Cuddy T, Tracewell WG, Salazar D. 2004. An open-label study on the pharmacokinetics (PK) of pitavastatin (NK-104) when administered concomitantly with fenofibrate or gemfibrozil in healthy volunteers. Clin. Pharmacol. Ther. 75:P33
    • (2004) Clin. Pharmacol. Ther. , vol.75
    • Mathew, P.1    Cuddy, T.2    Tracewell, W.G.3    Salazar, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.