Role of organic anion transporters in the pharmacokinetics of zonampanel, an α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, in rats

Drug Metabolism and Disposition

Volumn 36, Issue 8, 2008, Pages 1496-1504

  Minematsu, Tsuyoshi ^a   Hashimoto, Tadashi ^a   Aoki, Toshiko ^a   Usui, Takashi ^a   Kamimura, Hidetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1,2,3,4 TETRAHYDROQUINOXALIN 1 YL] PROPIONIC ACID; 4 AMINOHIPPURIC ACID; [1,2,3,4 TETRAHYDRO 7 (1H IMIDAZOL 1 YL) 6 NITRO 2,3 DIOXO 1 QUINOXALINYL]ACETIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID RECEPTOR ANTAGONIST; CIMETIDINE; ESTRONE SULFATE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 3; PROBENECID; PROSTAGLANDIN F2 ALPHA; SALICYLIC ACID; YM 53362; ZONAMPANEL;

ANIMAL CELL; ANION TRANSPORT; ARTICLE; BILIARY EXCRETION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BILE LEVEL; DRUG ELIMINATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG URINE LEVEL; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; IN VIVO STUDY; INHIBITION KINETICS; KIDNEY CLEARANCE; LIVER CELL; MALE; MICHAELIS CONSTANT; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SINGLE DRUG DOSE; SPECIES COMPARISON; TISSUE DISTRIBUTION; URINARY EXCRETION;

ANIMALS; CELL LINE; CIMETIDINE; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; IMIDAZOLES; LLC-PK1 CELLS; MALE; ORGANIC ANION TRANSPORTERS; PROBENECID; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; SWINE;

AVENA; RATTUS;

EID: 47949121279     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.019828     Document Type: Article

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