Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters

Pflugers Archiv European Journal of Physiology

Volumn 451, Issue 5, 2006, Pages 597-605

  Pajor, Ana M ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Citrate; Dicarboxylates; Sodium; Succinate; Sulfate

Indexed keywords

CARRIER PROTEIN; CYSTEINE; DICARBOXYLATE TRANSPORTER; MEMBRANE PROTEIN; ORGANIC ANION TRANSPORTER; SODIUM CITRATE TRANSPORTER; SODIUM COUPLED INORGANIC SULFATE TRANSPORTER; SODIUM DEPENDENT SULFATE TRANSPORTER; SODIUM DICARBOXYLATE TRANSPORTER 1; SODIUM DICARBOXYLATE TRANSPORTER 3; SULFATE TRANSPORTER; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; BACTERIUM; CAENORHABDITIS ELEGANS; ELECTRIC CURRENT; GENE; GENE FUNCTION; GENE STRUCTURE; GLYCOSYLATION; HUMAN; INSECT; ION CURRENT; MOLECULAR DYNAMICS; MULTIGENE FAMILY; MUTAGENESIS; NONHUMAN; PLANT; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; VERTEBRATE;

ANIMALS; ANION TRANSPORT PROTEINS; ELECTROPHYSIOLOGY; HUMANS; MULTIGENE FAMILY; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 29944444676     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-005-1487-2     Document Type: Review

References (69)

1. +-pump ligands modulate gating of palytoxin-induced ion channels. Proc Natl Acad Sci USA 100:501-505
2. +-dicarboxylate cotransporter NaDC-1. Am J Physiol Cell Physiol 287:C64-C72
3. Aruga S, Wehrli S, Kaissling B, Moe OW, Preisig PA, Pajor AM, Alpern RJ (2000) Chronic metabolic acidosis increases NaDC-1 mRNA and protein abundance in rat kidney. Kidney Int 58:206-215
4. +-dependent dicarboxylate transporter. Am J Physiol Gastrointest Liver 273:G267-G274
5. +-sulfate cotransporter gene Nas1. Cloning, tissue distribution, gene structure, chromosomal assignment, and transcriptional regulation by vitamin D. J Biol Chem 275:11880-11890
6. + exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B. Biochem Biophys Res Commun 313:998-1003
7. +-dependent dicarboxylate transporter, NaDC-3, translocates dimethyl- and disulfhydryl-compounds and contributes to renal heavy metal detoxification. J Am Soc Nephrol 13:2628-2638
8. Burckhardt BC, Lorenz J, Burckhardt G, Steffgen J (2004) Interactions of benzylpenicillin and non-steroidal anti-inflammatory drugs with the sodium-dependent dicarboxylate transporter NaDC-3. Cell Physiol Biochem 14:415-424
9. Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G (2005) Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. Am J Physiol Renal Fluid Electrolyte Physiol 288:F792-F799
10. Burckhardt BC, Steffgen J, Langheit D, Müller GA, Burckhardt G (2000) Potential-dependent steady-state kinetics of a dicarboxylate transporter cloned from winter flounder kidney. Pflügers Arch 441:323-330
11. 2- transport protein NaSi-1. J Biol Chem 269:12407-12409
12. Chen X, Tsukaguchi H, Chen XZ, Berger UV, Hediger MA (1999) Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter. J Clin Invest 103:1159-1168
13. +-dicarboxylate cotransporter. J Biol Chem 273:20972-20981
14. Dawson PA, Beck L, Markovich D (2003) Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene. Proc Natl Acad Sci USA 100:13704-13709
15. +-sulfate cotransporter rNaS2: functional characterization, tissue distribution, and gene (slc13a4) structure. Pflügers Arch 450: 262-268
16. Dawson PA, Steane SE, Markovich D (2004) Behavioural abnormalities of the hyposulphataemic Nas1 knock-out mouse. Behav Brain Res 154:457-463
17. Dawson PA, Steane SE, Markovich D (2005) Impaired memory and olfactory performance in NaSi-1 sulphate transporter deficient mice. Behav Brain Res 159:15-20
18. Emmerlich V, Linka N, Reinhold T, Hurth MA, Traub M, Martinoia E, Neuhaus HE (2003) The plant homolog to the human sodium/dicarboxylic cotransporter is the vacuolar malate carrier. Proc Natl Acad Sci USA 100:11122-11126
19. Fei YJ, Inoue K, Ganapathy V (2003) Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. J Biol Chem 278:6136-6144
20. +-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans. Biochem J 379:191-198
21. George RL, Huang W, Naggar HA, Smith SB, Ganapathy V (2004) Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse. Biochim Biophys Acta 1690:63-69
22. Girard JP, Baekkevold ES, Feliu J, Brandtzaeg P, Amalric F (1999) Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. Proc Natl Acad Sci USA 96:12772-12777
23. +/dicarboxylate cotransporter, NaDC-1. Biochemistry 38:7524-7531
24. Hagenbuch B, Meier PJ (2004) Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflügers Arch 447:653-665
25. Hagos Y, Burckhardt BC, Larsen A, Mathys C, Gronow T, Bahn A, Wolff NA, Burckhardt G, Steffgen J (2004) Regulation of sodium-dicarboxylate cotransporter-3 from winter flounder kidney by protein kinase C. Am J Physiol Renal Fluid Electrolyte Physiol 286:F86-F93
26. +-coupled dicarboxylate carrier protein from Staphylococcus aureus. J Bacteriol 187: 5189-5194
27. Hamm LL (1990) Renal handling of citrate. Kidney Int 38:728-735
28. +- dicarboxylate cotransporter (fNaDC-3) in the kidney of Pleuronectes americanus. Pflügers Arch 446:578-584
29. Hurth MA, Suh SJ, Kretzschmar T, Geis T, Bregante M, Gambale F, Martinoia E, Neuhaus HE (2005) Impaired pH homeostasis in Arabidopsis lacking the vacuolar dicarboxylate transporter and analysis of carboxylic acid transport across the tonoplast. Plant Physiol 137:901-910
30. Inoue K, Fei YJ, Huang W, Zhuang L, Chen Z, Ganapathy V (2002) Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates. Biochem J 367:313-319
31. Inoue K, Fei YJ, Zhuang L, Gopal E, Miyauchi S, Ganapathy V (2004) Functional features and genomic organization of mouse NaCT, a sodium-coupled transporter for tricarboxylic acid cycle intermediates. Biochem J 378:949-957
32. +-coupled citrate transporter: primary structure, genomic organization, and transport function. Biochem Biophys Res Commun 299:465-471
33. Inoue K, Zhuang L, Maddox DM, Smith SB, Ganapathy V (2002) Structure, function and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain. J Biol Chem 277:39469-39476
34. Inoue K, Zhuang L, Maddox DM, Smith SB, Ganapathy V (2003) Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. Biochem J 374:21-26
35. +/dicarboxylate cotransporter. Biochemistry 38:6151-6156
36. Karlin A, Akabas MH (1998) Substituted-cysteine accessibility method. Methods Enzymol 293:123-145
37. Kekuda R, Wang H, Huang W, Pajor AM, Leibach FH, Devoe LD, Prasad PD, Ganapathy V (1999) Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter. J Biol Chem 274:3422-3429
38. Knauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL (2002) Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proc Natl Acad Sci USA 99:14315-14319
39. Kushnir MM, Komaromy-Hiller G, Shushan B, Urry FM, Roberts WL (2001) Analysis of dicarboxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine. Clin Chem 47:1993-2002
40. Lee A, Beck L, Markovich D (2000) The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. Genomics 70:354-363
41. Li H, Pajor AM (2003) Serines 260 and 288 are involved in sulfate transport by hNaSi-1. J Biol Chem 278:37204-37212
42. Li H, Pajor AM (2003) Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. Am J Physiol Cell Physiol 285:C1188-C1196
43. 4-cotransport (NaSi-1) in rat kidney. Pflügers Arch 432:373-378
44. Markovich D (2000) Molecular regulation and membrane trafficking of mammalian renal phosphate and sulphate transporters. Eur J Cell Biol 79:531-538
45. Markovich D (2001) Physiological roles and regulation of mammalian sulfate transporters. Physiol Rev 81:1499-1533
46. 2- cotransport. Proc Natl Acad Sci USA 90:8073-8077
47. Markovich D, Murer H (2004) The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflügers Arch 447:594-602
48. +-sulfate cotransporter hNaS2 gene (SLC13A4). Biochem Biophys Res Commun 326:729-734
49. Nakada T, Zandi Nejad K, Kurita Y, Kudo H, Broumand V, Kwon CY, Mercado A, Mount DB, Hirose S (2005) Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater. Am J Physiol Regul Integr Comp Physiol 289: R575-R585
50. +/dicarboxylate cotransporter found in Xenopus laevis kidney and heart. Am J Physiol Cell Physiol (in press)
51. Pajor AM (1995) Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter. J Biol Chem 270:5779-5785
52. Pajor AM (1996) Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am J Physiol Renal Fluid Electrolyte Physiol 270:F642-F648
53. Pajor AM (1999) Sodium-coupled transporters for Krebs cycle intermediates. Annu Rev Physiol 61:663-682
54. Pajor AM (2000) Molecular properties of sodium/dicarboxylate cotransporters. J Membr Biol 175:1-8
55. +/dicarboxylate cotransporter. J Biol Chem 276:29961-29968
56. +/dicarboxylate cotransporter from mouse brain. Am J Physiol Cell Physiol 280:C1215-C1223
57. +/dicarboxylate cotransporter. J Biol Chem 273:18923-18929
58. +/dicarboxylate cotransporter, NaDC-1. Biochem J 344:205-209
59. +/dicarboxylate Cotransporter. J Biol Chem 280:18728-18735
60. Pajor AM, Sun N (2000) Molecular cloning, chromosomal localization and functional characterization of a sodium/dicarboxylate cotransporter from mouse kidney. Am J Physiol Renal Fluid Electrolyte Physiol 279:F482-F490
61. +/dicarboxylate cotransporter using anti-fusion protein antibodies. Am J Physiol Cell Physiol 271:C1808-C1816
62. +-dicarboxylate cotransporters, NaDC-1 and hNaDC-1. Am J Physiol Renal Fluid Electrolyte Physiol 271:F1093-F1099
63. Rogina B, Reenan RA, Nilsen SP, Helfand SL (2000) Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290:2137-2140
64. +-dicarboxylate cotransporter. Am J Physiol Renal Fluid Electrolyte Physiol 275:F298-F305
65. Steffgen J, Burckhardt BC, Langenberg C, Kuhne L, Müller GA, Burckhardt G, Wolff NA (1999) Expression cloning and characterization of a novel sodium-dicarboxylate cotransporter from winter flounder kidney. J Biol Chem 274:20190-20196
66. +-dependent high-affinity dicarboxylate transporter. Am J Physiol Cell Physiol 278:C1019-C1030
67. +/dicarboxylate cotransporter are conformationally sensitive residues. Biochemistry 41:1083-1090
68. +/dicarboxylate cotransporter under voltage clamp conditions. Am J Physiol Renal Fluid Electrolyte Physiol 279:F54-F64
69. +/dicarboxylate cotransporter: the N-terminus and hydrophilic loop 4 are located intracellularly. Biochim Biophys Acta 1511:80-89