COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex

Kidney International

Volumn 75, Issue 4, 2009, Pages 373-380

  Höcherl, Klaus ^a   Schmidt, Christoph ^a   Bucher, Michael ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Cyclooxygenase; Inflammation; Ischemia; Prostaglandins; Sepsis

Indexed keywords

4 AMINOHIPPURIC ACID; CREATININE; CYCLOOXYGENASE 2; LIPOPOLYSACCHARIDE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PARECOXIB; PROSTAGLANDIN E2;

4 AMINOHIPPURIC ACID CLEARANCE; AMINO ACID BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DOWN REGULATION; DRUG EFFECT; ENDOTOXEMIA; ENZYME INHIBITION; GENE EXPRESSION; GENE REPRESSION; IN VITRO STUDY; KIDNEY CORTEX; KIDNEY ISCHEMIA; KIDNEY TUBULE DISORDER; MALE; NONHUMAN; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SEPSIS; TISSUE LEVEL;

ACUTE DISEASE; ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DOWN-REGULATION; ISOXAZOLES; KIDNEY CORTEX; KIDNEY DISEASES; LIPOPOLYSACCHARIDES; MALE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 59149084250     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.557     Document Type: Article

References (48)

1. Thadhani R, Pascual M, Bonventre JV. Acute renal failure. N Engl J Med 1996; 334: 1448-1460.
2. Levy EM, Viscoli CM, Horwitz RI. The effect of acute renal failure on mortality. A cohort analysis. JAMA 1996; 275: 1489-1494.
3. De Vriese AS. Prevention and treatment of acute renal failure in sepsis. J Am Soc Nephrol 2003; 14: 792-805.
4. Inui KI, Masuda S, Saito H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int 2000; 58: 944-958.
5. Anzai N, Kanai Y, Endou H. Organic anion transporter family: current knowledge. J Pharmacol Sci 2006; 100: 411-426.
6. Burckhardt BC, Burckhardt G. Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol 2003; 146: 95-158.
7. Irish III JM. Secretion of prostaglandin E2 by rabbit proximal tubules. Am J Physiol 1979; 237: F268-F273.
8. Sauvant C, Holzinger H, Gekle M. Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3. J Am Soc Nephrol 2006; 17: 46-53.
9. Matsuzaki T, Watanabe H, Yoshitome K et al. Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute [corrected] renal failure. Kidney Int 2007; 71: 539-547.
10. Schneider R, Sauvant C, Betz B et al. Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats. Am J Physiol Renal Physiol 2007; 292: F1599-F1605.
11. Villar SR, Brandoni A, Anzai N et al. Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction. Kidney Int 2005; 68: 2704-2713.
12. Chatterjee PK, Brown PA, Cuzzocrea S et al. Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int 2001; 59: 2073-2083.
13. Norregaard R, Jensen BL, Li C et al. COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction. Am J Physiol Renal Physiol 2005; 289: F322-F333.
14. Ichitani Y, Holmberg K, Maunsbach AB et al. Cyclooxygenase-1 and cyclooxygenase-2 expression in rat kidney and adrenal gland after stimulation with systemic lipopolysaccharide: in situ hybridization and immunocytochemical studies. Cell Tissue Res 2001; 303: 235-252.
15. Bergeron MG, Bergeron Y. Influence of endotoxin on the intrarenal distribution of gentamicin, netilmicin, tobramycin, amikacin, and cephalothin. Antimicrob Agents Chemother 1986; 29: 7-12.
16. Ganzinger U, Haslberger A, Schiel H et al. Influence of endotoxin on the distribution of cephalosporins in rabbits. J Antimicrob Chemother 1986; 17: 785-793.
17. Lugon JR, Boim MA, Ramos OL et al. Renal function and glomerular hemodynamics in male endotoxemic rats. Kidney Int 1989; 36: 570-575.
18. Nadai M, Hasegawa T, Kato K et al. Alterations in pharmacokinetics and protein binding behavior of cefazolin in endotoxemic rats. Antimicrob Agents Chemother 1993; 37: 1781-1785.
19. Nadai M, Hasegawa T, Kato K et al. The disposition and renal handling of enprofylline in endotoxemic rats by bacterial lipopolysaccharide (LPS). Drug Metab Dispos 1993; 21: 611-616.
20. Nadai M, Hasegawa T, Wang L et al. Time-dependent changes in the pharmacokinetics and renal excretion of xanthine derivative enprofylline induced by bacterial endotoxin in rats. Biol Pharm Bull 1995; 18: 1089-1093.
21. Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacol Ther 2006; 109: 1-11.
22. Tardif D, Beauchamp D, Bergeron MG. Influence of endotoxin on the intracortical accumulation kinetics of gentamicin in rats. Antimicrob Agents Chemother 1990; 34: 576-580.
23. Churchill PC, Bidani AK, Schwartz MM. Renal effects of endotoxin in the male rat. Am J Physiol 1987; 253: F244-F250.
24. Hocherl K, Dreher F, Kurtz A et al. Cyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failure. Hypertension 2002; 40: 947-953.
25. Schmidt C, Hocherl K, Bucher M. Cytokine-mediated regulation of urea transporters during experimental endotoxemia. Am J Physiol Renal Physiol 2007; 292: F1479-F1489.
26. Schmidt C, Hocherl K, Schweda F et al. Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis. Crit Care Med 2007; 35: 2110-2119.
27. Schmidt C, Hocherl K, Schweda F et al. Regulation of renal sodium transporters during severe inflammation. J Am Soc Nephrol 2007; 18: 1072-1083.
28. Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 2000; 69: 145-182.
29. Burckhardt G, Bahn A, Wolff NA. Molecular physiology of renal p-aminohippurate secretion. News Physiol Sci 2001; 16: 114-118.
30. Lopez-Parra M, Claria J, Planaguma A et al. Cyclooxygenase-1 derived prostaglandins are involved in the maintenance of renal function in rats with cirrhosis and ascites. Br J Pharmacol 2002; 135: 891-900.
31. Patel NS, Cuzzocrea S, Collino M et al. The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo. Eur J Pharmacol 2007; 562: 148-154.
32. Matsuyama M, Nakatani T, Hase T et al. The expression of cyclooxygenases and lipoxygenases in renal ischemia-reperfusion injury. Transplant Proc 2004; 36: 1939-1942.
33. Matsuyama M, Yoshimura R, Hase T et al. Study of cyclooxygenase-2 in renal ischemia-reperfusion injury. Transplant Proc 2005; 37: 370-372.
34. Slimane MA, Ferlicot S, Conti M et al. Expression of cyclooxygenase 2 and prostaglandin E synthase after renal ischemia-reperfusion. Transplant Proc 2002; 34: 2841-2842.
35. Di Giusto G, Anzai N, Endou H et al. Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: role of basolateral plasma membrane transporters and cortical renal blood flow. Pharmacology 2008; 81: 127-136.
36. Bae EH, Lee KS, Lee J et al. Effects of {alpha}-lipoic acid on ischemia/ reperfusion-induced renal dysfunction in rats. Am J Physiol Renal Physiol 2008; 294: F272-F280.
37. Ogasawara K, Terada T, Asaka J et al. Human organic anion transporter 3 gene is regulated constitutively and inducibly via a cAMP-response element. J Pharmacol Exp Ther 2006; 319: 317-322.
38. Risoe PK, Wang Y, Stuestol JF et al. Lipopolysaccharide attenuates mRNA levels of several adenylyl cyclase isoforms in vivo. Biochim Biophys Acta 2007; 1772: 32-39.
39. Bucher M, Ittner KP, Hobbhahn J et al. Downregulation of angiotensin II type 1 receptors during sepsis. Hypertension 2001; 38: 177-182.
40. Hocherl K, Hensel C, Ulbricht B et al. Everolimus treatment downregulates renocortical cyclooxygenase-2 expression in the rat kidney. Br J Pharmacol 2005; 145: 1112-1122.
41. Schneider R, Raff U, Vornberger N et al. -arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in rats. Kidney Int 2003; 64: 216-225.
42. Matzdorf C, Kurtz A, Hocherl K. COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys. Am J Physiol Renal Physiol 2007; 292: F1782-F1790.
43. Hocherl K, Kees F, Kramer BK et al. Cyclosporine A attenuates the natriuretic action of loop diuretics by inhibition of renal COX-2 expression. Kidney Int 2004; 65: 2071-2080.
44. Ljubojevic M, Herak-Kramberger CM, Hagos Y et al. Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am J Physiol Renal Physiol 2004; 287: F124-F138.
45. Torres AM, Mac Laughlin M, Muller A et al. Altered renal elimination of organic anions in rats with chronic renal failure. Biochim Biophys Acta 2005; 1740: 29-37.
46. Zhang R, Yang X, Li J et al. Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/ reperfusion injury. Am J Nephrol 2008; 28: 772-783.
47. Sauter A, Machura K, Neubauer B et al. Development of renin expression in the mouse kidney. Kidney Int 2008; 73: 43-51.
48. Hocherl K, Wolf K, Castrop H et al. Renocortical expression of renin and of cyclooxygenase-2 in response to angiotensin II AT1 receptor blockade is closely coordinated but not causally linked. Pflugers Arch 2001; 442: 821-827.