Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury

American Journal of Nephrology

Volumn 28, Issue 5, 2008, Pages 772-783

  Zhang, Rui ^a   Yang, Xiao ^a   Li, Jun ^a   Wu, Jun ^a   Peng, Wen Xing ^a   Dong, Xiu Qing ^a   Zhou, Shu Feng ^b   Yu, Xue Qing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b RMIT UNIVERSITY   (Australia)

Author keywords

Ischemia reperfusion injury; Na+ K+ ATPase; Organic anion transporter; Para aminohippurate; Renal excretion

Indexed keywords

4 AMINOHIPPURIC ACID; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); MESSENGER RNA; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLAMP; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; KIDNEY CLEARANCE; KIDNEY CORTEX; KIDNEY HOMOGENATE; KIDNEY ISCHEMIA; KIDNEY TUBULE DAMAGE; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; IMMUNOHISTOCHEMISTRY; KIDNEY CORTEX; MALE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-AMINOHIPPURIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 51149108117     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000129073     Document Type: Article

References (51)

1. Lee W, Kim RB: Transporters and renal drug elimination. Annu Rev Pharmacol Toxicol 2004;44:137-166.
2. Wright SH: Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics. Toxicol Appl Pharmacol 2005;204:309-319.
3. Launay-Vacher V, Izzedine H, Karie S, Hulot JS, Baumelou A, Deray G: Renal tubular drug transporters. Nephron Physiol 2006;103:p97-p106.
4. Inui KI, Masuda S, Saito H: Cellular and molecular aspects of drug transport in the kidney. Kidney Int 2000;58:944-958.
5. Dantzler WH: Renal organic anion transport: a comparative and cellular perspective. Biochim Biophys Acta 2002;1566:169-181.
6. Rizwan AN, Burckhardt G: Organic anion transporters of the slc22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 2007;24:450-470.
7. Anzai N, Kanai Y, Endou H: Organic anion transporter family: current knowledge. J Pharmacol Sci 2006;100:411-426.
8. Miyazaki H, Sekine T, Endou H: The multispecific organic anion transporter family: properties and pharmacological significance. Trends Pharmacol Sci 2004;25:654-662.
9. Matsumoto S, Yoshida K, Ishiguro N, Maeda T, Tamai I: Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(s)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]. J Pharmacol Exp Ther 2007;322:1246-1252.
10. Sweet DH, Bush KT, Nigam SK: The organic anion transporter family: from physiology to ontogeny and the clinic. Am J Physiol Renal Physiol 2001;281:F197-F205.
11. Villar SR, Brandoni A, Anzai N, Endou H, Torres AM: Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction. Kidney Int 2005;68:2704-2713.
12. Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 1999;276:F122-F128.
13. Pritchard JB: Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles. Am J Physiol 1988;255:F597-F604.
14. Pritchard JB, Sweet DH, Miller DS, Walden R: Mechanism of organic anion transport across the apical membrane of choroid plexus. J Biol Chem 1999;274:33382-33387.
15. Kinsella JL, Holohan PD, Pessah NI, Ross CR: Transport of organic ions in renal cortical luminal and antiluminal membrane vesicles. J Pharmacol Exp Ther 1979;209:443-450.
16. Sokol PP: Effect of dq-2556, a new cephalosporin, on organic ion transport in renal plasma membrane vesicles from the dog, rabbit and rat. J Pharmacol Exp Ther 1990;255:436-441.
17. Miller DS, Pritchard JB: Nocodazole inhibition of organic anion secretion in teleost renal proximal tubules. Am J Physiol 1994;267:R695-R704.
18. Thadhani R, Pascual M, Bonventre JV: Acute renal failure. N Engl J Med 1996;334:1448-1460.
19. Kotsch K, Francuski M, Pascher A, Klemz R, Seifert M, Mittler J, Schumacher G, Buelow R, Volk HD, Tullius SG, Neuhaus P, Pratschke J: Improved long-term graft survival after HO-1 induction in brain-dead donors. Am J Transplant 2006;6:477-486.
20. Shoskes DA, Parfrey NA, Halloran PF: Increased major histocompatibility complex antigen expression in unilateral ischemic acute tubular necrosis in the mouse. Transplantation 1990;49:201-207.
21. Jones EA, Shoskes DA: The effect of mycophenolate mofetil and polyphenolic bioflavonoids on renal ischemia reperfusion injury and repair. J Urol 2000;163:999-1004.
22. Kwon O, Hong SM, Blouch K: Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts. J Histochem Cytochem 2007;55:575-584.
23. Villar SR, Brandoni A, Quaglia NB, Torres AM: Renal elimination of organic anions in rats with bilateral ureteral obstruction. Biochim Biophys Acta 2004;1688:204-209.
24. Di Giusto G, Anzai N, Endou H, Torres AM: Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: role of basolateral plasma membrane transporters and cortical renal blood flow. Pharmacology 2008;81:127-136.
25. Monica Torres A, Mac Laughlin M, Muller A, Brandoni A, Anzai N, Endou H: Altered renal elimination of organic anions in rats with chronic renal failure. Biochim Biophys Acta 2005;1740:29-37.
26. Enomoto A, Takeda M, Tojo A, Sekine T, Cha SH, Khamdang S, Takayama F, Aoyama I, Nakamura S, Endou H, Niwa T: Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J Am Soc Nephrol 2002;13:1711-1720.
27. Sung FL, Zhu TY, Au-Yeung KK, Siow YL, O K: Enhanced MCP-1 expression during ischemia/reperfusion injury is mediated by oxidative stress and NF-kappaB. Kidney Int 2002;62:1160-1170.
28. Herrero F, Morales D, Baamonde C, Salas E, Berrazueta JR, Casanova D: Ischemic preconditioning and kidney transplantation: in vivo nitric oxide monitoring in a rat ischemia-reperfusion experimental model. Transplant Proc 2006;38:2600-2602.
29. Saito M, Miyagawa I: Real-time monitoring of nitric oxide in ischemia-reperfusion rat kidney. Urol Res 2000;28:141-146.
30. Kang DH, Han L, Ouyang X, Kahn AM, Kanellis J, Li P, Feng L, Nakagawa T, Watanabe S, Hosoyamada M, Endou H, Lipkowitz M, Abramson R, Mu W, Johnson RJ: Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter. Am J Nephrol 2005;25:425-433.
31. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
32. Jensen RE, Berndt WO: Epinephrine and norepinephrine enhance p-aminohippurate transport into basolateral membrane vesicles. J Pharmacol Exp Ther 1988;244:543-549.
33. Cerrutti JA, Brandoni A, Quaglia NB, Torres AM: Sex differences in p-aminohippuric acid transport in rat kidney: role of membrane fluidity and expression of OAT1. Mol Cell Biochem 2002;233:175-179.
34. +-activated ATPase from ox brain. Eur J Biochem 1967;1:334-343.
35. Widnell CC: Purification of rat liver 5′-nucleotidase as a complex with sphingomyelin. Methods Enzymol 1974;32:368-374.
36. Cerrutti JA, Quaglia NB, Torres AM: Characterization of the mechanisms involved in the gender differences in p-aminohippurate renal elimination in rats. Can J Physiol Pharmacol 2001;79:805-813.
37. Jakobsson SV: Subfractionation and properties of rat kidney cortex microsomal fraction. Exp Cell Res 1974;84:319-334.
38. Kielar ML, Jeyarajah DR, Zhou XJ, Lu CY: Docosahexaenoic acid ameliorates murine ischemic acute renal failure and prevents increases in mRNA abundance for both TNF-alpha and inducible nitric oxide synthase. J Am Soc Nephrol 2003;14:389-396.
39. Yoshida T, Kurella M, Beato F, Min H, Ingelfinger JR, Stears RL, Swinford RD, Gullans SR, Tang SS: Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. Kidney Int 2002;61:1646-1654.
40. Sakurai Y, Motohashi H, Ogasawara K, Terada T, Masuda S, Katsura T, Mori N, Matsuura M, Doi T, Fukatsu A, Inui K: Pharmacokinetic significance of renal OAT3 (slc22a8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis. Pharm Res 2005;22:2016-2022.
41. Nozaki Y, Kusuhara H, Kondo T, Iwaki M, Shiroyanagi Y, Nakayama H, Horita S, Nakazawa H, Okano T, Sugiyama Y: Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices. J Pharmacol Exp Ther 2007;322:1162-1170.
42. Sun H, Frassetto L, Benet LZ: Effects of renal failure on drug transport and metabolism. Pharmacol Ther 2006;109:1-11.
43. Quaglia NB, Brandoni A, Ferri A, Torres AM: Early manifestation of nephropathy in rats with arterial calcinosis. Ren Fail 2003;25:355-366.
44. Yang CW, Lee SH, Lim SW, Jung JY, Kim WY, Kim HW, Choi BS, Li C, Cha JH, Kim YS, Kim J, Bang BK: Cyclosporine or fk506 decrease mature epidermal growth factor protein expression and renal tubular regeneration in rat kidneys with ischemia/reperfusion injury. Nephron 2002;92:914-921.
45. Gobe G, Zhang XJ, Cuttle L, Pat B, Willgoss D, Hancock J, Barnard R, Endre RB: Bcl-2 genes and growth factors in the pathology of ischaemic acute renal failure. Immunol Cell Biol 1999;77:279-286.
46. Lash LH, Hueni SE, Putt DA, Zalups RK: Role of organic anion and amino acid carriers in transport of inorganic mercury in rat renal basolateral membrane vesicles: influence of compensatory renal growth. Toxicol Sci 2005;88:630-644.
47. Schneider R, Sauvant C, Betz B, Otremba M, Fischer D, Holzinger H, Wanner C, Galle J, Gekle M: Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats. Am J Physiol Renal Physiol 2007;292:F1599-F1605.
48. Matsuzaki T, Watanabe H, Yoshitome K, Morisaki T, Hamada A, Nonoguchi H, Kohda Y, Tomita K, Inui K, Saito H: Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute [corrected] renal failure. Kidney Int 2007;71:539-547.
49. Deguchi T, Kusuhara H, Takadate A, Endou H, Otagiri M, Sugiyama Y: Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int 2004;65:162-174.
50. Preuss HG, Massry SG, Maher JF, Gilliece M, Schreiner GE: Effects of uremic sera on renal tubular p-aminohippurate transport. Nephron 1966;3:265-273.
51. Henderson SJ, Lindup WE: Renal organic acid transport: uptake by rat kidney slices of a furan dicarboxylic acid which inhibits plasma protein binding of acidic ligands in uremia. J Pharmacol Exp Ther 1992;263:54-60.