Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels

Drug Metabolism and Disposition

Volumn 32, Issue 6, 2004, Pages 620-625

  Buist, Susan C N ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; ORGANIC ANION TRANSPORTER; SLC22A6 ORGANIC ANION TRANSPORTER; SLC22A7 ORGANIC ANION TRANSPORTER; SLC22A8 ORGANIC ANION TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRANCHED DNA SIGNAL AMPLIFICATION ASSAY; CEREBELLUM; CONTROLLED STUDY; FEMALE; GENDER; GENE EXPRESSION; INTESTINE; KIDNEY PROXIMAL TUBULE; LIVER; LUNG; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE PROBE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; STOMACH;

ANIMALS; BRANCHED DNA SIGNAL AMPLIFICATION ASSAY; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; KIDNEY; MALE; MICE; MICE, INBRED C57BL; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SEX FACTORS;

ANIMALIA; AVENA; EUKARYOTA;

EID: 2442700344     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.6.620     Document Type: Article

References (24)

1. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, and Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389-3402.
2. Barnett HL, McNamara H, Shultz S, and Tompsett R (1949) Renal clearances of sodium penicillin G, procaine penicillin G and inulin in infants and children. Pediatrics 3:418-422.
3. Brady KP, Dushkin H, Fornzler D, Koike T, Magner F, Her H, Gullans S, Segre GV, Green RM, and Beier DR (1999) A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56:254-261.
4. Buist SCN, Cherrington NJ, Choudhuri S, Hartley DP, and Klaassen CD (2002) Gender-specific and developmental influences on the expression of rat organic anion transporters (Oats). J Pharmacol Exp Ther 301:145-151.
5. Buist SCN and Klaassen CD (2003) Endocrine regulation of rat organic anion transporters. Drug Metab Dispos 31:559-564.
6. Fetterman GH, Shuplock NA, Philipp FJ, and Gregg HS (1965) The growth and maturation of human glomeruli and proximal convolutions from term to adulthood. Pediatrics 35:601-619.
7. Griffith FD and Long JE (1980) Animal toxicity studies with ammonium perfluorooctanoate. Am Ind Hyg Assoc J 41:576-583.
8. Hanhijärvi H, Ophaug RH, and Singer L (1982) The sex-related difference in perfluorooctanoate excretion in the rat. Proc Soc Exp Biol Med 171:50-55.
9. Hartley DP and Klaassen CD (2000) Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology. Drug Metab Dispos 28:608-616.
10. Kobayashi Y, Hirokawa N, Ohshiro N, Sekine T, Sasaki T, Tokuyama S, Endou H, and Yamamoto T (2002) Differential gene expression of organic anion transporters in male and female rats. Biochem Biophys Res Commun 290:482-487.
11. Kudo N, Katakura M, Sato Y, and Kawashima Y (2002) Sex hormone-regulated renal transport of perfluorooctanoic acid. Chem Biol Interact 139:301-316.
12. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680.
13. Lehman-McKeeman LD, Rodriguez PA, Takigiku R, Caudill D, and Fey MI (1989) d-Limonene-induced male rat-specific nephropathy: evaluation of the association between d-limonene and alpha 2u-globulin. Toxicol Appl Pharmacol 99:250-259.
14. Lopez-Nieto CE, You G, Bush KT, Barros JG, Beier DR, and Nigam SK (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 272:6471-6478.
15. Nakajima N, Sekine T, Cha SH, Tojo A, Hosoyamada M, Kanai Y, Yan K, Awa S, and Endou H (2000) Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney. Kidney Int 57:1608-1616.
16. Pavlova A, Sakurai H, Leclercq B, Beier DR, Yu ASL, and Nigam SK (2000) Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2) and Roct. Am J Physiol 278:F635-F643.
17. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, and Endou H (1998) Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429:179-182.
18. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, and Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
19. Short BG, Burnett VL, Cox MG, Bus JS, and Swenberg JA (1987) Site-specific renal toxicity and cell proliferation in male rats exposed to petroleum hydrocarbons. Lab Investig 57:564-577.
20. Short BG, Burnett VL, and Swenberg JA (1989) Elevated proliferation of proximal tubule cells and localization of accumulated alpha 2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentane. Toxicol Appl Pharmacol 101:414-431.
21. Simonson GD, Vincent AC, Roberg KJ, Huang Y, and Iwanij V (1994) Molecular cloning and characterization of a novel liver-specific transport protein. J Cell Sci 107:1065-1072.
22. Sohlenius AK, Andersson K, and DePierre JW (1992) The effects of perfluoro-octanoic acid on hepatic peroxisome proliferation and related parameters show no sex-related differences in mice. Biochem J 285:779-783.
23. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, and Nigam SK (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277:26934-26943.
24. West JR, Smith HS, and Chasis H (1948) Glomerular filtration rate, effective renal blood flow and maximal tubular excretory capacity in infancy. J Pediatr 32:10-18. Financial support for this research was provided by National Institutes of Health Grants ES-09649 and ES-07079.