메뉴 건너뛰기




Volumn 25, Issue 4-5, 2010, Pages 511-522

Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney

Author keywords

Carnitine; Organic anion transport; Renal tubular epithelial cells; Zwitterions

Indexed keywords

AMPHOLYTE; CARNITINE; CIMETIDINE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 9L; ORGANIC ANION TRANSPORTER 9S; SALICYLIC ACID; UNCLASSIFIED DRUG;

EID: 77949922736     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000303060     Document Type: Article
Times cited : (19)

References (51)
  • 1
    • 0027133590 scopus 로고
    • Mechanisms mediating renal secretion of organic anions and cations
    • Pritchard JB, Miller DS: Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 1993;73:765-796.
    • (1993) Physiol Rev , vol.73 , pp. 765-796
    • Pritchard, J.B.1    Miller, D.S.2
  • 2
    • 33847139479 scopus 로고    scopus 로고
    • Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
    • Rizwan AN, Burckhardt G: Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 2007;24:450-470.
    • (2007) Pharm Res , vol.24 , pp. 450-470
    • Rizwan, A.N.1    Burckhardt, G.2
  • 3
    • 34547208011 scopus 로고    scopus 로고
    • Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues
    • Nigam SK, Bush KT, Bhatnagar V: Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol 2007;3:443-447.
    • (2007) Nat Clin Pract Nephrol , vol.3 , pp. 443-447
    • Nigam, S.K.1    Bush, K.T.2    Bhatnagar, V.3
  • 4
    • 0033921479 scopus 로고    scopus 로고
    • Structure of renal organic anion and cation transporters
    • Burckhardt G, Wolff NA: Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol 2000;278:F853-F866.
    • (2000) Am J Physiol Renal Physiol , vol.278
    • Burckhardt, G.1    Wolff, N.A.2
  • 5
    • 1242295185 scopus 로고    scopus 로고
    • The SLC22 drug transporter family
    • Koepsell H, Endou H: The SLC22 drug transporter family. Pflugers Arch 2004;447:666-676.
    • (2004) Pflugers Arch , vol.447 , pp. 666-676
    • Koepsell, H.1    Endou, H.2
  • 6
    • 0028063302 scopus 로고
    • Drug excretion mediated by a new prototype of polyspecific transporter
    • Gründemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature 1994;372:549-552.
    • (1994) Nature , vol.372 , pp. 549-552
    • Gründemann, D.1    Gorboulev, V.2    Gambaryan, S.3    Veyhl, M.4    Koepsell, H.5
  • 7
    • 0030590117 scopus 로고    scopus 로고
    • CDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2
    • Okuda M, Saito H, Urakami Y, Takano M, Inui K-I: cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun 1996;224:500-507.
    • (1996) Biochem Biophys Res Commun , vol.224 , pp. 500-507
    • Okuda, M.1    Saito, H.2    Urakami, Y.3    Takano, M.4    Inui, K.-I.5
  • 8
    • 0032569029 scopus 로고    scopus 로고
    • Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta
    • Kekuda R, Prasad PD, Wu X, Wang H, Fei Y-J, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 1998;273:15971-15979.
    • (1998) J Biol Chem , vol.273 , pp. 15971-15979
    • Kekuda, R.1    Prasad, P.D.2    Wu, X.3    Wang, H.4    Fei, Y.-J.5    Leibach, F.H.6    Ganapathy, V.7
  • 9
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • Tamai I, Yabuuchi H, Nezu J-I, Sai Y, Oku A, Shimane M, Tsuji A: Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 1997;419:107-111.
    • (1997) FEBS Lett , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.-I.3    Sai, Y.4    Oku, A.5    Shimane, M.6    Tsuji, A.7
  • 10
    • 0032577202 scopus 로고    scopus 로고
    • CDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
    • Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 1998;246:589-595.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 589-595
    • Wu, X.1    Prasad, P.D.2    Leibach, F.H.3    Ganapathy, V.4
  • 11
    • 0034704135 scopus 로고    scopus 로고
    • Molecular and functional characterization of organic cation/ carnitine transporter family in mice
    • Tamai I, Ohashi R, Nezu J-I, Sai Y, Kobayashi D, Oku A, Shimane M, Tsuji A: Molecular and functional characterization of organic cation/ carnitine transporter family in mice. J Biol Chem 2000;275:40064-40072.
    • (2000) J Biol Chem , vol.275 , pp. 40064-40072
    • Tamai, I.1    Ohashi, R.2    Nezu, J.-I.3    Sai, Y.4    Kobayashi, D.5    Oku, A.6    Shimane, M.7    Tsuji, A.8
  • 12
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium-ion-dependent, high affinity human carnitine transporter OCTN2
    • Tamai I, Ohashi R, Nezu J-I, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A: Molecular and functional identification of sodium-ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 1998;273:20378-20382.
    • (1998) J Biol Chem , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.-I.3    Yabuuchi, H.4    Oku, A.5    Shimane, M.6    Sai, Y.7    Tsuji, A.8
  • 13
    • 0032767691 scopus 로고    scopus 로고
    • Functional characterization and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
    • Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characterization and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther 1999;290:1482-1492.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 1482-1492
    • Wu, X.1    Huang, W.2    Prasad, P.D.3    Seth, P.4    Rajan, D.P.5    Leibach, F.H.6    Chen, J.7    Conway, S.J.8    Ganapathy, V.9
  • 16
    • 0021024932 scopus 로고
    • Carnitine-metabolism and functions
    • Bremer J: Carnitine-metabolism and functions. Physiol Rev 1983;63:1420-1480.
    • (1983) Physiol Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 20
    • 33747616258 scopus 로고    scopus 로고
    • Organic anion transporter family: Current knowledge
    • Anzai N, Kanai Y, Endou H: Organic Anion Transporter Family: Current Knowledge. J Pharmacol Sci 2006;100:411-426.
    • (2006) J Pharmacol Sci , vol.100 , pp. 411-426
    • Anzai, N.1    Kanai, Y.2    Endou, H.3
  • 21
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 1997;272:18526-18529.
    • (1997) J Biol Chem , vol.272 , pp. 18526-18529
    • Sekine, T.1    Watanabe, N.2    Hosoyamada, M.3    Kanai, Y.4    Endou, H.5
  • 22
    • 0030781076 scopus 로고    scopus 로고
    • Expression cloning and characterization of ROAT1. the basolateral organic anion transporter in rat kidney
    • Sweet DH, Wolff NA, Pritchard JB: Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 1997;272:30088-30095.
    • (1997) J Biol Chem , vol.272 , pp. 30088-30095
    • Sweet, D.H.1    Wolff, N.A.2    Pritchard, J.B.3
  • 23
    • 17144449057 scopus 로고    scopus 로고
    • Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
    • Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 1998;429:179-182
    • (1998) FEBS Lett , vol.429 , pp. 179-182
    • Sekine, T.1    Cha, S.H.2    Tsuda, M.3    Apiwattanakul, N.4    Nakajima, N.5    Kanai, Y.6    Endou, H.7
  • 25
    • 0000518648 scopus 로고    scopus 로고
    • Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    • Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 2000;275:4507-4512.
    • (2000) J Biol Chem , vol.275 , pp. 4507-4512
    • Cha, S.H.1    Sekine, T.2    Kusuhara, H.3    Yu, E.4    Kim, J.Y.5    Kim, D.K.6    Sugiyama, Y.7    Kanai, Y.8    Endou, H.9
  • 26
    • 3242707822 scopus 로고    scopus 로고
    • Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney
    • Youngblood GL, Sweet DH: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol 2004;287:F236-F244.
    • (2004) Am J Physiol Renal Physiol , vol.287
    • Youngblood, G.L.1    Sweet, D.H.2
  • 27
    • 4544322271 scopus 로고    scopus 로고
    • Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa
    • Monte JC, Nagle MA, Eraly SA, Nigam SK: Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 2004;323:429-436.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 429-436
    • Monte, J.C.1    Nagle, M.A.2    Eraly, S.A.3    Nigam, S.K.4
  • 28
    • 34247400616 scopus 로고    scopus 로고
    • Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate
    • Shin HJ, Anzai N, Enomoto A, He X, Kim DK, Endou H, Kanai Y: Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology 2007;45:1046-1055
    • (2007) Hepatology , vol.45 , pp. 1046-1055
    • Shin, H.J.1    Anzai, N.2    Enomoto, A.3    He, X.4    Kim, D.K.5    Endou, H.6    Kanai, Y.7
  • 33
    • 0035843770 scopus 로고    scopus 로고
    • Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters
    • Takeda M, Narikawa S, Hosoyamada M, Sekine T, Cha SH, Endou H: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol 2001;419:113-120
    • (2001) Eur J Pharmacol , vol.419 , pp. 113-120
    • Takeda, M.1    Narikawa, S.2    Hosoyamada, M.3    Sekine, T.4    Cha, S.H.5    Endou, H.6
  • 35
    • 0024246260 scopus 로고
    • Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts
    • Tream WR, Stanley CA, Finegold DN, Hale DE, Coates PM: Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle, and fibroblasts. N Engl J Med 1988;17:1331-1336.
    • (1988) N Engl J Med , vol.17 , pp. 1331-1336
    • Tream, W.R.1    Stanley, C.A.2    Finegold, D.N.3    Hale, D.E.4    Coates, P.M.5
  • 37
    • 0021238167 scopus 로고
    • Absorption of D-and L-carnitine by the intestine and kidney tubule in the rat
    • Gross CJ, Henderson LM: Absorption of D-and L-carnitine by the intestine and kidney tubule in the rat. Biochim Biophys Acta 1984;772:209-219.
    • (1984) Biochim Biophys Acta , vol.772 , pp. 209-219
    • Gross, C.J.1    Henderson, L.M.2
  • 38
    • 0019156822 scopus 로고
    • Properties of carnitine transport in rat kidney cortex slices
    • Huth PJ, Shug AL: Properties of carnitine transport in rat kidney cortex slices. Biochem Biophys Acta 1980;602:621-634.
    • (1980) Biochem Biophys Acta , vol.602 , pp. 621-634
    • Huth, P.J.1    Shug, A.L.2
  • 39
    • 0021743458 scopus 로고
    • Sodium gradient-stimulated transport of L-carnitine into renal brush border membrane vesicles: Kinetics, specificity, and regulation by dietary carnitine
    • Rebouche CJ, Mack DL: Sodium gradient-stimulated transport of L-carnitine into renal brush border membrane vesicles: kinetics, specificity, and regulation by dietary carnitine. Arch Biochem Biophys 1984;235:393-402.
    • (1984) Arch Biochem Biophys , vol.235 , pp. 393-402
    • Rebouche, C.J.1    MacK, D.L.2
  • 40
    • 0029030612 scopus 로고
    • Characterization of L-carnitine transport by rat kidney brush-border membrane vesicles
    • Stieger B, O'Neill B, Krähenbühl S: Characterization of L-carnitine transport by rat kidney brush-border membrane vesicles. Biochem J 1995;309:643-647.
    • (1995) Biochem J , vol.309 , pp. 643-647
    • Stieger, B.1    O'Neill, B.2    Krähenbühl, S.3
  • 41
    • 0017106006 scopus 로고
    • Active transport of butyrobetaine and carnitine into isolated liver cells
    • Christiansen RZ, Bremer J: Active transport of butyrobetaine and carnitine into isolated liver cells. Biochim Biophys Acta 1976;448:562-577.
    • (1976) Biochim Biophys Acta , vol.448 , pp. 562-577
    • Christiansen, R.Z.1    Bremer, J.2
  • 42
    • 0017876814 scopus 로고
    • Carnitine metabolism in the fasting rat
    • Brass EP, Hoppel CL: Carnitine metabolism in the fasting rat. J Biol Chem 1978;253:2688-2693.
    • (1978) J Biol Chem , vol.253 , pp. 2688-2693
    • Brass, E.P.1    Hoppel, C.L.2
  • 43
    • 0033585084 scopus 로고    scopus 로고
    • Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function
    • Seth P, Wu X, Huang W, Leibach FH, Ganapathy V: Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function. J Biol Chem 1999;274:33388-33392.
    • (1999) J Biol Chem , vol.274 , pp. 33388-33392
    • Seth, P.1    Wu, X.2    Huang, W.3    Leibach, F.H.4    Ganapathy, V.5
  • 44
    • 0032525016 scopus 로고    scopus 로고
    • Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency
    • Hashimoto N, Suzuki F, Tamai I, Nikaido H, Kuwajima M, Hayakawa J, Tsuji A: Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency. Biochem Pharmacol 1998;55:1729-1732.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1729-1732
    • Hashimoto, N.1    Suzuki, F.2    Tamai, I.3    Nikaido, H.4    Kuwajima, M.5    Hayakawa, J.6    Tsuji, A.7
  • 45
    • 0035815991 scopus 로고    scopus 로고
    • Na+-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney
    • Tamai I, China K, Sai Y, Kobayashi D, Nezu J-I, Kawahara E, Tsuji A: Na+-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim Biophys Acta 2001;1512:273-284.
    • (2001) Biochim Biophys Acta , vol.1512 , pp. 273-284
    • Tamai, I.1    China, K.2    Sai, Y.3    Kobayashi, D.4    Nezu, J.-I.5    Kawahara, E.6    Tsuji, A.7
  • 46
    • 0036294807 scopus 로고    scopus 로고
    • CDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney
    • Urakami Y, Akazawa M, Saito H, Okuda M, Inui I-K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol 2002;13:1703-1710.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1703-1710
    • Urakami, Y.1    Akazawa, M.2    Saito, H.3    Okuda, M.4    Inui, I.-K.5
  • 47
    • 0032943652 scopus 로고    scopus 로고
    • Cloning and functional characterization of new multispecific organic anion transporter, OAT-K2, in rat kidney
    • Masuda S, Ibaramoto K, Takeuchi A, Saito H, Hashimoto Y, Inui K-I: Cloning and functional characterization of new multispecific organic anion transporter, OAT-K2, in rat kidney. Mol Pharmacol 1999;55:743-752.
    • (1999) Mol Pharmacol , vol.55 , pp. 743-752
    • Masuda, S.1    Ibaramoto, K.2    Takeuchi, A.3    Saito, H.4    Hashimoto, Y.5    Inui, K.-I.6
  • 48
    • 0027378438 scopus 로고
    • Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines
    • Ullrich KJ, Rumrich G, David C, Fritzsch G: Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflügers Arch 1993;425:280-299.
    • (1993) Pflügers Arch , vol.425 , pp. 280-299
    • Ullrich, K.J.1    Rumrich, G.2    David, C.3    Fritzsch, G.4
  • 49
    • 0027373329 scopus 로고
    • Bisubstrates: Substances that interact with both, renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: Dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; Nonionizable substrates: Steroid hormones and cyclophosphamides
    • Ullrich KJ, Rumrich G, David C, Fritzsch G: Bisubstrates: substances that interact with both, renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; nonionizable substrates: steroid hormones and cyclophosphamides. Pflügers Arch 1993;425:300-312.
    • (1993) Pflügers Arch , vol.425 , pp. 300-312
    • Ullrich, K.J.1    Rumrich, G.2    David, C.3    Fritzsch, G.4
  • 50
    • 0032696186 scopus 로고    scopus 로고
    • Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
    • Ohashi R, Tamai I, Yabuuchi H, Nezu J-I, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther 1999;291:778-784.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 778-784
    • Ohashi, R.1    Tamai, I.2    Yabuuchi, H.3    Nezu, J.-I.4    Oku, A.5    Sai, Y.6    Shimane, M.7    Tsuji, A.8
  • 51
    • 0030850803 scopus 로고    scopus 로고
    • Renal transporters for organic anions and organic cations. Structural requirements for substrates
    • Ullrich KJ: Renal transporters for organic anions and organic cations. Structural requirements for substrates. J Membr Biol 1997;158:95-107.
    • (1997) J Membr Biol , vol.158 , pp. 95-107
    • Ullrich, K.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.