Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs

Journal of Neurochemistry

Volumn 90, Issue 4, 2004, Pages 931-941

  Mori, Shinobu ^a   Ohtsuki, Sumio ^a,b   Takanaga, Hitomi ^a,b   Kikkawa, Tazuru ^a   Kang, Young Sook ^a,c   Terasaki, Tetsuya ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Sookmyung Women's University   (South Korea)

Author keywords

Blood brain barrier; Chemotherapy; Efflux transport; Organic anion transporter 3; Thiopurine

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; INDOMETACIN; MERCAPTOPURINE; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 3; PENICILLIN G; TIOGUANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; DRUG UPTAKE; LEUKEMIA; LEUKEMIA CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; TIME;

6-MERCAPTOPURINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; INDOMETHACIN; MALE; METHOTREXATE; OOCYTES; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PENICILLIN G; RATS; RATS, WISTAR; THIOGUANINE; XENOPUS LAEVIS;

ANIMALIA;

EID: 4143113395     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02552.x     Document Type: Article

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