Organic anion transporter 3 contributes to the regulation of blood pressure

Journal of the American Society of Nephrology

Volumn 19, Issue 9, 2008, Pages 1732-1740

  Vallon, Volker ^a,b,e,g   Eraly, Satish A ^a   Wikoff, William R ^e   Rieg, Timo ^a,e   Kaler, Gregory ^a   Truong, David M ^a   Ahn, Sun Young ^a   Mahapatra, Nitish R ^a,f   Mahata, Sushil K ^a,e   Gangoiti, Jon A ^c   Wu, Wei ^a   Barshop, Bruce A ^c   Siuzdak, Gary ^e   Nigam, Sanjay K ^a,c,d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ORGANIC ANION TRANSPORTER 3; THYMIDINE; CORTICOSTERONE; CORTICOTROPIN; ORGANIC ANION TRANSPORTER; RENIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE REGULATION; GENETIC POLYMORPHISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SODIUM RESTRICTION; ANIMAL; BLOOD; BLOOD PRESSURE; C57BL MOUSE; DRUG ANTAGONISM; METABOLISM; MOUSE MUTANT; OOCYTE; XENOPUS;

ADRENOCORTICOTROPIC HORMONE; ALDOSTERONE; ANIMALS; BLOOD PRESSURE; CORTICOSTERONE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OOCYTES; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RENIN; XENOPUS;

EID: 54749112371     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008020180     Document Type: Article

References (50)

1. Robertson EE, Rankin GO: Human renal organic anion transporters: Characteristics and contributions to drug and drug metabolite excretion. Pharmacol Ther 109: 399-412, 2006
2. Eraly SA, Blantz RC, Bhatnagar V, Nigam SK: Novel aspects of renal organic anion transporters. Curr Opin Nephrol Hypertens 12: 551-558, 2003
3. Eraly SA, Bush KT, Sampogna RV, Bhatnagar V, Nigam SK: The molecular pharmacology of organic anion transporters: From DNA to FDA? Mol Pharmacol 65: 479-487, 2004
4. Koepsell H, Endou H: The SLC22 drug transporter family. Pflugers Arch 447: 666-676, 2004
5. Sweet DH, Bush KT, Nigam SK: The organic anion transporter family: From physiology to ontogeny and the clinic. Am J Physiol Renal Physiol 281: F197-F205, 2001
6. Burckhardt BC, Burckhardt G: Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol 146: 95-158, 2003
7. Wright SH, Dantzler WH: Molecular and cellular physiology of renal organic cation and anion transport. Physiol Rev 84: 987-1049, 2004
8. Nigam SK, Bush KT, Bhatnagar V: Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol 3: 443-448, 2007
9. Burckhardt G, Bahn A, Wolff NA: Molecular physiology of renal p-aminohippurate secretion. News Physiol Sci 16: 114-118, 2001
10. Sweet DH, Wolff NA, Pritchard JB: Expression cloning and characterization of ROAT1: The basolateral organic anion transporter in rat kidney. J Biol Chem 272: 30088-30095, 1997
11. Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, Nigam SK: Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 272: 6471-6478, 1997
12. Lopez-Nieto CE, You G, Barros EJ, Beier DR, Nigam SK: Molecular cloning and characterization of a novel transport protein with very high expression in the kidney [Abstract]. J Am Soc Nephrol 7: 1301, 1996
13. Brady KP, Dushkin H, Fornzler D, Koike T, Magner F, Her H, Gullans S, Segre GV, Green RM, Beier DR: A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56: 254-261, 1999
14. Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276: F122-F128, 1999
15. Ljubojevic M, Herak-Kramberger CM, Hagos Y, Bahn A, Endou H, Burckhardt G, Sabolic I: Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am J Physiol Renal Physiol 287: F124-F138, 2004
16. Bahn A, Ljubojevic M, Lorenz H, Schultz C, Ghebremedhin E, Ugele B, Sabolic I, Burckhardt G, Hagos Y: Murine renal organic anion transporter 1 (mOAT1) and organic anion transporter 3 (mOAT3) facilitate the transport of neuroactive tryptophan metabolites. Am J Physiol Cell Physiol 289: C1075-C1084, 2005
17. Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, Inui K: Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13: 866-874, 2002
18. Kojima R, Sekine T, Kawachi M, Cha SH, Suzuki Y, Endou H: Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol 13: 848-857, 2002
19. Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, Sugiyama Y: Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther 300: 746-753, 2002
20. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59: 1277-1286, 2001
21. Tojo A, Sekine T, Nakajima N, Hosoyamada M, Kanai Y, Kimura K, Endou H: Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J Am Soc Nephrol 10: 464-471, 1999
22. Sweet DH, Chan LM, Walden R, Yang XP, Miller DS, Pritchard JB: Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. Am J Physiol Renal Physiol 284: F763-F769, 2003
23. Bakhiya A, Bahn A, Burckhardt G, Wolff N: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem 13: 249-256, 2003
24. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK: Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277: 26934-26943, 2002
25. Vanwert AL, Bailey RM, Sweet DH: Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G. Am J Physiol Renal Physiol 293: F1332-F1341, 2007
26. Vallon V, Rieg T, Ahn SY, Wu W, Eraly SA, Nigam SK: Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol 294: F867-F873, 2008
27. Vanwert AL, Sweet DH: Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: A gender specific impact of reduced folates. Pharm Res 25: 453-462, 2008
28. Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M, Monte JC, Rieg T, Truong DM, Long JM, Barshop BA, Kaler G, Nigam SK: Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem 281: 5072-5083, 20061
29. Mori K, Ogawa Y, Ebihara K, Aoki T, Tamura N, Sugawara A, Kuwahara T, Ozaki S, Mukoyama M, Tashiro K, Tanaka I, Nakao K: Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett 417: 371-374, 1997
30. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H: Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417: 447-452, 2002
31. Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, Nigam SK: Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics 33: 180-192, 2008
32. Truong DM, Kaler G, Khandelwal A, Swaan PW, Nigam SK: Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem 283: 8654-8663, 2008
33. Dantzler WH, Wright SH: The molecular and cellular physiology of basolateral organic anion transport in mammalian renal tubules. Biochim Biophys Acta 1618: 185-193, 2003
34. Kaler G, Truong DM, Khandelwal A, Nagle M, Eraly SA, Swaan PW, Nigam SK: Structural variation governs substrate specificity for organic anion transporter (OA1) homologs. J Biol Chem 282: 23841-23853, 2007
35. Kim SM, Mizel D, Huang YG, Briggs JP, Schnermann J: Adenosine as a mediator of macula densa-dependent inhibition of renin secretion. Am J Physiol Renal Physiol 290: F1016-F1023, 2006
36. Harris RC, Zhang MZ, Cheng HF: Cyclooxygenase-2 and the renal renin-angiotensin system. Acta Physiol Scand 181: 543-547, 2004
37. Asif AR, Steffgen J, Metten M, Grunewald RW, Muller GA, Bahn A, Burckhardt G, Hagos Y: Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells. Pflugers Arch 450: 88-95, 2005
38. Vinson GP: Glomerulosa function and aldosterone synthesis in the rat. Mol Cell Endocrinol 217: 59-65, 2004
39. Ishimura K, Fujita H: Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes. Microsc Res Tech 36: 445-453, 1997
40. Schneider JS, Stone MK, Wynne-Edwards KE, Horton TH, Lydon J, O'Malley B, Levine JE: Progesterone receptors mediate male aggression toward infants. Proc Natl Acad Sci U S A 100: 2951-2956, 2003
41. Vincent M, Gomez-Sanchez CE, Bataillard A, Sassard J: Steroids during development of genetic hypertension in rats of Lyon strain. Am J Physiol 257: H506-H510, 1989
42. Nilwarangkoon S, Anzai N, Shiraya K, Yu E, Islam R, Cha SH, Onozato ML, Miura D, Jutabha P, Tojo A, Kanai Y, Endou H: Role of mouse organic anion transporter 3 (mOat3) as a basolateral prostaglandin E(2) transport pathway. J Pharmacol Sci 103: 48-55, 2007
43. Lee DJ, Prensky W, Krause G, Hughes WL: Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets. Cancer Res 36: 4577-4583, 1976
44. Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K, Lang F: KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci U S A 102: 17864-17869, 2005
45. Rieg T, Bundey RA, Chen Y, Deschenes G, Junger W, Insel PA, Vallon V: Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB J 21: 3717-3726, 2007
46. Vallon V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F, Belaiba RS, Gorlach A, Wulff P, Daut J, Dalton ND, Ross J Jr, Flogel U, Schrader J, Osswald H, Kandolf R, Kuhl D, Lang F: SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. J Mol Med 84: 396-404, 2006
47. Vallon V, Huang DY, Grahammer F, Wyatt AW, Osswald H, Wulff P, Kuhl D, Lang F: SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess. Am J Physiol Regul Integr Comp Physiol 289: R395-R401, 2005
48. Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G: XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem 78: 779-787, 2006
49. Meiner VL, Cases S, Myers HM, Sande ER, Bellosta S, Schambelan M, Pitas RE, McGuire J, Herz J, Farese RV Jr: Disruption of the acyl-CoA: cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc Natl Acad Sci U S A 93:14041-14046, 1996
50. Rieg T, Schnermann J, Vallon V: Adenosine A(1) receptors determine effects of caffeine on total fluid intake but not caffeine appetite. Eur J Pharmacol 555: 174-177, 2007