Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1762, Issue 7, 2006, Pages 673-682

  Brandoni, Anabel ^a   Anzai, Naohiko ^b   Kanai, Yoshikatsu ^b   Endou, Hitoshi ^b   Torres, Adriana Mónica ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cholestasis; OAT1; OAT3; p aminohippurate; Renal depuration

Indexed keywords

4 AMINOHIPPURIC ACID; BILE ACID; BILIRUBIN; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; BASOLATERAL MEMBRANE; BILE ACID BLOOD LEVEL; BILE DUCT LIGATION; BILE DUCT OBSTRUCTION; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG CLEARANCE; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; KIDNEY CLEARANCE; KIDNEY CORTEX; KIDNEY HOMOGENATE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE;

ANIMALS; BILE DUCTS; BLOOD PROTEINS; CELL MEMBRANE; CHOLESTASIS; KIDNEY; KIDNEY CORTEX; KINETICS; MALE; METABOLIC CLEARANCE RATE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-AMINOHIPPURIC ACID; RATS; RATS, WISTAR;

RATTUS NORVEGICUS;

EID: 33746808149     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2006.05.011     Document Type: Article

References (54)

1. Koopen N.R., Müller M., Vonk R.J., Zimniak P., and Kuipers F. Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation. Biochim. Biophys. Acta 1408 (1998) 1-17
2. Reichen J., and Simon F.R. Cholestasis. In: Arias M., Jakoby W.B., Popper H., Schachter D., and Shafritz D.A. (Eds). The Liver: Biology and Pathobiology. 2nd ed. (1988), Raven Press, New York 1105-1124
3. Kramer H.J. Impaired renal function in obstructive jaundice: roles of the thromboxane and endothelin systems. Nephron 77 (1997) 1-12
4. Wójcicki M., Drozdzik M., Sulikowski T., Wójcicki J., Gawronska-Szklarz B., Zielinski S., and Rózewicka L. Pharmacokinetics of intravenously administered digoxin and histopathological picture in rabbits with experimental bile duct obstruction. Eur. J. Pharm. Sci. 11 (2000) 215-222
5. Fleck Ch., and Bräunlich H. Interrelationships between excretion of drugs via urine and bile. Prog. Pharmacol. Clin. Pharmacol. 8 (1991) 511-529
6. Orellana M., Rodrigo R., Thielemann L., and Guajardo V. Bile duct ligation and oxidative stress in the rat: effects in liver and kidney. Comp. Biochem. Physiol., Part C Pharmacol. Toxicol. 126 (2000) 105-111
7. Holt S., Marley R., Fernando B., Harry D., Anand R., Goodier D., and Moore K. Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. Kidney Int. 55 (1999) 271-277
8. Talbert R. Drug dosing in renal insufficiency. J. Clin. Pharmacol. 34 (1994) 99-110
9. Anzai N., Jutabha P., Kanai Y., and Endou H. Integrated physiology of proximal tubular organic anion transport. Curr. Opin. Nephrol. Hypertens. 14 (2005) 472-479
10. Sekine T., Miyazaki H., and Endou H. Molecular physiology of renal organic anion transporters. Am. J. Physiol. 290 (2006) F251-F261
11. Wright S.H., and Dantzler W.H. Molecular and cellular physiology of renal organic cation and anion transport. Physiol. Rev. 84 (2004) 987-1049
12. Sweet D.H., Chan L.M.S., Walden R., Yang X., Miller D.S., and Pritchard J.B. Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na gradient. Am. J. Physiol. 284 (2003) F763-F769
13. Sekine T., Watanabe N., Hosoyamada M., Kanai Y., and Endou H. Expression cloning and characterization of a novel multispecific organic anions transporter. J. Biol. Chem. 272 (1997) 18526-18529
14. Cha S.H., Sekine T., Fukushima J.-I., Kanai Y., Kobayashi Y., Goya T., and Endou H. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol. 59 (2001) 1277-1286
15. Kojima R., Sekine T., Kawachi M., Cha S.H., Suzuki Y., and Endou H. Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J. Am. Soc. Nephrol. 13 (2002) 848-857
16. Leier I., Hummel-Eisenbeiss J., Cui Y., and Keppler D. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 57 (2000) 1636-1642
17. Smeets P.H., van Aubel R.A., Wouterse A.C., van den Heuvel J.J., and Russel F.G. Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J. Am. Soc. Nephrol. 15 (2004) 2828-2835
18. Tanaka Y., Kobayashi Y., Gabazza E.C., Higuchi K., Kamisako T., Kuroda M., Takeuchi K., Iwasa M., Kaito M., and Adachi Y. Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. Am. J. Physiol. 282 (2002) G656-G662
19. Lee J., Azzaroli F., Wang L., Soroka C.J., Gigliozzi A., Setchell K.D.R., Kramer W., and Boyer J.L. Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 121 (2001) 1473-1484
20. Pei Q.-L., Kobayashi Y., Tanaka Y., Taguchi Y., Higuchi K., Kaito M., Ma N., Semba R., Kamisako T., and Adachi Y. Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol. Res. 22 (2002) 58-64
21. Denk G.U., Soroka C.J., Takeyama Y., Chen W.-S., Schuetz J.D., and Boyer J.L. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidneys in obstructive cholestasis in the rat. J. Hepatol. 40 (2004) 585-591
22. Brandoni A., Quaglia N.B., and Torres A.M. Compensation increase in organic anion excretion in rats with acute biliary obstruction: Role of the renal organic anion transporter 1. Pharmacology 68 (2003) 57-63
23. National Institutes of Health. Guide for Care and Use of Laboratory Animals, Publication 86-23 (1985), National Institutes of Health, Bethesda
24. Cerrutti J.A., Quaglia N.B., and Torres A.M. Characterization of the mechanisms involved in the gender differences in p-aminohippurate renal elimination in rats. Can. J. Physiol. Pharm. 79 (2001) 805-813
25. Shumaker R. A basic interactive computer program for statistical and pharmacokinetic analysis of data. Drug Metab. Rev. 17 (1986) 331-348
26. Motulsky H. Using nonlinear regression to fit curves. In: Motulsky H. (Ed). Intuitive Biostatistics (1995), Oxford University Press, New York 227-283
27. Waugh W.H., and Beall P.T. Simplified measurement of PAH and other arylamines in plasma and urine. Kidney Int. 5 (1974) 429-432
28. Villar S.R., Brandoni A., Quaglia N.B., and Torres A.M. Renal elimination of organic anions in rats with bilateral ureteral obstruction. Biochim. Biophys. Acta 1688 (2004) 204-209
29. Villar S.R., Brandoni A., Anzai N., Endou H., and Torres A.M. Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction. Kidney Int. 68 (2005) 2704-2713
30. Torres A.M., Mac Laughlin M., Muller A., Brandoni A., Anzai N., and Endou H. Altered renal elimination of organic anions in rats with chronic renal failure. Biochim. Biophys. Acta 1740 (2005) 29-37
31. Quaglia N.B., Brandoni A., Ferri A., and Torres A.M. Early manifestation of nephropathy in rats with arterial calcinosis. Renal Failure 25 (2003) 355-366
32. Roe H.H. A photometric method for determination of inulin in plasma and urine. J. Biol. Chem. 178 (1949) 839-844
33. Jensen R.E., and Berndt W.O. Epinephrine and norephinephrine enhance p-aminohippurate transport into basolateral membrane vesicles. J. Pharmacol. Exp. Ther. 244 (1988) 543-549
34. Sedmak J.J., and Grossberg S.E. A rapid, sensitive and versatile assay for protein using Coomassie Brilliant Blue G250. Anal. Biochem. 79 (1977) 544-552
35. Wilkinson G.R. Clearance approaches in pharmacology. Pharmacol. Rev. 39 (1987) 1-47
36. Lu R., Chan B.S., and Schuster V.L. Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C. Am. J. Physiol. 276 (1999) F295-F303
37. You G., Kuze K., Kohanski R.A., Amsler K., and Henderson S. Regulation of mOAT-mediated organic anion transport by okadaic acid and protein kinase C in LLC-PK1 cells. J. Biol. Chem. 275 (2000) 10278-10284
38. Wolff N.A., Thies K., Kuhnke N., Reid G., Friedrich B., Lang F., and Burckhardt G. Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization. J. Am. Soc. Nephrol. 14 (2003) 1959-1968
39. Karim Z., Defontaine N., Paillard M., and Poggioli J. Protein kinase C isoforms in rat kidney proximal tubule: acute effect of angiotensin II. Am. J. Physiol. 269 (1995) C134-C140
40. Rao Y.-P., Stravitz R.T., Vlahcevic Z.R., Gurley E.C., Sando J.J., and Hylemon P.B. Activation of protein kinase C α and δ by bile acids: correlation with bile acid structure and diacylglycerol formation. J. Lipid Res. 38 (1997) 2446-2454
41. Hirohata Y., Fujii M., Okabayashi Y., Nagashio Y., Tashiro M., Imoto I., Akiyama T., and Otsuki M. Stimulatory effects of bilirubin on amylase release from isolated rat pancreatic acini. Am. J. Physiol. 282 (2002) 242-256
42. Kwak J.O., Kim H.-W., Oh K.-J., Kim D.S., Han K.O., and Cha S.H. Co-localization and interaction of organic anion transporter 1 with caveolin-2 in the kidney. Exp. Mol. Med. 37 (2005) 204-212
43. Denk G.U., Soroka C.J., Mennone A., Koepsell H., Beuers U., and Boyer J.L. Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. Hepatology 39 (2004) 1382-1389
44. Denson L.A., Bohan A., Held M.A., and Boyer J.L. Organ-specific alterations in RARα:RXRα abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis. Gastroenterology 123 (2002) 599-607
45. Kusuhara H., Sekine T., Utsunomiya-Tate N., Tsuda M., Kojima R., Cha S.H., Sugiyama Y., Kanai Y., and Endou H. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 19 (1999) 13675-13680
46. Uwai Y., Okuda M., Takami K., Hashimoto Y., and Inui K. Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett. 438 (1998) 321-324
47. Aslamkhan A., Han U.-H., Walden R., Sweet D.H., and Pritchard J.B. Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells. Am. J. Physiol. 285 (2003) F775-F783
48. Sweet D.H., Miller D.S., Pritchard J.B., Fujiwara Y., Beier D.R., and Nigam S.K. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J. Biol. Chem. 30 (2002) 26934-26943
49. Rost D., Herrmann T., Sauer P., Schmidts H.-L., Stieger B., Meier P.J., Stremmel W., and Stiehl A. Regulation of rat organic anion transporters in bile salt-induced cholestatic hepatitis: effect of ursodeoxycolate. Hepatology 38 (2003) 187-195
50. Jung D., Podvinec M., Meyer U.A., Mangelsdorf D.J., Fried M., Meier P.J., and Kullak-Ublick G.A. Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor. Gastroenterology 122 (2002) 1954-1966
51. Boyer J.L., Trauner M., Mennone A., Soroka C.J., Cai S.-Y., Moustafa T., Zollner G., Lee J.Y., and Ballatori N. Up-regulation of a basolateral FXR-dependent bile acid efflux transporter, OSTα-OSTβ, in cholestasis in humans and rodents. Am. J. Physiol. 290 (2006) G1124-G1130
52. Bow D.A., Perry J.L., Simon J.D., and Pritchard J.B. The impact of plasma protein binding on the renal transport of organic anions. J. Pharmacol. Exp. Ther. 316 (2006) 349-355
53. Brandoni A., Villar S.R., Picena J.C., Anzai N., Endou H., and Torres A.M. Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction. Hepatology 43 (2006) 1092-1100
54. Eraly S.A., Vallon V., Vaughn D.A., Gangoiti J.A., Richter K., Nagle M., Monte J.C., Rieg T., Truong D.M., Long J.M., Barshop B.A., Kaler G., and Nigam S.K. Decrease renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J. Biol. Chem. 281 (2006) 5072-5083