Comparison of the interaction of human organic anion transporter hOAT4 with PDZ proteins between kidney cells and placental cells

Pharmaceutical Research

Volumn 25, Issue 2, 2008, Pages 475-480

  Zhou, Fanfan ^a   Xu, Wen ^a   Tanaka, Kunihiko ^a   You, Guofeng ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Cell surface biotinylation; Co immunoprecipitation.; Drug transporter; Estrone sulfate transport; Organ specific interaction; PDZ proteins

Indexed keywords

ESTRONE SULFATE; NHERF1 PROTEIN; ORGANIC ANION TRANSPORTER 4; ORGANIC ANION TRANSPORTER 4 DELTA; PDZ PROTEIN; PDZK1 PROTEIN; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CELL SURFACE; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CELL; NUCLEOTIDE SEQUENCE; PLACENTA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL POLARITY; HUMANS; LLC-PK1 CELLS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PHOSPHOPROTEINS; PLACENTA; SODIUM-HYDROGEN ANTIPORTER;

EID: 39149097829     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9359-4     Document Type: Article

References (14)

1. B. C. Burckhardt, and G. Burckhardt. Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev. Physiol. Biochem. Pharmacol. 146:95-158 (2003).
2. S. A. Eraly, K. T. Bush, R. V. Sampogna, V. Bhatnagar, and S. K. Nigam. The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol. Pharmacol. 65:479-487 (2004).
3. T. Sekine, H. Miyazaki, and H. Endou. Molecular physiology of renal organic anion transporters. Am. J. Physiol. Renal. Physiol. 290:F251-261 (2006).
4. D. H. Sweet. Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicol. Appl. Pharmacol. 204:198-215 (2005).
5. G. You. Structure, function, and regulation of renal organic anion transporters. Med. Res. Rev. 22:602-616 (2002).
6. S. H. Cha, T. Sekine, H. Kusuhara, E. Yu, J. Y. Kim, D. K. Kim, Y. Sugiyama, Y. Kanai, and H. Endu. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem. 275:4507-4512 (2000).
7. S. Ekaratanawong, N. Anzai, P. Jutabha, H. Miyazaki, R. Noshiro, M. Takeda, Y. Kanai, S. Sophasan, and H. Endou. Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J. Pharmacol. Sci. 94:297-304 (2004).
8. B. Ugele, M. V. St-Pierre, M. Pihusch, A. Bahn, and P. Hantschmann. Characterization and identification of steroid sulfate transporters of human placenta. Am. J. Physiol. Endocrinol. Metab. 284:E390-398 (2003).
9. T. Rabe, R. Hosch, and B. Runnebaum. Diagnosis of intrauterine fetal growth retardation (IUGR) and placental insufficiency by a dehydroepiandrosterone sulfate (DHAS) loading test. Biol. Res. Pregnancy. Perinatol. 4:130-136 (1983).
10. F. Zhou, W. Xu, M. Hong, Z. Pan, P. J. Sinko, J. Ma, and G. You. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Mol. Pharmacol. 67:868-876 (2005).
11. H. Miyazaki, N. Anzai, S. Ekaratanawong, T. Sakata, H. J. Shin, P. Jutabha, T. Hirata, X. He, H. Nonoguchi, K. Tomita, Y. Kanai, and H. Endou. Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins. J. Am. Soc. Nephrol. 16(12):3498-506 (2005).
12. N. Anzai, H. Miyazaki, R. Noshiro, S. Khamdang, A. Chairoungdua, H. J. Shin, A. Enomoto, S. Sakamoto, T. Hirata, K. Tomita, Y. Kanai, and H. Endou. The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. J. Biol. Chem. 279(44):45942-45950 (2004).
13. P. Wang, J. J. Wang, Y. Xiao, J. W. Murray, P. M. Novikoff, R. H. Angeletti, G. A. Orr, D. Lan, D. L. Silver, and A. W. Wolkoff. Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J. Biol Chem. 280(34):30143-30149 (2005).
14. F. Zhou, M. Hong, G. You. Regulation of human organic anion transporter 4 (hOAT4) by progesterone and protein kinase C in human placental BeWo cells. Am. J. Physiol. Endocrinol. Metab. (2007) (in press).