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Volumn 276, Issue 2 45-2, 1999, Pages

Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C

Author keywords

Biological transport; Carrier proteins; Hormonal control; Organic anion transport; p aminohippurate; Phorbol ester; Renal secretion

Indexed keywords

2 OXOGLUTARIC ACID; 4 AMINOHIPPURIC ACID; ANTIPORTER; COMPLEMENTARY DNA; FUROSEMIDE; GLUTARIC ACID; INDOMETACIN; MESSENGER RNA; METHOTREXATE; PHORBOL 13 ACETATE 12 MYRISTATE; PROBENECID; PROSTAGLANDIN E2; PROTEIN KINASE C; STAUROSPORINE; TRITIUM;

EID: 0032995116     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1999.276.2.f295     Document Type: Article
Times cited : (170)

References (41)
  • 1
    • 0030865871 scopus 로고    scopus 로고
    • Functional role of high-affinity anandamide transport, as revealed by selective inhibition
    • Beltramo, M., N. Stella, A. Calignano, S. Y. Lin, A. Makriyannis, and D. Piomelli. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277: 1094-1097, 1997.
    • (1997) Science , vol.277 , pp. 1094-1097
    • Beltramo, M.1    Stella, N.2    Calignano, A.3    Lin, S.Y.4    Makriyannis, A.5    Piomelli, D.6
  • 2
    • 0024577426 scopus 로고
    • Potential involvement of renal transport mechanisms in nephrotoxicity
    • Berndt, W. O. Potential involvement of renal transport mechanisms in nephrotoxicity. Toxicology 46: 77-82, 1989.
    • (1989) Toxicology , vol.46 , pp. 77-82
    • Berndt, W.O.1
  • 3
    • 0024565170 scopus 로고
    • Facilitation by serum albumin of renal tubular secretion of organic anions
    • Renal Fluid Electrolyte Physiol. 25
    • Bessseghir, K., D. Mosig, and F. Roch-Ramel. Facilitation by serum albumin of renal tubular secretion of organic anions. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25): F475-F484, 1989.
    • (1989) Am. J. Physiol. , vol.256
    • Bessseghir, K.1    Mosig, D.2    Roch-Ramel, F.3
  • 4
    • 0018840360 scopus 로고
    • pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles
    • Blomstedt, J. W., and P. S. Aronson. pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles. J. Clin. Invest. 65: 931-934, 1980.
    • (1980) J. Clin. Invest. , vol.65 , pp. 931-934
    • Blomstedt, J.W.1    Aronson, P.S.2
  • 5
    • 0032549175 scopus 로고    scopus 로고
    • 2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter "PGT"
    • 2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter "PGT". J. Biol. Chem. 273: 6689-6697, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6689-6697
    • Chan, B.1    Satriano, J.A.2    Pucci, M.3    Schuster, V.L.4
  • 6
    • 15844388825 scopus 로고    scopus 로고
    • Differential translocation of protein kinase C ε during HeLa cell adhesion to a gelatin substratum
    • Chun, J.-S., M.-J. Ha, and B. S. Jacobson. Differential translocation of protein kinase C ε during HeLa cell adhesion to a gelatin substratum. J. Biol. Chem. 271: 13008-13012, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13008-13012
    • Chun, J.-S.1    Ha, M.-J.2    Jacobson, B.S.3
  • 7
    • 0002906194 scopus 로고
    • Comparative aspects of renal function
    • edited by D. W. Seldin and G. Giebisch. New York: Raven
    • Dantzler, W. H. Comparative aspects of renal function. In: The Kidney: Physiology and Pathophysiology (2nd ed.), edited by D. W. Seldin and G. Giebisch. New York: Raven, 1992, p. 885-942.
    • (1992) The Kidney: Physiology and Pathophysiology (2nd Ed.) , pp. 885-942
    • Dantzler, W.H.1
  • 8
    • 0027281009 scopus 로고
    • NIGMS human/rodent somatic cell hybrid mapping panels 1 and 2
    • Drwinga, H. L., L. H. Toji, C. H. Kim, A. E. Greene, and R. A. Mulivor. NIGMS human/rodent somatic cell hybrid mapping panels 1 and 2. Genomics 16: 311-314, 1993.
    • (1993) Genomics , vol.16 , pp. 311-314
    • Drwinga, H.L.1    Toji, L.H.2    Kim, C.H.3    Greene, A.E.4    Mulivor, R.A.5
  • 9
    • 0024504376 scopus 로고
    • Anion transport through the contralateral cell membrane of renal proximal tubule. The influence of hydrophobicity and molecular charge distribution on the inhibitory activity of organic anions
    • Fritzsch, G., G. Rumrich, and K. J. Ullrich. Anion transport through the contralateral cell membrane of renal proximal tubule. The influence of hydrophobicity and molecular charge distribution on the inhibitory activity of organic anions. Biochim. Biophys. Acta 978: 249-256, 1989.
    • (1989) Biochim. Biophys. Acta , vol.978 , pp. 249-256
    • Fritzsch, G.1    Rumrich, G.2    Ullrich, K.J.3
  • 10
    • 0020081481 scopus 로고
    • Rapid formation of poly-γ-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro
    • Fry, D. W., J. C. Yalowich, and I. D. Goldman. Rapid formation of poly-γ-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro. J. Biol. Chem. 257: 1890-1896, 1982.
    • (1982) J. Biol. Chem. , vol.257 , pp. 1890-1896
    • Fry, D.W.1    Yalowich, J.C.2    Goldman, I.D.3
  • 11
    • 0000233999 scopus 로고
    • Eukaryotic transient expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase
    • Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. Eukaryotic transient expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83: 8122-8126, 1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 8122-8126
    • Fuerst, T.R.1    Niles, E.G.2    Studier, F.W.3    Moss, B.4
  • 12
    • 0029902410 scopus 로고    scopus 로고
    • Renal organic anion secretion: Evidence for dopaminergic and adrenergic regulation
    • Regulatory Integrative Comp. Physiol. 40
    • Halpin, P. A., and J. L. Renfro. Renal organic anion secretion: evidence for dopaminergic and adrenergic regulation. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R1372-R1379, 1996.
    • (1996) Am. J. Physiol. , vol.271
    • Halpin, P.A.1    Renfro, J.L.2
  • 13
    • 34447584316 scopus 로고
    • Versuche über den Vorgang der Harnabsonderung
    • Heidenhain, R. Versuche über den Vorgang der Harnabsonderung. Pflügers Arch. 9: 1-27, 1874.
    • (1874) Pflügers Arch. , vol.9 , pp. 1-27
    • Heidenhain, R.1
  • 14
    • 0017348754 scopus 로고
    • Development of mechanisms for drug excretion
    • Hook, J. B., and W. R. Hewitt. Development of mechanisms for drug excretion. Am. J. Med. 62: 497-506, 1993.
    • (1993) Am. J. Med. , vol.62 , pp. 497-506
    • Hook, J.B.1    Hewitt, W.R.2
  • 15
    • 0029078231 scopus 로고
    • Identification and characterization of a prostaglandin transporter
    • Kanai, N., R. Lu, J. A. Satriano, Y. Bao, A. W. Wolkoff, and V. L. Schuster. Identification and characterization of a prostaglandin transporter. Science 268: 866-869, 1995.
    • (1995) Science , vol.268 , pp. 866-869
    • Kanai, N.1    Lu, R.2    Satriano, J.A.3    Bao, Y.4    Wolkoff, A.W.5    Schuster, V.L.6
  • 16
    • 0026040191 scopus 로고
    • Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases
    • Kennelly, P. J., and E. G. Krebs. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J. Biol. Chem. 266: 15555-15558, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 15555-15558
    • Kennelly, P.J.1    Krebs, E.G.2
  • 17
    • 0019212370 scopus 로고
    • Effects of environmental chemicals on kidney metabolism and function
    • Kluwe, W. M., and J. B. Hook. Effects of environmental chemicals on kidney metabolism and function. Kidney Int. 18: 648-655, 1980.
    • (1980) Kidney Int. , vol.18 , pp. 648-655
    • Kluwe, W.M.1    Hook, J.B.2
  • 18
    • 0020475449 scopus 로고
    • A simple method for displaying the hydropathic character of a protein
    • Kyte, J., and R. F. Doolittle. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157: 105-132, 1982.
    • (1982) J. Mol. Biol. , vol.157 , pp. 105-132
    • Kyte, J.1    Doolittle, R.F.2
  • 19
    • 0030940999 scopus 로고    scopus 로고
    • Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
    • Lopez-Nieto, C. E., G. You, K. T. Bush, E. J. Barros, D. R. Beier, and S. K. Nigam. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J. Biol. Chem. 272: 6471-6478, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6471-6478
    • Lopez-Nieto, C.E.1    You, G.2    Bush, K.T.3    Barros, E.J.4    Beier, D.R.5    Nigam, S.K.6
  • 20
    • 0029739973 scopus 로고    scopus 로고
    • Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (hPGT)
    • Lu, R., N. Kanai, Y. Bao, and V. L. Schuster. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (hPGT). J. Clin. Invest. 98: 1142-1149, 1996.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1142-1149
    • Lu, R.1    Kanai, N.2    Bao, Y.3    Schuster, V.L.4
  • 21
    • 0031939970 scopus 로고    scopus 로고
    • Protein kinase C regulation of organic anion transport in renal proximal tubule
    • Renal Physiol. 43
    • Miller, D. S. Protein kinase C regulation of organic anion transport in renal proximal tubule. Am. J. Physiol. 274 (Renal Physiol. 43): F156-F164, 1998.
    • (1998) Am. J. Physiol. , vol.274
    • Miller, D.S.1
  • 22
    • 0031543441 scopus 로고    scopus 로고
    • Dual pathways for organic anion secretion in renal proximal tubule
    • Miller, D. S., and J. B. Pritchard. Dual pathways for organic anion secretion in renal proximal tubule. J. Exp. Zool. 279: 462-470, 1997.
    • (1997) J. Exp. Zool. , vol.279 , pp. 462-470
    • Miller, D.S.1    Pritchard, J.B.2
  • 23
    • 0020273461 scopus 로고
    • Renal organic anion transport system: Pharmacological, physiological, and biochemical aspects
    • Moller, J. V., and M. I. Sheikh. Renal organic anion transport system: pharmacological, physiological, and biochemical aspects. Pharmacol. Rev. 34: 315-358, 1983.
    • (1983) Pharmacol. Rev. , vol.34 , pp. 315-358
    • Moller, J.V.1    Sheikh, M.I.2
  • 24
    • 0030669602 scopus 로고    scopus 로고
    • Inhibition of PAH transport by parathyroid hormone in OK cells: Involvement of protein kinase C pathway
    • Renal Physiol. 42
    • Nagai, J., I. Yano, Y. Hashimoto, M. Takano, and K. Inui. Inhibition of PAH transport by parathyroid hormone in OK cells: involvement of protein kinase C pathway. Am. J. Physiol. 273 (Renal Physiol. 42): F674-F679, 1997.
    • (1997) Am. J. Physiol. , vol.273
    • Nagai, J.1    Yano, I.2    Hashimoto, Y.3    Takano, M.4    Inui, K.5
  • 25
    • 0026355413 scopus 로고
    • Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations
    • Pearson, R. B., and B. E. Kemp. Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations. Methods Enzymol. 200: 62-81, 1991.
    • (1991) Methods Enzymol. , vol.200 , pp. 62-81
    • Pearson, R.B.1    Kemp, B.E.2
  • 26
    • 0023765854 scopus 로고
    • Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles
    • Renal Fluid Electrolyte Physiol. 24
    • Pritchard, J. B. Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F597-F604, 1988.
    • (1988) Am. J. Physiol. , vol.255
    • Pritchard, J.B.1
  • 27
    • 0025677180 scopus 로고
    • Rat renal cortical slices demonstrate p-aminohippurate/glutarate exchange and sodium/glutarate coupled p-aminohippurate transport
    • Pritchard, J. B. Rat renal cortical slices demonstrate p-aminohippurate/glutarate exchange and sodium/glutarate coupled p-aminohippurate transport. J. Pharmacol. Exp. Ther. 255: 969-975, 1990.
    • (1990) J. Pharmacol. Exp. Ther. , vol.255 , pp. 969-975
    • Pritchard, J.B.1
  • 28
    • 0026331869 scopus 로고
    • Comparative insights into the mechanisms of renal organic anion and cation secretion
    • Regulatory Integrative Comp. Physiol. 30
    • Pritchard, J. B., and D. S. Miller. Comparative insights into the mechanisms of renal organic anion and cation secretion. Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R1329-R1340, 1991.
    • (1991) Am. J. Physiol. , vol.261
    • Pritchard, J.B.1    Miller, D.S.2
  • 29
    • 0005716324 scopus 로고
    • Proximal tubular transport of organic anions and cations
    • edited by D. W. Seldin and G. Giebisch. New York: Raven
    • Pritchard, J. B., and D. S. Miller. Proximal tubular transport of organic anions and cations. In: The Kidney: Physiology and Pathophysiology (2nd ed.), edited by D. W. Seldin and G. Giebisch. New York: Raven, 1992, p. 2921-2945.
    • (1992) The Kidney: Physiology and Pathophysiology (2nd Ed.) , pp. 2921-2945
    • Pritchard, J.B.1    Miller, D.S.2
  • 30
    • 0026755943 scopus 로고
    • A linkage map of mouse chromosome 19: Definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus
    • Rochelle, J. M., M. L. Watson, R. J. Oakey, and M. F. Seldin. A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus. Genomics 14: 26-31, 1992.
    • (1992) Genomics , vol.14 , pp. 26-31
    • Rochelle, J.M.1    Watson, M.L.2    Oakey, R.J.3    Seldin, M.F.4
  • 31
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • Sekine, T., N. Watanabe, M. Hosoyamada, Y. Kanai, and H. Endou. Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272: 18526-18529, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18526-18529
    • Sekine, T.1    Watanabe, N.2    Hosoyamada, M.3    Kanai, Y.4    Endou, H.5
  • 32
    • 0024577540 scopus 로고
    • Operational modes of the organic anion exchanger in canine renal brush-border membrane vesicles
    • Renal Fluid Electrolyte Physiol. 25
    • Steffens, T. G., P. D. Holohan, and C. R. Ross. Operational modes of the organic anion exchanger in canine renal brush-border membrane vesicles. Am. J. Physlol. 256 (Renal Fluid Electrolyte Physiol. 25): F596-F609, 1989.
    • (1989) Am. J. Physlol. , vol.256
    • Steffens, T.G.1    Holohan, P.D.2    Ross, C.R.3
  • 33
    • 0026494183 scopus 로고
    • Specificity of basolateral organic anion exchanger in proximal tubule for cellular and extracellular solutes
    • Sullivan, L. P., and J. J. Grantham. Specificity of basolateral organic anion exchanger in proximal tubule for cellular and extracellular solutes. J. Am. Soc. Nephrol. 2: 1192-1200, 1992.
    • (1992) J. Am. Soc. Nephrol. , vol.2 , pp. 1192-1200
    • Sullivan, L.P.1    Grantham, J.J.2
  • 34
    • 0030781076 scopus 로고    scopus 로고
    • Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney
    • Sweet, D. H., N. A. Wolff, and J. B. Pritchard. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J. Biol. Chem. 272: 30088-30095, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30088-30095
    • Sweet, D.H.1    Wolff, N.A.2    Pritchard, J.B.3
  • 35
    • 0029737131 scopus 로고    scopus 로고
    • Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells
    • Renal Fluid Electrolyte Physiol. 40
    • Takano, M., J. Nagai, M. Yasuhara, and K. Inui. Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells. Am. J. Physiol. 271 (Renal Fluid Electrolyte Physiol. 40): F469-F475, 1996.
    • (1996) Am. J. Physiol. , vol.271
    • Takano, M.1    Nagai, J.2    Yasuhara, M.3    Inui, K.4
  • 36
    • 0030850803 scopus 로고    scopus 로고
    • Renal transporters for organic anions and organic cations. Structural requirements for substrates
    • Ullrich, K. J. Renal transporters for organic anions and organic cations. Structural requirements for substrates. J. Membr. Biol. 158: 95-107, 1997.
    • (1997) J. Membr. Biol. , vol.158 , pp. 95-107
    • Ullrich, K.J.1
  • 37
    • 0023916963 scopus 로고
    • Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions
    • Renal Fluid Electrolyte Physiol. 23
    • Ullrich, K. J., and G. Rumrich. Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions. Am. J. Physiol. 254 (Renal Fluid Electrolyte Physiol. 23): F453-F462, 1988.
    • (1988) Am. J. Physiol. , vol.254
    • Ullrich, K.J.1    Rumrich, G.2
  • 38
    • 0030777903 scopus 로고    scopus 로고
    • Expression cloning and characterization of a renal organic anion transporter from winter flounder
    • Wolff, N. A., A. Werner, S. Burkhardt, and G. Burckhardt. Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett. 417: 287-291, 1997.
    • (1997) FEBS Lett. , vol.417 , pp. 287-291
    • Wolff, N.A.1    Werner, A.2    Burkhardt, S.3    Burckhardt, G.4
  • 39
    • 0032577202 scopus 로고    scopus 로고
    • cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
    • Wu, X., P. D. Prasad, F. H. Leibach, and V. Ganapathy. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem. Biophys. Res. Commun. 246: 589-595, 1998.
    • (1998) Biochem. Biophys. Res. Commun. , vol.246 , pp. 589-595
    • Wu, X.1    Prasad, P.D.2    Leibach, F.H.3    Ganapathy, V.4
  • 40
    • 0031923777 scopus 로고    scopus 로고
    • Participation of mercuric conjugates of cysteine, homocysteine, and N-acetylcysteine in mechanisms involved in the renal tubular 'uptake of inorganic mercury
    • Zalups, R. K., and D. W. Barfuss. Participation of mercuric conjugates of cysteine, homocysteine, and N-acetylcysteine in mechanisms involved in the renal tubular 'uptake of inorganic mercury. J. Am. Soc. Nephrol. 9: 551-561, 1998.
    • (1998) J. Am. Soc. Nephrol. , vol.9 , pp. 551-561
    • Zalups, R.K.1    Barfuss, D.W.2


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