Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 3, 2002, Pages 746-753

  Maki, Hasegawa ^a   Kusuhara, Horoyuki ^a,d   Sugiyama, Daisuke ^a   Ito, Kousei ^b   Ueda, Sirou ^b   Endou, Hitoshi ^c   Sugiyama, Yuichi ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c KYORIN UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; CARRIER PROTEIN; ORGANIC COMPOUND; PENICILLIN G; PRAVASTATIN; PROTEIN ROAT3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE ABSORPTION; KINETICS; LIVER METABOLISM; MALE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ALGORITHMS; ANIMALS; ANIONS; BLOTTING, WESTERN; FLUORESCENT ANTIBODY TECHNIQUE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KIDNEY; KINETICS; LIGANDS; LLC-PK1 CELLS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-AMINOHIPPURIC ACID; PENICILLIN G; PENICILLINS; PRAVASTATIN; RATS; RATS, SPRAGUE-DAWLEY; SWINE;

EID: 0036175127     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.3.746     Document Type: Article

References (29)

1. Immunologic distribution of an organic anion transport protein in rat liver and kidney
2. Structure of renal organic anion and cation transporters
3. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
4. Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
5. Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats
6. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
7. Cellular and molecular aspects of drug transport in the kidney
8. The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1
9. Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
10. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
11. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatpl, the hepatic sinusoidal organic solute transporter
12. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
13. Expression and localization of multidrug resistant protein mrp2 in rat small intestine
14. Molecular aspects of hepatobiliary transport
15. Developmental changes in multispecific organic anion transporter 1 expression in the rat kidney
16. Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules
17. The multispecific organic anion transporter (OAT) family
18. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver
19. Expression cloning and characterization of a novel multispecific organic anion transporter
20. Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects
21. Characterization of the efflux transport of 17b-estradiol-D-17b-glucuronide from thr brain across the blood-brain barrier
22. Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2
23. Transport of drugs across the hepatic sinusoidal membrane; sinusoidal drug influx and efflux in the liver
24. Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2
25. Renal transport mechanisms for xenobiotics: Chemicals and drugs
26. Gender differences in expression of organic cation transporter OCT2 in rat kidney
27. Molecular pharmacology of renal organic anion transporters
28. A pharmacokinetic analysis program (multi) for microcomputer
29. Tissue-selective uptake of pravastatin in rats: Contribution of a specific carrier-mediated uptake system