-
1
-
-
0017900464
-
The interaction between methotrexate and probenecid in man
-
Aherne GW, Marks V, Mould GP et al (1978) The interaction between methotrexate and probenecid in man. Br J Pharmacol 63:369P
-
(1978)
Br. J. Pharmacol.
, vol.63
-
-
Aherne, G.W.1
Marks, V.2
Mould, G.P.3
-
2
-
-
71449118407
-
Interaction of organic cations with organic anion transporters
-
Ahn S-Y, Eraly SA, Tsigelny I, Nigam SK (2009) Interaction of organic cations with organic anion transporters. J Biol Chem 284:31422-31430
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 31422-31430
-
-
Ahn, S.-Y.1
Eraly, S.A.2
Tsigelny, I.3
Nigam, S.K.4
-
3
-
-
10744223047
-
Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites
-
Alebouyeh M, Takeda M, Onozato ML et al (2003) Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites. J Pharmacol Sci 93:430-436
-
(2003)
J. Pharmacol. Sci.
, vol.93
, pp. 430-436
-
-
Alebouyeh, M.1
Takeda, M.2
Onozato, M.L.3
-
4
-
-
49849086125
-
Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment
-
Aleksunes LM, Augustine LM, Scheffer GL et al (2008) Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment. Toxicology 250:82-88
-
(2008)
Toxicology
, vol.250
, pp. 82-88
-
-
Aleksunes, L.M.1
Augustine, L.M.2
Scheffer, G.L.3
-
5
-
-
8544277306
-
The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus
-
Anzai N, Miyazaki H, Noshiro R et al (2004) The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. J Biol Chem 279:45942-45950
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45942-45950
-
-
Anzai, N.1
Miyazaki, H.2
Noshiro, R.3
-
6
-
-
27144483941
-
Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules
-
Anzai N, Jutabha P, Enomoto A et al (2005) Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules. J Pharmacol Exp Ther 315:534-544
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 534-544
-
-
Anzai, N.1
Jutabha, P.2
Enomoto, A.3
-
7
-
-
33747616258
-
Organic anion transporter family: Current knowledge
-
Anzai N, Kanai Y, Endou H (2006) Organic anion transporter family: current knowledge. J Pharm Sci 100:411-426
-
(2006)
J. Pharm. Sci.
, vol.100
, pp. 411-426
-
-
Anzai, N.1
Kanai, Y.2
Endou, H.3
-
8
-
-
53549131575
-
Nitric oxide and peroxinitrite regulate transporter transcription in rat liver slices
-
Aoki J, Saso N, Kato S et al (2008) Nitric oxide and peroxinitrite regulate transporter transcription in rat liver slices. Biol Pharm Bull 31:1882-1887
-
(2008)
Biol. Pharm. Bull.
, vol.31
, pp. 1882-1887
-
-
Aoki, J.1
Saso, N.2
Kato, S.3
-
9
-
-
0032931612
-
Transport properties of nonsteroidal antiinflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes
-
Apiwattanakul N, Sekine T, Chairoungdua A et al (1999) Transport properties of nonsteroidal antiinflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol 55:847-854
-
(1999)
Mol. Pharmacol.
, vol.55
, pp. 847-854
-
-
Apiwattanakul, N.1
Sekine, T.2
Chairoungdua, A.3
-
10
-
-
18744370748
-
Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells
-
Asif AR, Steffgen J, Metten M et al (2005) Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells. Pflügers Arch Eur J Physiol 450:88-95
-
(2005)
Pflügers Arch. Eur. J. Physiol.
, vol.450
, pp. 88-95
-
-
Asif, A.R.1
Steffgen, J.2
Metten, M.3
-
11
-
-
0037333435
-
Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells
-
Aslamkhan AS, Han Y-H, Yang X-P et al (2003) Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells. Mol Pharm 63:590-596
-
(2003)
Mol. Pharm.
, vol.63
, pp. 590-596
-
-
Aslamkhan, A.S.1
Han, Y.-H.2
Yang, X.-P.3
-
12
-
-
33845454743
-
The flounder organic anion transporter (fOAT) has sequence, function and substrate specificity similar to both mammalian Oats 1 and 3
-
Aslamkhan AG, Thompson DM, Perry JL et al (2006) The flounder organic anion transporter (fOAT) has sequence, function and substrate specificity similar to both mammalian Oats 1 and 3. Am J Physiol Regul Integr Comp Physiol 291: R1773-R1780
-
(2006)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.291
-
-
Aslamkhan, A.G.1
Thompson, D.M.2
Perry, J.L.3
-
14
-
-
0036166487
-
Human organic anion transporters mediate the transport of tetracycline
-
DOI 10.1254/jjp.88.69
-
Babu E, Takeda M, Narikawa S et al (2002) Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol 88:69-76 (Pubitemid 34139841)
-
(2002)
Japanese Journal of Pharmacology
, vol.88
, Issue.1
, pp. 69-76
-
-
Babu, E.1
Takeda, M.2
Narikawa, S.3
Kobayashi, Y.4
Yamamoto, T.5
Cha, S.H.6
Sekine, T.7
Sakthisekaran, D.8
Endou, H.9
-
15
-
-
0037067159
-
Role of human organic anion transporter 4 in the transport of ochratoxin A
-
DOI 10.1016/S0167-4889(02)00187-8, PII S0167488902001878
-
Babu E, Takeda M, Narikawa S et al (2002) Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta 1590:64-75 (Pubitemid 34626769)
-
(2002)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1590
, Issue.1-3
, pp. 64-75
-
-
Babu, E.1
Takeda, M.2
Narikawa, S.3
Kobayashi, Y.4
Enomoto, A.5
Tojo, A.6
Cha, S.H.7
Sekine, T.8
Sakthisekaran, D.9
Endou, H.10
-
16
-
-
0034726674
-
Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene
-
Bahn A, Prawitt D, Butler G et al (2000) Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene. Biochem Biophys Res Commun 275:623-630
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.275
, pp. 623-630
-
-
Bahn, A.1
Prawitt, D.2
Butler, G.3
-
17
-
-
0036841360
-
Interaction of the metal chelator 2, 3-dimercapto-1-propane sulfonate with the rabbit multispecific organic anion transporter 1 (rbOAT1)
-
Bahn A, Knabe M, Hagos Y et al (2002) Interaction of the metal chelator 2, 3-dimercapto-1-propane sulfonate with the rabbit multispecific organic anion transporter 1 (rbOAT1). Mol Pharmacol 62:1128-1136
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 1128-1136
-
-
Bahn, A.1
Knabe, M.2
Hagos, Y.3
-
18
-
-
1842589279
-
Expression studies and functional characterization of human organic anion transporter 1 isoforms
-
Bahn A, Ebbinghaus D, Ebbinghaus EG et al (2004) Expression studies and functional characterization of human organic anion transporter 1 isoforms. Drug Metab Dispos 32:424-430
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 424-430
-
-
Bahn, A.1
Ebbinghaus, D.2
Ebbinghaus, E.G.3
-
19
-
-
26844476662
-
Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites
-
Bahn A, Ljubojevic M, Lorenz H et al (2005) Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites. Am J Physiol Cell Physiol 289: C1075-C1084
-
(2005)
Am. J. Physiol. Cell. Physiol.
, vol.289
-
-
Bahn, A.1
Ljubojevic, M.2
Lorenz, H.3
-
20
-
-
47749112096
-
Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13)
-
Bahn A, Hagos Y, Reuter S et al (2008) Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem 283:16332-16341
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16332-16341
-
-
Bahn, A.1
Hagos, Y.2
Reuter, S.3
-
21
-
-
0242290366
-
Human organic anion transporter 3 (hOAT3) can operate as an exchanger accepting urate as a substrate
-
Bakhiya N, Bahn A, Burckhardt G, Wolff NA (2003) Human organic anion transporter 3 (hOAT3) can operate as an exchanger accepting urate as a substrate. Cell Physiol Biochem 13:249-256
-
(2003)
Cell. Physiol. Biochem.
, vol.13
, pp. 249-256
-
-
Bakhiya, N.1
Bahn, A.2
Burckhardt, G.3
Wolff, N.A.4
-
22
-
-
34748840493
-
Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic hydrocarbons
-
Bakhiya N, Batke M, Laake J et al (2007) Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic hydrocarbons. Drug Metab Dispos 35:1824-1831
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1824-1831
-
-
Bakhiya, N.1
Batke, M.2
Laake, J.3
-
23
-
-
69449105950
-
Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy
-
Bakhiya N, Arlt VM, Bahn A et al (2009) Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology 264:74-79
-
(2009)
Toxicology
, vol.264
, pp. 74-79
-
-
Bakhiya, N.1
Arlt, V.M.2
Bahn, A.3
-
24
-
-
59149087698
-
Activation of protein kinase Cz increases OAT1 (SLC22A6) - And OAT3 (SLC22A8)-mediated transport
-
Barros SA, Srimaroeng C, Perry JL et al (2009) Activation of protein kinase Cz increases OAT1 (SLC22A6) - and OAT3 (SLC22A8)-mediated transport. J Biol Chem 284:2672-2679
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 2672-2679
-
-
Barros, S.A.1
Srimaroeng, C.2
Perry, J.L.3
-
25
-
-
0141562099
-
Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression
-
Beéry E, Middel P, Bahn A et al (2003) Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin- regulated zonal expression. Endocrinology 144:4519-4526
-
(2003)
Endocrinology
, vol.144
, pp. 4519-4526
-
-
Beéry, E.1
Middel, P.2
Bahn, A.3
-
26
-
-
0001632037
-
'Benemid', p-(di-n-propylsulfamyl)-benzoic acid: Its renal affinity and its elimination
-
Beyer KH, Russo HF, Tillson EK et al (1951) 'Benemid', p-(di-n-propylsulfamyl)-benzoic acid: its renal affinity and its elimination. Am J Physiol 166:625-649
-
(1951)
Am. J. Physiol.
, vol.166
, pp. 625-649
-
-
Beyer, K.H.1
Russo, H.F.2
Tillson, E.K.3
-
27
-
-
33745444581
-
Analyses of 50 regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3)
-
Bhatnagar V, Xu G, Hamilton BA et al (2006) Analyses of 50 regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet 51:575-580
-
(2006)
J. Hum. Genet.
, vol.51
, pp. 575-580
-
-
Bhatnagar, V.1
Xu, G.2
Hamilton, B.A.3
-
28
-
-
22944433202
-
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)
-
Bleasby K, Hall LA, Perry JL et al (2005) Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther 314:923-931
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.314
, pp. 923-931
-
-
Bleasby, K.1
Hall, L.A.2
Perry, J.L.3
-
29
-
-
33751578245
-
Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition
-
Bleasby K, Castle JC, Robert CJ et al (2006) Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition. Xenobiotica 36:963-988
-
(2006)
Xenobiotica
, vol.36
, pp. 963-988
-
-
Bleasby, K.1
Castle, J.C.2
Robert, C.J.3
-
30
-
-
0033559052
-
A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse
-
Brady KP, Dushkin H, Förnzler D et al (1999) A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56:254-261
-
(1999)
Genomics
, vol.56
, pp. 254-261
-
-
Brady, K.P.1
Dushkin, H.2
Förnzler, D.3
-
31
-
-
0037266213
-
Compensation increase in organic anion secretion in rats with acute biliary obstruction: Role of the renal organic anion transporter 1
-
Brandoni A, Quaglia NB, Torres AM (2003) Compensation increase in organic anion secretion in rats with acute biliary obstruction: role of the renal organic anion transporter 1. Pharmacology 68:57-63
-
(2003)
Pharmacology
, vol.68
, pp. 57-63
-
-
Brandoni, A.1
Quaglia, N.B.2
Torres, A.M.3
-
32
-
-
33746808149
-
Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3
-
Brandoni A, Anzai N, Kanai Y et al (2006) Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3. Biochim Biophys Acta 1762:673-681
-
(2006)
Biochim. Biophys. Acta
, vol.1762
, pp. 673-681
-
-
Brandoni, A.1
Anzai, N.2
Kanai, Y.3
-
33
-
-
33646567499
-
Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction
-
Brandoni A, Villar SR, Picena JC et al (2006) Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction. Hepatology 43:1092-1110
-
(2006)
Hepatology
, vol.43
, pp. 1092-1110
-
-
Brandoni, A.1
Villar, S.R.2
Picena, J.C.3
-
34
-
-
0027417835
-
Cephalosporin-probenecid drug interactions
-
Brown GR (1993) Cephalosporin-probenecid drug interactions. Clin Pharmacokinet 24:289-300
-
(1993)
Clin. Pharmacokinet.
, vol.24
, pp. 289-300
-
-
Brown, G.R.1
-
35
-
-
2442700344
-
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3, Slc22a6-8) mRNA levels
-
Buist S C N, Klaassen CD (2004) Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3, Slc22a6-8) mRNA levels. Drug Metab Dispos 32:620-625
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 620-625
-
-
Buist, S.C.N.1
Klaassen, C.D.2
-
36
-
-
0036198703
-
Gender-specific and developmental influences on the expression of rat organic anion transporters
-
Buist S C N, Cherrington NJ, Choudhuri S et al (2002) Gender-specific and developmental influences on the expression of rat organic anion transporters. J Pharmacol Exp Ther 301:145-151
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.301
, pp. 145-151
-
-
Buist, S.C.N.1
Cherrington, N.J.2
Choudhuri, S.3
-
38
-
-
0038728565
-
Transport of organic anions across the basolateral membrane of proximal tubule cells
-
Burckhardt BC, Burckhardt G (2003) Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol 146:95-158
-
(2003)
Rev. Physiol. Biochem. Pharmacol.
, vol.146
, pp. 95-158
-
-
Burckhardt, B.C.1
Burckhardt, G.2
-
40
-
-
0037370996
-
Transport of cimetidine by flounder and human renal organic anion transporter 1
-
Burckhardt BC, Brai S, Wallis S et al (2003) Transport of cimetidine by flounder and human renal organic anion transporter 1. Am J Physiol Renal Physiol 284: F503-F509
-
(2003)
Am. J. Physiol. Renal Physiol.
, vol.284
-
-
Burckhardt, B.C.1
Brai, S.2
Wallis, S.3
-
41
-
-
0000518648
-
Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
-
Cha SH, Sekine T, Kusuhara H et al (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 275:4507-4512
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 4507-4512
-
-
Cha, S.H.1
Sekine, T.2
Kusuhara, H.3
-
42
-
-
0035039326
-
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
-
Cha SH, Sekine T, Fukushima J-I et al (2001) Identification and characterization of human organic anion transporter 3 expressing predominantely in the kidney. Mol Pharm 59:1277-1286 (Pubitemid 32385197)
-
(2001)
Molecular Pharmacology
, vol.59
, Issue.5
, pp. 1277-1286
-
-
Cha, S.H.1
Sekine, T.2
Fukushima, J.-I.3
Kanai, Y.4
Kobayashi, Y.5
Goya, T.6
Endou, H.7
-
43
-
-
0036761059
-
Down-regulation of organic anion transporter 2 mRNA expression by nitric oxide in primary cultured rat hepatocytes
-
Cha SH, Kim HP, Jung N-H et al (2002) Down-regulation of organic anion transporter 2 mRNA expression by nitric oxide in primary cultured rat hepatocytes. IUBMB Life 54:129-135
-
(2002)
IUBMB Life
, vol.54
, pp. 129-135
-
-
Cha, S.H.1
Kim, H.P.2
Jung, N.-H.3
-
45
-
-
39749101222
-
Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity
-
Cheng Q, Aleksunes LM, Manautou JE et al (2008) Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Mol Pharm 5:77-91
-
(2008)
Mol. Pharm.
, vol.5
, pp. 77-91
-
-
Cheng, Q.1
Aleksunes, L.M.2
Manautou, J.E.3
-
46
-
-
21344469277
-
Mutational analysis of idiopathic renal hypouricemia
-
Cheong HI, Kang JH, Lee JH et al (2005) Mutational analysis of idiopathic renal hypouricemia. Pediatr Nephrol 20:886-890
-
(2005)
Pediatr. Nephrol.
, vol.20
, pp. 886-890
-
-
Cheong, H.I.1
Kang, J.H.2
Lee, J.H.3
-
47
-
-
3042599451
-
Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats
-
Cherrington NJ, Slitt AL, Li N, Klaassen CD (2004) Lipopolysaccharide- mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos 32:734-741
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 734-741
-
-
Cherrington, N.J.1
Slitt, A.L.2
Li, N.3
Klaassen, C.D.4
-
48
-
-
0142212154
-
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus
-
Choudhuri S, Cherrington NJ, Li N, Klaassen CD (2003) Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus. Drug Metab Dispos 31:1337-1345
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 1337-1345
-
-
Choudhuri, S.1
Cherrington, N.J.2
Li, N.3
Klaassen, C.D.4
-
49
-
-
34247236764
-
Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein
-
Chu X-Y, Bleasby K, Yabut J et al (2007) Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther 321:673-683
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.321
, pp. 673-683
-
-
Chu, X.-Y.1
Bleasby, K.2
Yabut, J.3
-
50
-
-
0034662273
-
Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1
-
Cihlar T, Ho ES (2000) Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem 283:49-55
-
(2000)
Anal. Biochem.
, vol.283
, pp. 49-55
-
-
Cihlar, T.1
Ho, E.S.2
-
51
-
-
0032856603
-
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
-
Cihlar T, Lin DC, Pritchard JB et al (1999) The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharm 56:570-580
-
(1999)
Mol. Pharm.
, vol.56
, pp. 570-580
-
-
Cihlar, T.1
Lin, D.C.2
Pritchard, J.B.3
-
52
-
-
41149136735
-
Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP
-
Cropp CD, Komori T, Shima JE et al (2008) Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol 73:1151-1158
-
(2008)
Mol. Pharmacol.
, vol.73
, pp. 1151-1158
-
-
Cropp, C.D.1
Komori, T.2
Shima, J.E.3
-
53
-
-
0029000871
-
Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients
-
Cundy KC, Petty BC, Flaherty J et al (1995) Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 39:1247-1251
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 1247-1251
-
-
Cundy, K.C.1
Petty, B.C.2
Flaherty, J.3
-
54
-
-
9044229716
-
Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbits
-
Cundy KC, Li Z-H, Lee WA (1996) Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbits. Drug Metab Dispos 24:315-321
-
(1996)
Drug Metab. Dispos
, vol.24
, pp. 315-321
-
-
Cundy, K.C.1
Li, Z.-H.2
Lee, W.A.3
-
56
-
-
34248148043
-
Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport
-
Cunningham R, Brazie M, Kanumuru S et al (2007) Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. J Am Soc Nephrol 18:1419-1425
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 1419-1425
-
-
Cunningham, R.1
Brazie, M.2
Kanumuru, S.3
-
57
-
-
58149235139
-
Segment-specific proximal tubule injury in tripterygium glycosides intoxicated rats
-
Dan H, Peng R-X, Ao Y, Liu Y-H (2008) Segment-specific proximal tubule injury in tripterygium glycosides intoxicated rats. J Biochem Mol Toxicol 22:422-428
-
(2008)
J. Biochem. Mol. Toxicol.
, vol.22
, pp. 422-428
-
-
Dan, H.1
Peng, R.-X.2
Ao, Y.3
Liu, Y.-H.4
-
59
-
-
0347362498
-
Characterization of uremic toxin transport by organic anion transporters in the kidney
-
Deguchi T, Kusuhara H, Takadate A et al (2004) Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int 65:162-174
-
(2004)
Kidney Int.
, vol.65
, pp. 162-174
-
-
Deguchi, T.1
Kusuhara, H.2
Takadate, A.3
-
60
-
-
38749117869
-
Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: Role of basolateral plasma transporters and cortical renal blood flow
-
Di Giusto G, Anzai N, Endou H, Torres AM (2008) Elimination of organic anions in response to an early stage of renal ischemia-reperfusion in the rat: role of basolateral plasma transporters and cortical renal blood flow. Pharmacology 81:127-136
-
(2008)
Pharmacology
, vol.81
, pp. 127-136
-
-
Di Giusto, G.1
Anzai, N.2
Endou, H.3
Torres, A.M.4
-
61
-
-
70349618596
-
Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride
-
Di Giusto G, Anzai N, Ruiz ML et al (2009) Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride. Arch Toxicol 83:889-897
-
(2009)
Arch. Toxicol.
, vol.83
, pp. 889-897
-
-
Di Giusto, G.1
Anzai, N.2
Ruiz, M.L.3
-
62
-
-
70350233303
-
The influence of chronic renal failure on drug metabolism and transport
-
Dreisbach AW (2009) The influence of chronic renal failure on drug metabolism and transport. Clin Pharmacol Ther 86:553-556
-
(2009)
Clin. Pharmacol. Ther.
, vol.86
, pp. 553-556
-
-
Dreisbach, A.W.1
-
63
-
-
51049095076
-
The effect of chronic renal failure on drug metabolism and transport
-
Dreisbach AW, Lertora J J L (2008) The effect of chronic renal failure on drug metabolism and transport. Expert Opin Drug Metab Toxicol 4:1065-1074
-
(2008)
Expert Opin. Drug Metab. Toxicol.
, vol.4
, pp. 1065-1074
-
-
Dreisbach, A.W.1
Lertora, J.J.L.2
-
64
-
-
0035066252
-
Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
-
Dresser MJ, Leabman MK, Giacomini KM (2001) Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J Pharm Sci 90:397-421
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 397-421
-
-
Dresser, M.J.1
Leabman, M.K.2
Giacomini, K.M.3
-
65
-
-
1842732504
-
Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules
-
Ekaratanawong S, Anzai N, Jutabha P et al (2004) Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J Pharm Sci 94:297-304
-
(2004)
J. Pharm. Sci.
, vol.94
, pp. 297-304
-
-
Ekaratanawong, S.1
Anzai, N.2
Jutabha, P.3
-
66
-
-
26244449838
-
Roles of organic anion transporters (OATs) and urate transporter (URAT1) in the pathophysiology of human disease
-
Enomoto A, Endou H (2005) Roles of organic anion transporters (OATs) and urate transporter (URAT1) in the pathophysiology of human disease. Clin Exp Nephrol 9:195-205
-
(2005)
Clin. Exp. Nephrol.
, vol.9
, pp. 195-205
-
-
Enomoto, A.1
Endou, H.2
-
67
-
-
35748939040
-
Roles of organic anion transporters in the progression of chronic renal failure
-
Enomoto A, Niwa T (2007) Roles of organic anion transporters in the progression of chronic renal failure. Ther Apher Dial 11:327-331
-
(2007)
Ther. Apher Dial.
, vol.11
, pp. 327-331
-
-
Enomoto, A.1
Niwa, T.2
-
68
-
-
0037161834
-
Molecular identification of a renal urateanion exchanger that regulates blood urate levels
-
Enomoto A, Kimura H, Chairoungdua A et al (2002) Molecular identification of a renal urateanion exchanger that regulates blood urate levels. Nature 417:447-452
-
(2002)
Nature
, vol.417
, pp. 447-452
-
-
Enomoto, A.1
Kimura, H.2
Chairoungdua, A.3
-
69
-
-
0036260663
-
Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
-
DOI 10.1124/jpet.301.3.797
-
Enomoto A, Takeda M, Shimoda S et al (2002) Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther 301:797-802 (Pubitemid 34595067)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.301
, Issue.3
, pp. 797-802
-
-
Enomoto, A.1
Takeda, M.2
Shimoda, M.3
Narikawa, S.4
Kobayashi, Y.5
Kobayashi, Y.6
Yamamoto, T.7
Sekine, T.8
Cha, S.H.9
Niwa, T.10
Endou, H.11
-
70
-
-
18444385667
-
Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity
-
Enomoto A, Takeda M, Tojo A et al (2002) Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J Am Soc Nephrol 13:1711-1720
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 1711-1720
-
-
Enomoto, A.1
Takeda, M.2
Tojo, A.3
-
71
-
-
12244299845
-
Interactions of human organic anion as well as cation transporters with indoxyl sulfate
-
Enomoto A, Takeda M, Taki K et al (2003) Interactions of human organic anion as well as cation transporters with indoxyl sulfate. Eur J Pharmacol 466:13-20
-
(2003)
Eur. J. Pharmacol.
, vol.466
, pp. 13-20
-
-
Enomoto, A.1
Takeda, M.2
Taki, K.3
-
73
-
-
0037427506
-
Organic anion and cation transporters occur in pairs of similar and similarly expressed genes
-
Eraly SA, Hamilton BA, Nigam SK (2003) Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun 300:333-342
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.300
, pp. 333-342
-
-
Eraly, S.A.1
Hamilton, B.A.2
Nigam, S.K.3
-
74
-
-
33646165531
-
Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice
-
Eraly SA, Vallon V, Vaughn DA et al (2006) Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem 281:5072-5083
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 5072-5083
-
-
Eraly, S.A.1
Vallon, V.2
Vaughn, D.A.3
-
75
-
-
33645743694
-
The human organic anion transporter 3 (OAT3; SLC22A8): Genetic variation and functional genomics
-
Erdman AR, Mangravite LM, Urban TJ et al (2005) The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol 290:905-912
-
(2005)
Am. J. Physiol. Renal Physiol.
, vol.290
, pp. 905-912
-
-
Erdman, A.R.1
Mangravite, L.M.2
Urban, T.J.3
-
76
-
-
0035826582
-
Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3
-
Feng B, Dresser MJ, Shu Y et al (2001) Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3. Biochemistry 40:5511-5520
-
(2001)
Biochemistry
, vol.40
, pp. 5511-5520
-
-
Feng, B.1
Dresser, M.J.2
Shu, Y.3
-
77
-
-
0037118701
-
Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition
-
Feng B, Shu Y, Giacomini KM (2002) Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition. Biochemistry 41:8941-8947
-
(2002)
Biochemistry
, vol.41
, pp. 8941-8947
-
-
Feng, B.1
Shu, Y.2
Giacomini, K.M.3
-
78
-
-
0026570125
-
Methotrexate and nonsteroidal anti-inflammatory drug interactions
-
Frenia ML, Long KS (1992) Methotrexate and nonsteroidal anti-inflammatory drug interactions. Ann Pharmacother 26:342-343
-
(1992)
Ann. Pharmacother.
, vol.26
, pp. 342-343
-
-
Frenia, M.L.1
Long, K.S.2
-
79
-
-
20244389716
-
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)
-
Fujita T, Brown C, Carlson EJ et al (2005) Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics 15:201-209
-
(2005)
Pharmacogenet. Genomics
, vol.15
, pp. 201-209
-
-
Fujita, T.1
Brown, C.2
Carlson, E.J.3
-
80
-
-
0032717159
-
Molecular cloning and characterization of a polyspecific organic anion transporter from Caenorhabditis elegans
-
George RL, Wu X, Fei FH et al (1999) Molecular cloning and characterization of a polyspecific organic anion transporter from Caenorhabditis elegans. J Pharmacol Exp Ther 291:596-603
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.291
, pp. 596-603
-
-
George, R.L.1
Wu, X.2
Fei, F.H.3
-
81
-
-
7244236578
-
Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate
-
Gopal E, Fei Y-J, Sugawara M et al (2004) Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate. J Biol Chem 279:44533-44532
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 44533-44532
-
-
Gopal, E.1
Fei, Y.-J.2
Sugawara, M.3
-
82
-
-
31144465910
-
Sex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubules
-
Groves CE, Suhre WB, Cherrington NJ, Wright SH (2006) Sex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubules. J Pharmacol Exp Ther 316:743-752
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.316
, pp. 743-752
-
-
Groves, C.E.1
Suhre, W.B.2
Cherrington, N.J.3
Wright, S.H.4
-
83
-
-
14644430364
-
Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney
-
Habu Y, Yano I, Okuda M et al (2005) Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney. Biochem Pharmacol 69:993-999
-
(2005)
Biochem. Pharmacol.
, vol.69
, pp. 993-999
-
-
Habu, Y.1
Yano, I.2
Okuda, M.3
-
84
-
-
0036963238
-
Cloning of the pig renal organic anion transporter 1 (pOAT1)
-
PII S0300908402000226
-
Hagos Y, Bahn A, Asif AR et al (2002) Cloning of the pig renal organic anion transporter 1 (pOAT1). Biochimie 84:1221-1224 (Pubitemid 36372170)
-
(2002)
Biochimie
, vol.84
, Issue.12
, pp. 1221-1224
-
-
Hagos, Y.1
Bahn, A.2
Asif, A.R.3
Krick, W.4
Sendler, M.5
Burckhardt, G.6
-
85
-
-
16844379360
-
Functional expression of pig renal organic anion transporter 3 (pOAT3)
-
Hagos Y, Braun IM, Krick W et al (2005) Functional expression of pig renal organic anion transporter 3 (pOAT3). Biochimie 87:421-424
-
(2005)
Biochimie
, vol.87
, pp. 421-424
-
-
Hagos, Y.1
Braun, I.M.2
Krick, W.3
-
86
-
-
36849071941
-
Torasemide transport by organic anion transporters contributes to hyperuricemia
-
Hagos Y, Bahn A, Vormfelde SV et al (2007) Torasemide transport by organic anion transporters contributes to hyperuricemia. J Am Soc Nephrol 18:3101-3109
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 3101-3109
-
-
Hagos, Y.1
Bahn, A.2
Vormfelde, S.V.3
-
87
-
-
33846692496
-
Human renal organic anion transporter 4 operates as an asymmetric urate transporter
-
DOI 10.1681/ASN.2006040415
-
Hagos Y, Stein D, Ugele B et al (2007) Human renal organic anion transporter 4 operates as an asymmetric urate transporter. J Am Soc Nephrol 18:430-439 (Pubitemid 46193309)
-
(2007)
Journal of the American Society of Nephrology
, vol.18
, Issue.2
, pp. 430-439
-
-
Hagos, Y.1
Stein, D.2
Ugele, B.3
Burckhardt, G.4
Bahn, A.5
-
88
-
-
52549111946
-
Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias
-
Hagos Y, Krick W, Braulke T et al (2008) Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias. Pflügers Arch Eur J Physiol 457:223-231
-
(2008)
Pflügers Arch. Eur. J. Physiol.
, vol.457
, pp. 223-231
-
-
Hagos, Y.1
Krick, W.2
Braulke, T.3
-
89
-
-
10744233574
-
Interactions of human organic anion transporters with diuretics
-
Hasannejad H, Takeda M, Taki K et al (2003) Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther 308:1021-1029
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.308
, pp. 1021-1029
-
-
Hasannejad, H.1
Takeda, M.2
Taki, K.3
-
90
-
-
0036175127
-
Functional involvement of rat organic anion transporter 3 (rOAT3; Slc22a8) in the uptake of organic anions
-
Hasegawa M, Kusuhara H, Sugiyama D et al (2002) Functional involvement of rat organic anion transporter 3 (rOAT3; Slc22a8) in the uptake of organic anions. J Pharmacol Exp Ther 300:746-753
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.300
, pp. 746-753
-
-
Hasegawa, M.1
Kusuhara, H.2
Sugiyama, D.3
-
91
-
-
0038137530
-
Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat
-
Hasegawa M, Kusuhara H, Endou H, Sugiyama Y (2003) Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. J Pharmacol Exp Ther 305:1087-1097
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.305
, pp. 1087-1097
-
-
Hasegawa, M.1
Kusuhara, H.2
Endou, H.3
Sugiyama, Y.4
-
92
-
-
4644333578
-
Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters
-
Hashimoto T, Narikawa S, Huang X-L et al (2004) Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5- methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters. Drug Metab Dispos 32:1096-1102
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 1096-1102
-
-
Hashimoto, T.1
Narikawa, S.2
Huang, X.-L.3
-
94
-
-
34547169521
-
Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
-
Hilgendorf C, Ahlin G, Seithel A et al (2007) Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab Dispos 35:1333-1340
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1333-1340
-
-
Hilgendorf, C.1
Ahlin, G.2
Seithel, A.3
-
95
-
-
24344439264
-
Transporters and drug therapy: Implications for drug disposition and disease
-
Ho RH, Kim RB (2005) Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther 78:260-277
-
(2005)
Clin. Pharmacol. Ther.
, vol.78
, pp. 260-277
-
-
Ho, R.H.1
Kim, R.B.2
-
96
-
-
0034008388
-
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1
-
Ho ES, Lin DC, Mendel DB, Cihlar T (2000) Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J Am Soc Nephrol 11:383-393
-
(2000)
J. Am. Soc. Nephrol.
, vol.11
, pp. 383-393
-
-
Ho, E.S.1
Lin, D.C.2
Mendel, D.B.3
Cihlar, T.4
-
97
-
-
59149084250
-
COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex
-
Höcherl K, Schmidt C, Bucher M (2009) COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex. Kidney Int 75:373-380
-
(2009)
Kidney Int.
, vol.75
, pp. 373-380
-
-
Höcherl, K.1
Schmidt, C.2
Bucher, M.3
-
98
-
-
0017757983
-
Influence of probenecid and spironolacton on furosemide kinetics and dynamics in man
-
Homeida M, Roberts C, Branch RA (1977) Influence of probenecid and spironolacton on furosemide kinetics and dynamics in man. Clin Pharmacol Ther 22:402-409
-
(1977)
Clin. Pharmacol. Ther.
, vol.22
, pp. 402-409
-
-
Homeida, M.1
Roberts, C.2
Branch, R.A.3
-
99
-
-
0017652767
-
Effects of probenecid on furosemide kinetics and natriuresis in man
-
Honari J, Blair AD, Cutler RE (1977) Effects of probenecid on furosemide kinetics and natriuresis in man. Clin Pharmacol Ther 22:395-401
-
(1977)
Clin. Pharmacol. Ther.
, vol.22
, pp. 395-401
-
-
Honari, J.1
Blair, A.D.2
Cutler, R.E.3
-
100
-
-
3843123206
-
Critical amino acid residues in transmembrane domain 1 of human organic anion transporter 1 OAT1
-
Hong M, Zhou F, You G (2004) Critical amino acid residues in transmembrane domain 1 of human organic anion transporter 1 OAT1. J Biol Chem 279:31478-31482
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31478-31482
-
-
Hong, M.1
Zhou, F.2
You, G.3
-
101
-
-
33846505456
-
Determination of the external loops and the cellular orientation of the N-and the C-termini of the human organic anion transporter hOAT1
-
Hong M, Tanaka K, Pan Z et al (2007) Determination of the external loops and the cellular orientation of the N-and the C-termini of the human organic anion transporter hOAT1. Biochem J 401:515-520
-
(2007)
Biochem. J.
, vol.401
, pp. 515-520
-
-
Hong, M.1
Tanaka, K.2
Pan, Z.3
-
103
-
-
0942265459
-
Function and localization of urate transporter 1 in mouse kidney
-
Hosoyamada M, Ichida K, Enomoto A et al (2004) Function and localization of urate transporter 1 in mouse kidney. J Am Soc Nephrol 15:261-268
-
(2004)
J. Am. Soc. Nephrol.
, vol.15
, pp. 261-268
-
-
Hosoyamada, M.1
Ichida, K.2
Enomoto, A.3
-
104
-
-
49649092002
-
Interaction of imatinib with human organic ion carriers
-
Hu S, Franke RM, Filipski KK et al (2008) Interaction of imatinib with human organic ion carriers. Clin Cancer Res 14:3141-3148
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3141-3148
-
-
Hu, S.1
Franke, R.M.2
Filipski, K.K.3
-
105
-
-
0034779861
-
Assessmant of cisplatin-induced nephrotoxicity by microarray technology
-
Huang Q, Dunn RT, Jayadev S et al (2001) Assessmant of cisplatin-induced nephrotoxicity by microarray technology. Toxicol Sci 63:196-207
-
(2001)
Toxicol. Sci.
, vol.63
, pp. 196-207
-
-
Huang, Q.1
Dunn, R.T.2
Jayadev, S.3
-
106
-
-
0037213731
-
Urate transport via human PAH transporter hOAT1 and its gene structure
-
Ichida K, Hosoyamada M, Kimura H et al (2003) Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int 63:143-155
-
(2003)
Kidney Int.
, vol.63
, pp. 143-155
-
-
Ichida, K.1
Hosoyamada, M.2
Kimura, H.3
-
107
-
-
0346734163
-
Clinical and molecular analysis of patients with renal hypouricemia in Japan - Influence of URAT1 gene on urinary urate excretion
-
Ichida K, Hosoyamada M, Hisatome I et al (2004) Clinical and molecular analysis of patients with renal hypouricemia in Japan - influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol 15:164-173
-
(2004)
J. Am. Soc. Nephrol.
, vol.15
, pp. 164-173
-
-
Ichida, K.1
Hosoyamada, M.2
Hisatome, I.3
-
108
-
-
3543124167
-
The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules
-
Imaoka T, Kusuhara H, Adachi-Akahane S et al (2004) The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules. J Am Soc Nephrol 15:2012-2022
-
(2004)
J. Am. Soc. Nephrol.
, vol.15
, pp. 2012-2022
-
-
Imaoka, T.1
Kusuhara, H.2
Adachi-Akahane, S.3
-
109
-
-
0034757988
-
Interaction of 2, 3-dimercapto-1-propane sulfonate with the human organic anion transporter hOAT1
-
Islinger F, Gekle M, Wright SH (2001) Interaction of 2, 3-dimercapto-1-propane sulfonate with the human organic anion transporter hOAT1. J Pharmacol Exp Ther 299:741-747
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 741-747
-
-
Islinger, F.1
Gekle, M.2
Wright, S.H.3
-
110
-
-
28144462450
-
Involvement of uric acid transporter in increased clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone
-
Iwanaga T, Kobayashi D, Hirayama M et al (2005) Involvement of uric acid transporter in increased clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone. Drug Metab Dispos 33:1791-1795
-
(2005)
Drug Metab. Dispos
, vol.33
, pp. 1791-1795
-
-
Iwanaga, T.1
Kobayashi, D.2
Hirayama, M.3
-
111
-
-
33845887252
-
Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter
-
Iwanaga T, Sato M, Maeda T et al (2007) Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter. J Pharmacol Exp Ther 320:211-217
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.320
, pp. 211-217
-
-
Iwanaga, T.1
Sato, M.2
Maeda, T.3
-
112
-
-
35548966750
-
Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family
-
Jacobsson JA, Haitina T, Lindblom J, Fredriksson R (2007) Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics 90:595-609
-
(2007)
Genomics
, vol.90
, pp. 595-609
-
-
Jacobsson, J.A.1
Haitina, T.2
Lindblom, J.3
Fredriksson, R.4
-
113
-
-
0032780906
-
The interaction and transport of ß-lactam antibiotics with the cloned rat renal organic anion transporter 1
-
Jariyawat S, Sekine T, Takeda M et al (1999) The interaction and transport of ß-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther 290:672-677
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.290
, pp. 672-677
-
-
Jariyawat, S.1
Sekine, T.2
Takeda, M.3
-
114
-
-
0035991421
-
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy
-
Ji L, Masuda S, Saito H, Inui K (2002) Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int 62:514-524
-
(2002)
Kidney Int.
, vol.62
, pp. 514-524
-
-
Ji, L.1
Masuda, S.2
Saito, H.3
Inui, K.4
-
115
-
-
33748894676
-
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
-
Jigorel E, Le Vee M, Boursier-Neyret C et al (2006) Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos 34:1756-1763
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 1756-1763
-
-
Jigorel, E.1
Le Vee, M.2
Boursier-Neyret, C.3
-
116
-
-
33646561528
-
Interaction of zalcitabine with human organic anion transporter 1
-
Jin MJ, Han HK (2006) Interaction of zalcitabine with human organic anion transporter 1. Pharmazie 61:491-492
-
(2006)
Pharmazie
, vol.61
, pp. 491-492
-
-
Jin, M.J.1
Han, H.K.2
-
117
-
-
0035929163
-
Characterization of ochratoxin A transport by human organic anion transporters
-
Jung KY, Takeda M, Kim DK et al (2001) Characterization of ochratoxin A transport by human organic anion transporters. Life Sci 69:2123-2135
-
(2001)
Life Sci.
, vol.69
, pp. 2123-2135
-
-
Jung, K.Y.1
Takeda, M.2
Kim, D.K.3
-
118
-
-
18344371636
-
Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: In comparison with rOAT1
-
Jung KY, Takeda M, Shimoda M et al. (2002) Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci 70:1861-1874
-
(2002)
Life Sci.
, vol.70
, pp. 1861-1874
-
-
Jung, K.Y.1
Takeda, M.2
Shimoda, M.3
-
119
-
-
34547196949
-
Structural variation governs substrate specificity for organic anion transporter (OAT) homologs
-
Kaler G, Truong DM, Khandelwal A et al (2007) Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. J Biol Chem 282:23841-23853
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 23841-23853
-
-
Kaler, G.1
Truong, D.M.2
Khandelwal, A.3
-
120
-
-
33750821441
-
Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions
-
Kaler G, Truong DM, Sweeney DE et al (2007) Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochem Biophys Res Commun 351:872-876
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.351
, pp. 872-876
-
-
Kaler, G.1
Truong, D.M.2
Sweeney, D.E.3
-
121
-
-
0036073213
-
Gender difference in the urinary excretion of organic anions in rats
-
Kato Y, Kuge K, Kusuhara H et al (2002) Gender difference in the urinary excretion of organic anions in rats. J Pharmacol Exp Ther 302:483-489
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.302
, pp. 483-489
-
-
Kato, Y.1
Kuge, K.2
Kusuhara, H.3
-
122
-
-
6344251595
-
Screening of the interaction between xenobiotic transporters and PDZ proteins
-
Kato Y, Yoshida K, Watanabe C et al (2004) Screening of the interaction between xenobiotic transporters and PDZ proteins. Pharm Res 21:1886-1894
-
(2004)
Pharm. Res.
, vol.21
, pp. 1886-1894
-
-
Kato, Y.1
Yoshida, K.2
Watanabe, C.3
-
123
-
-
42049096315
-
Cell free expression and functional reconstitution of eukaryotic drug transporters
-
Keller T, Schwarz D, Bernhard F et al (2008) Cell free expression and functional reconstitution of eukaryotic drug transporters. Biochemistry 47:4552-4564
-
(2008)
Biochemistry
, vol.47
, pp. 4552-4564
-
-
Keller, T.1
Schwarz, D.2
Bernhard, F.3
-
124
-
-
0036827850
-
Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs
-
DOI 10.1124/jpet.102.037580
-
Khamdang S, Takeda M, Noshiro R et al (2002) Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 303:534-539 (Pubitemid 35231223)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.303
, Issue.2
, pp. 534-539
-
-
Khamdang, S.1
Takeda, M.2
Noshiro, R.3
Narikawa, S.4
Enomoto, A.5
Anzai, N.6
Piyachaturawat, P.7
Endou, H.8
-
125
-
-
10744219672
-
Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics
-
Khamdang S, Takeda M, Babu E et al (2003) Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol 465:1-7
-
(2003)
Eur. J. Pharmacol.
, vol.465
, pp. 1-7
-
-
Khamdang, S.1
Takeda, M.2
Babu, E.3
-
126
-
-
1642422265
-
Interaction of human-and rat-organic anion transporters with pravastatin and cimetidine
-
Khamdang S, Takeda M, Shimoda M (2004) Interaction of human-and rat-organic anion transporters with pravastatin and cimetidine. J Pharmacol Sci 94:197-202
-
(2004)
J. Pharmacol. Sci.
, vol.94
, pp. 197-202
-
-
Khamdang, S.1
Takeda, M.2
Shimoda, M.3
-
127
-
-
0038274495
-
Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier
-
Kikuchi R, Kusuhara H, Sugiyama D, Sugiyama Y (2003) Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier. J Pharmacol Exp Ther 306:51-58
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.306
, pp. 51-58
-
-
Kikuchi, R.1
Kusuhara, H.2
Sugiyama, D.3
Sugiyama, Y.4
-
128
-
-
33747606242
-
Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1a/b and DNA methylation
-
Kikuchi R, Kusuhara H, Hattori N et al (2006) Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1a/b and DNA methylation. Mol Pharm 70:887-896
-
(2006)
Mol. Pharm.
, vol.70
, pp. 887-896
-
-
Kikuchi, R.1
Kusuhara, H.2
Hattori, N.3
-
129
-
-
36348965458
-
Regulation of the tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1a/b and DNA methylation
-
Kikuchi R, Kusuhara H, Hattori N et al (2007) Regulation of the tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1a/b and DNA methylation. Mol Pharm 72:1619-1925
-
(2007)
Mol. Pharm.
, vol.72
, pp. 1619-1925
-
-
Kikuchi, R.1
Kusuhara, H.2
Hattori, N.3
-
130
-
-
0042665566
-
Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney
-
Kim G-H, Na KY, Kim S-Y et al (2003) Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney. Nephrol Dial Transplant 18:1505-1511
-
(2003)
Nephrol. Dial. Transplant.
, vol.18
, pp. 1505-1511
-
-
Kim, G.-H.1
Na, K.Y.2
Kim, S.-Y.3
-
131
-
-
0036198625
-
Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins
-
DOI 10.1124/jpet.301.1.293
-
Kimura H, Takeda M, Narikawa S et al (2002) Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther 301:293-298 (Pubitemid 34250307)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.301
, Issue.1
, pp. 293-298
-
-
Kimura, H.1
Takeda, M.2
Narikawa, S.3
Enomoto, A.4
Ichida, K.5
Endou, H.6
-
132
-
-
33644664085
-
Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1
-
Kimura N, Masuda S, Tanihara Y et al (2005) Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet 20:379-386
-
(2005)
Drug Metab. Pharmacokinet.
, vol.20
, pp. 379-386
-
-
Kimura, N.1
Masuda, S.2
Tanihara, Y.3
-
133
-
-
35748934165
-
Development and characterization of immobilized human organic anion transporter based liquid chromatography stationary phase: Hoat1 and hOAT2
-
Kimura T, Perry J, Anzai N et al (2007) Development and characterization of immobilized human organic anion transporter based liquid chromatography stationary phase: hOAT1 and hOAT2. J Chromatogr B 15:267-271
-
(2007)
J. Chromatogr. B
, vol.15
, pp. 267-271
-
-
Kimura, T.1
Perry, J.2
Anzai, N.3
-
134
-
-
0036296016
-
Differential gene expression of organic anion transporters in male and female rats
-
Kobayashi Y, Hirokawa N, Ohshiro N et al (2002) Differential gene expression of organic anion transporters in male and female rats. Biochem Biophys Res Commun 290:482-487
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.290
, pp. 482-487
-
-
Kobayashi, Y.1
Hirokawa, N.2
Ohshiro, N.3
-
135
-
-
0036084956
-
Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice
-
Kobayashi Y, Ohshiro N, Shibusawa T et al (2002) Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol 62:7-14
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 7-14
-
-
Kobayashi, Y.1
Ohshiro, N.2
Shibusawa, T.3
-
136
-
-
2042542061
-
Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOAT3): Further substrate specificity of mOAT3
-
Kobayashi Y, Ohshiro N, Tsuchiya A et al (2004) Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOAT3): further substrate specificity of mOAT3. Drug Metab Dispos 32:479-483
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 479-483
-
-
Kobayashi, Y.1
Ohshiro, N.2
Tsuchiya, A.3
-
137
-
-
17644380567
-
Transport mechanism and substrate specificity of human organic anion transporter 2 (hOAT2[SLC22A7])
-
Kobayashi Y, Ohshiro N, Sakai R et al (2005) Transport mechanism and substrate specificity of human organic anion transporter 2 (hOAT2[SLC22A7]). J Pharm Pharmacol 57:573-578
-
(2005)
J. Pharm. Pharmacol.
, vol.57
, pp. 573-578
-
-
Kobayashi, Y.1
Ohshiro, N.2
Sakai, R.3
-
139
-
-
0036206004
-
Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney
-
Kojima R, Sekine T, Kawachi M et al (2002) Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol 13:848-857
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 848-857
-
-
Kojima, R.1
Sekine, T.2
Kawachi, M.3
-
140
-
-
3142674476
-
The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia
-
Komoda F, Sekine T, Inatomi J et al (2004) The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia. Pediatr Nephrol 19:728-733
-
(2004)
Pediatr. Nephrol.
, vol.19
, pp. 728-733
-
-
Komoda, F.1
Sekine, T.2
Inatomi, J.3
-
141
-
-
0033532065
-
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
-
Kusuhara H, Sekine T, Utsunomiya-Tate N et al (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13675-13680
-
-
Kusuhara, H.1
Sekine, T.2
Utsunomiya-Tate, N.3
-
142
-
-
0033555578
-
Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells
-
Kuze K, Graves P, Leahy A et al (1999) Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem 274:1519-1524
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 1519-1524
-
-
Kuze, K.1
Graves, P.2
Leahy, A.3
-
143
-
-
27744444788
-
Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter
-
Kwak J-O, Kim H-W, Oh K-J et al (2005) Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter. J Steroid Biochem Mol Biol 97:369-375
-
(2005)
J. Steroid Biochem. Mol. Biol.
, vol.97
, pp. 369-375
-
-
Kwak, J.-O.1
Kim, H.-W.2
Oh, K.-J.3
-
144
-
-
22244453727
-
Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney
-
Kwak J-O, Kim H-W, Oh K-J et al (2005) Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney. Exp Mol Med 37:204-212
-
(2005)
Exp. Mol. Med.
, vol.37
, pp. 204-212
-
-
Kwak, J.-O.1
Kim, H.-W.2
Oh, K.-J.3
-
145
-
-
34248997530
-
Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts
-
Kwon O, Hong S-M, Blouch K (2007) Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts. J Histochem Cytochem 55:575-584
-
(2007)
J. Histochem. Cytochem.
, vol.55
, pp. 575-584
-
-
Kwon, O.1
Hong, S.-M.2
Blouch, K.3
-
146
-
-
0031716603
-
Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys
-
Lacy SA, Hitchcock M J M, Lee WA et al (1998) Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys. Toxicol Sci 44:97-106
-
(1998)
Toxicol. Sci.
, vol.44
, pp. 97-106
-
-
Lacy, S.A.1
Hitchcock, M.J.M.2
Lee, W.A.3
-
147
-
-
0028936048
-
(S)-1-[3-hydroxy-2-(phosphonylmethoxy) propyl] cytosine (Cidofovir): Results of a phase I/II study of a novel antiviral nucleotide analogue
-
Lalezari JP, Drew WL, Glutzer E et al (1995) (S)-1-[3-hydroxy-2- (phosphonylmethoxy) propyl] cytosine (Cidofovir): results of a phase I/II study of a novel antiviral nucleotide analogue. J Infect Dis 171:788-796
-
(1995)
J. Infect. Dis.
, vol.171
, pp. 788-796
-
-
Lalezari, J.P.1
Drew, W.L.2
Glutzer, E.3
-
148
-
-
0037309819
-
The presence of xenobiotic transporters in the placenta
-
Leazer TM, Klaassen CD (2003) The presence of xenobiotic transporters in the placenta. Drug Metab Dispos 31:153-167
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 153-167
-
-
Leazer, T.M.1
Klaassen, C.D.2
-
150
-
-
9244264985
-
Molecular cloning and characterization of a human urate transporter (hURAT1) gene promoter
-
DOI 10.1016/j.bbaexp.2004.10.001, PII S0167478104002118
-
Li T, Walsh JR, Ghishan FK, Bai L (2004) Molecular cloning and characterization of a human urate transporter (hURAT1) gene promoter. Biochim Biophys Acta 1681:53-58 (Pubitemid 39550371)
-
(2004)
Biochimica et Biophysica Acta - Gene Structure and Expression
, vol.1681
, Issue.1
, pp. 53-58
-
-
Li, T.1
Walsh, J.R.2
Ghishan, F.K.3
Bai, L.4
-
151
-
-
33747834042
-
Drug-drug interactions involving membrane transporters in the human kidney
-
Li M, Anderson GD, Wang J (2006) Drug-drug interactions involving membrane transporters in the human kidney. Expert Opin Drug Metab Toxicol 2:505-532
-
(2006)
Expert Opin. Drug Metab. Toxicol.
, vol.2
, pp. 505-532
-
-
Li, M.1
Anderson, G.D.2
Wang, J.3
-
152
-
-
56149092989
-
Effects of angiotensin II receptor blockers on renal handling of uric acid in rats
-
Li Y, Sato M, Yanagisawa Y et al (2008) Effects of angiotensin II receptor blockers on renal handling of uric acid in rats. Drug Metab Pharmacokinet 23:263-270
-
(2008)
Drug Metab. Pharmacokinet.
, vol.23
, pp. 263-270
-
-
Li, Y.1
Sato, M.2
Yanagisawa, Y.3
-
153
-
-
2942675119
-
Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition
-
Ljubojevic M, Herak-Kramberger CM, Hagos Y et al (2004) Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am J Physiol Renal Physiol 287: F124-F138
-
(2004)
Am. J. Physiol. Renal Physiol.
, vol.287
-
-
Ljubojevic, M.1
Herak-Kramberger, C.M.2
Hagos, Y.3
-
154
-
-
33846265359
-
Renal expression of organic anion transporter Oat2 in rats and mice is regulated by sex hormones
-
Ljubojevic M, Balen D, Breljak D et al (2007) Renal expression of organic anion transporter Oat2 in rats and mice is regulated by sex hormones. Am J Physiol Renal Physiol 292: F361-F372
-
(2007)
Am. J. Physiol. Renal Physiol.
, vol.292
-
-
Ljubojevic, M.1
Balen, D.2
Breljak, D.3
-
155
-
-
0030940999
-
Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
-
Lopez-Nieto CE, You GF, Bush KT et al (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 272:6471-6478
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6471-6478
-
-
Lopez-Nieto, C.E.1
You, G.F.2
Bush, K.T.3
-
156
-
-
0032995116
-
Cloning of the human PAH transporter: Narrow substrate specificity and regulation by protein kinase C
-
Lu R, Chan BS, Schuster VL (1999) Cloning of the human PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol Renal Physiol 276: F295-F303
-
(1999)
Am. J. Physiol. Renal Physiol.
, vol.276
-
-
Lu, R.1
Chan, B.S.2
Schuster, V.L.3
-
157
-
-
33745952758
-
Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha
-
Maher JM, Slitt AL, Callaghan TN et al (2006) Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. Biochem Pharmacol 72:512-522
-
(2006)
Biochem. Pharmacol.
, vol.72
, pp. 512-522
-
-
Maher, J.M.1
Slitt, A.L.2
Callaghan, T.N.3
-
158
-
-
40949103171
-
Renal and hepatic transporter expression in type 2 diabetic rats
-
Manautou JE, Nowicki MT, Aleksunes LM et al (2008) Renal and hepatic transporter expression in type 2 diabetic rats. Drug Metab Lett 2:11-17
-
(2008)
Drug Metab. Lett.
, vol.2
, pp. 11-17
-
-
Manautou, J.E.1
Nowicki, M.T.2
Aleksunes, L.M.3
-
159
-
-
34548103253
-
Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy- camptothecin hydrochloride]
-
Matsumoto S, Yoshida K, Ishiguro N et al (2007) Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]. J Pharmacol Exp Ther 322:1246-1252
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.322
, pp. 1246-1252
-
-
Matsumoto, S.1
Yoshida, K.2
Ishiguro, N.3
-
160
-
-
33947114449
-
Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute renal failure
-
Matsuzaki T, Watanabe H, Yoshitome K et al (2007) Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute renal failure. Kidney Int 71:539-547
-
(2007)
Kidney Int.
, vol.71
, pp. 539-547
-
-
Matsuzaki, T.1
Watanabe, H.2
Yoshitome, K.3
-
161
-
-
47949121279
-
Role of the organic anion transporters in the pharmacokinetics of zonampanel, and α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist, in rats
-
Minematsu T, Hashimoto T, Aoki T et al (2008) Role of the organic anion transporters in the pharmacokinetics of zonampanel, and α-amino-3-hydroxy- 5-methylisoxazole-4-propionate receptor antagonist, in rats. Drug Metab Dispos 36:1496-1504
-
(2008)
Drug Metab. Dispos
, vol.36
, pp. 1496-1504
-
-
Minematsu, T.1
Hashimoto, T.2
Aoki, T.3
-
162
-
-
33645909146
-
Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins
-
Miyazaki H, Anzai N, Ekaratanawong S et al (2005) Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins. J Am Soc Nephrol 16:3498-3506
-
(2005)
J. Am. Soc. Nephrol.
, vol.16
, pp. 3498-3506
-
-
Miyazaki, H.1
Anzai, N.2
Ekaratanawong, S.3
-
163
-
-
0042468096
-
Impact of drug transporter studies on drug discovery and development
-
Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (2003) Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 55:425-461
-
(2003)
Pharmacol. Rev.
, vol.55
, pp. 425-461
-
-
Mizuno, N.1
Niwa, T.2
Yotsumoto, Y.3
Sugiyama, Y.4
-
164
-
-
4544322271
-
Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa
-
Monte JC, Nagle MA, Eraly SA, Nigam SK (2004) Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 323:429-436
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.323
, pp. 429-436
-
-
Monte, J.C.1
Nagle, M.A.2
Eraly, S.A.3
Nigam, S.K.4
-
165
-
-
0030772953
-
Kidney-specific expression of a novel mouse organic cation transporter-like protein
-
Mori K, Ogawa Y, Ebihara K et al (1997) Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett 417:371-374
-
(1997)
FEBS Lett.
, vol.417
, pp. 371-374
-
-
Mori, K.1
Ogawa, Y.2
Ebihara, K.3
-
166
-
-
0037383621
-
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells
-
Mori S, Takanaga H, Ohtsuki S et al (2003) Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab 23:432-440
-
(2003)
J. Cereb. Blood Flow Metab.
, vol.23
, pp. 432-440
-
-
Mori, S.1
Takanaga, H.2
Ohtsuki, S.3
-
167
-
-
4143113395
-
Organic anion transporter 3 is involved in the brain-toblood efflux transport of thiopurine nucleobase analogs
-
Mori S, Ohtsuki S, Takanaga H (2004) Organic anion transporter 3 is involved in the brain-toblood efflux transport of thiopurine nucleobase analogs. J Neurochem 90:931-941
-
(2004)
J. Neurochem.
, vol.90
, pp. 931-941
-
-
Mori, S.1
Ohtsuki, S.2
Takanaga, H.3
-
168
-
-
0034892457
-
Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells
-
Morita N, Kusuhara H, Sekine T et al (2001) Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther 298:1179-1184 (Pubitemid 32761937)
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.298
, Issue.3
, pp. 1179-1184
-
-
Morita, N.1
Kusuhara, H.2
Sekine, T.3
Endou, H.4
Sugiyama, Y.5
-
169
-
-
0036205460
-
Gene expression levels and immunolocalization of organic ion transporters in human kidney
-
Motohashi H, Sakurai Y, Saito H et al (2002) Gene expression levels and immunolocalization of organic ion transporters in human kidney. J Am Soc Nephrol 13:866-874
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 866-874
-
-
Motohashi, H.1
Sakurai, Y.2
Saito, H.3
-
170
-
-
7444254904
-
Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)
-
Motohashi H, Uwai Y, Hiramoto K et al (2004) Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol 503:25-30
-
(2004)
Eur. J. Pharmacol.
, vol.503
, pp. 25-30
-
-
Motohashi, H.1
Uwai, Y.2
Hiramoto, K.3
-
171
-
-
0036179812
-
Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake
-
Motojima M, Hosokawa A, Yamato H et al (2002) Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake. Br J Pharmacol 135:555-563
-
(2002)
Br. J. Pharmacol.
, vol.135
, pp. 555-563
-
-
Motojima, M.1
Hosokawa, A.2
Yamato, H.3
-
172
-
-
0033815816
-
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1
-
Mulato AS, Ho ES, Cihlar T (2000) Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther 295:10-15
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 10-15
-
-
Mulato, A.S.1
Ho, E.S.2
Cihlar, T.3
-
173
-
-
0036235889
-
Expression and functional characterization of rat organic anion transporter 3 (rOAT3) in the choroid plexus
-
Nagata Y, Kusuhara H, Endou H, Sugiyama Y (2002) Expression and functional characterization of rat organic anion transporter 3 (rOAT3) in the choroid plexus. Mol Pharmacol 61:982-988
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 982-988
-
-
Nagata, Y.1
Kusuhara, H.2
Endou, H.3
Sugiyama, Y.4
-
174
-
-
34147133352
-
Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans
-
Nakagomi-Hagihara R, Nakai D, Tokiu T (2007) Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans. Xenobiotica 37:416-426
-
(2007)
Xenobiotica
, vol.37
, pp. 416-426
-
-
Nakagomi-Hagihara, R.1
Nakai, D.2
Tokiu, T.3
-
175
-
-
0034030211
-
Developmental changes in multispecific organic anion transporter 1 expression in rat kidney
-
Nakajima N, Sekine T, Cha SH et al (2000) Developmental changes in multispecific organic anion transporter 1 expression in rat kidney. Kidney Int 57:1608-1616
-
(2000)
Kidney Int.
, vol.57
, pp. 1608-1616
-
-
Nakajima, N.1
Sekine, T.2
Cha, S.H.3
-
177
-
-
33847101474
-
Down-regulation of intestinal drug transporters in chronic renal failure in rats
-
Naud J, Michaud J, Boisvert C et al (2007) Down-regulation of intestinal drug transporters in chronic renal failure in rats. J Pharmacol Exp Ther 320:978-985
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.320
, pp. 978-985
-
-
Naud, J.1
Michaud, J.2
Boisvert, C.3
-
178
-
-
33846562050
-
Role of mouse organic anion transporter 3 (mOAT3) as a basolateral prostaglandin E2 transport pathway
-
Nilwarangkoon S, Anzai N, Shiraya K (2007) Role of mouse organic anion transporter 3 (mOAT3) as a basolateral prostaglandin E2 transport pathway. J Pharmacol Sci 103:48-55
-
(2007)
J. Pharmacol. Sci.
, vol.103
, pp. 48-55
-
-
Nilwarangkoon, S.1
Anzai, N.2
Shiraya, K.3
-
179
-
-
33644854071
-
Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter families
-
Nishimura M, Naito S (2005) Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter families. Drug Metab Pharmacokinet 20:452-477
-
(2005)
Drug Metab. Pharmacokinet.
, vol.20
, pp. 452-477
-
-
Nishimura, M.1
Naito, S.2
-
180
-
-
0032469687
-
Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORTCL4, bearing homology to organic-cation transporters
-
Nishiwaki T, Daigo Y, Tamari M et al (1998) Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORTCL4, bearing homology to organic-cation transporters. Cytogenet Cell Genet 83:251-255
-
(1998)
Cytogenet. Cell. Genet.
, vol.83
, pp. 251-255
-
-
Nishiwaki, T.1
Daigo, Y.2
Tamari, M.3
-
181
-
-
0038209381
-
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
-
DOI 10.1016/S0009-9236(03)00060-2
-
Nishizato Y, Ieiri I, Suzuki H et al (2003) Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. Clin Pharmacol Ther 73:554-565 (Pubitemid 37249126)
-
(2003)
Clinical Pharmacology and Therapeutics
, vol.73
, Issue.6
, pp. 554-565
-
-
Nishizato, Y.1
Ieiri, I.2
Suzuki, H.3
Kimura, M.4
Kawabata, K.5
Hirota, T.6
Takane, H.7
Irie, S.8
Kusuhara, H.9
Urasaki, Y.10
Urae, A.11
Higuchi, S.12
Otsubo, K.13
Sugiyama, Y.14
-
182
-
-
1642388976
-
Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporter and reduced folate transporter
-
Nozaki Y, Kusuhara H, Endou H, Sugiyama Y (2004) Quantitative evaluation of the drug-drug interactions between methotrexate and nonsteroidal anti-inflammatory drugs in the renal uptake process based on the contribution of organic anion transporter and reduced folate transporter. J Pharmacol Exp Ther 309:226-234
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.309
, pp. 226-234
-
-
Nozaki, Y.1
Kusuhara, H.2
Endou, H.3
Sugiyama, Y.4
-
183
-
-
33947426344
-
Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices
-
Nozaki Y, Kusuhara H, Kondo T et al (2007) Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices. J Pharmacol Exp Ther 321:362-369
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.321
, pp. 362-369
-
-
Nozaki, Y.1
Kusuhara, H.2
Kondo, T.3
-
184
-
-
34548103547
-
Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices
-
Nozaki Y, Kusuhara H, Kondo T et al (2007) Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices. J Pharmacol Exp Ther 322:1162-1170
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.322
, pp. 1162-1170
-
-
Nozaki, Y.1
Kusuhara, H.2
Kondo, T.3
-
185
-
-
57149091788
-
Elevated uric acid increases the risk for kidney disease
-
Obermayr RP, Temml C, Gutjahr G et al (2008) Elevated uric acid increases the risk for kidney disease. J Am Soc Nephrol 19:2407-2413
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
, pp. 2407-2413
-
-
Obermayr, R.P.1
Temml, C.2
Gutjahr, G.3
-
186
-
-
33749030747
-
Human organic anion transporter 3 gene is regulated constitutively and inducibly via a cAMP-responsive element
-
Ogasawara K, Terada T, Asaka J-I et al (2006) Human organic anion transporter 3 gene is regulated constitutively and inducibly via a cAMP-responsive element. J Pharmacol Exp Ther 319:317-322
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.319
, pp. 317-322
-
-
Ogasawara, K.1
Terada, T.2
Asaka, J.-I.3
-
187
-
-
34447634890
-
Hepatocyte nuclear factor-4a regulates the human organic anion transporter 1 gene in the kidney
-
Ogasawara K, Terada T, Asaka J-I et al (2007) Hepatocyte nuclear factor-4a regulates the human organic anion transporter 1 gene in the kidney. Am J Physiol Renal Physiol 292: F1819-F1826
-
(2007)
Am. J. Physiol. Renal Physiol.
, vol.292
-
-
Ogasawara, K.1
Terada, T.2
Asaka, J.-I.3
-
188
-
-
46149091944
-
Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney
-
Ogasawara K, Terada T, Motohashi H et al (2008) Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney. J Hum Genet 53:607-614
-
(2008)
J. Hum. Genet.
, vol.53
, pp. 607-614
-
-
Ogasawara, K.1
Terada, T.2
Motohashi, H.3
-
189
-
-
0036788234
-
Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: Its involvement in neurotransmitter metabolite clearance from the brain
-
Ohtsuki S, Asaba H, Takanaga H et al (2002) Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem 83:57-66
-
(2002)
J. Neurochem.
, vol.83
, pp. 57-66
-
-
Ohtsuki, S.1
Asaba, H.2
Takanaga, H.3
-
190
-
-
2442720194
-
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier
-
Ohtsuki S, Kikkawa T, Mori S et al (2004) Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther 309:1273-1281
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.309
, pp. 1273-1281
-
-
Ohtsuki, S.1
Kikkawa, T.2
Mori, S.3
-
192
-
-
0034004157
-
Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct
-
Pavlova A, Sakurai H, Leclercq B et al (2000) Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Am J Physiol Renal Physiol 278: F635-F643
-
(2000)
Am. J. Physiol. Renal Physiol.
, vol.278
-
-
Pavlova, A.1
Sakurai, H.2
Leclercq, B.3
-
193
-
-
33846010171
-
A three-dimensional model of human organic anion transporter 1. Aromatic amino acids required for substrate transport
-
Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB (2006) A three-dimensional model of human organic anion transporter 1. Aromatic amino acids required for substrate transport. J Biol Chem 281:38071-38079
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 38071-38079
-
-
Perry, J.L.1
Dembla-Rajpal, N.2
Hall, L.A.3
Pritchard, J.B.4
-
194
-
-
33846454704
-
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans
-
Pfohl-Leszkowics A, Manderville RA (2007) Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans. Mol Nutr Food Res 51:61-99
-
(2007)
Mol. Nutr. Food Res.
, vol.51
, pp. 61-99
-
-
Pfohl-Leszkowics, A.1
Manderville, R.A.2
-
195
-
-
0034753085
-
Mercapturic acids (N-acetylcysteine-S-conjugates) as endogenous substrates for the renal organic anion transporter 1
-
Pombrio JM, Giangreco A, Li L et al (2001) Mercapturic acids (N-acetylcysteine-S-conjugates) as endogenous substrates for the renal organic anion transporter 1. Mol Pharmacol 60:1091-1099
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 1091-1099
-
-
Pombrio, J.M.1
Giangreco, A.2
Li, L.3
-
196
-
-
17844385785
-
The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4a and suppressed by bile acids
-
Popowski K, Eloranta JJ, Saborowski M et al (2005) The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4a and suppressed by bile acids. Mol Pharm 67:1629-1638
-
(2005)
Mol. Pharm.
, vol.67
, pp. 1629-1638
-
-
Popowski, K.1
Eloranta, J.J.2
Saborowski, M.3
-
197
-
-
33745821728
-
Human vascular smooth muscle cells express a urate transporter
-
Price KL, Sautin YY, Long DA et al (2006) Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol 17:1791-1795
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 1791-1795
-
-
Price, K.L.1
Sautin, Y.Y.2
Long, D.A.3
-
198
-
-
0033585013
-
Mechanism of organic anion transport across the apical membrane of choroid plexus
-
Pritchard JB, Sweet DH, Miller DS, Walden R (1999) Mechanism of organic anion transport across the apical membrane of choroid plexus. J Biol Chem 274:33382-33387
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33382-33387
-
-
Pritchard, J.B.1
Sweet, D.H.2
Miller, D.S.3
Walden, R.4
-
199
-
-
11244309788
-
Renal elimination of a novel and potent avb3 integrin antagonist in animals
-
Prueksaritanont T, Hochman JH, Meng Y et al (2004) Renal elimination of a novel and potent avb3 integrin antagonist in animals. Xenobiotica 34:1059-1974
-
(2004)
Xenobiotica
, vol.34
, pp. 1059-1974
-
-
Prueksaritanont, T.1
Hochman, J.H.2
Meng, Y.3
-
200
-
-
0033574034
-
Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)
-
Race JE, Grassl SM, Williams WJ, Holtzmann EJ (1999) Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun 255:508-514
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.255
, pp. 508-514
-
-
Race, J.E.1
Grassl, S.M.2
Williams, W.J.3
Holtzmann, E.J.4
-
201
-
-
0031785948
-
Cloning of a human renal p-aminohippurate transporter, hROAT
-
Reid G, Wolff NA, Dautzenberg FM, Burckhardt G (1998) Cloning of a human renal p-aminohippurate transporter, hROAT. Kidney Blood Press Res 21:233-237
-
(1998)
Kidney Blood Press Res.
, vol.21
, pp. 233-237
-
-
Reid, G.1
Wolff, N.A.2
Dautzenberg, F.M.3
Burckhardt, G.4
-
202
-
-
33847139479
-
Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
-
Rizwan AN, Burckhardt G (2007) Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 24:450-470
-
(2007)
Pharm. Res.
, vol.24
, pp. 450-470
-
-
Rizwan, A.N.1
Burckhardt, G.2
-
203
-
-
34250318936
-
The chloride dependence of human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid
-
Rizwan AN, Krick W, Burckhardt G (2007) The chloride dependence of human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid. J Biol Chem 282:13402-13409
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 13402-13409
-
-
Rizwan, A.N.1
Krick, W.2
Burckhardt, G.3
-
204
-
-
72049089059
-
Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: Pharmacological and toxicological implications
-
Epub 2009 Oct. 24
-
Saito H (2010) Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications. Pharmacol Ther 125(1):79-91, Epub 2009 Oct. 24
-
(2010)
Pharmacol. Ther.
, vol.125
, Issue.1
, pp. 79-91
-
-
Saito, H.1
-
205
-
-
38749113889
-
Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 a/b
-
Saji T, Kikuchi R, Kusuhara H et al (2008) Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 a/b. J Pharmacol Exp Ther 324:784-790
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.324
, pp. 784-790
-
-
Saji, T.1
Kikuchi, R.2
Kusuhara, H.3
-
206
-
-
1642539149
-
Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases
-
Sakurai Y, Motohashi H, Ueo H et al (2004) Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res 21:61-67
-
(2004)
Pharm. Res.
, vol.21
, pp. 61-67
-
-
Sakurai, Y.1
Motohashi, H.2
Ueo, H.3
-
207
-
-
40549090278
-
Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers
-
Sato M, Iwanaga T, Mamada H et al (2008) Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res 25:639-646
-
(2008)
Pharm. Res.
, vol.25
, pp. 639-646
-
-
Sato, M.1
Iwanaga, T.2
Mamada, H.3
-
208
-
-
0036066084
-
Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA2, and COX1
-
Sauvant C, Holzinger H, Gekle M (2002) Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA2, and COX1. J Am Soc Nephrol 13:1981-1991
-
(2002)
J. Am. Soc. Nephrol.
, vol.13
, pp. 1981-1991
-
-
Sauvant, C.1
Holzinger, H.2
Gekle, M.3
-
210
-
-
1642376462
-
Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells
-
Sauvant C, Hesse D, Holzinger H et al (2004) Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells. Am J Physiol Renal Physiol 286: F774-F783
-
(2004)
Am. J. Physiol. Renal Physiol.
, vol.286
-
-
Sauvant, C.1
Hesse, D.2
Holzinger, H.3
-
211
-
-
33645457811
-
2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3
-
2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3. J Am Soc Nephrol 17:46-53
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 46-53
-
-
Sauvant, C.1
Holzinger, H.2
Gekle, M.3
-
213
-
-
34247885858
-
Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats
-
Schneider R, Sauvant C, Betz B et al (2007) Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats. Am J Physiol Renal Physiol 292: F1599-F1605
-
(2007)
Am. J. Physiol. Renal Physiol.
, vol.292
-
-
Schneider, R.1
Sauvant, C.2
Betz, B.3
-
214
-
-
71449084765
-
Low-dose indomethacin after ischemic acute kidney injury prevents down regulation of Oat1/3 and improves renal outcome
-
Schneider R, Meusel M, Renker S et al (2009) Low-dose indomethacin after ischemic acute kidney injury prevents down regulation of Oat1/3 and improves renal outcome. Am J Physiol Renal Physiol 297: F1614-F1621
-
(2009)
Am. J. Physiol. Renal Physiol.
, vol.297
-
-
Schneider, R.1
Meusel, M.2
Renker, S.3
-
215
-
-
0032549690
-
Molecular cloning and characterization of two novel transport proteins from rat kidney
-
Schömig E, Spitzenberger F, Engelhardt M et al (1998) Molecular cloning and characterization of two novel transport proteins from rat kidney. FEBS Lett 425:79-86
-
(1998)
FEBS Lett.
, vol.425
, pp. 79-86
-
-
Schömig, E.1
Spitzenberger, F.2
Engelhardt, M.3
-
216
-
-
0030855487
-
Expression cloning and characterization of a novel multispecific organic anion transporter
-
Sekine T, Watanabe N, Hosoyamada M et al (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18526-18529
-
-
Sekine, T.1
Watanabe, N.2
Hosoyamada, M.3
-
217
-
-
17144449057
-
Identification of multispecific organic anion transporter 2 expressed predominantly in liver
-
Sekine T, Cha SH, Tsuda N et al (1998) Identification of multispecific organic anion transporter 2 expressed predominantly in liver. FEBS Lett 429:179-182
-
(1998)
FEBS Lett.
, vol.429
, pp. 179-182
-
-
Sekine, T.1
Cha, S.H.2
Tsuda, N.3
-
219
-
-
70350710164
-
The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects
-
Shah MM, Tee JB, Meyer T et al (2009) The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol 297: F1330-F1341
-
(2009)
Am. J. Physiol. Renal Physiol.
, vol.297
-
-
Shah, M.M.1
Tee, J.B.2
Meyer, T.3
-
220
-
-
33748942990
-
Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats
-
Shibayama Y, Ushinohama K, Ikeda R et al (2006) Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats. Cancer Sci 96:1260-1266
-
(2006)
Cancer Sci.
, vol.96
, pp. 1260-1266
-
-
Shibayama, Y.1
Ushinohama, K.2
Ikeda, R.3
-
222
-
-
34247400616
-
Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate
-
Shin HJ, Anzai N, Enomoto A et al (2007) Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology 45:1046-1055
-
(2007)
Hepatology
, vol.45
, pp. 1046-1055
-
-
Shin, H.J.1
Anzai, N.2
Enomoto, A.3
-
223
-
-
13844314148
-
Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs
-
Shitara Y, Sato H, Sugiyama Y (2005) Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs. Annu Rev Pharmacol Toxicol 45:689-723
-
(2005)
Annu. Rev. Pharmacol. Toxicol.
, vol.45
, pp. 689-723
-
-
Shitara, Y.1
Sato, H.2
Sugiyama, Y.3
-
224
-
-
0028285029
-
Molecular cloning and characterization of a novel liver-specific transport protein
-
Simonson GD, Vincent AC, Roberg KJ et al (1994) Molecular cloning and characterization of a novel liver-specific transport protein. J Cell Sci 7:1065-1072
-
(1994)
J. Cell. Sci.
, vol.7
, pp. 1065-1072
-
-
Simonson, G.D.1
Vincent, A.C.2
Roberg, K.J.3
-
225
-
-
6344289334
-
Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules
-
Soodvilai S, Chatsudthipong V, Evans KK et al (2004) Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol 287: F1021-1029
-
(2004)
Am. J. Physiol. Renal Physiol.
, vol.287
-
-
Soodvilai, S.1
Chatsudthipong, V.2
Evans, K.K.3
-
226
-
-
26844436872
-
Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules
-
Soodvilai S, Wright SH, Dantzler WH, Chatsudthipong V (2005) Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol 289: F1057-F1064
-
(2005)
Am. J. Physiol. Renal Physiol.
, vol.289
-
-
Soodvilai, S.1
Wright, S.H.2
Dantzler, W.H.3
Chatsudthipong, V.4
-
227
-
-
18044390526
-
Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)
-
Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB (2005) Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). J Pharmacol Exp Ther 313:621-628
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.313
, pp. 621-628
-
-
Srimaroeng, C.1
Chatsudthipong, V.2
Aslamkhan, A.G.3
Pritchard, J.B.4
-
228
-
-
21244505457
-
Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices
-
Srimaroeng C, Jutabha P, Pritchard JB et al (2005) Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices. Pharm Res 22:858-866
-
(2005)
Pharm. Res.
, vol.22
, pp. 858-866
-
-
Srimaroeng, C.1
Jutabha, P.2
Pritchard, J.B.3
-
229
-
-
48749084010
-
Physiology, structure, and regulation of the cloned organic anion transporters
-
Srimaroeng C, Perry JL, Pritchard JB (2008) Physiology, structure, and regulation of the cloned organic anion transporters. Xenobiotica 38:889-935
-
(2008)
Xenobiotica
, vol.38
, pp. 889-935
-
-
Srimaroeng, C.1
Perry, J.L.2
Pritchard, J.B.3
-
230
-
-
23644457833
-
Structure-activity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites
-
Sugawara M, Mochizuki T, Takekuma Y, Miyazaki K (2005) Structure-activity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites. Biochim Biophys Acta 1714:85-92
-
(2005)
Biochim. Biophys. Acta
, vol.1714
, pp. 85-92
-
-
Sugawara, M.1
Mochizuki, T.2
Takekuma, Y.3
Miyazaki, K.4
-
231
-
-
0034978374
-
Characterization of the efflux transport of 17β-estradiol-D- 17β-glucuronide from the brain across the blood-brain barrier
-
Sugiyama D, Kusuhara H, Shitara Y et al (2001) Characterization of the efflux transport of 17ß-estradiol-D-17ß-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther 298:316-322 (Pubitemid 32574542)
-
(2001)
Journal of Pharmacology and Experimental Therapeutics
, vol.298
, Issue.1
, pp. 316-322
-
-
Sugiyama, D.1
Kusuhara, H.2
Shitara, Y.3
Abe, T.4
Meier, P.J.5
Sekine, T.6
Endou, H.7
Suzuki, H.8
Sugiyama, Y.9
-
233
-
-
17444420647
-
Organic anion transporter (Slc22a) family members as mediators of toxicity
-
Sweet DH (2005) Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicol Appl Pharmacol 204:198-215
-
(2005)
Toxicol. Appl. Pharmacol.
, vol.204
, pp. 198-215
-
-
Sweet, D.H.1
-
234
-
-
0030781076
-
Expression cloning and characterization of ROAT1
-
Sweet DH, Wolff NA, Pritchard JB (1997) Expression cloning and characterization of ROAT1. J Biol Chem 272:30088-30095
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30088-30095
-
-
Sweet, D.H.1
Wolff, N.A.2
Pritchard, J.B.3
-
235
-
-
0037178852
-
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice
-
Sweet DH, Miller DS, Pritchard JB et al (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277:26934-26943
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26934-26943
-
-
Sweet, D.H.1
Miller, D.S.2
Pritchard, J.B.3
-
237
-
-
33644499212
-
Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models
-
Sweet DH, Eraly SA, Vaughn DA et al (2006) Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Kidney Int 69:837-845
-
(2006)
Kidney Int.
, vol.69
, pp. 837-845
-
-
Sweet, D.H.1
Eraly, S.A.2
Vaughn, D.A.3
-
238
-
-
25644452793
-
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters
-
Tahara H, Kusuhara H, Endou H et al (2005) A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther 315:337-345
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 337-345
-
-
Tahara, H.1
Kusuhara, H.2
Endou, H.3
-
239
-
-
18044374088
-
Molecular cloning and functional analysis of OAT1 and OAT3 from Cynomolgus monkey kidney
-
Tahara H, Shono M, Kusuhara H et al (2005) Molecular cloning and functional analysis of OAT1 and OAT3 from Cynomolgus monkey kidney. Pharm Res 22:647-660
-
(2005)
Pharm. Res.
, vol.22
, pp. 647-660
-
-
Tahara, H.1
Shono, M.2
Kusuhara, H.3
-
240
-
-
33644749355
-
Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists
-
Tahara H, Kusuhara H, Chida M et al (2006) Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther 316:1187-1194
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.316
, pp. 1187-1194
-
-
Tahara, H.1
Kusuhara, H.2
Chida, M.3
-
241
-
-
33645798634
-
Inhibition of OAT3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid
-
Tahara H, Kusuhara H, Maeda K et al (2006) Inhibition of OAT3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. Drug Metab Dispos 34:743-747
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 743-747
-
-
Tahara, H.1
Kusuhara, H.2
Maeda, K.3
-
242
-
-
0033458777
-
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER9)-induced nephrotoxicity
-
Takeda M, Tojo A, Sekine T et al (1999) Role of organic anion transporter 1 (OAT1) in cephaloridine (CER9)-induced nephrotoxicity. Kidney Int 56:2128-2136
-
(1999)
Kidney Int.
, vol.56
, pp. 2128-2136
-
-
Takeda, M.1
Tojo, A.2
Sekine, T.3
-
243
-
-
0034731355
-
Hydrogen peroxide downregulates human organic anion transporters in the basolateral membrane of the proximal tubule
-
Takeda M, Hosoyamada M, Cha SH et al (2000) Hydrogen peroxide downregulates human organic anion transporters in the basolateral membrane of the proximal tubule. Life Sci 68:679-687
-
(2000)
Life Sci.
, vol.68
, pp. 679-687
-
-
Takeda, M.1
Hosoyamada, M.2
Cha, S.H.3
-
244
-
-
0034698403
-
Regulation by protein kinase C of organic anion transport driven by rat organic anion transporter 3 (rOAT3)
-
Takeda M, Sekine T, Endou H (2000) Regulation by protein kinase C of organic anion transport driven by rat organic anion transporter 3 (rOAT3). Life Sci 67:1087-1093
-
(2000)
Life Sci.
, vol.67
, pp. 1087-1093
-
-
Takeda, M.1
Sekine, T.2
Endou, H.3
-
245
-
-
0035843770
-
Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters
-
Takeda M, Narikawa S, Hosoyamada M et al (2001) Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur J Pharmacol 419:113-120
-
(2001)
Eur. J. Pharmacol.
, vol.419
, pp. 113-120
-
-
Takeda, M.1
Narikawa, S.2
Hosoyamada, M.3
-
246
-
-
0037040390
-
Interaction of human organic anion transporters with various cephalosporin antibiotics
-
DOI 10.1016/S0014-2999(02)01306-7, PII S0014299902013067
-
Takeda M, Babu E, Narikawa S, Endou H (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol 438:137-142 (Pubitemid 34241501)
-
(2002)
European Journal of Pharmacology
, vol.438
, Issue.3
, pp. 137-142
-
-
Takeda, M.1
Babu, E.2
Narikawa, S.3
Endou, H.4
-
248
-
-
0036175142
-
Human organic anion transporters and human organic cation transporters mediate renal antiviral transport
-
DOI 10.1124/jpet.300.3.918
-
Takeda M, Khamdang S, Narikawa S et al (2002) Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther 300:918-924 (Pubitemid 34164996)
-
(2002)
Journal of Pharmacology and Experimental Therapeutics
, vol.300
, Issue.3
, pp. 918-924
-
-
Takeda, M.1
Khamdang, S.2
Narikawa, S.3
Kimura, H.4
Kobayashi, Y.5
Yamamoto, T.6
Cha, S.H.O.7
Sekine, T.8
Endou, H.9
-
249
-
-
0036076780
-
Characterization of methotrexate transport and its drug interactions with human organic anion transporters
-
Takeda M, Khamdang S, Narikawa S et al (2002) Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther 302:666-671
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.302
, pp. 666-671
-
-
Takeda, M.1
Khamdang, S.2
Narikawa, S.3
-
250
-
-
0347318099
-
Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors
-
Takeda M, Noshiro R, Onozato ML et al (2004) Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors. Eur J Pharmacol 483:133-138
-
(2004)
Eur. J. Pharmacol.
, vol.483
, pp. 133-138
-
-
Takeda, M.1
Noshiro, R.2
Onozato, M.L.3
-
251
-
-
2442479788
-
Role of glycosylation in the organic anion transporter 1
-
DOI 10.1074/jbc.M400197200
-
Tanaka K, Xu W, Zhou F, You G (2004) Role of glycosylation in the organic anion transporter 1. J Biol Chem 279:14961-14966 (Pubitemid 38618888)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.15
, pp. 14961-14966
-
-
Tanaka, K.1
Xu, W.2
Zhou, F.3
You, G.4
-
252
-
-
0037727835
-
Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport
-
Terlouw SA, Masereeuw R, Russel F G M (2003) Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport. Biochem Pharmacol 265:1393-1404
-
(2003)
Biochem. Pharmacol.
, vol.265
, pp. 1393-1404
-
-
Terlouw, S.A.1
Masereeuw, R.2
Russel, F.G.M.3
-
253
-
-
0022613399
-
Clinical and pharmacokinetic evidence of a lifethreatening interaction between methotrexate and ketoprofen
-
Thyss A, Milano G, Kubar J et al (1986) Clinical and pharmacokinetic evidence of a lifethreatening interaction between methotrexate and ketoprofen. Lancet 1:256-258
-
(1986)
Lancet
, vol.1
, pp. 256-258
-
-
Thyss, A.1
Milano, G.2
Kubar, J.3
-
254
-
-
0032979273
-
Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney
-
Tojo A, Sekine T, Nakjima N et al (1999) Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J Am Soc Nephrol 10:464-471 (Pubitemid 29117627)
-
(1999)
Journal of the American Society of Nephrology
, vol.10
, Issue.3
, pp. 464-471
-
-
Tojo, A.1
Sekine, T.2
Nakajima, N.3
Hosoyamada, M.4
Kanai, Y.5
Kimura, K.6
Endou, H.7
-
255
-
-
63449108001
-
Renal elimination of organic anions in cholestasis
-
Torres AM (2008) Renal elimination of organic anions in cholestasis. World J Gastroenterol 14:6616-6621
-
(2008)
World J. Gastroenterol.
, vol.14
, pp. 6616-6621
-
-
Torres, A.M.1
-
256
-
-
43749115381
-
Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
-
Truong DM, Kaler G, Khandelwal A et al (2008) Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. J Biol Chem 283:8654-8663
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 8654-8663
-
-
Truong, D.M.1
Kaler, G.2
Khandelwal, A.3
-
257
-
-
0033060904
-
Transport of ochratoxin a by renal multispecific organic anion transporter 1
-
Tsuda M, Sekine T, Takeda M et al (1999) Transport of ochratoxin A by renal multispecific organic anion transporter 1. J Pharmacol Exp Ther 289:1301-1305 (Pubitemid 29246658)
-
(1999)
Journal of Pharmacology and Experimental Therapeutics
, vol.289
, Issue.3
, pp. 1301-1305
-
-
Tsuda, M.1
Sekine, T.2
Takeda, M.3
Cha, S.H.4
Kanai, Y.5
Kimura, M.6
Endou, H.7
-
258
-
-
0025355827
-
In vivo evidence for carrier-mediated uptake of ß-lactam antibiotics through organic anion transport systems in rat kidney and liver
-
Tsuji A, Terasaki T, Tamai I, Takeda K (1990) In vivo evidence for carrier-mediated uptake of ß-lactam antibiotics through organic anion transport systems in rat kidney and liver. J Pharmacol Exp Ther 253:315-320
-
(1990)
J. Pharmacol. Exp. Ther.
, vol.253
, pp. 315-320
-
-
Tsuji, A.1
Terasaki, T.2
Tamai, I.3
Takeda, K.4
-
259
-
-
24344461838
-
Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1
-
Ueo H, Motohashi H, Katsura T, Inui K-I (2005) Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol 70:1104-1113
-
(2005)
Biochem. Pharmacol.
, vol.70
, pp. 1104-1113
-
-
Ueo, H.1
Motohashi, H.2
Katsura, T.3
Inui, K.-I.4
-
260
-
-
34548022843
-
--dependent upregulation of human organic anion transporters: Different effects on transport kinetics between hOAT1 and hOAT3
-
DOI 10.1152/ajprenal.00376.2006
-
Ueo H, Motohashi H, Inui K (2007) Cl-dependent up-regulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3. Am J Physiol Renal Physiol 293: F391-F397 (Pubitemid 47345040)
-
(2007)
American Journal of Physiology - Renal Physiology
, vol.293
, Issue.1
-
-
Ueo, H.1
Motohashi, H.2
Katsura, T.3
Inui, K.-I.4
-
261
-
-
0037305411
-
Characterization and identification of steroid sulfate transporters in human placenta
-
Ugele B, St-Pierre MV, Pihusch M et al (2003) Characterization and identification of steroid sulfate transporters in human placenta. Am J Physiol Endocrinol Metab 284: E390-E398
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.284
-
-
Ugele, B.1
St-Pierre, M.V.2
Pihusch, M.3
-
262
-
-
47849114075
-
Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta
-
Ugele B, Bahn A, Rex-Haffner M (2008) Functional differences in steroid sulfate uptake of organic anion transporter 4 (OAT4) and organic anion transporting polypeptide 2B1 (OATP2B1) in human placenta. J Steroid Biochem Mol Biol 111:1-6
-
(2008)
J. Steroid Biochem. Mol. Biol.
, vol.111
, pp. 1-6
-
-
Ugele, B.1
Bahn, A.2
Rex-Haffner, M.3
-
263
-
-
0032717266
-
Gender differences in expression of organic cation transporter OCT2 in rat kidney
-
Urakami Y, Nakamura N, Takahashi K et al (1999) Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett 461:339-342
-
(1999)
FEBS Lett.
, vol.461
, pp. 339-342
-
-
Urakami, Y.1
Nakamura, N.2
Takahashi, K.3
-
264
-
-
32044435382
-
Functional genomics of membrane transporters in human populations
-
Urban TJ, Sebro R, Hurowitz EH et al (2006) Functional genomics of membrane transporters in human populations. Genome Res 16:2223-2230
-
(2006)
Genome Res.
, vol.16
, pp. 2223-2230
-
-
Urban, T.J.1
Sebro, R.2
Hurowitz, E.H.3
-
265
-
-
0031768564
-
Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney
-
Uwai Y, Okuda M, Takami K et al (1998) Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett 438:321-324
-
(1998)
FEBS Lett.
, vol.438
, pp. 321-324
-
-
Uwai, Y.1
Okuda, M.2
Takami, K.3
-
266
-
-
0034674381
-
Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1
-
Uwai Y, Saito H, Hashimoto Y, Inui K (2000) Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1. Eur J Pharmacol 398:193-197
-
(2000)
Eur. J. Pharmacol.
, vol.398
, pp. 193-197
-
-
Uwai, Y.1
Saito, H.2
Hashimoto, Y.3
Inui, K.4
-
267
-
-
0033803165
-
Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1
-
Uwai Y, Saito H, Hashimoto Y, Inui K (2000) Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther 295:261-265
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 261-265
-
-
Uwai, Y.1
Saito, H.2
Hashimoto, Y.3
Inui, K.4
-
268
-
-
0034560136
-
Interaction between methotrexate and nonsteroidal antiinflammatory drugs in organic anion transporter
-
Uwai Y, Saito H, Inui K (2000) Interaction between methotrexate and nonsteroidal antiinflammatory drugs in organic anion transporter. Eur J Pharmacol 409:31-36
-
(2000)
Eur. J. Pharmacol.
, vol.409
, pp. 31-36
-
-
Uwai, Y.1
Saito, H.2
Inui, K.3
-
269
-
-
16644373437
-
Methotrexate-loxoprofen interaction: Involvement of human organic anion transporters hOAT1 and hOAT3
-
Uwai Y, Taniguchi R, Motohashi H et al (2004) Methotrexate-loxoprofen interaction: Involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Dispos 19:369-374
-
(2004)
Drug Metab. Dispos
, vol.19
, pp. 369-374
-
-
Uwai, Y.1
Taniguchi, R.2
Motohashi, H.3
-
270
-
-
33947138325
-
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2)
-
Uwai Y, Ida H, Tsuji Y et al (2007) Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res 24:811-815
-
(2007)
Pharm. Res.
, vol.24
, pp. 811-815
-
-
Uwai, Y.1
Ida, H.2
Tsuji, Y.3
-
271
-
-
34249014286
-
Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3
-
Uwai Y, Motohashi H, Tsuji Y et al (2007) Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3. Biochem Pharmacol 74:161-168
-
(2007)
Biochem. Pharmacol.
, vol.74
, pp. 161-168
-
-
Uwai, Y.1
Motohashi, H.2
Tsuji, Y.3
-
272
-
-
54749112371
-
Organic anion transporter 3 contributes to the regulation of blood pressure
-
Vallon V, Eraly S, Wikoff WR et al (2008) Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol 19:1732-1740
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
, pp. 1732-1740
-
-
Vallon, V.1
Eraly, S.2
Wikoff, W.R.3
-
273
-
-
44949088665
-
Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics
-
Vallon V, Rieg T, Ahn SY et al (2008) Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol 294: F867-F873
-
(2008)
Am. J. Physiol. Renal Physiol.
, vol.294
-
-
Vallon, V.1
Rieg, T.2
Ahn, S.Y.3
-
276
-
-
0037406406
-
Review on uremic toxins: Classification, concentration, and interindividual variability
-
for the European Uremic Toxin Work Group EUTox
-
Vanholder R, De Smet R, Glorieux G, for the European Uremic Toxin Work Group (EUTox) et al (2003) Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 63:1934-1943
-
(2003)
Kidney Int.
, vol.63
, pp. 1934-1943
-
-
Vanholder, R.1
De Smet, R.2
Glorieux, G.3
-
277
-
-
35348889668
-
Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G
-
VanWert AL, Bailey RM, Sweet DH (2007) Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G. Am J Physiol Renal Physiol 293: F1332-F1341
-
(2007)
Am. J. Physiol. Renal Physiol.
, vol.293
-
-
VanWert, A.L.1
Bailey, R.M.2
Sweet, D.H.3
-
278
-
-
39149106149
-
Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: A gender specific impact on reduced folates
-
VanWert AL, Sweet DH (2007) Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact on reduced folates. Pharm Res 25:453-462
-
(2007)
Pharm. Res.
, vol.25
, pp. 453-462
-
-
VanWert, A.L.1
Sweet, D.H.2
-
279
-
-
45749158039
-
Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin
-
VanWert AL, Srimaroeng C, Sweet DH (2008) Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. Mol Pharm 74:122-131
-
(2008)
Mol. Pharm.
, vol.74
, pp. 122-131
-
-
VanWert, A.L.1
Srimaroeng, C.2
Sweet, D.H.3
-
280
-
-
75349105185
-
Organic anion transporters: Discovery, pharmacology, regulation and roles in pathopysiology
-
VanWert AL, Gionfriddo MR, Sweet DH (2010) Organic anion transporters: discovery, pharmacology, regulation and roles in pathopysiology. Biopharm Drug Dispos 31:1-71
-
(2010)
Biopharm. Drug Dispos
, vol.31
, pp. 1-71
-
-
VanWert, A.L.1
Gionfriddo, M.R.2
Sweet, D.H.3
-
281
-
-
32844454648
-
Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction
-
Villar SR, Brandoni A, Anzai N et al (2005) Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction. Kidney Int 68:2704-2713
-
(2005)
Kidney Int.
, vol.68
, pp. 2704-2713
-
-
Villar, S.R.1
Brandoni, A.2
Anzai, N.3
-
282
-
-
54449102183
-
Time course of organic anion excretion in rats with bilateral ureteral obstruction: Role of organic anion transporters (Oat1 and Oat3)
-
Villar SR, Brandoni A, Torres AM (2008) Time course of organic anion excretion in rats with bilateral ureteral obstruction: role of organic anion transporters (Oat1 and Oat3). Nephron Physiol 110: p45-p56
-
(2008)
Nephron Physiol.
, vol.110
-
-
Villar, S.R.1
Brandoni, A.2
Torres, A.M.3
-
284
-
-
0033849375
-
Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs
-
Wada S, Tsuda M, Sekine T et al (2000) Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther 294:844-849
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.294
, pp. 844-849
-
-
Wada, S.1
Tsuda, M.2
Sekine, T.3
-
285
-
-
34548060345
-
The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin
-
Windass AS, Lowes S, Wang Y, Brown C D A (2007) The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. J Pharmacol Exp Ther 322:1221-1227
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.322
, pp. 1221-1227
-
-
Windass, A.S.1
Lowes, S.2
Wang, Y.3
Brown, C.D.A.4
-
286
-
-
0030777903
-
Expression cloning and characterization of a renal organic anion transporter from winter flounder
-
Wolff NA, Werner A, Burkhardt S, Burckhardt G (1997) Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett 417:287-291
-
(1997)
FEBS Lett.
, vol.417
, pp. 287-291
-
-
Wolff, N.A.1
Werner, A.2
Burkhardt, S.3
Burckhardt, G.4
-
287
-
-
0042844712
-
Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization
-
Wolff NA, Thies K, Kuhnke N et al (2003) Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization. J Am Soc Nephrol 14:1959-1968
-
(2003)
J. Am. Soc. Nephrol.
, vol.14
, pp. 1959-1968
-
-
Wolff, N.A.1
Thies, K.2
Kuhnke, N.3
-
288
-
-
34548414188
-
Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of human kidney
-
Wolff NA, Burckhardt BC, Burckhardt G et al (2007) Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of human kidney. Nephrol Dial Transplant 22:2497-2503
-
(2007)
Nephrol. Dial. Transplant.
, vol.22
, pp. 2497-2503
-
-
Wolff, N.A.1
Burckhardt, B.C.2
Burckhardt, G.3
-
289
-
-
27144533245
-
Ontogeny of expression of organic anion transporters 1 and 3 in ovine fetal and neonatal kidney
-
Wood CE, Coursins R, Zhang D, Keller-Wood M (2005) Ontogeny of expression of organic anion transporters 1 and 3 in ovine fetal and neonatal kidney. Exp Biol Med 230:668-673
-
(2005)
Exp. Biol. Med.
, vol.230
, pp. 668-673
-
-
Wood, C.E.1
Coursins, R.2
Zhang, D.3
Keller-Wood, M.4
-
290
-
-
3042542425
-
Molecular and cellular physiology of renal organic cation and anion transport
-
Wright SH, Dantzler WB (2004) Molecular and cellular physiology of renal organic cation and anion transport. Physiol Rev 84:987-1049
-
(2004)
Physiol. Rev.
, vol.84
, pp. 987-1049
-
-
Wright, S.H.1
Dantzler, W.B.2
-
291
-
-
31644434086
-
Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT1 (RST)]
-
Xu G, Bhatnagar V, Wen G et al (2005) Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT1 (RST)]. Kidney Int 68:1491-1499
-
(2005)
Kidney Int.
, vol.68
, pp. 1491-1499
-
-
Xu, G.1
Bhatnagar, V.2
Wen, G.3
-
292
-
-
33845421704
-
Development of high-specificity antibodies against renal urate transporters using genetic immunization
-
Xu G, Chen X, Wu D et al (2006) Development of high-specificity antibodies against renal urate transporters using genetic immunization. J Biochem Mol Biol 39:696-702
-
(2006)
J. Biochem. Mol. Biol.
, vol.39
, pp. 696-702
-
-
Xu, G.1
Chen, X.2
Wu, D.3
-
293
-
-
33845983672
-
Functional role of the C-terminus of human organic anion transporter hOAT1
-
Xu G, Tanaka K, Sun A-Q, You G (2006) Functional role of the C-terminus of human organic anion transporter hOAT1. J Biol Chem 281:31178-31183
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 31178-31183
-
-
Xu, G.1
Tanaka, K.2
Sun, A.-Q.3
You, G.4
-
294
-
-
36348943537
-
Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor
-
Yamada A, Maeda K, Kamiyama E et al (2007) Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos 35:2166-2176
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 2166-2176
-
-
Yamada, A.1
Maeda, K.2
Kamiyama, E.3
-
295
-
-
33751224444
-
Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4
-
Yamashita F, Ohtani H, Koyabu N et al (2006) Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. J Pharm Pharmacol 58:1499-1505
-
(2006)
J. Pharm. Pharmacol.
, vol.58
, pp. 1499-1505
-
-
Yamashita, F.1
Ohtani, H.2
Koyabu, N.3
-
296
-
-
42549088613
-
Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct
-
Yokoyama H, Anzai N, Ljubojevic M et al (2008) Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct. Cell Physiol Biochem 21:269-278
-
(2008)
Cell. Physiol. Biochem.
, vol.21
, pp. 269-278
-
-
Yokoyama, H.1
Anzai, N.2
Ljubojevic, M.3
-
298
-
-
3242707822
-
Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney
-
Youngblood GL, Sweet DH (2004) Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol 287: F236-F244
-
(2004)
Am. J. Physiol. Renal Physiol.
, vol.287
-
-
Youngblood, G.L.1
Sweet, D.H.2
-
299
-
-
67649886935
-
Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril
-
Yuan H, Feng B, Yu Y et al (2009) Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril. J Pharmacol Exp Ther 330:191-197
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.330
, pp. 191-197
-
-
Yuan, H.1
Feng, B.2
Yu, Y.3
-
300
-
-
23944510034
-
Transport of N-acetyl-S-cysteine conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1
-
Zalups RK, Ahmad S (2005) Transport of N-acetyl-S-cysteine conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1. J Pharmacol Exp Ther 314:1158-1168
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.314
, pp. 1158-1168
-
-
Zalups, R.K.1
Ahmad, S.2
-
301
-
-
6344240973
-
Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule
-
Zhang X, Groves CE, Bahn A et al (2004) Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule. Am J Physiol Renal Physiol 287: F999-F1010
-
(2004)
Am. J. Physiol. Renal Physiol.
, vol.287
-
-
Zhang, X.1
Groves, C.E.2
Bahn, A.3
-
302
-
-
57749119509
-
Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin-and clathrin-dependent pathway
-
Zhang Q, Hong M, Duan P et al (2008) Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin-and clathrin-dependent pathway. J Biol Chem 283:32570-32579
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 32570-32579
-
-
Zhang, Q.1
Hong, M.2
Duan, P.3
-
303
-
-
9444256962
-
Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4)
-
DOI 10.1042/BJ20040751
-
Zhou F, Pan Z, Ma J, You G (2004) Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). Biochem J 384:87-92 (Pubitemid 39564164)
-
(2004)
Biochemical Journal
, vol.384
, Issue.1
, pp. 87-92
-
-
Zhou, F.1
Pan, Z.2
Ma, J.3
You, G.4
-
304
-
-
2142772675
-
The role of glycine residues in the function of human organic anion transporter 4
-
DOI 10.1124/mol.65.5.1141
-
Zhou F, Tanaka K, Pan Z et al (2004) The role of glycine residues in the function of human organic anion transporter 4. Mol Pharm 65:1141-1147 (Pubitemid 38543485)
-
(2004)
Molecular Pharmacology
, vol.65
, Issue.5
, pp. 1141-1147
-
-
Zhou, F.1
Tanaka, K.2
Pan, Z.3
Ma, J.4
You, G.5
-
305
-
-
14944353459
-
The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter OAT4
-
Zhou F, Xu W, Hong M et al (2005) The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter OAT4. Mol Pharm 67:868-876
-
(2005)
Mol. Pharm.
, vol.67
, pp. 868-876
-
-
Zhou, F.1
Xu, W.2
Hong, M.3
-
306
-
-
33644841714
-
Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells
-
Zhou F, Illsley NP, You G (2006) Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells. Eur J Pharm Sci 27:518-523
-
(2006)
Eur. J. Pharm. Sci.
, vol.27
, pp. 518-523
-
-
Zhou, F.1
Illsley, N.P.2
You, G.3
-
307
-
-
34547134693
-
Regulation of the human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells
-
Zhou F, Hong M, You G (2007) Regulation of the human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells. Am J Physiol Endocrinol Metab 293: E57-E61
-
(2007)
Am. J. Physiol. Endocrinol. Metab.
, vol.293
-
-
Zhou, F.1
Hong, M.2
You, G.3
-
308
-
-
39149097829
-
Comparison of the interaction of human organic anion transporter hOAT4 with PDZ proteins between kidney cells and placental cells
-
Zhou F, Xu W, Tanaka K, You G (2007) Comparison of the interaction of human organic anion transporter hOAT4 with PDZ proteins between kidney cells and placental cells. Pharm Res 25:475-480
-
(2007)
Pharm. Res.
, vol.25
, pp. 475-480
-
-
Zhou, F.1
Xu, W.2
Tanaka, K.3
You, G.4
-
309
-
-
69049119083
-
Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex
-
Zlender V, Breljak D, Ljubojevic M et al (2009) Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex. Toxicol Appl Pharmacol 239:284-296
-
(2009)
Toxicol. Appl. Pharmacol.
, vol.239
, pp. 284-296
-
-
Zlender, V.1
Breljak, D.2
Ljubojevic, M.3
|