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Volumn 2, Issue 4, 2006, Pages 505-532

Drug-drug interactions involving membrane transporters in the human kidney

Author keywords

Drug interactions; Drug transporters; Kidney; Organic anion transporters; Organic cation transporters; Pharmacokinetics

Indexed keywords

CLARITHROMYCIN; CYCLOSPORIN; DIGOXIN; ITRACONAZOLE; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; PROPAFENONE; QUINIDINE; RITONAVIR; TRIMETHOPRIM; VALSPODAR; VERAPAMIL; CARRIER PROTEIN; DRUG;

EID: 33747834042     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425255.2.4.505     Document Type: Review
Times cited : (71)

References (232)
  • 1
    • 13844314148 scopus 로고    scopus 로고
    • Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs
    • SHITARA Y, SATO H, SUGIYAMA Y: Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs. Ann. Rev. Pharmacol. Toxicol. (2005) 45:689-723.
    • (2005) Ann. Rev. Pharmacol. Toxicol , vol.45 , pp. 689-723
    • SHITARA, Y.1    SATO, H.2    SUGIYAMA, Y.3
  • 2
    • 0042391834 scopus 로고    scopus 로고
    • Transporter-mediated drug interactions
    • TSUJI A: Transporter-mediated drug interactions. Drug Metab. Pharmacokinet. (2002) 17(4):253-274.
    • (2002) Drug Metab. Pharmacokinet , vol.17 , Issue.4 , pp. 253-274
    • TSUJI, A.1
  • 4
    • 0031947633 scopus 로고    scopus 로고
    • Drug interactions at the renal level. Implications for drug development
    • BONATE PL, REITH K, WEIR S: Drug interactions at the renal level. Implications for drug development. Clin. Pharmacokinet. (1998) 34(5):375-404.
    • (1998) Clin. Pharmacokinet , vol.34 , Issue.5 , pp. 375-404
    • BONATE, P.L.1    REITH, K.2    WEIR, S.3
  • 5
    • 0027133590 scopus 로고
    • Mechanisms mediating renal secretion of organic anions and cations
    • PRITCHARD JB, MILLER DS: Mechanisms mediating renal secretion of organic anions and cations. Physiol. Rev. (1993) 73(4):765-796.
    • (1993) Physiol. Rev , vol.73 , Issue.4 , pp. 765-796
    • PRITCHARD, J.B.1    MILLER, D.S.2
  • 6
    • 3042542425 scopus 로고    scopus 로고
    • Molecular and cellular physiology of renal organic cation and anion transport
    • WRIGHT SH, DANTZLER WH: Molecular and cellular physiology of renal organic cation and anion transport. Physiol. Rev. (2004) 84(3):987-1049.
    • (2004) Physiol. Rev , vol.84 , Issue.3 , pp. 987-1049
    • WRIGHT, S.H.1    DANTZLER, W.H.2
  • 7
    • 0031800792 scopus 로고    scopus 로고
    • Role of organic cation transporters in drug absorption and elimination
    • ZHANG L, BRETT CM, GIACOMINI KM: Role of organic cation transporters in drug absorption and elimination. Ann. Rev. Pharmacol. Toxicol. (1998) 38:431-460.
    • (1998) Ann. Rev. Pharmacol. Toxicol , vol.38 , pp. 431-460
    • ZHANG, L.1    BRETT, C.M.2    GIACOMINI, K.M.3
  • 8
    • 0029820968 scopus 로고    scopus 로고
    • Peptide transporters in the intestine and the kidney
    • LEIBACH FH, GANAPATHY V: Peptide transporters in the intestine and the kidney. Ann. Rev. Nutr. (1996) 16:99-119.
    • (1996) Ann. Rev. Nutr , vol.16 , pp. 99-119
    • LEIBACH, F.H.1    GANAPATHY, V.2
  • 9
    • 1442302331 scopus 로고    scopus 로고
    • Mammalian nucleoside transporters
    • KONG W, ENGEL K, WANG J: Mammalian nucleoside transporters. Curr. Drug Metab. (2004) 5(1):63-84.
    • (2004) Curr. Drug Metab , vol.5 , Issue.1 , pp. 63-84
    • KONG, W.1    ENGEL, K.2    WANG, J.3
  • 10
    • 0033849976 scopus 로고    scopus 로고
    • Cellular and molecular aspects of drug transport in the kidney
    • INUI KI, MASUDA S, SAITO H: Cellular and molecular aspects of drug transport in the kidney. Kidney Int. (2000) 58(3):944-958.
    • (2000) Kidney Int , vol.58 , Issue.3 , pp. 944-958
    • INUI, K.I.1    MASUDA, S.2    SAITO, H.3
  • 11
    • 1342344851 scopus 로고    scopus 로고
    • Transporters and renal drug elimination
    • LEE W, KIM RB: Transporters and renal drug elimination. Ann. Rev. Pharmacol. Toxicol. (2004) 44:137-166.
    • (2004) Ann. Rev. Pharmacol. Toxicol , vol.44 , pp. 137-166
    • LEE, W.1    KIM, R.B.2
  • 12
    • 0035209269 scopus 로고    scopus 로고
    • Mechanisms and clinical implications of renal drug excretion
    • MASEREEUW R, RUSSEL FG: Mechanisms and clinical implications of renal drug excretion. Drug Metab. Rev. (2001) 33(3-4):299-351.
    • (2001) Drug Metab. Rev , vol.33 , Issue.3-4 , pp. 299-351
    • MASEREEUW, R.1    RUSSEL, F.G.2
  • 13
    • 29144523534 scopus 로고    scopus 로고
    • A human transporter protein that mediates the final excretion step for toxic organic cations
    • OTSUKA M, MATSUMOTO T, MORIMOTO R et al.: A human transporter protein that mediates the final excretion step for toxic organic cations. Proc. Natl. Acad. Sci. USA (2005) 102(50):17923-17928.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.50 , pp. 17923-17928
    • OTSUKA, M.1    MATSUMOTO, T.2    MORIMOTO, R.3
  • 14
    • 33644848884 scopus 로고    scopus 로고
    • Molecular physiology of renal organic anion transporters
    • SEKINE T, MIYAZAKI H, ENDOU H: Molecular physiology of renal organic anion transporters. Am. J. Physiol. Renal Physiol. (2006) 290(2):F251-F261.
    • (2006) Am. J. Physiol. Renal Physiol , vol.290 , Issue.2
    • SEKINE, T.1    MIYAZAKI, H.2    ENDOU, H.3
  • 15
    • 0036842911 scopus 로고    scopus 로고
    • Structure, function, and regulation of renal organic anion transporters
    • YOU G: Structure, function, and regulation of renal organic anion transporters. Med. Res. Rev. (2002) 22(6):602-616.
    • (2002) Med. Res. Rev , vol.22 , Issue.6 , pp. 602-616
    • YOU, G.1
  • 17
    • 0034817065 scopus 로고    scopus 로고
    • Isolation of a family of organic anion transporters from human liver and kidney
    • SUN W, WU RR, VAN POELJE PD, ERION MD: Isolation of a family of organic anion transporters from human liver and kidney. Biochem. Biophys. Res. Commun. (2001) 283(2):417-422.
    • (2001) Biochem. Biophys. Res. Commun , vol.283 , Issue.2 , pp. 417-422
    • SUN, W.1    WU, R.R.2    VAN POELJE, P.D.3    ERION, M.D.4
  • 18
    • 0036205460 scopus 로고    scopus 로고
    • Gene expression levels and immunolocalization of organic ion transporters in the human kidney
    • MOTOHASHI H, SAKURAI Y, SAITO H et al.: Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J. Am. Soc. Nephrol. (2002) 13(4):866-874.
    • (2002) J. Am. Soc. Nephrol , vol.13 , Issue.4 , pp. 866-874
    • MOTOHASHI, H.1    SAKURAI, Y.2    SAITO, H.3
  • 19
    • 0242290366 scopus 로고    scopus 로고
    • Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux
    • BAKHIYA A, BAHN A, BURCKHARDT G, WOLFF N: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Pysiol. Biochem. (2003) 13(5):249-256.
    • (2003) Cell Pysiol. Biochem , vol.13 , Issue.5 , pp. 249-256
    • BAKHIYA, A.1    BAHN, A.2    BURCKHARDT, G.3    WOLFF, N.4
  • 20
    • 0035066252 scopus 로고    scopus 로고
    • Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
    • DRESSER MJ, LEABMAN MK, GIACOMINI KM: Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J. Pharm. Sci. (2001) 90(4):397-421.
    • (2001) J. Pharm. Sci , vol.90 , Issue.4 , pp. 397-421
    • DRESSER, M.J.1    LEABMAN, M.K.2    GIACOMINI, K.M.3
  • 21
    • 0035843770 scopus 로고    scopus 로고
    • Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters
    • TAKEDA M, NARIKAWA S, HOSOYAMADA M et al.: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. Eur. J. Pharmacol. (2001) 419(2-3):113-120.
    • (2001) Eur. J. Pharmacol , vol.419 , Issue.2-3 , pp. 113-120
    • TAKEDA, M.1    NARIKAWA, S.2    HOSOYAMADA, M.3
  • 22
    • 0037067159 scopus 로고    scopus 로고
    • Role of human organic anion transporter 4 in the transport of ochratoxin A
    • BABU E, TAKEDA M, NARIKAWA S et al.: Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim. Biophys. Acta (2002) 1590(1-3):64-75.
    • (2002) Biochim. Biophys. Acta , vol.1590 , Issue.1-3 , pp. 64-75
    • BABU, E.1    TAKEDA, M.2    NARIKAWA, S.3
  • 23
    • 0000518648 scopus 로고    scopus 로고
    • Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta
    • CHA SH, SEKINE T, KUSUHARA H et al.: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J. Biol. Chem. (2000) 275(6):4507-4512.
    • (2000) J. Biol. Chem , vol.275 , Issue.6 , pp. 4507-4512
    • CHA, S.H.1    SEKINE, T.2    KUSUHARA, H.3
  • 24
    • 1842732504 scopus 로고    scopus 로고
    • Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules
    • EKARATANAWONG S, ANZAI N, JUTABHA P et al.: Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J. Pharmacol. Sci. (2004) 94(3):297-304.
    • (2004) J. Pharmacol. Sci , vol.94 , Issue.3 , pp. 297-304
    • EKARATANAWONG, S.1    ANZAI, N.2    JUTABHA, P.3
  • 25
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • HAGENBUCH B, MEIER PJ: Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch. (2004) 447(5):653-665.
    • (2004) Pflugers Arch , vol.447 , Issue.5 , pp. 653-665
    • HAGENBUCH, B.1    MEIER, P.J.2
  • 26
    • 0037427972 scopus 로고    scopus 로고
    • The superfamily of organic anion transporting polypeptides
    • HAGENBUCH B, MEIER PJ: The superfamily of organic anion transporting polypeptides. Biochim. Biophys. Acta (2003) 1609(1):1-18.
    • (2003) Biochim. Biophys. Acta , vol.1609 , Issue.1 , pp. 1-18
    • HAGENBUCH, B.1    MEIER, P.J.2
  • 27
    • 0034709561 scopus 로고    scopus 로고
    • Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
    • TAMAI I, NEZU J, UCHINO H et al.: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem. Biophys. Res. Commun. (2000) 273(1):251-260.
    • (2000) Biochem. Biophys. Res. Commun , vol.273 , Issue.1 , pp. 251-260
    • TAMAI, I.1    NEZU, J.2    UCHINO, H.3
  • 28
    • 12144288563 scopus 로고    scopus 로고
    • Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney
    • MIKKAICHI T, SUZUKI T, ONOGAWA T et al.: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc. Natl. Acad. Sci. USA (2004) 101(10):3569-3574.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.10 , pp. 3569-3574
    • MIKKAICHI, T.1    SUZUKI, T.2    ONOGAWA, T.3
  • 29
    • 26444539011 scopus 로고    scopus 로고
    • Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions
    • VAN DE WATER FM, MASEREEUW R, RUSSEL FG: Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions. Drug Metab. Rev. (2005) 37(3):443-471.
    • (2005) Drug Metab. Rev , vol.37 , Issue.3 , pp. 443-471
    • VAN DE WATER, F.M.1    MASEREEUW, R.2    RUSSEL, F.G.3
  • 30
    • 0036186107 scopus 로고    scopus 로고
    • The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: Putative efflux pump for urinary cAMP and cGMP
    • VAN AUBEL RA, SMEETS PH, PETERS JG, BINDELS RJ, RUSSEL FG: The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J. Am. Soc. Nephrol. (2002) 13(3):595-603.
    • (2002) J. Am. Soc. Nephrol , vol.13 , Issue.3 , pp. 595-603
    • VAN AUBEL, R.A.1    SMEETS, P.H.2    PETERS, J.G.3    BINDELS, R.J.4    RUSSEL, F.G.5
  • 31
    • 0033032730 scopus 로고    scopus 로고
    • Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma
    • SCHAUB TP, KARTENBECK J, KONIG J et al.: Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. J. Am. Soc. Nephrol. (1999) 10(6):1159-1169.
    • (1999) J. Am. Soc. Nephrol , vol.10 , Issue.6 , pp. 1159-1169
    • SCHAUB, T.P.1    KARTENBECK, J.2    KONIG, J.3
  • 32
    • 12144269640 scopus 로고    scopus 로고
    • Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
    • SMEETS PH, VAN AUBEL RA, WOUTERSE AC, VAN DEN HEUVEL JJ, RUSSEL FG: Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J. Am. Soc. Nephrol. (2004) 15(11):2828-2835.
    • (2004) J. Am. Soc. Nephrol , vol.15 , Issue.11 , pp. 2828-2835
    • SMEETS, P.H.1    VAN AUBEL, R.A.2    WOUTERSE, A.C.3    VAN DEN HEUVEL, J.J.4    RUSSEL, F.G.5
  • 33
    • 12144257103 scopus 로고    scopus 로고
    • Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites
    • VAN AUBEL RA, SMEETS PH, VAN DEN HEUVEL JJ, RUSSEL FG: Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am. J. Physiol. Renal Physiol. (2005) 288(2):F327-F333.
    • (2005) Am. J. Physiol. Renal Physiol , vol.288 , Issue.2
    • VAN AUBEL RA, S.P.1    VAN DEN HEUVEL JJ, R.F.2
  • 34
    • 1242295185 scopus 로고    scopus 로고
    • The SLC22 drug transporter family
    • KOEPSELL H, ENDOU H: The SLC22 drug transporter family. Pflugers Arch. (2004) 447(5):666-676.
    • (2004) Pflugers Arch , vol.447 , Issue.5 , pp. 666-676
    • KOEPSELL, H.1    ENDOU, H.2
  • 35
    • 33645220096 scopus 로고    scopus 로고
    • Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants
    • FUJITA T, URBAN TJ, LEABMAN MK, FUJITA K, GIACOMINI KM: Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. J. Pharm. Sci. (2006) 95(1):25-36.
    • (2006) J. Pharm. Sci , vol.95 , Issue.1 , pp. 25-36
    • FUJITA, T.1    URBAN, T.J.2    LEABMAN, M.K.3    FUJITA, K.4    GIACOMINI, K.M.5
  • 36
    • 0033829943 scopus 로고    scopus 로고
    • Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney
    • WU X, HUANG W, GANAPATHY ME et al.: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am. J. Physiol. Renal Physiol. (2000) 279(3):F449-F458.
    • (2000) Am. J. Physiol. Renal Physiol , vol.279 , Issue.3
    • WU, X.1    HUANG, W.2    GANAPATHY, M.E.3
  • 37
    • 0035815991 scopus 로고    scopus 로고
    • +)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney
    • +)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim. Biophys. Acta (2001) 1512(2):273-284.
    • (2001) Biochim. Biophys. Acta , vol.1512 , Issue.2 , pp. 273-284
    • TAMAI, I.1    CHINA, K.2    SAI, Y.3
  • 38
    • 0345974472 scopus 로고    scopus 로고
    • Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations
    • TAMAI I, NAKANISHI T, KOBAYASHI D et al.: Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations. Mol. Pharm. (2004) 1(1):57-66.
    • (2004) Mol. Pharm , vol.1 , Issue.1 , pp. 57-66
    • TAMAI, I.1    NAKANISHI, T.2    KOBAYASHI, D.3
  • 39
    • 0032935034 scopus 로고    scopus 로고
    • Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations
    • YABUUCHI H, TAMAI I, NEZU J et al.: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J. Pharmacol. Exp. Ther. (1999) 289(2):768-773.
    • (1999) J. Pharmacol. Exp. Ther , vol.289 , Issue.2 , pp. 768-773
    • YABUUCHI, H.1    TAMAI, I.2    NEZU, J.3
  • 41
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • TAMAI I, OHASHI R, NEZU J et al.: Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem. (1998) 273(32):20378-20382.
    • (1998) J. Biol. Chem , vol.273 , Issue.32 , pp. 20378-20382
    • TAMAI, I.1    OHASHI, R.2    NEZU, J.3
  • 42
    • 0032767691 scopus 로고    scopus 로고
    • Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
    • WU X, HUANG W, PRASAD PD et al.: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J. Pharmacol. Exp. Ther. (1999) 290(3):1482-1492.
    • (1999) J. Pharmacol. Exp. Ther , vol.290 , Issue.3 , pp. 1482-1492
    • WU, X.1    HUANG, W.2    PRASAD, P.D.3
  • 43
    • 0032900953 scopus 로고    scopus 로고
    • Biochemical, cellular, and pharmacological aspects of the multidrug transporter
    • AMBUDKAR SV, DEY S, HRYCYNA CA et al.: Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Ann. Rev. Pharmacol. Toxicol. (1999) 39:361-398.
    • (1999) Ann. Rev. Pharmacol. Toxicol , vol.39 , pp. 361-398
    • AMBUDKAR, S.V.1    DEY, S.2    HRYCYNA, C.A.3
  • 44
    • 0037229942 scopus 로고    scopus 로고
    • Role of P-glycoprotein in pharmacokinetics: Clinical implications
    • LIN JH, YAMAZAKI M: Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin. Pharmacokinet. (2003) 42(1):59-98.
    • (2003) Clin. Pharmacokinet , vol.42 , Issue.1 , pp. 59-98
    • LIN, J.H.1    YAMAZAKI, M.2
  • 45
    • 0023447098 scopus 로고
    • Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
    • THIEBAUT F, TSURUO T, HAMADA H et al.: Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA (1987) 84(21):7735-7738.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , Issue.21 , pp. 7735-7738
    • THIEBAUT, F.1    TSURUO, T.2    HAMADA, H.3
  • 46
    • 1242272750 scopus 로고    scopus 로고
    • The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology
    • DANIEL H, KOTTRA G: The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch. (2004) 447(5):610-618.
    • (2004) Pflugers Arch , vol.447 , Issue.5 , pp. 610-618
    • DANIEL, H.1    KOTTRA, G.2
  • 47
    • 0032967296 scopus 로고    scopus 로고
    • Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney
    • SHEN H, SMITH DE, YANG T et al.: Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney. Am. J. Physiol. (1999) 276(5 Pt 2):F658-F665.
    • (1999) Am. J. Physiol , vol.276 , Issue.5 PART 2
    • SHEN, H.1    SMITH, D.E.2    YANG, T.3
  • 48
    • 33644849472 scopus 로고    scopus 로고
    • Cytosolic COOH terminus of the peptide transporter PEPT2 is involved in apical membrane localization of the protein
    • KLAPPER M, DANIEL H, DORING F: Cytosolic COOH terminus of the peptide transporter PEPT2 is involved in apical membrane localization of the protein. Am. J. Physiol. Cell Physiol. (2006) 290(2):C472-C483.
    • (2006) Am. J. Physiol. Cell Physiol , vol.290 , Issue.2
    • KLAPPER, M.1    DANIEL, H.2    DORING, F.3
  • 49
    • 33645101081 scopus 로고    scopus 로고
    • Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters
    • LI M, ANDERSON GD, PHILLIPS BR et al.: Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab. Dispos. (2006) 34(4):547-555.
    • (2006) Drug Metab. Dispos , vol.34 , Issue.4 , pp. 547-555
    • LI, M.1    ANDERSON, G.D.2    PHILLIPS, B.R.3
  • 52
    • 28444444126 scopus 로고    scopus 로고
    • Effects of renal failure on drug transport and metabolism
    • SUN H, FRASSETTO L, BENET LZ: Effects of renal failure on drug transport and metabolism. Pharmacol. Ther. (2006) 109(1-2):1-11.
    • (2006) Pharmacol. Ther , vol.109 , Issue.1-2 , pp. 1-11
    • SUN, H.1    FRASSETTO, L.2    BENET, L.Z.3
  • 53
    • 0017169928 scopus 로고
    • Pharmacokinetics of the penicillins in man
    • BARZA M, WEINSTEIN L: Pharmacokinetics of the penicillins in man. Clin. Pharmacokinet. (1976) 1(4):297-308.
    • (1976) Clin. Pharmacokinet , vol.1 , Issue.4 , pp. 297-308
    • BARZA, M.1    WEINSTEIN, L.2
  • 54
    • 0001579719 scopus 로고
    • On the mechanism of action of probenecid on renal tubular secretion
    • WEINER IM, WASHINGTON JA 2nd, MUDGE GH: On the mechanism of action of probenecid on renal tubular secretion. Bull. Johns Hopkins Hosp. (1960) 106:333-346.
    • (1960) Bull. Johns Hopkins Hosp , vol.106 , pp. 333-346
    • WEINER, I.M.1    WASHINGTON, J.A.2    MUDGE, G.H.3
  • 55
    • 0029846479 scopus 로고    scopus 로고
    • Renal transport of drugs: Specificity and molecular mechanisms
    • SOMOGYI A: Renal transport of drugs: specificity and molecular mechanisms. Clin. Exp. Pharmacol. Physiol. (1996) 23(10-11):986-989.
    • (1996) Clin. Exp. Pharmacol. Physiol , vol.23 , Issue.10-11 , pp. 986-989
    • SOMOGYI, A.1
  • 57
    • 0027417835 scopus 로고
    • Cephalosporin-probenecid drug interactions
    • BROWN GR: Cephalosporin-probenecid drug interactions. Clin. Pharmacokinet. (1993) 24(4):289-300.
    • (1993) Clin. Pharmacokinet , vol.24 , Issue.4 , pp. 289-300
    • BROWN, G.R.1
  • 59
    • 0036260663 scopus 로고    scopus 로고
    • Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
    • ENOMOTO A, TAKEDA M, SHIMODA M et al.: Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J. Pharmacol. Exp. Ther. (2002) 301(3):797-802.
    • (2002) J. Pharmacol. Exp. Ther , vol.301 , Issue.3 , pp. 797-802
    • ENOMOTO, A.1    TAKEDA, M.2    SHIMODA, M.3
  • 61
    • 0018765196 scopus 로고
    • Clinical pharmacological studies of amoxycillin: Effect of probenecid
    • BARBHAIYA R, THIN RN, TURNER P, WADSWORTH J: Clinical pharmacological studies of amoxycillin: effect of probenecid. Br. J. Vener. Dis. (1979) 55(3):211-213.
    • (1979) Br. J. Vener. Dis , vol.55 , Issue.3 , pp. 211-213
    • BARBHAIYA, R.1    THIN, R.N.2    TURNER, P.3    WADSWORTH, J.4
  • 62
    • 0027171710 scopus 로고
    • Effect of probenecid on cefazolin serum concentrations
    • BROWN G, ZEMCOV SJ, CLARKE AM: Effect of probenecid on cefazolin serum concentrations. J. Antimicrob. Chemother. (1993) 31(6):1009-1011.
    • (1993) J. Antimicrob. Chemother , vol.31 , Issue.6 , pp. 1009-1011
    • BROWN, G.1    ZEMCOV, S.J.2    CLARKE, A.M.3
  • 63
    • 0015663986 scopus 로고
    • Pharmacodynamics of cefazolin in the presence of normal and impaired renal function
    • REIN MF, WESTERVELT FB, SANDE MA: Pharmacodynamics of cefazolin in the presence of normal and impaired renal function. Antimicrob. Agents Chemother. (1973) 4(3):366-371.
    • (1973) Antimicrob. Agents Chemother , vol.4 , Issue.3 , pp. 366-371
    • REIN, M.F.1    WESTERVELT, F.B.2    SANDE, M.A.3
  • 64
    • 0037406327 scopus 로고    scopus 로고
    • Effect of chronic probenecid therapy on cefazolin serum concentrations
    • SPINA SP, DILLON EC Jr: Effect of chronic probenecid therapy on cefazolin serum concentrations. Ann. Pharmacother. (2003) 37(5):621-624.
    • (2003) Ann. Pharmacother , vol.37 , Issue.5 , pp. 621-624
    • SPINA, S.P.1    DILLON Jr, E.C.2
  • 65
    • 1642539149 scopus 로고    scopus 로고
    • Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases
    • SAKURAI Y, MOTOHASHI H, UEO H et al.: Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm. Res. (2004) 21(1):61-67.
    • (2004) Pharm. Res , vol.21 , Issue.1 , pp. 61-67
    • SAKURAI, Y.1    MOTOHASHI, H.2    UEO, H.3
  • 66
    • 18344371636 scopus 로고    scopus 로고
    • Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: In comparison with rOAT1
    • JUNG KY, TAKEDA M, SHIMODA M et al.: Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. (2002) 70(16):1861-1874.
    • (2002) Life Sci , vol.70 , Issue.16 , pp. 1861-1874
    • JUNG, K.Y.1    TAKEDA, M.2    SHIMODA, M.3
  • 67
    • 24344461838 scopus 로고    scopus 로고
    • Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1
    • UEO H, MOTOHASHI H, KATSURA T, INUI K: Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem. Pharmacol. (2005) 70(7):1104-1113.
    • (2005) Biochem. Pharmacol , vol.70 , Issue.7 , pp. 1104-1113
    • UEO, H.1    MOTOHASHI, H.2    KATSURA, T.3    INUI, K.4
  • 68
    • 0029000871 scopus 로고
    • Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients
    • CUNDY KC, PETTY BG, FLAHERTY J et al.: Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. (1995) 39(6):1247-1252.
    • (1995) Antimicrob. Agents Chemother , vol.39 , Issue.6 , pp. 1247-1252
    • CUNDY, K.C.1    PETTY, B.G.2    FLAHERTY, J.3
  • 69
    • 0032997095 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir
    • CUNDY KC: Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir. Clin. Pharmacokinet. (1999) 36(2):127-143.
    • (1999) Clin. Pharmacokinet , vol.36 , Issue.2 , pp. 127-143
    • CUNDY, K.C.1
  • 70
    • 0032856603 scopus 로고    scopus 로고
    • The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1
    • CIHLAR T, LIN DC, PRITCHARD JB et al.: The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol. Pharmacol. (1999) 56(3):570-580.
    • (1999) Mol. Pharmacol , vol.56 , Issue.3 , pp. 570-580
    • CIHLAR, T.1    LIN, D.C.2    PRITCHARD, J.B.3
  • 71
    • 0034008388 scopus 로고    scopus 로고
    • Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1
    • HO ES, LIN DC, MENDEL DB, CIHLAR T: Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J. Am. Soc. Nephrol. (2000) 11(3):383-393.
    • (2000) J. Am. Soc. Nephrol , vol.11 , Issue.3 , pp. 383-393
    • HO, E.S.1    LIN, D.C.2    MENDEL, D.B.3    CIHLAR, T.4
  • 72
    • 0020325272 scopus 로고
    • Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans
    • LASKIN OL, DE MIRANDA P, KING DH et al.: Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans. Antimicrob. Agents Chemother. (1982) 21(5):804-807.
    • (1982) Antimicrob. Agents Chemother , vol.21 , Issue.5 , pp. 804-807
    • LASKIN, O.L.1    DE MIRANDA, P.2    KING, D.H.3
  • 73
    • 0036146750 scopus 로고    scopus 로고
    • Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir
    • DE BONY F, TOD M, BIDAULT R et al.: Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir. Antimicrob. Agents Chemother. (2002) 46(2):458-463.
    • (2002) Antimicrob. Agents Chemother , vol.46 , Issue.2 , pp. 458-463
    • DE BONY, F.1    TOD, M.2    BIDAULT, R.3
  • 74
    • 0025061746 scopus 로고
    • Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteers
    • HEDAYA MA, ELMQUIST WF, SAWCHUK RJ: Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteers. Pharm. Res. (1990) 7(4):411-417.
    • (1990) Pharm. Res , vol.7 , Issue.4 , pp. 411-417
    • HEDAYA, M.A.1    ELMQUIST, W.F.2    SAWCHUK, R.J.3
  • 75
    • 0036175142 scopus 로고    scopus 로고
    • Human organic anion transporters and human organic cation transporters mediate renal antiviral transport
    • TAKEDA M, KHAMDANG S, NARIKAWA S et al.: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J. Pharmacol. Exp. Ther. (2002) 300(3):918-924.
    • (2002) J. Pharmacol. Exp. Ther , vol.300 , Issue.3 , pp. 918-924
    • TAKEDA, M.1    KHAMDANG, S.2    NARIKAWA, S.3
  • 76
    • 0022601216 scopus 로고
    • Competition of organic anions for furosemide and p-aminohippurate secretion in the rabbit
    • BIDIVILLE J, ROCH-RAMEL F: Competition of organic anions for furosemide and p-aminohippurate secretion in the rabbit. J. Pharmacol. Exp. Ther. (1986) 237(2):636-643.
    • (1986) J. Pharmacol. Exp. Ther , vol.237 , Issue.2 , pp. 636-643
    • BIDIVILLE, J.1    ROCH-RAMEL, F.2
  • 77
    • 0019466698 scopus 로고
    • Effect of bumetanide on p-aminohippurate transport in renal cortical slices
    • GEMBA M, TANIGUCHI M, MATSUSHIMA Y: Effect of bumetanide on p-aminohippurate transport in renal cortical slices. J. Pharmacobiodyn. (1981) 4(3):162-166.
    • (1981) J. Pharmacobiodyn , vol.4 , Issue.3 , pp. 162-166
    • GEMBA, M.1    TANIGUCHI, M.2    MATSUSHIMA, Y.3
  • 78
    • 0018725963 scopus 로고
    • Pharmacodynamic analysis of the furosemide-probenecid interaction in man
    • CHENNAVASIN P, SEIWELL R, BRATER DC, LIANG WM: Pharmacodynamic analysis of the furosemide-probenecid interaction in man. Kidney Int. (1979) 16(2):187-195.
    • (1979) Kidney Int , vol.16 , Issue.2 , pp. 187-195
    • CHENNAVASIN, P.1    SEIWELL, R.2    BRATER, D.C.3    LIANG, W.M.4
  • 79
    • 0013800021 scopus 로고
    • Influence of probenecid and alterations in acid-base balance of the saluretic activity of furosemide
    • HOOK JB, WILLIAMSON HE: Influence of probenecid and alterations in acid-base balance of the saluretic activity of furosemide. J. Pharmacol. Exp. Ther. (1965) 149(3):404-408.
    • (1965) J. Pharmacol. Exp. Ther , vol.149 , Issue.3 , pp. 404-408
    • HOOK, J.B.1    WILLIAMSON, H.E.2
  • 80
    • 0019865608 scopus 로고
    • Saturable kinetics of intravenous chlorothiazide in the rhesus monkey
    • GUSTAFSON JH, BENET LZ: Saturable kinetics of intravenous chlorothiazide in the rhesus monkey. J. Pharmacokinet. Biopharm. (1981) 9(4):461-476.
    • (1981) J. Pharmacokinet. Biopharm , vol.9 , Issue.4 , pp. 461-476
    • GUSTAFSON, J.H.1    BENET, L.Z.2
  • 81
    • 0031050381 scopus 로고    scopus 로고
    • Saturable accumulation and diuretic activity of hydrochlorothiazide in the isolated perfused rat kidney
    • MASEREEUW R, MOONS WM, RUSSEL FG: Saturable accumulation and diuretic activity of hydrochlorothiazide in the isolated perfused rat kidney. Pharmacology (1997) 54(1):33-42.
    • (1997) Pharmacology , vol.54 , Issue.1 , pp. 33-42
    • MASEREEUW, R.1    MOONS, W.M.2    RUSSEL, F.G.3
  • 82
    • 0029020208 scopus 로고
    • Probenecid inhibits the renal clearance of frusemide and its acyl glucuronide
    • VREE TB, VAN DEN BIGGELAAR-MARTEA M, VERWEY-VAN WISSEN CP: Probenecid inhibits the renal clearance of frusemide and its acyl glucuronide. Br. J. Clin. Pharmacol. (1995) 39(6):692-695.
    • (1995) Br. J. Clin. Pharmacol , vol.39 , Issue.6 , pp. 692-695
    • VREE, T.B.1    VAN DEN BIGGELAAR-MARTEA, M.2    VERWEY-VAN, W.C.3
  • 83
    • 0018886475 scopus 로고
    • Renal tubular secretion and effects of furosemide
    • ODLIND B, BEERMANN B: Renal tubular secretion and effects of furosemide. Clin. Pharmacol. Ther. (1980) 27(6):784-790.
    • (1980) Clin. Pharmacol. Ther , vol.27 , Issue.6 , pp. 784-790
    • ODLIND, B.1    BEERMANN, B.2
  • 84
    • 10744233574 scopus 로고    scopus 로고
    • Interactions of human organic anion transporters with diuretics
    • HASANNEJAD H, TAKEDA M, TAKI K et al.: Interactions of human organic anion transporters with diuretics. J. Pharmacol. Exp. Ther. (2004) 308(3):1021-1029.
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , Issue.3 , pp. 1021-1029
    • HASANNEJAD, H.1    TAKEDA, M.2    TAKI, K.3
  • 85
    • 33646165531 scopus 로고    scopus 로고
    • Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knockout mice
    • ERALY SA, VALLON V, VAUGHN DA et al.: Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knockout mice. J. Biol. Chem. (2006) 281(8):5072-5083.
    • (2006) J. Biol. Chem , vol.281 , Issue.8 , pp. 5072-5083
    • ERALY, S.A.1    VALLON, V.2    VAUGHN, D.A.3
  • 86
    • 0028792273 scopus 로고
    • The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: Impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg
    • KREMER JM, HAMILTON RA: The effects of nonsteroidal antiinflammatory drugs on methotrexate (MTX) pharmacokinetics: impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg. J. Rheumatol. (1995) 22(11):2072-2077.
    • (1995) J. Rheumatol , vol.22 , Issue.11 , pp. 2072-2077
    • KREMER, J.M.1    HAMILTON, R.A.2
  • 88
    • 0026570125 scopus 로고
    • Methotrexate and nonsteroidal antiinflammatory drug interactions
    • FRENIA ML, LONG KS: Methotrexate and nonsteroidal antiinflammatory drug interactions. Ann. Pharmacother. (1992) 26(2):234-237.
    • (1992) Ann. Pharmacother , vol.26 , Issue.2 , pp. 234-237
    • FRENIA, M.L.1    LONG, K.S.2
  • 89
    • 0022613399 scopus 로고
    • Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen
    • THYSSA, MILANO G, KUBAR J, NAMER M, SCHNEIDER M: Clinical and pharmacokinetic evidence of a life-threatening interaction between methotrexate and ketoprofen. Lancet (1986) 1(8475):256-258.
    • (1986) Lancet , vol.1 , Issue.8475 , pp. 256-258
    • THYSSA, M.G.1    KUBAR, J.2    NAMER, M.3    SCHNEIDER, M.4
  • 90
    • 0036076780 scopus 로고    scopus 로고
    • Characterization of methotrexate transport and its drug interactions with human organic anion transporters
    • TAKEDA M, KHAMDANG S, NARIKAWA S et al.: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J. Pharmacol. Exp. Ther. (2002) 302(2):666-671.
    • (2002) J. Pharmacol. Exp. Ther , vol.302 , Issue.2 , pp. 666-671
    • TAKEDA, M.1    KHAMDANG, S.2    NARIKAWA, S.3
  • 91
    • 0033152212 scopus 로고    scopus 로고
    • Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
    • HOOIJBERG JH, BROXTERMAN HJ, KOOL M et al.: Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. (1999) 59(11):2532-2535.
    • (1999) Cancer Res , vol.59 , Issue.11 , pp. 2532-2535
    • HOOIJBERG, J.H.1    BROXTERMAN, H.J.2    KOOL, M.3
  • 92
    • 0036827850 scopus 로고    scopus 로고
    • Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs
    • KHAMDANG S, TAKEDA M, NOSHIRO R et al.: Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. (2002) 303(2):534-539.
    • (2002) J. Pharmacol. Exp. Ther , vol.303 , Issue.2 , pp. 534-539
    • KHAMDANG, S.1    TAKEDA, M.2    NOSHIRO, R.3
  • 93
    • 0020488482 scopus 로고
    • Cimetidine reduces procainamide elimination
    • SOMOGYI A, HEINZOW B: Cimetidine reduces procainamide elimination. N. Engl. J. Med. (1982) 307(17):1080.
    • (1982) N. Engl. J. Med , vol.307 , Issue.17 , pp. 1080
    • SOMOGYI, A.1    HEINZOW, B.2
  • 94
    • 0020510972 scopus 로고
    • Clinical pharmacokinetics of cimetidine
    • SOMOGYI A, GUGLER R: Clinical pharmacokinetics of cimetidine. Clin. Pharmacokinet. (1983) 8(6):463-495.
    • (1983) Clin. Pharmacokinet , vol.8 , Issue.6 , pp. 463-495
    • SOMOGYI, A.1    GUGLER, R.2
  • 95
    • 0020635466 scopus 로고
    • Cimetidine-procainamide pharmacokinetic interaction in man: Evidence of competition for tubular secretion of basic drugs
    • SOMOGYI A, MCLEAN A, HEINZOW B: Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs. Eur. J. Clin. Pharmacol. (1983) 25(3):339-345.
    • (1983) Eur. J. Clin. Pharmacol , vol.25 , Issue.3 , pp. 339-345
    • SOMOGYI, A.1    MCLEAN, A.2    HEINZOW, B.3
  • 96
    • 0023248835 scopus 로고
    • Pharmacokinetic interactions of cimetidine 1987
    • SOMOGYI A, MUIRHEAD M: Pharmacokinetic interactions of cimetidine 1987. Clin. Pharmacokinet. (1987) 12(5):321-366.
    • (1987) Clin. Pharmacokinet , vol.12 , Issue.5 , pp. 321-366
    • SOMOGYI, A.1    MUIRHEAD, M.2
  • 97
    • 25644452793 scopus 로고    scopus 로고
    • 2 receptor antagonists by rat and human renal organic anion and cation transporters
    • 2 receptor antagonists by rat and human renal organic anion and cation transporters. J. Pharmacol. Exp. Ther. (2005) 315(1):337-345.
    • (2005) J. Pharmacol. Exp. Ther , vol.315 , Issue.1 , pp. 337-345
    • TAHARA, H.1    KUSUHARA, H.2    ENDOU, H.3
  • 98
    • 7444254904 scopus 로고    scopus 로고
    • Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)
    • MOTOHASHI H, UWAI Y, HIRAMOTO K, OKUDA M, INUI K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur. J. Pharmacol. (2004) 503(1-3):25-30.
    • (2004) Eur. J. Pharmacol , vol.503 , Issue.1-3 , pp. 25-30
    • MOTOHASHI, H.1    UWAI, Y.2    HIRAMOTO, K.3    OKUDA, M.4    INUI, K.5
  • 99
    • 6344240973 scopus 로고    scopus 로고
    • Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule
    • ZHANG X, GROVES CE, BAHN A et al.: Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule. Am. J. Physiol. Renal Physiol. (2004) 287(5):F999-F1010.
    • (2004) Am. J. Physiol. Renal Physiol , vol.287 , Issue.5
    • ZHANG, X.1    GROVES, C.E.2    BAHN, A.3
  • 101
    • 0036689433 scopus 로고    scopus 로고
    • Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2)
    • DRESSER MJ, XIAO G, LEABMAN MK, GRAV AT, GIACOMINI KM: Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharm. Res. (2002) 19(8):1244-1247.
    • (2002) Pharm. Res , vol.19 , Issue.8 , pp. 1244-1247
    • DRESSER, M.J.1    XIAO, G.2    LEABMAN, M.K.3    GRAV, A.T.4    GIACOMINI, K.M.5
  • 102
    • 16844384592 scopus 로고    scopus 로고
    • Metformin transport by renal basolateral organic cation transporter hOCT2
    • KIMURA N, OKUDA M, INUI K: Metformin transport by renal basolateral organic cation transporter hOCT2. Pharm. Res. (2005) 22(2):255-259.
    • (2005) Pharm. Res , vol.22 , Issue.2 , pp. 255-259
    • KIMURA, N.1    OKUDA, M.2    INUI, K.3
  • 103
    • 0024546822 scopus 로고
    • Renal tubular secretion of amiloride and its inhibition by cimetidine in humans and in an animal model
    • SOMOGYI AA, HOVENS CM, MUIRHEAD MR, BOCHNER F: Renal tubular secretion of amiloride and its inhibition by cimetidine in humans and in an animal model. Drug Metab. Dispos. (1989) 17(2):190-196.
    • (1989) Drug Metab. Dispos , vol.17 , Issue.2 , pp. 190-196
    • SOMOGYI, A.A.1    HOVENS, C.M.2    MUIRHEAD, M.R.3    BOCHNER, F.4
  • 104
    • 33744824064 scopus 로고    scopus 로고
    • Characterization of regulatory mechanisms and states of human organic cation transporter 2
    • BIERMANN J, LANG D, GORBOULEV V et al.: Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am. J. Physiol. Cell Physiol. (2006) 290(6):C1521-C1531.
    • (2006) Am. J. Physiol. Cell Physiol , vol.290 , Issue.6
    • BIERMANN, J.1    LANG, D.2    GORBOULEV, V.3
  • 105
    • 0026606632 scopus 로고
    • Stereoselective inhibition of pindolol renal clearance by cimetidine in humans
    • SOMOGYI AA, BOCHNER F, SALLUSTIO BC: Stereoselective inhibition of pindolol renal clearance by cimetidine in humans. Clin. Pharmacol. Ther. (1992) 51(4):379-387.
    • (1992) Clin. Pharmacol. Ther , vol.51 , Issue.4 , pp. 379-387
    • SOMOGYI, A.A.1    BOCHNER, F.2    SALLUSTIO, B.C.3
  • 106
    • 0023796147 scopus 로고
    • Trimethoprim alters the disposition of procainamide and N-acetylprocainamide
    • KOSOGLOU T, ROCCI ML Jr, VLASSES PH: Trimethoprim alters the disposition of procainamide and N-acetylprocainamide. Clin. Pharmacol. Ther. (1988) 44(4):467-477.
    • (1988) Clin. Pharmacol. Ther , vol.44 , Issue.4 , pp. 467-477
    • KOSOGLOU, T.1    ROCCI Jr, M.L.2    VLASSES, P.H.3
  • 107
    • 0024316504 scopus 로고
    • Trimethoprim inhibition of the renal clearance of procainamide and N-acetylprocainamide
    • VLASSES PH, KOSOGLOU T, CHASE SL et al.: Trimethoprim inhibition of the renal clearance of procainamide and N-acetylprocainamide. Arch. Intent. Med. (1989) 149(6):1350-1353.
    • (1989) Arch. Intent. Med , vol.149 , Issue.6 , pp. 1350-1353
    • VLASSES, P.H.1    KOSOGLOU, T.2    CHASE, S.L.3
  • 108
    • 0026096151 scopus 로고
    • Pharmacokinetics of digoxin and main metabolites/derivatives in healthy humans
    • HINDERLING PH, HARTMANN D: Pharmacokinetics of digoxin and main metabolites/derivatives in healthy humans. Ther. Drug Monit. (1991) 13(5):381-401.
    • (1991) Ther. Drug Monit , vol.13 , Issue.5 , pp. 381-401
    • HINDERLING, P.H.1    HARTMANN, D.2
  • 109
    • 0032705762 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice
    • KAWAHARA M, SAKATA A, MIYASHITA T, TAMAI I, TSUJI A: Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice. J. Pharm. Sci. (1999) 88(12): 1281-1287.
    • (1999) J. Pharm. Sci , vol.88 , Issue.12 , pp. 1281-1287
    • KAWAHARA, M.1    SAKATA, A.2    MIYASHITA, T.3    TAMAI, I.4    TSUJI, A.5
  • 110
    • 0034520267 scopus 로고    scopus 로고
    • St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4
    • DURR D, STIEGER B, KULLAK-UBLICK GA et al.: St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin. Pharmacol. Ther. (2000) 68(6):598-604.
    • (2000) Clin. Pharmacol. Ther , vol.68 , Issue.6 , pp. 598-604
    • DURR, D.1    STIEGER, B.2    KULLAK-UBLICK, G.A.3
  • 111
    • 0027102401 scopus 로고
    • The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin
    • DELANNOY IA, SILVERMAN M: The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochem. Biophys. Res. Commun. (1992) 189(1):551-557.
    • (1992) Biochem. Biophys. Res. Commun , vol.189 , Issue.1 , pp. 551-557
    • DELANNOY, I.A.1    SILVERMAN, M.2
  • 112
    • 0018750834 scopus 로고
    • Digoxin-quinidine interaction. Pharmacokinetic evaluation
    • HAGER WD, FENSTER P, MAYERSOHN M et al.: Digoxin-quinidine interaction. Pharmacokinetic evaluation. N. Engl. J. Med. (1979) 300(22):1238-1241.
    • (1979) N. Engl. J. Med , vol.300 , Issue.22 , pp. 1238-1241
    • HAGER, W.D.1    FENSTER, P.2    MAYERSOHN, M.3
  • 113
    • 0025092259 scopus 로고
    • Interactions in the renal and biliary elimination of digoxin: Stereoselective difference between quinine and quinidine
    • HEDMAN A, ANGELIN B, ARVIDSSON A, DAHLQVIST R, NILSSON B: Interactions in the renal and biliary elimination of digoxin: stereoselective difference between quinine and quinidine. Clin. Pharmacol. Ther. (1990) 47(1):20-26.
    • (1990) Clin. Pharmacol. Ther , vol.47 , Issue.1 , pp. 20-26
    • HEDMAN, A.1    ANGELIN, B.2    ARVIDSSON, A.3    DAHLQVIST, R.4    NILSSON, B.5
  • 114
    • 0021722205 scopus 로고
    • Quinidine-induced changes in serum and skeletal muscle digoxin concentration; evidence of saturable binding of digoxin to skeletal muscle
    • JOGESTRAND T, SCHENCK-GUSTAFSSON K, NORDLANDER R, DAHLQVIST R: Quinidine-induced changes in serum and skeletal muscle digoxin concentration; evidence of saturable binding of digoxin to skeletal muscle. Eur. J. Clin. Pharmacol. (1984) 27(5):571-575.
    • (1984) Eur. J. Clin. Pharmacol , vol.27 , Issue.5 , pp. 571-575
    • JOGESTRAND, T.1    SCHENCK-GUSTAFSSON, K.2    NORDLANDER, R.3    DAHLQVIST, R.4
  • 116
    • 0026459449 scopus 로고
    • Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1)
    • TANIGAWARA Y, OKAMURA N, HIRAI M et al.: Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J. Pharmacol. Exp. Ther. (1992) 263(2):840-845.
    • (1992) J. Pharmacol. Exp. Ther , vol.263 , Issue.2 , pp. 840-845
    • TANIGAWARA, Y.1    OKAMURA, N.2    HIRAI, M.3
  • 117
    • 0033514320 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
    • FROMM MF, KIM RB, STEIN CM, WILKINSON GR, RODEN DM: Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine. Circulation (1999) 99(4):552-557.
    • (1999) Circulation , vol.99 , Issue.4 , pp. 552-557
    • FROMM, M.F.1    KIM, R.B.2    STEIN, C.M.3    WILKINSON, G.R.4    RODEN, D.M.5
  • 118
    • 3042568988 scopus 로고    scopus 로고
    • Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers
    • DING R, TAYROUZ Y, RIEDEL KD et al.: Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers. Clin. Pharmacol. Ther. (2004) 76(1):73-84.
    • (2004) Clin. Pharmacol. Ther , vol.76 , Issue.1 , pp. 73-84
    • DING, R.1    TAYROUZ, Y.2    RIEDEL, K.D.3
  • 119
    • 0032765899 scopus 로고    scopus 로고
    • Interactions of HIV protease inhibitors with ATP-dependent drug export proteins
    • GUTMANN H, FRICKER G, DREWE J, TOEROEK M, MILLER DS: Interactions of HIV protease inhibitors with ATP-dependent drug export proteins. Mol. Pharmacol. (1999) 56(2):383-389.
    • (1999) Mol. Pharmacol , vol.56 , Issue.2 , pp. 383-389
    • GUTMANN, H.1    FRICKER, G.2    DREWE, J.3    TOEROEK, M.4    MILLER, D.S.5
  • 120
    • 0033562673 scopus 로고    scopus 로고
    • HIV protease inhibitor ritonavir: A more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC-833
    • DREWE J, GUTMANN H, FRICKER G et al.: HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC-833. Biochem. Pharmacol. (1999) 57(10):1147-1152.
    • (1999) Biochem. Pharmacol , vol.57 , Issue.10 , pp. 1147-1152
    • DREWE, J.1    GUTMANN, H.2    FRICKER, G.3
  • 121
    • 0027455141 scopus 로고
    • The mechanism of the verapamil-digoxin interaction in renal tubular cells (LLC-PK1)
    • ITO S, WOODLAND C, HARPER PA, KOREN G: The mechanism of the verapamil-digoxin interaction in renal tubular cells (LLC-PK1). Life Sci. (1993) 53(24):PL399-PL403.
    • (1993) Life Sci , vol.53 , Issue.24
    • ITO, S.1    WOODLAND, C.2    HARPER, P.A.3    KOREN, G.4
  • 122
    • 0032848316 scopus 로고    scopus 로고
    • P-glycoprotein system as a determinant of drug interactions: The case of digoxin-verapamil
    • VERSCHRAAGEN M, KOKS CH, SCHELLENS JH, BEIJNEN JH: P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil. Pharmacol. Res. (1999) 40(4):301-306.
    • (1999) Pharmacol. Res , vol.40 , Issue.4 , pp. 301-306
    • VERSCHRAAGEN, M.1    KOKS, C.H.2    SCHELLENS, J.H.3    BEIJNEN, J.H.4
  • 124
    • 0027856015 scopus 로고
    • Digoxin-cyclosporin A interaction: Modulation of the multidrug transporter P-glycoprotein in the kidney
    • OKAMURA N, HIRAI M, TANIGAWARA Y et al.: Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney. J. Pharmacol. Exp. Ther. (1993) 266(3):1614-1619.
    • (1993) J. Pharmacol. Exp. Ther , vol.266 , Issue.3 , pp. 1614-1619
    • OKAMURA, N.1    HIRAI, M.2    TANIGAWARA, Y.3
  • 125
    • 0031845356 scopus 로고    scopus 로고
    • Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein
    • WAKASUGI H, YANO I, ITO T et al.: Effect of clarithromycin on renal excretion of digoxin: interaction with P-glycoprotein. Clin. Pharmacol. Ther. (1998) 64(1):123-128.
    • (1998) Clin. Pharmacol. Ther , vol.64 , Issue.1 , pp. 123-128
    • WAKASUGI, H.1    YANO, I.2    ITO, T.3
  • 126
    • 12344296912 scopus 로고    scopus 로고
    • Interactions between clarithromycin and digoxin in patients with end-stage renal disease
    • HIRATA S, IZUMI S, FURUKUBO T et al.: Interactions between clarithromycin and digoxin in patients with end-stage renal disease. Int. J. Clin. Pharmacol. Ther. (2005) 43(1):30-36.
    • (2005) Int. J. Clin. Pharmacol. Ther , vol.43 , Issue.1 , pp. 30-36
    • HIRATA, S.1    IZUMI, S.2    FURUKUBO, T.3
  • 127
    • 4544326030 scopus 로고    scopus 로고
    • Clarithromycin induced digoxin toxicity: Case report and review
    • KIRAN N, AZAM S, DHAKAM S: Clarithromycin induced digoxin toxicity: case report and review. J. Pak. Med. Assoc. (2004) 54(8):440-441.
    • (2004) J. Pak. Med. Assoc , vol.54 , Issue.8 , pp. 440-441
    • KIRAN, N.1    AZAM, S.2    DHAKAM, S.3
  • 128
    • 0038336620 scopus 로고    scopus 로고
    • Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction
    • RENGELSHAUSEN J, GOGGELMANN C, BURHENNE J et al.: Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction. Br. J. Clin. Pharmacol. (2003) 56(1):32-38.
    • (2003) Br. J. Clin. Pharmacol , vol.56 , Issue.1 , pp. 32-38
    • RENGELSHAUSEN, J.1    GOGGELMANN, C.2    BURHENNE, J.3
  • 129
    • 0034794892 scopus 로고    scopus 로고
    • Clarithromycin-induced digoxin toxicity: A case report and a review of the literature
    • XU H, RASHKOW A: Clarithromycin-induced digoxin toxicity: a case report and a review of the literature. Conn. Med. (2001) 65(9):527-529.
    • (2001) Conn. Med , vol.65 , Issue.9 , pp. 527-529
    • XU, H.1    RASHKOW, A.2
  • 130
    • 0030868579 scopus 로고    scopus 로고
    • The digoxin-propafenone interaction: Characterization of a mechanism using renal tubular cell monolayers
    • WOODLAND C, VERJEE Z, GIESBRECHT E, KOREN G, ITO S: The digoxin-propafenone interaction: characterization of a mechanism using renal tubular cell monolayers. J. Pharmacol. Exp. Ther. (1997) 283(1):39-45.
    • (1997) J. Pharmacol. Exp. Ther , vol.283 , Issue.1 , pp. 39-45
    • WOODLAND, C.1    VERJEE, Z.2    GIESBRECHT, E.3    KOREN, G.4    ITO, S.5
  • 131
    • 0031443240 scopus 로고    scopus 로고
    • Itraconazole decreases renal clearance of digoxin
    • JALAVA KM, PARTANEN J, NEUVONEN PJ: Itraconazole decreases renal clearance of digoxin. Ther. Drug Monit. (1997) 19(6):609-613.
    • (1997) Ther. Drug Monit , vol.19 , Issue.6 , pp. 609-613
    • JALAVA, K.M.1    PARTANEN, J.2    NEUVONEN, P.J.3
  • 132
    • 0031980141 scopus 로고    scopus 로고
    • A model for the prediction of digoxin-drug interactions at the renal tubular cell level
    • WOODLAND C, ITO S. KOREN G: A model for the prediction of digoxin-drug interactions at the renal tubular cell level. Ther. Drug Monit. (1998) 20(2):134-138.
    • (1998) Ther. Drug Monit , vol.20 , Issue.2 , pp. 134-138
    • WOODLAND, C.1    ITO, S.2    KOREN, G.3
  • 134
    • 0345411341 scopus 로고    scopus 로고
    • P-glycoprotein and cytochrome P450 3A inhibition: Dissociation of inhibitory potencies
    • WANDEL C, KIM RB, KAJIJI S et al.: P-glycoprotein and cytochrome P450 3A inhibition: dissociation of inhibitory potencies. Cancer Res. (1999) 59(16):3944-3948.
    • (1999) Cancer Res , vol.59 , Issue.16 , pp. 3944-3948
    • WANDEL, C.1    KIM, R.B.2    KAJIJI, S.3
  • 135
    • 1542771649 scopus 로고    scopus 로고
    • Mechanisms of cefadroxil uptake in the choroid plexus: Studies in wild-type and PEPT2 knockout mice
    • OCHELTREE SM, SHEN H, HU Y et al.: Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. J. Pharmacol. Exp. Ther. (2004) 308(2):462-467.
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , Issue.2 , pp. 462-467
    • OCHELTREE, S.M.1    SHEN, H.2    HU, Y.3
  • 136
    • 0034825921 scopus 로고    scopus 로고
    • Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: Uptake and transport of fosinopril in cell cultures
    • SHU C, SHEN H, HOPFER U, SMITH DE: Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures. Drug Metab. Dispos. (2001) 29(10):1307-1315.
    • (2001) Drug Metab. Dispos , vol.29 , Issue.10 , pp. 1307-1315
    • SHU, C.1    SHEN, H.2    HOPFER, U.3    SMITH, D.E.4
  • 137
    • 22944433202 scopus 로고    scopus 로고
    • Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)
    • BLEASBY K, HALL LA, PERRY JL, MOHRENWEISER HW, PRITCHARD JB: Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J. Pharmacol. Exp. Ther. (2005) 314(2):923-931.
    • (2005) J. Pharmacol. Exp. Ther , vol.314 , Issue.2 , pp. 923-931
    • BLEASBY, K.1    HALL, L.A.2    PERRY, J.L.3    MOHRENWEISER, H.W.4    PRITCHARD, J.B.5
  • 138
    • 0036020986 scopus 로고    scopus 로고
    • Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function
    • LEABMAN MK, HUANG CC, KAWAMOTO M et al.: Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics (2002) 12(5):395-405.
    • (2002) Pharmacogenetics , vol.12 , Issue.5 , pp. 395-405
    • LEABMAN, M.K.1    HUANG, C.C.2    KAWAMOTO, M.3
  • 139
    • 33645743694 scopus 로고    scopus 로고
    • The human organic anion transporter 3 (OAT3; SLC22A8): Genetic variation and functional genomics
    • ERDMAN AR, MANGRAVITE LM, URBAN TJ et al.: The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am. J. Physiol. Renal Physiol. (2006) 290(4):F905-F912.
    • (2006) Am. J. Physiol. Renal Physiol , vol.290 , Issue.4
    • ERDMAN, A.R.1    MANGRAVITE, L.M.2    URBAN, T.J.3
  • 140
    • 1642523162 scopus 로고    scopus 로고
    • Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance
    • MARZOLINI C, PAUS E, BUCLIN T, KIM RB: Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin. Pharmacol. Ther. (2004) 75(1):13-33.
    • (2004) Clin. Pharmacol. Ther , vol.75 , Issue.1 , pp. 13-33
    • MARZOLINI, C.1    PAUS, E.2    BUCLIN, T.3    KIM, R.B.4
  • 141
    • 27544453846 scopus 로고    scopus 로고
    • Interaction of organic cations with a newly identified plasma membrane monoamine transporter
    • ENGEL K, WANG J: Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol. Pharmacol. (2005) 68(5):1397-1407.
    • (2005) Mol. Pharmacol , vol.68 , Issue.5 , pp. 1397-1407
    • ENGEL, K.1    WANG, J.2
  • 142
    • 9644268195 scopus 로고    scopus 로고
    • Identification and characterization of a novel monoamine transporter in the human brain
    • ENGEL K, ZHOU M, WANG J: Identification and characterization of a novel monoamine transporter in the human brain. J. Biol. Chem. (2004) 279(48):50042-50049.
    • (2004) J. Biol. Chem , vol.279 , Issue.48 , pp. 50042-50049
    • ENGEL, K.1    ZHOU, M.2    WANG, J.3
  • 143
    • 0037040390 scopus 로고    scopus 로고
    • Interaction of human organic anion transporters with various cephalosporin antibiotics
    • TAKEDA M, BABU E, NARIKAWA S, ENDOU H: Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur. J. Pharmacol. (2002) 438(3):137-142.
    • (2002) Eur. J. Pharmacol , vol.438 , Issue.3 , pp. 137-142
    • TAKEDA, M.1    BABU, E.2    NARIKAWA, S.3    ENDOU, H.4
  • 144
    • 0033815816 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1
    • MULATO AS, HO ES, CIHLAR T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J. Pharmacol. Exp. Ther. (2000) 295(1):10-15.
    • (2000) J. Pharmacol. Exp. Ther , vol.295 , Issue.1 , pp. 10-15
    • MULATO, A.S.1    HO, E.S.2    CIHLAR, T.3
  • 145
    • 1642422265 scopus 로고    scopus 로고
    • Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine
    • KHAMDANG S, TAKEDA M, SHIMODA M et al.: Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine. J. Pharmacol. Sci. (2004) 94(2):197-202.
    • (2004) J. Pharmacol. Sci , vol.94 , Issue.2 , pp. 197-202
    • KHAMDANG, S.1    TAKEDA, M.2    SHIMODA, M.3
  • 146
    • 21244505457 scopus 로고    scopus 로고
    • Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices
    • SRIMAROENG C, JUTABHA P, PRITCHARD JB, ENDOU H, CHATSUDTHIPONG V: Interactions of stevioside and steviol with renal organic anion transporters in S2 cells and mouse renal cortical slices. Pharm. Res. (2005) 22(6):858-866.
    • (2005) Pharm. Res , vol.22 , Issue.6 , pp. 858-866
    • SRIMAROENG, C.1    JUTABHA, P.2    PRITCHARD, J.B.3    ENDOU, H.4    CHATSUDTHIPONG, V.5
  • 147
    • 0034757988 scopus 로고    scopus 로고
    • Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter hOATL1
    • ISLINGER F, GEKLE M, WRIGHT SH: Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter hOATL1. Pharmacol. Exp. Ther. (2001) 299(2):741-747.
    • (2001) Pharmacol. Exp. Ther , vol.299 , Issue.2 , pp. 741-747
    • ISLINGER, F.1    GEKLE, M.2    WRIGHT, S.H.3
  • 148
    • 33645798634 scopus 로고    scopus 로고
    • Inhibition of OAT3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid
    • TAHARA H, KUSUHARA H, MAEDA K et al.: Inhibition of OAT3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. Drug Metab. Dispos. (2006) 34(5):743-747.
    • (2006) Drug Metab. Dispos , vol.34 , Issue.5 , pp. 743-747
    • TAHARA, H.1    KUSUHARA, H.2    MAEDA, K.3
  • 149
    • 0035039326 scopus 로고    scopus 로고
    • Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney
    • CHA SH, SEKINE T, FUKUSHIMA JI et al.: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol. Pharmacol. (2001) 59(5):1277-1286.
    • (2001) Mol. Pharmacol , vol.59 , Issue.5 , pp. 1277-1286
    • CHA, S.H.1    SEKINE, T.2    FUKUSHIMA, J.I.3
  • 150
    • 0036198625 scopus 로고    scopus 로고
    • Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins
    • KIMURA H, TAKEDA M, NARIKAWA S et al.: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J. Pharmacol. Exp. Ther. (2002) 301(1):293-298.
    • (2002) J. Pharmacol. Exp. Ther , vol.301 , Issue.1 , pp. 293-298
    • KIMURA, H.1    TAKEDA, M.2    NARIKAWA, S.3
  • 151
    • 27744570434 scopus 로고    scopus 로고
    • Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)
    • BOURDET DL, PRITCHARD JB, THAKKER DR: Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J. Pharmacol. Exp. Ther. (2005) 315(3):1288-1297.
    • (2005) J. Pharmacol. Exp. Ther , vol.315 , Issue.3 , pp. 1288-1297
    • BOURDET, D.L.1    PRITCHARD, J.B.2    THAKKER, D.R.3
  • 152
    • 28244486151 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2
    • CIARIMBOLI G, LUDWIG T, LANG D et al.: Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am. J. Pathol. (2005) 167(6):1477-1484.
    • (2005) Am. J. Pathol , vol.167 , Issue.6 , pp. 1477-1484
    • CIARIMBOLI, G.1    LUDWIG, T.2    LANG, D.3
  • 153
    • 0030763035 scopus 로고    scopus 로고
    • Cloning and characterization of two human polyspecific organic cation transporters
    • GORBOULEV V, ULZHEIMER JC, AKHOUNDOVA A et al.: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. (1997) 16(7):871-881.
    • (1997) DNA Cell Biol , vol.16 , Issue.7 , pp. 871-881
    • GORBOULEV, V.1    ULZHEIMER, J.C.2    AKHOUNDOVA, A.3
  • 154
    • 0031824347 scopus 로고    scopus 로고
    • Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine
    • BUSCH AE, KARBACH U, MISKA D et al.: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol. Pharmacol. (1998) 54(2):342-352.
    • (1998) Mol. Pharmacol , vol.54 , Issue.2 , pp. 342-352
    • BUSCH, A.E.1    KARBACH, U.2    MISKA, D.3
  • 155
    • 0032696186 scopus 로고    scopus 로고
    • +)-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
    • +)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J. Pharmacol. Exp. Ther. (1999) 291(2):778-784.
    • (1999) J. Pharmacol. Exp. Ther , vol.291 , Issue.2 , pp. 778-784
    • OHASHI, R.1    TAMAI, I.2    YABUUCHI, H.3
  • 156
    • 0034695673 scopus 로고    scopus 로고
    • β-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter
    • GANAPATHY ME, HUANG W, RAJAN DP et al.: β-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J. Biol. Chem. (2000) 275(3):1699-1707.
    • (2000) J. Biol. Chem , vol.275 , Issue.3 , pp. 1699-1707
    • GANAPATHY, M.E.1    HUANG, W.2    RAJAN, D.P.3
  • 157
    • 0344572686 scopus 로고    scopus 로고
    • CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs
    • HAN HK, RHIE JK, OH DM et al.: CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J. Pharm. Sci. (1999) 88(3):347-350.
    • (1999) J. Pharm. Sci , vol.88 , Issue.3 , pp. 347-350
    • HAN, H.K.1    RHIE, J.K.2    OH, D.M.3
  • 158
    • 0032544684 scopus 로고    scopus 로고
    • Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir
    • BALIMANE PV, TAMAI I, GUO A et al.: Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir. Biochem. Biophys. Res. Commun. (1998) 250(2):246-251.
    • (1998) Biochem. Biophys. Res. Commun , vol.250 , Issue.2 , pp. 246-251
    • BALIMANE, P.V.1    TAMAI, I.2    GUO, A.3
  • 159
    • 0032546467 scopus 로고    scopus 로고
    • Valacyclovir: A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2
    • GANAPATHY ME, HUANG W, WANG H, GANAPATHY V, LEIBACH FH: Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem. Biophys. Res. Commun. (1998) 246(2):470-475.
    • (1998) Biochem. Biophys. Res. Commun , vol.246 , Issue.2 , pp. 470-475
    • GANAPATHY, M.E.1    HUANG, W.2    WANG, H.3    GANAPATHY, V.4    LEIBACH, F.H.5
  • 160
    • 0032916827 scopus 로고    scopus 로고
    • Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line
    • GUO A, HU P, BALIMANE PV, LEIBACH FH, SINKO PJ: Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. J. Pharmacol. Exp. Ther. (1999) 289(1):448-454.
    • (1999) J. Pharmacol. Exp. Ther , vol.289 , Issue.1 , pp. 448-454
    • GUO, A.1    HU, P.2    BALIMANE, P.V.3    LEIBACH, F.H.4    SINKO, P.J.5
  • 161
    • 0040699988 scopus 로고    scopus 로고
    • +/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux
    • +/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm. Res. (1999) 16(1):55-61.
    • (1999) Pharm. Res , vol.16 , Issue.1 , pp. 55-61
    • BRETSCHNEIDER, B.1    BRANDSCH, M.2    NEUBERT, R.3
  • 162
    • 9644252691 scopus 로고    scopus 로고
    • +/peptide symporter PEPT2: Analysis of affinity constants and comparison with PEPT1
    • +/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur. J. Pharm. Biopharm. (2005) 59(1):17-24.
    • (2005) Eur. J. Pharm. Biopharm , vol.59 , Issue.1 , pp. 17-24
    • LUCKNER, P.1    BRANDSCH, M.2
  • 164
    • 0028826927 scopus 로고
    • Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2
    • GANAPATHY ME, BRANDSCH M, PRASAD PD, GANAPATHY V, LEIBACH FH: Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J. Biol. Chem. (1995) 270(43):25672-25677.
    • (1995) J. Biol. Chem , vol.270 , Issue.43 , pp. 25672-25677
    • GANAPATHY, M.E.1    BRANDSCH, M.2    PRASAD, P.D.3    GANAPATHY, V.4    LEIBACH, F.H.5
  • 165
    • 0030892709 scopus 로고    scopus 로고
    • Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2
    • GANAPATHY ME, PRASAD PD, MACKENZIE B, GANAPATHY V, LEIBACH FH: Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. Biochim. Biophys. Acta (1997) 1324(2):296-308.
    • (1997) Biochim. Biophys. Acta , vol.1324 , Issue.2 , pp. 296-308
    • GANAPATHY, M.E.1    PRASAD, P.D.2    MACKENZIE, B.3    GANAPATHY, V.4    LEIBACH, F.H.5
  • 166
    • 0034960419 scopus 로고    scopus 로고
    • A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells
    • GAO J, MURASE O, SCHOWEN RL, AUBE J, BORCHARDT RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm. Res. (2001) 18(2):171-176.
    • (2001) Pharm. Res , vol.18 , Issue.2 , pp. 171-176
    • GAO, J.1    MURASE, O.2    SCHOWEN, R.L.3    AUBE, J.4    BORCHARDT, R.T.5
  • 167
    • 0033862088 scopus 로고    scopus 로고
    • Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines
    • VAN DER SANDT IC, BLOM-ROOSEMALEN MC, DE BOERAG, BREIMER DD: Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. Eur. J. Pharm. Sci. (2000) 11(3):207-214.
    • (2000) Eur. J. Pharm. Sci , vol.11 , Issue.3 , pp. 207-214
    • VAN DER SANDT IC1    Blom-Roosemalen, M.C.2    DE BOERAG3    Breimer, D.D.4
  • 168
    • 0026777528 scopus 로고
    • Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells
    • SPOELSTRA EC, WESTERHOFF HV, DEKKER H, LANKELMA J: Kinetics of daunorubicin transport by P-glycoprotein of intact cancer cells. Eur. J. Biochem. (1992) 207(2):567-579.
    • (1992) Eur. J. Biochem , vol.207 , Issue.2 , pp. 567-579
    • SPOELSTRA, E.C.1    WESTERHOFF, H.V.2    DEKKER, H.3    LANKELMA, J.4
  • 169
    • 0031719032 scopus 로고    scopus 로고
    • Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells
    • MAKHEY VD, GUO A, NORRIS DA et al.: Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells. Pharm. Res. (1998) 15(8):1160-1167.
    • (1998) Pharm. Res , vol.15 , Issue.8 , pp. 1160-1167
    • MAKHEY, V.D.1    GUO, A.2    NORRIS, D.A.3
  • 170
    • 0031941789 scopus 로고    scopus 로고
    • Taxol transport by human intestinal epithelial Caco-2 cells
    • WALLE UK, WALLE T: Taxol transport by human intestinal epithelial Caco-2 cells. Drug Metab. Dispos. (1998) 26(4):343-346.
    • (1998) Drug Metab. Dispos , vol.26 , Issue.4 , pp. 343-346
    • WALLE, U.K.1    WALLE, T.2
  • 171
    • 27544483787 scopus 로고    scopus 로고
    • Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: Influence of cell line and modulator concentration on P-gp activity
    • TAUB ME, PODILA L, ELY D, ALMEIDA I: Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity. Drug Metab. Dispos. (2005) 33(11):1679-1687.
    • (2005) Drug Metab. Dispos , vol.33 , Issue.11 , pp. 1679-1687
    • TAUB, M.E.1    PODILA, L.2    ELY, D.3    ALMEIDA, I.4
  • 172
    • 2942682950 scopus 로고    scopus 로고
    • Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery
    • BALIMANE PV, PATEL K, MARINO A, CHONG S: Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery. Eur. J. Pharm. Biopharm. (2004) 58(1):99-105.
    • (2004) Eur. J. Pharm. Biopharm , vol.58 , Issue.1 , pp. 99-105
    • BALIMANE, P.V.1    PATEL, K.2    MARINO, A.3    CHONG, S.4
  • 173
    • 0027181852 scopus 로고
    • Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
    • HUNTER J, JEPSON MA, TSURUO T, SIMMONS NL, HIRST BH: Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. J. Biol. Chem. (1993) 268(20):14991-14997.
    • (1993) J. Biol. Chem , vol.268 , Issue.20 , pp. 14991-14997
    • HUNTER, J.1    JEPSON, M.A.2    TSURUO, T.3    SIMMONS, N.L.4    HIRST, B.H.5
  • 174
    • 0032804327 scopus 로고    scopus 로고
    • Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor
    • POLLI JW, JARRETT JL, STUDENBERG SD et al: Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor. Pharm. Res. (1999) 16(8):1206-1212.
    • (1999) Pharm. Res , vol.16 , Issue.8 , pp. 1206-1212
    • POLLI, J.W.1    JARRETT, J.L.2    STUDENBERG, S.D.3
  • 175
    • 18344364851 scopus 로고    scopus 로고
    • Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates
    • EKINS S, KIM RB, LEAKE BF et al: Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. Mol. Pharmacol. (2002) 61(5):974-981.
    • (2002) Mol. Pharmacol , vol.61 , Issue.5 , pp. 974-981
    • EKINS, S.1    KIM, R.B.2    LEAKE, B.F.3
  • 176
    • 27144514512 scopus 로고    scopus 로고
    • MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells
    • WOODAHL EL, YANG Z, BUI T, SHEN DD, HO RJ: MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells. AIDS (2005) 19(15):1617-1625.
    • (2005) AIDS , vol.19 , Issue.15 , pp. 1617-1625
    • WOODAHL, E.L.1    YANG, Z.2    BUI, T.3    SHEN, D.D.4    HO, R.J.5
  • 177
    • 18344390872 scopus 로고    scopus 로고
    • Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein
    • EKINS S, KIM RB, LEAKE BF et al.: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol. Pharmacol. (2002) 61(5):964-973.
    • (2002) Mol. Pharmacol , vol.61 , Issue.5 , pp. 964-973
    • EKINS, S.1    KIM, R.B.2    LEAKE, B.F.3
  • 179
    • 0029986277 scopus 로고    scopus 로고
    • Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: In vitro-in vivo correlation
    • FRICKER G, DREWE J, HUWYLER J, GUTMANN H, BEGLINGER C: Relevance of P-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation. Br. J. Pharmacol. (1996) 118(7):1841-1847.
    • (1996) Br. J. Pharmacol , vol.118 , Issue.7 , pp. 1841-1847
    • FRICKER, G.1    DREWE, J.2    HUWYLER, J.3    GUTMANN, H.4    BEGLINGER, C.5
  • 180
    • 0027418815 scopus 로고
    • Human P-glycoprotein transports cyclosporin A and FK-506
    • SAEKI T, UEDA K, TANIGAWARA Y, HORI R, KOMANO T: Human P-glycoprotein transports cyclosporin A and FK-506. J. Biol. Chem. (1993) 268(9):6077-6080.
    • (1993) J. Biol. Chem , vol.268 , Issue.9 , pp. 6077-6080
    • SAEKI, T.1    UEDA, K.2    TANIGAWARA, Y.3    HORI, R.4    KOMANO, T.5
  • 181
    • 0032807119 scopus 로고    scopus 로고
    • P-glycoprotein-dependent disposition kinetics of tacrolimus: Studies in mdr1a knockout mice
    • YOKOGAWA K, TAKAHASHI M, TAMAI I et al.: P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice. Pharm. Res. (1999) 16(8):1213-1218.
    • (1999) Pharm. Res , vol.16 , Issue.8 , pp. 1213-1218
    • YOKOGAWA, K.1    TAKAHASHI, M.2    TAMAI, I.3
  • 182
    • 11344284146 scopus 로고    scopus 로고
    • P-glycoprotein and surfactants: Effect on intestinal talinolol absorption
    • BOGMAN K, ZYSSET Y, DEGEN L et al.: P-glycoprotein and surfactants: effect on intestinal talinolol absorption. Clin. Pharmacol. Ther. (2005) 77(1):24-32.
    • (2005) Clin. Pharmacol. Ther , vol.77 , Issue.1 , pp. 24-32
    • BOGMAN, K.1    ZYSSET, Y.2    DEGEN, L.3
  • 183
    • 0032589932 scopus 로고    scopus 로고
    • Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2
    • COLLETT A, HIGGS NB, SIMS E, ROWLAND M, WARHURST G: Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2. J. Pharmacol. Exp. Ther. (1999) 288(1):171-178.
    • (1999) J. Pharmacol. Exp. Ther , vol.288 , Issue.1 , pp. 171-178
    • COLLETT, A.1    HIGGS, N.B.2    SIMS, E.3    ROWLAND, M.4    WARHURST, G.5
  • 184
    • 4344594700 scopus 로고    scopus 로고
    • Transport characteristics of fexofenadine in the Caco-2 cell model
    • PETRI N, TANNERGREN C, RUNGSTAD D, LENNERNAS H: Transport characteristics of fexofenadine in the Caco-2 cell model. Pharm. Res. (2004) 21(8):1398-1404.
    • (2004) Pharm. Res , vol.21 , Issue.8 , pp. 1398-1404
    • PETRI, N.1    TANNERGREN, C.2    RUNGSTAD, D.3    LENNERNAS, H.4
  • 185
    • 0035146553 scopus 로고    scopus 로고
    • Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia
    • STEPHENS RH, O'NEILL CA, WARHURST A et al.: Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia. J. Pharmacol. Exp. Ther. (2001) 296(2):584-591.
    • (2001) J. Pharmacol. Exp. Ther , vol.296 , Issue.2 , pp. 584-591
    • STEPHENS, R.H.1    O'NEILL, C.A.2    WARHURST, A.3
  • 186
    • 0026707951 scopus 로고
    • P-glycoprotein transports corticosterone and is photoaffinity-Iabeled by the steroid
    • WOLF DC, HORWITZ SB: P-glycoprotein transports corticosterone and is photoaffinity-Iabeled by the steroid. Int. J. Cancer (1992) 52(1):141-146.
    • (1992) Int. J. Cancer , vol.52 , Issue.1 , pp. 141-146
    • WOLF, D.C.1    HORWITZ, S.B.2
  • 187
    • 0036839699 scopus 로고    scopus 로고
    • Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2)
    • WILLIAMS GC, LIU A, KNIPP G, SINKO PJ: Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob. Agents Chemother. (2002) 46(11):3456-3462.
    • (2002) Antimicrob. Agents Chemother , vol.46 , Issue.11 , pp. 3456-3462
    • WILLIAMS, G.C.1    LIU, A.2    KNIPP, G.3    SINKO, P.J.4
  • 188
    • 0034072174 scopus 로고    scopus 로고
    • Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
    • BAKOS E, EVERS R, SINKO E et al.: Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol. Pharmacol. (2000) 57(4):760-768.
    • (2000) Mol. Pharmacol , vol.57 , Issue.4 , pp. 760-768
    • BAKOS, E.1    EVERS, R.2    SINKO, E.3
  • 189
    • 0031788927 scopus 로고    scopus 로고
    • Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters
    • SRINIVAS RV, MIDDLEMAS D, FLYNN P, FRIDLAND A: Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters. Antimicrob. Agents Chemother. (1998) 42(12):3157-3162.
    • (1998) Antimicrob. Agents Chemother , vol.42 , Issue.12 , pp. 3157-3162
    • SRINIVAS, R.V.1    MIDDLEMAS, D.2    FLYNN, P.3    FRIDLAND, A.4
  • 190
    • 0033021424 scopus 로고    scopus 로고
    • ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1
    • RENES J, DE VRIES EG, NIENHUIS EF, JANSEN PL, MULLER M: ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. Br. J. Pharmacol. (1999) 126(3):681-688.
    • (1999) Br. J. Pharmacol , vol.126 , Issue.3 , pp. 681-688
    • RENES, J.1    DE VRIES EG2    Nienhuis, E.F.3    Jansen, P.L.4    Muller, M.5
  • 191
    • 11144264060 scopus 로고    scopus 로고
    • Potentiation by α-tocopheryl succinate of the etoposide response in multidrug resistance protein 1-expressing glioblastoma cells
    • KANG YH, LEE E, YOUK HJ et al.: Potentiation by α-tocopheryl succinate of the etoposide response in multidrug resistance protein 1-expressing glioblastoma cells. Cancer Lett. (2005) 217(2):181-190.
    • (2005) Cancer Lett , vol.217 , Issue.2 , pp. 181-190
    • KANG, Y.H.1    LEE, E.2    YOUK, H.J.3
  • 192
    • 0027984511 scopus 로고
    • The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
    • LEIER I, JEDLITSCHKY G, BUCHHOLZ U et al: The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J. Biol. Chem. (1994) 269(45):27807-27810.
    • (1994) J. Biol. Chem , vol.269 , Issue.45 , pp. 27807-27810
    • LEIER, I.1    JEDLITSCHKY, G.2    BUCHHOLZ, U.3
  • 193
    • 0030063480 scopus 로고    scopus 로고
    • Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
    • JEDLITSCHKY G, LEIER I, BUCHHOLZ U et al.: Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. (1996) 56(5):988-994.
    • (1996) Cancer Res , vol.56 , Issue.5 , pp. 988-994
    • JEDLITSCHKY, G.1    LEIER, I.2    BUCHHOLZ, U.3
  • 194
    • 0034083906 scopus 로고    scopus 로고
    • ATP-dependent para-aminohippurare transport by apical multidrug resistance protein MRP2
    • LEIER I, HUMMEL-EISENBEISS J, CUI Y, KEPPLER D: ATP-dependent para-aminohippurare transport by apical multidrug resistance protein MRP2. Kidney Int. (2000) 57(4):1636-1642.
    • (2000) Kidney Int , vol.57 , Issue.4 , pp. 1636-1642
    • LEIER, I.1    HUMMEL-EISENBEISS, J.2    CUI, Y.3    KEPPLER, D.4
  • 195
    • 0345299165 scopus 로고    scopus 로고
    • Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
    • CUI Y, KONIG J, BUCHHOLZ JK et al.: Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol. Pharmacol. (1999) 55(5):929-937.
    • (1999) Mol. Pharmacol , vol.55 , Issue.5 , pp. 929-937
    • CUI, Y.1    KONIG, J.2    BUCHHOLZ, J.K.3
  • 196
    • 0036206470 scopus 로고    scopus 로고
    • Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT)
    • GUO A, MARINARO W, HU P, SINKO PJ: Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab. Dispos. (2002) 30(4):457-463.
    • (2002) Drug Metab. Dispos , vol.30 , Issue.4 , pp. 457-463
    • GUO, A.1    MARINARO, W.2    HU, P.3    SINKO, P.J.4
  • 197
    • 0036166635 scopus 로고    scopus 로고
    • Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2)
    • FLANAGAN SD, CUMMINS CL, SUSANTO M et al.: Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology (2002) 64(3):126-134.
    • (2002) Pharmacology , vol.64 , Issue.3 , pp. 126-134
    • FLANAGAN, S.D.1    CUMMINS, C.L.2    SUSANTO, M.3
  • 198
    • 0032781499 scopus 로고    scopus 로고
    • Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)
    • KAWABE T, CHEN ZS, WADA M et al.: Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). FEBS Lett. (1999) 456(2):327-331.
    • (1999) FEBS Lett , vol.456 , Issue.2 , pp. 327-331
    • KAWABE, T.1    CHEN, Z.S.2    WADA, M.3
  • 199
    • 0037613131 scopus 로고    scopus 로고
    • The potential for an interaction be ween MRP2 (ABCC2) and various therapeutic agents: Probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites
    • HORIKAWA M, KATO Y, TYSON CA, SUGIYAMA Y: The potential for an interaction be ween MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab. Pharmacokinet. (2002) 17(1):23-33.
    • (2002) Drug Metab. Pharmacokinet , vol.17 , Issue.1 , pp. 23-33
    • HORIKAWA, M.1    KATO, Y.2    TYSON, C.A.3    SUGIYAMA, Y.4
  • 200
    • 0034282991 scopus 로고    scopus 로고
    • Transport of amphipathic anions by human multidrug resistance protein 3
    • ZENG H, LIU G, REA PA, KRUH GD: Transport of amphipathic anions by human multidrug resistance protein 3. Cancer Res. (2000) 60(17):4779-4784.
    • (2000) Cancer Res , vol.60 , Issue.17 , pp. 4779-4784
    • ZENG, H.1    LIU, G.2    REA, P.A.3    KRUH, G.D.4
  • 201
    • 0035824674 scopus 로고    scopus 로고
    • Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3)
    • ZELCER N, SAEKIT, REID G, BEIJNEN JH, BURST P: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J. Biol. Chem. (2001) 276(49):46400-46407.
    • (2001) J. Biol. Chem , vol.276 , Issue.49 , pp. 46400-46407
    • ZELCER, N.1    SAEKIT, R.G.2    BEIJNEN, J.H.3    BURST, P.4
  • 202
    • 0035823559 scopus 로고    scopus 로고
    • Transport of cyclic nucleotides and estradiol 17-β-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine
    • CHEN ZS, LEE K, KRUH GD: Transport of cyclic nucleotides and estradiol 17-β-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J. Biol. Chem. (2001) 276(36):33747-33754.
    • (2001) J. Biol. Chem , vol.276 , Issue.36 , pp. 33747-33754
    • CHEN, Z.S.1    LEE, K.2    KRUH, G.D.3
  • 203
    • 0036471128 scopus 로고    scopus 로고
    • Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues
    • LAI L, TAN TM: Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem. J. (2002) 361(Pt 3):497-503.
    • (2002) Biochem. J , vol.361 , Issue.PART 3 , pp. 497-503
    • LAI, L.1    TAN, T.M.2
  • 204
    • 0036606023 scopus 로고    scopus 로고
    • Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system
    • CHEN ZS, LEE K, WALTHER S et al.: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. (2002) 62(11):3144-3150.
    • (2002) Cancer Res , vol.62 , Issue.11 , pp. 3144-3150
    • CHEN, Z.S.1    LEE, K.2    WALTHER, S.3
  • 205
    • 0043132421 scopus 로고    scopus 로고
    • The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
    • REID G, WIELINGA P, ZELCER N et al.: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc. Natl. Acad. Sci. USA (2003) 100(16):9244-9249.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.16 , pp. 9244-9249
    • REID, G.1    WIELINGA, P.2    ZELCER, N.3
  • 206
  • 207
    • 0016205272 scopus 로고
    • Pharmacokinetics of parenteral sodium cephalexin in comparison with cephalothin and cefazolin
    • REGAMEY C, LIBKE RD, CLARKE JT, KIRBY WM: Pharmacokinetics of parenteral sodium cephalexin in comparison with cephalothin and cefazolin. Infection (1974) 2(3):132-136.
    • (1974) Infection , vol.2 , Issue.3 , pp. 132-136
    • REGAMEY, C.1    LIBKE, R.D.2    CLARKE, J.T.3    KIRBY, W.M.4
  • 208
    • 0017645455 scopus 로고
    • Effect of probenecid on the blood levels and urinary excretion of cefamandole
    • GRIFFITH RS, BLACK HR, BRIER GL, WOLNY JD: Effect of probenecid on the blood levels and urinary excretion of cefamandole. Antimicrob. Agents Chemother. (1977) 11(5):809-812.
    • (1977) Antimicrob. Agents Chemother , vol.11 , Issue.5 , pp. 809-812
    • GRIFFITH, R.S.1    BLACK, H.R.2    BRIER, G.L.3    WOLNY, J.D.4
  • 210
    • 0019497381 scopus 로고
    • Pharmacokinetics of cephradine given intravenously with and without probenecid
    • ROBERTS DH, KENDALL MJ, JACK DB, WELLING PG: Pharmacokinetics of cephradine given intravenously with and without probenecid. Br. J. Clin. Pharmacol. (1981) 11(6):561-564.
    • (1981) Br. J. Clin. Pharmacol , vol.11 , Issue.6 , pp. 561-564
    • ROBERTS, D.H.1    KENDALL, M.J.2    JACK, D.B.3    WELLING, P.G.4
  • 211
    • 0028285829 scopus 로고
    • The renal clearance of cefuroxime and ceftazidime and the effect of probenecid on their tubular excretion
    • VERHAGEN CA, MATTIE H, VAN STRIJEN E: The renal clearance of cefuroxime and ceftazidime and the effect of probenecid on their tubular excretion. Br. J. Clin. Pharmacol. (1994) 37(2):193-197.
    • (1994) Br. J. Clin. Pharmacol , vol.37 , Issue.2 , pp. 193-197
    • VERHAGEN, C.A.1    MATTIE, H.2    VAN STRIJEN, E.3
  • 212
    • 0021154184 scopus 로고
    • Inhibition of cis-diamminedichloroplarinum secretion by the human kidney with probenecid
    • JACOBS C, COLEMAN CN, RICH L, HIRST K, WEINER MW: Inhibition of cis-diamminedichloroplarinum secretion by the human kidney with probenecid. Cancer Res. (1984) 44(8):3632-3635.
    • (1984) Cancer Res , vol.44 , Issue.8 , pp. 3632-3635
    • JACOBS, C.1    COLEMAN, C.N.2    RICH, L.3    HIRST, K.4    WEINER, M.W.5
  • 213
    • 0025055624 scopus 로고
    • The inhibitory effect of probenecid on renal excretion of famotidine in young, healthy volunteers
    • INOTSUME N, NISHIMURA M, NAKANO M, FUJIYAMA S, SATO T: The inhibitory effect of probenecid on renal excretion of famotidine in young, healthy volunteers. J. Clin. Pharmacol. (1990) 30(1):50-56.
    • (1990) J. Clin. Pharmacol , vol.30 , Issue.1 , pp. 50-56
    • INOTSUME, N.1    NISHIMURA, M.2    NAKANO, M.3    FUJIYAMA, S.4    SATO, T.5
  • 214
    • 11344279702 scopus 로고    scopus 로고
    • Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics
    • YASUI-FURUKORI N, UNO T, SUGAWARA K, TATEISHI T: Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics. Clin. Pharmacol. Ther. (2005) 77(1):17-23.
    • (2005) Clin. Pharmacol. Ther , vol.77 , Issue.1 , pp. 17-23
    • YASUI-FURUKORI, N.1    UNO, T.2    SUGAWARA, K.3    TATEISHI, T.4
  • 215
    • 0029923717 scopus 로고    scopus 로고
    • The effect of probenecid on the pharmacokinetics of zalcitabine in HIV-positive patients
    • MASSARELLA JW, NAZARENO LA, PASSE S, MIN B: The effect of probenecid on the pharmacokinetics of zalcitabine in HIV-positive patients. Pharm. Res. (1996) 13(3):449-452.
    • (1996) Pharm. Res , vol.13 , Issue.3 , pp. 449-452
    • MASSARELLA, J.W.1    NAZARENO, L.A.2    PASSE, S.3    MIN, B.4
  • 216
    • 0032030860 scopus 로고    scopus 로고
    • Pharmacokinetics of oral ganciclovir alone and in combination with zidovudine, didanosine, and probenecid in HIV-infected subjects
    • CIMOCH PJ, LAVELLE J, POLLARD R et al.: Pharmacokinetics of oral ganciclovir alone and in combination with zidovudine, didanosine, and probenecid in HIV-infected subjects. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. (1998) 17(3):227-234.
    • (1998) J. Acquir. Immune Defic. Syndr. Hum. Retrovirol , vol.17 , Issue.3 , pp. 227-234
    • CIMOCH, P.J.1    LAVELLE, J.2    POLLARD, R.3
  • 217
    • 0028822282 scopus 로고
    • Effect of probenecid on the distribution and elimination of ciprofloxacin in humans
    • JAEHDE U, SORGEL F, REITER A et al.: Effect of probenecid on the distribution and elimination of ciprofloxacin in humans. Clin. Pharmacol. Ther. (1995) 58(5):532-541.
    • (1995) Clin. Pharmacol. Ther , vol.58 , Issue.5 , pp. 532-541
    • JAEHDE, U.1    SORGEL, F.2    REITER, A.3
  • 219
    • 0031919208 scopus 로고    scopus 로고
    • Stereoselective disposition of sulbenicillin in humans
    • ITOH T, WATANABE N, ISHIDA M et al.: Stereoselective disposition of sulbenicillin in humans. Antimicrob. Agents Chemother. (1998) 42(2):325-331.
    • (1998) Antimicrob. Agents Chemother , vol.42 , Issue.2 , pp. 325-331
    • ITOH, T.1    WATANABE, N.2    ISHIDA, M.3
  • 220
    • 0023730329 scopus 로고
    • Lack of effect of cimetidine on the metabolism of quinidine: Effect on renal clearance
    • HARDY BG, SCHENTAG JJ: Lack of effect of cimetidine on the metabolism of quinidine: effect on renal clearance. Int. J. Clin. Pharmacol. Ther. Toxicol. (1988) 26(8):388-391.
    • (1988) Int. J. Clin. Pharmacol. Ther. Toxicol , vol.26 , Issue.8 , pp. 388-391
    • HARDY, B.G.1    SCHENTAG, J.J.2
  • 221
    • 0022631053 scopus 로고
    • Selectivity of the cimetidine-induced alterations in the renal handling of organic substrates in humans. Studies with anionic, cationic and zwitterionic drugs
    • VAN CRUGTEN J, BOCHNER F, KEAL J, SOMOGYI A: Selectivity of the cimetidine-induced alterations in the renal handling of organic substrates in humans. Studies with anionic, cationic and zwitterionic drugs. J Pharmacol. Exp. Ther. (1986) 236(2):481-487.
    • (1986) J Pharmacol. Exp. Ther , vol.236 , Issue.2 , pp. 481-487
    • VAN CRUGTEN, J.1    BOCHNER, F.2    KEAL, J.3    SOMOGYI, A.4
  • 222
    • 0034025366 scopus 로고    scopus 로고
    • Effect of cimetidine and probenecid on pilsicainide renal clearance in humans
    • SHIGA T, HASHIGUCHI M, URAE A, KASANUKI H, RIKIHISA T: Effect of cimetidine and probenecid on pilsicainide renal clearance in humans. Clin. Pharmacol. Ther. (2000) 67(3):222-228.
    • (2000) Clin. Pharmacol. Ther , vol.67 , Issue.3 , pp. 222-228
    • SHIGA, T.1    HASHIGUCHI, M.2    URAE, A.3    KASANUKI, H.4    RIKIHISA, T.5
  • 224
    • 0023855201 scopus 로고
    • Pharmacokinetic drug interactions between triamterene and ranitidine in humans: Alterations in renal and hepatic clearances and gastrointestinal absorption
    • MUIRHEAD M, BOCHNER F, SOMOGYI A: Pharmacokinetic drug interactions between triamterene and ranitidine in humans: alterations in renal and hepatic clearances and gastrointestinal absorption. J. Pharmacol. Exp. Ther. (1988) 244(2):734-739.
    • (1988) J. Pharmacol. Exp. Ther , vol.244 , Issue.2 , pp. 734-739
    • MUIRHEAD, M.1    BOCHNER, F.2    SOMOGYI, A.3
  • 225
    • 0021133374 scopus 로고
    • Dose and concentration dependent effect of ranitidine on procainamide disposition and renal clearance in man
    • SOMOGYI A, BOCHNER F: Dose and concentration dependent effect of ranitidine on procainamide disposition and renal clearance in man. Br. J. Clin. Pharmacol. (1984) 18(2):175-181.
    • (1984) Br. J. Clin. Pharmacol , vol.18 , Issue.2 , pp. 175-181
    • SOMOGYI, A.1    BOCHNER, F.2
  • 226
    • 16244408295 scopus 로고    scopus 로고
    • Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances
    • BAUER LA, BLACK DJ, LILL JS et al.: Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances. Antimicrob. Agents Chemother. (2005) 49(4):1649-1651.
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.4 , pp. 1649-1651
    • BAUER, L.A.1    BLACK, D.J.2    LILL, J.S.3
  • 227
    • 0026475448 scopus 로고
    • Trimethoprim, alone or in combination with sulphamethoxazole, decreases the renal excretion of zidovudine and its glucuronide
    • CHATTON JY, MUNAFO A, CHAVE JP et al.: Trimethoprim, alone or in combination with sulphamethoxazole, decreases the renal excretion of zidovudine and its glucuronide. Br. J. Clin. Pharmacol. (1992) 34(6):551-554.
    • (1992) Br. J. Clin. Pharmacol , vol.34 , Issue.6 , pp. 551-554
    • CHATTON, J.Y.1    MUNAFO, A.2    CHAVE, J.P.3
  • 228
    • 0032698091 scopus 로고    scopus 로고
    • Longitudinal assessment of a P-glycoprotein-mediated drug interaction of valspodar on digoxin
    • KOVARIK JM, RIGAUDY L, GUERRET M, GERBEAU C, ROST KL: Longitudinal assessment of a P-glycoprotein-mediated drug interaction of valspodar on digoxin. Clin. Pharmacol. Ther. (1999) 66(4):391-400.
    • (1999) Clin. Pharmacol. Ther , vol.66 , Issue.4 , pp. 391-400
    • KOVARIK, J.M.1    RIGAUDY, L.2    GUERRET, M.3    GERBEAU, C.4    ROST, K.L.5
  • 229
    • 0023922967 scopus 로고
    • Digoxin-cyclosporine interaction: Severe digitalis toxicity after cyclosporine treatment
    • DORIAN P, STRAUSS M, CARDELLA C et al.: Digoxin-cyclosporine interaction: severe digitalis toxicity after cyclosporine treatment. Clin. Invest. Med. (1988) 11(2):108-112.
    • (1988) Clin. Invest. Med , vol.11 , Issue.2 , pp. 108-112
    • DORIAN, P.1    STRAUSS, M.2    CARDELLA, C.3
  • 230
    • 0020614706 scopus 로고
    • Interaction between digoxin and calcium antagonists and antiarrhythmic drugs
    • BELZ GG, DOERING W, MUNKES R, MATTHEWS J: Interaction between digoxin and calcium antagonists and antiarrhythmic drugs. Clin. Pharmacol. Ther. (1983) 33(4):410-417.
    • (1983) Clin. Pharmacol. Ther , vol.33 , Issue.4 , pp. 410-417
    • BELZ, G.G.1    DOERING, W.2    MUNKES, R.3    MATTHEWS, J.4
  • 232
    • 0031412569 scopus 로고    scopus 로고
    • Itraconazole increases plasma concentrations of quinidine
    • KAUKONEN KM, OLKKOLA KT, NEUVONEN PJ: Itraconazole increases plasma concentrations of quinidine. Clin. Pharmacol. Ther. (1997) 62(5):510-517.
    • (1997) Clin. Pharmacol. Ther , vol.62 , Issue.5 , pp. 510-517
    • KAUKONEN, K.M.1    OLKKOLA, K.T.2    NEUVONEN, P.J.3


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