Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis

American Journal of Physiology - Renal Physiology

Volumn 295, Issue 1, 2008, Pages

  Chen, Jiarong ^a   Terada, Tomohiro ^a   Ogasawara, Ken ^a   Katsura, Toshiya ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Eisai hyperbilirubinemic rat; Renal secretion; SLC22A8

Indexed keywords

BILE ACID; CEFOTIAM; CHENODEOXYCHOLIC ACID; CHOLIC ACID; GLYCOCHOLIC ACID; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; TAUROCHOLIC ACID; URSODEOXYCHOLIC ACID; ORGANIC ANION TRANSPORTER; SLC22A6 PROTEIN, RAT;

ACIDURIA; ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; CHOLESTASIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERBILIRUBINEMIA; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RAT; UPREGULATION; URINE LEVEL; WILD TYPE; ANIMAL; KIDNEY; METABOLISM; PHYSIOLOGY;

ADAPTATION, BIOLOGICAL; ANIMALS; BILE ACIDS AND SALTS; CEFOTIAM; CHOLESTASIS; HUMANS; HYPERBILIRUBINEMIA; KIDNEY; MALE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS;

EID: 49949091747     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00139.2008     Document Type: Article

References (36)

1. Alrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res 24: 1803-1823, 2007.
2. Anwer MS. Cellular regulation of hepatic bile acid transport in health and cholestasis. Hepatology 39: 581-590, 2004.
3. Beuers U, Bilzer M, Chittattu A, Kullak-Ublick GA, Keppler D, Paumgartner G, Dombrowski F. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 33: 1206-1216, 2001.
4. Brandoni A, Anzai N, Kanai Y, Endou H, Torres AM. Renal elimination of p-aminohippurate (PAH) in response to three days of biliary obstruction in the rat. The role of OAT1 and OAT3. Biochim Biophys Acta 1762: 673-682, 2006.
5. Brandoni A, Villar SR, Picena JC, Anzai N, Endou H, Torres AM. Expression of rat renal cortical OAT1 and OAT3 in response to acute biliary obstruction. Hepatology 43: 1092-1100, 2006.
6. Bremmelgaard A, Alme B. Analysis of plasma bile acid profiles in patients with liver diseases associated with cholestasis. Scand J Gastroenterol 15: 593-600, 1980.
7. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H. Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59: 1277-1286, 2001.
8. Chen C, Slitt AL, Dieter MZ, Tanaka Y, Scheffer GL, Klaassen CD. Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR rats. Biochem Pharmacol 70: 1088-1095, 2005.
9. 50) of an enzymatic reaction. Biochem Pharmacol 22: 3099-3108, 1973.
10. Daschner FD, Hemmer KA, Offermann P, Slanicka J. Pharmacokinetics of cefotiam in normal humans. Antimicrob Agents Chemother 22: 958-960, 1982.
11. Geier A, Wagner M, Dietrich CG, Trauner M. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim Biophys Acta 1773: 283-308, 2007.
12. Inui K, Masuda S, Saito H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int 58: 944-958, 2000.
13. Ji L, Masuda S, Saito H, Inui K. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int 62: 514-524, 2002.
14. Kipp H, Arias IM. Trafficking of canalicular ABC transporters in hepatocytes. Annu Rev Physiol 64: 595-608, 2002.
15. Kipp H, Pichetshote N, Arias IM. Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver. J Biol Chem 276: 7218-7224, 2001.
16. Konikoff FM. Gallstones - approach to medical management. MedGenMed 5: 8, 2003.
17. Kubitz R, Sutfels G, Kuhlkamp T, Kolling R, Haussinger D. Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. Gastroenterology 126: 541-553, 2004.
18. Kuroda M, Kobayashi Y, Tanaka Y, Itani T, Mifuji R, Araki J, Kaito M, Adachi Y. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. J Gastroenterol Hepatol 19: 146-153, 2004.
19. Kurz AK, Graf D, Schmitt M, Vom Dahl S, Haussinger D. Taurour-sodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 121: 407-419, 2001.
20. Misra S, Ujhazy P, Gatmaitan Z, Varticovski L, Arias IM. The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver. J Biol Chem 273: 26638-26644, 1998.
21. Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, Inui K. Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13: 866-874, 2002.
22. Pan X, Terada T, Okuda M, Inui K. Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten. J Pharmacol Exp Ther 307: 626-632, 2003.
23. Paumgartner G, Beuers U. Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease. Clin Liver Dis 8: 67-81, 2004.
24. Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res 24: 450-470, 2007.
25. Sakurai Y, Motohashi H, Ogasawara K, Terada T, Masuda S, Katsura T, Mori N, Matsuura M, Doi T, Fukatsu A, Inui K. Pharmacokinetic significance of renal OAT3 (SLC22A8) for anionic drug elimination in patients with mesangial proliferative glomerulonephritis. Pharm Res 22: 2016-2022, 2005.
26. Sakurai Y, Motohashi H, Ueo H, Masuda S, Saito H, Okuda M, Mori N, Matsuura M, Doi T, Fukatsu A, Ogawa O, Inui K. Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res 21: 61-67, 2004.
27. Schmitt M, Kubitz R, Lizun S, Wettstein M, Haussinger D. Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity. Hepatology 33: 509-518, 2001.
28. Sekine T, Cha SH, Endou H. The multispecific organic anion transporter (OAT) family. Pflügers Arch 440: 337-350, 2000.
29. Shimakura J, Terada T, Saito H, Katsura T, Inui K. Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor . Am J Physiol Gastrointest Liver Physiol 291: G851-G856, 2006.
30. Soodvilai S, Chatsudthipong V, Evans KK, Wright SH, Dantzler WH. Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol 287: F1021-F1029, 2004.
31. Soodvilai S, Wright SH, Dantzler WH, Chatsudthipong V. Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol 289: F1057-F1064, 2005.
32. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277: 26934-26943, 2002.
33. Terada T, Inui K. Gene expression and regulation of drug transporters in the intestine and kidney. Biochem Pharmacol 73: 440-449, 2007.
34. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 83: 633-671, 2003.
35. Ueo H, Motohashi H, Katsura T, Inui K. Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol 70: 1104-1113, 2005.
36. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K. cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol 13: 1703-1710, 2002.