Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination

Journal of Biological Chemistry

Volumn 283, Issue 13, 2008, Pages 8654-8663

  Truong, David M ^b   Kaler, Gregory ^b   Khandelwal, Akash ^d   Swaan, Peter W ^d   Nigam, Sanjay K ^a,b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINES; BINDING SITES; COMPLEXATION; DRUG PRODUCTS; DRUG THERAPY; DYES; FLOW INTERACTIONS; FLUORESCENCE; HISTOLOGY; HYDROGEN; HYDROGEN BONDS; KETONES; LIGHT EMISSION; LUMINESCENCE; NEGATIVE IONS; ORGANIC COMPOUNDS; SULFUR COMPOUNDS;

ADEFOVIR; ANTIVIRAL DRUGS; ANTIVIRAL THERAPIES; ANTIVIRALS; BINDING POCKETS; BOND NUMBERS; CARBOXY FLUORESCEINS; CELLULAR TOXICITIES; CELLULAR UPTAKES; CIDOFOVIR; DRUG DESIGNS; EMBRYONIC KIDNEYS; EX-VIVO; HYDROGEN BOND ACCEPTORS; HYDROGEN BOND DONORS; IN VITRO; ISOFORMS; KNOCK OUTS; ORGAN CULTURE SYSTEMS; ORGANIC ANION TRANSPORTERS; PHOSPHATE GROUPS; PHYSICOCHEMICAL DESCRIPTORS; POLAR SURFACE AREAS; QUANTITATIVE STRUCTURES; SEQUENCE HOMOLOGIES; STRUCTURAL DETERMINANTS; SUBSTRATE INTERACTIONS; XENOPUS OOCYTES;

DRUG INTERACTIONS;

ACICLOVIR; ADEFOVIR; ALCOHOL; AMIDE; CARBOXYFLUORESCEIN; CIDOFOVIR; DIDANOSINE; FLUORESCEIN; LAMIVUDINE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 6; STAVUDINE; TENOFOVIR; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE; ANTIVIRUS AGENT; ORGANIC ANION TRANSPORTER 2;

ANIMAL CELL; ANTIVIRAL THERAPY; ARTICLE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG TARGETING; EMBRYO; EMBRYO CULTURE; ENZYME SUBSTRATE; FLUORESCENCE ANALYSIS; HYDROGEN BOND; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; WILD TYPE; XENOPUS; ANIMAL; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; FEMALE; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS; KIDNEY; KINETICS; METABOLISM; MOUSE MUTANT; OOCYTE; PRENATAL DEVELOPMENT; XENOPUS LAEVIS;

AVENA;

ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; FEMALE; HIV; KIDNEY; KINETICS; MICE; MICE, KNOCKOUT; MOLECULAR STRUCTURE; OOCYTES; ORGANIC ANION TRANSPORT POLYPEPTIDE C; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; XENOPUS LAEVIS;

EID: 43749115381     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708615200     Document Type: Article

References (47)

1. Kaler, G., Truong, D. M., Sweeney, D. E., Logan, D. W., Nagle, M., Wu, W., Eraly, S. A., and Nigam, S. K. (2006) Biochem. Biophys. Res. Commun. 351, 872-876
2. Eraly, S. A., Bush, K. T., Sampogna, R. V., Bhatnagar, V., and Nigam, S. K. (2004) Mol. Pharmacol. 65, 479-487
3. Lopez-Nieto, C. E., You, G., Barros, E. J. G., Beier, D. R., and Nigam, S. K. (1996) J. Am. Soc. Nephrol. 7, 1301
4. Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K. (1997) J. Biol. Chem. 272, 6471-6478
5. Sweet, D. H., Wolff, N. A., and Pritchard, J. B. (1997) J. Biol. Chem. 272, 30088-30095
6. Brady, K. P., Dushkin, H., Fornzler, D., Koike, T., Magner, F., Her, H., Gullans, S., Segre, G. V., Green, R. M., and Beier, D. R. (1999) Genomics 56, 254-261
7. Monte, J. C., Nagle, M. A., Eraly, S. A., and Nigam, S. K. (2004) Biochem. Biophys. Res. Commun. 323, 429-436
8. Burckhardt, B. C., and Burckhardt, G. (2003) Rev. Physiol. Biochem. Pharmacol. 146, 95-158
9. Sweet, D. H. (2005) Toxicol. Appl. Pharmacol. 204, 198-215
10. Young, B. (2005) AIDS Patient Care STDS 19, 286-297
11. Lewis, W. (2003) Prog. Cardiovasc. Dis. 45, 305-318
12. Anderson, P. L., Kakuda, T. N., and Lichtenstein, K. A. (2004) Clin. Infect. Dis. 38, 743-753
13. Wada, S., Tsuda, M., Sekine, T., Cha, S. H., Kimura, M., Kanai, Y., and Endou, H. (2000) J. Pharmacol. Exp. Ther. 294, 844-849
14. Cihlar, T., Lin, D. C., Pritchard, J. B., Fuller, M. D., Mendel, D. B., and Sweet, D. H. (1999) Mol. Pharmacol. 56, 570-580
15. Takeda, M., Khamdang, S., Narikawa, S., Kimura, H., Kobayashi, Y., Yamamoto, T., Cha, S. H., Sekine, T., and Endou, H. (2002) J. Pharmacol. Exp. Ther. 300, 918-924
16. Cha, S. H., Sekine, T., Fukushima, J. I., Kanai, Y., Kobayashi, Y., Goya, T., and Endou, H. (2001) Mol. Pharmacol. 59, 1277-1286
17. Uwai, Y., Ida, H., Tsuji, Y., Katsura, T., and Inui, K. (2007) Pharm. Res. (N. Y.) 24, 811-815
18. Sweet, D. H., Eraly, S. A., Vaughn, D. A., Bush, K. T., and Nigam, S. K. (2006) Kidney Int. 69, 837-845
19. Cihlar, T., and Ho, E. S. (2000) Anal. Biochem. 283, 49-55
20. De Clerck, L. S., Bridts, C. H., Mertens, A. M., Moens, M. M., and Stevens, W. J. (1994) J. Immunol. Methods 172, 115-124
21. De Clercq, E. (2004) J. Clin. Virol. 30, 115-133
22. Eraly, S. A., Vallon, V., Vaughn, D. A., Gangoiti, J. A., Richter, K., Nagle, M., Monte, J. C., Rieg, T., Truong, D. M., Long, J. M., Barshop, B. A., Kaler, G., and Nigam, S. K. (2006) J. Biol. Chem. 281, 5072-5083
23. Kaler, G., Truong, D. M., Khandelwal, A., Nagle, M., Eraly, S. A., Swaan, P. W., and Nigam, S. K. (2007) J. Biol. Chem. 282, 23841-23853
24. Sweet, D. H., Miller, D. S., Pritchard, J. B., Fujiwara, Y., Beier, D. R., and Nigam, S. K. (2002) J. Biol. Chem. 277, 26934-26943
25. Laitinen, L., Virtanen, I., and Saxen, L. (1987) J. Histochem. Cytochem. 35, 55-65
26. Cihlar, T., Ho, E. S., Lin, D. C., and Mulato, A. S. (2001) Nucleosides Nucleotides Nucleic Acids 20, 641-648
27. Vidal, F., Domingo, J. C., Guallar, J., Saumoy, M., Cordobilla, B., Sanchez de la Rosa, R., Giralt, M., Alvarez, M. L., Lopez-Dupla, M., Torres, F., Villarroya, F., Cihlar, T., and Domingo, P. (2006) Antimicrob. Agents Chemother. 50, 3824-3832
28. Bongiovanni, M., and Tordato, F. (2006) Curr. Med. Chem. 13, 2789-2793
29. Hitchcock, M. J. (1993) Clin. Infect. Dis. 16, Suppl. 1, S16-S21
30. Antonelli, A., Brandi, G., Casabianca, A., and Magnani, M. (1997) Biochim. Biophys. Acta 1358, 39-45
31. Kojima, R., Sekine, T., Kawachi, M., Cha, S. H., Suzuki, Y., and Endou, H. (2002) J. Am. Soc. Nephrol. 13, 848-857
32. Ljubojevic, M., Herak-Kramberger, C. M., Hagos, Y., Bahn, A., Endou, H., Burckhardt, G., and Sabolic, I. (2004) Am. J. Physiol. 287, F124-F138
33. Eraly, S. A., Blantz, R. C., Bhatnagar, V., and Nigam, S. K. (2003) Curr. Opin. Nephrol. Hypertension 12, 551-558
34. Ross, B. D., Espinal, J., and Silva, P. (1986) Kidney Int. 29, 54-67
35. Bonventre, J. V. (1988) Annu. Rev. Med. 39, 531-544
36. Epstein, F. H., Agmon, Y., and Brezis, M. (1994) Ann. N. Y. Acad. Sci. 718, 72-81
37. Epstein, F. H. (1997) Kidney Int. 51, 381-385
38. Anzai, N., Jutabha, P., Kanai, Y., and Endou, H. (2005) Curr. Opin. Nephrol. Hypertens. 14, 472-479
39. Cha, S. H., Sekine, T., Kusuhara, H., Yu, E., Kim, J. Y., Kim, D. K., Sugiyama, Y., Kanai, Y., and Endou, H. (2000) J. Biol. Chem. 275, 4507-4512
40. Jacqz-Aigrain, E., and Koren, G. (2005) Semin. Fetal Neonatal. Med. 10, 139-147
41. Pacifici, G. M. (2005) Early Hum. Dev. 81, 647-654
42. Dresser, M. J., Leabman, M. K., and Giacomini, K. M. (2001) J. Pharmacol. Sci. 90, 397-421
43. Miller, D. S. (2004) Adv. Drug Deliv. Rev. 56, 1811-1824
44. Pietruck, F., Horbelt, M., Feldkamp, T., Engeln, K., Herget-Rosenthal, S., Philipp, T., and Kribben, A. (2006) Drug Metab. Dispos. 34, 339-342
45. Bednarczyk, D., Mash, E. A., Aavula, B. R., and Wright, S. H. (2000) Pflugers Arch. 440, 184-192
46. Zubercova, O., and Babusikova, O. (1998) Neoplasma 45, 53-59
47. Twentyman, P. R., Rhodes, T., and Rayner, S. (1994) Eur. J. Cancer 30A, 1360-1369