Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): Further substrate specificity of mOat3

Drug Metabolism and Disposition

Volumn 32, Issue 5, 2004, Pages 479-483

  Kobayashi, Yasuna ^a   Ohshiro, Naomi ^b   Tsuchiya, Ayumi ^a   Kohyama, Noriko ^a   Ohbayashi, Masayuki ^a   Yamamoto, Toshinori ^a  

^a SHOWA UNIVERSITY   (Japan)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; 6 MERCAPTOPURINE DERIVATIVE; ALLOPURINOL; CARNITINE; ESTRONE; FLUOROURACIL; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 3; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; UNCLASSIFIED DRUG;

4 AMINOHIPPURIC ACID CLEARANCE; ANIMAL CELL; ANION EXCHANGE; ARTICLE; CONTROLLED STUDY; DRUG TRANSPORT; DRUG UPTAKE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE LOCATION; GENETIC CODE; KIDNEY; KIDNEY TUBULE ABSORPTION; MICHAELIS MENTEN KINETICS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; XENOPUS LAEVIS;

ALLOPURINOL; ANIMALS; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; KIDNEY; MALE; MICE; OOCYTES; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; SUBSTRATE SPECIFICITY; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 2042542061     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.5.479     Document Type: Article

References (35)

1. Bonadonna G and Valagussa P (1988) The contribution of medicine to the primary treatment of breast cancer. Cancer Res 48:2314-2323.
2. Brady KP, Dushkin H, Fornzler D, Koike T, Magner F, Her H, Gullans S, Segre GV, Green RM, and Beier DR (1999) A novel putative transporter maps to the osteosclerosis (oc) mutation and is not expressed in the oc mutant mouse. Genomics 56:254-261.
3. Bremer J (1983) Carnitine - metabolism and functions. Physiol Rev 63:1420-1480.
4. Cha SH, Sekine T, Fukushima J, Kanai Y, Kobayashi Y, Goya T, and Endou H (2001) Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59:1277-1286.
5. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, and Endou H (2000) Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 275:4507-4512.
6. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
7. Colleoni M, Litman HJ, Castiglione-Gertsch M, Sauerbrei W, Gelber RD, Bonetti M, Coates AS, Schumacher M, Bastert G, Rundenstam CM, et al. (2002) Duration of adjuvant chemotherapy for breast cancer: a joint analysis of two randomised trials investigating three versus six courses of CMF. Br J Cancer 86:1705-1714.
8. Deguchi T, Ohtsuki S, Otagiri M, Takanaga H, Asaba H, Mori S, and Terasaki T (2002) Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney. Kidney Int 61:1760-1768.
9. Diasio RB and Harris BE (1989) Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 16:215-237.
10. Elion GB, Kovensky A, and Hitchings GH (1966) Metabolic studies of allopurinol, an inhibitor of xanthine oxidase. Biochem Pharmacol 15:863-880.
11. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, et al. (2002a) Molecular identification of a renal urate-anion exchanger that regulates blood urate level. Nature (Lond) 417:447-452.
12. Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto A, Niwa T, Kanai Y, and Endou H (2002b) Molecular identification of a novel carnitine transporter specific to human testis. J Biol Chem 277:36262-36271.
13. Feinberg AP and Vogelstein B (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6-13.
14. Hasegawa M, Kusuhara H, Sugiyama D, Ito K, Ueda S, Endou H, and Sugiyama Y (2002) Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther 300:746-753.
15. Jeung HC, Rha SY, Noh SH, Min JS, Kim BS, and Chung HC (2001) Adjuvant 5-fluorouracil plus doxorubicin in D2-3 resected gastric carcinoma: 15-year experience at a single institute. Cancer 91:2016-2025.
16. Koepsell H (1998) Organic cation transporters in intestine, kidney, liver and brain. Annu Rev Physiol 60:243-266.
17. Kuriyama T, Hasunuma K, Tateno J, Hamazaki T, Nakazawa R, Isoda K, Shishido H, Ohiwa T, and Hamaguchi K (1984) A case of mesangiolysis caused by anticancer drugs. Jin To Toseki 16:345-350.
18. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680.
19. Moller JV and Sheikh MI (1983) Renal organic anion transport system: pharmacological, physiological and biochemical aspects. Pharmacol Rev 34:315-358.
20. Nagata Y, Kusuhara H, Endou H, and Sugiyama Y (2002) Expression and functional characterization of rat organic anion transponer 3 (rOat3) in the choroid plexus. Mol Pharmacol 61:982-988.
21. Pritchard JB and Miller DS (1993) Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 73:765-796.
22. Race JE, Grassl SM, Williams WJ, and Holtzman EJ (1999) Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun 255:508-514.
23. Russel FG, Masereeuw R, and van Aubel RA (2002) Molecular aspects of renal anionic drug transport. Annu Rev Physiol 64:563-594.
24. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Kanai Y, and Endou H (1998a) Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429:179-182.
25. Sekine T, Kusuhara H, Utsunomiya-Tate N, Tsuda M, Sugiyama Y, Kanai Y, and Endou H (1998b) Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine. Biochem Biophys Res Commun 251:586-591.
26. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, and Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
27. Simonson GD, Vincent AC, Roberg KJ, Huang Y, and Iwanji V (1994) Molecular cloning and characterization of a novel liver-specific transport protein. J Cell Sci 107:1065-1072.
28. Sun W, Wu RR, van Poelje PD, and Erion MD (2001) Isolation of a family of organic anion transporters from human liver and kidney. Biochem Biophys Res Commun 283:417-422.
29. Sweet DH, Chan LMS, Walden R, Yang X, Miller DS, and Pritchard JB (2003) Organic anion transporter 3 (Oat3 [Slc22a8]) is a dicarboxylate exchanger indirectly coupled to the Na gradient. Am J Physiol 284:F763-F769.
30. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, and Nigam SK (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 [Slc22a8]) knockout mice. J Biol Chem 272:26934-26943.
31. Sweet DH, Wolff NA, and Pritchard JB (1997) Expression cloning and characterization of ROAT1. J Biol Chem 272:30088-30095.
32. Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, and Tsuji A (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273:20378-20382.
33. Ullrich KJ (1997) Renal transporters for organic anions and organic cations, structure requirements for substrates. J Membr Biol 158:95-107.
34. Ullrich KJ and Rumrich G (1993) Renal transport mechanism for xenobiotics: chemicals and drugs. Clin Investig 71:843-848.
35. van Montfoort JE, Hangenbuch B, Groothuis GM, Koepsell H, Meier PJ, and Meijer DK (2003) Drug uptake systems in liver and kidney. Curr Drug Metab 4:185-211.