Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 α/β and DNA methylation

Molecular Pharmacology

Volumn 72, Issue 6, 2007, Pages 1619-1625

  Kikuchi, Ryota ^a   Kusuhara, Hiroyuki ^a   Hattori, Naka ^a   Kim, Insook ^b   Shiota, Kunio ^a   Gonzalez, Frank J ^b   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 1BETA; MESSENGER RNA; UNCLASSIFIED DRUG; URATE; URATE TRANSPORTER 1;

ADOLESCENT; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KIDNEY CORTEX; KIDNEY MEDULLA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; URAT1 GENE;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; ORGANIC ANION TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; TISSUE DISTRIBUTION; TRANS-ACTIVATION (GENETICS);

EID: 36348965458     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.039701     Document Type: Article

References (35)

1. Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6-21.
2. Blumenfeld M, Maury M, Chouard T, Yaniv M, and Condamine H (1991) Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse. Development 113:589-599.
3. Cheret C, Doyen A, Yaniv M, and Pontoglio M (2002) Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus. J Mol Biol 322:929-941.
4. De Simone V, De Magistris L, Lazzaro D, Gerstner J, Monaci P, Nicosia A, and Cortese R (1991) LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J 10:1435-1443.
5. Enomoto A and Endou H (2005) Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease. Clin Exp Nephrol 9:195-205.
6. Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, et al. (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417:447-452.
7. Froguel P and Velho G (1999) Molecular genetics of maturity-onset diabetes of the young. Trends Endocrinol Metab 10:142-146.
8. Golik A, Weissgarten J, Cotariu D, Cohen N, Zaidenstein R, Ramot Y, Averbukh Z, and Modai D (1993) Renal uric acid handling in non-insulin-dependent diabetic patients with elevated glomerular filtration rates. Clin Sci (Lond) 85:713-716.
9. Gresh L, Fischer E, Reimann A, Tanguy M, Garbay S, Shao X, Hiesberger T, Fiette L, Igarashi P, Yaniv M, et al. (2004) A transcriptional network in polycystic kidney disease. EMBO J 23:1657-1668.
10. Hediger MA, Johnson RJ, Miyazaki H, and Endou H (2005) Molecular physiology of urate transport. Physiology (Bethesda) 20:125-133.
11. Horikawa Y, Iwasaki N, Hara M, Furuta H, Hinokio Y, Cockburn BN, Lindner T, Yamagata K, Ogata M, Tomonaga O, et al. (1997) Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY. Nat Genet 17:384-385.
12. Hosoyamada M, Ichida K, Enomoto A, Hosoya T, and Endou H (2004) Function and localization of urate transporter 1 in mouse kidney. J Am Soc Nephrol 15:261-268.
13. Ichida K, Hosoyamada M, Hisatome I, Enomoto A, Hikita M, Endou H, and Hosoya T (2004) Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol 15:164-173.
14. Imaoka T, Kusuhara H, Adachi-Akahane S, Hasegawa M, Morita N, Endou H, and Sugiyama Y (2004) The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules. J Am Soc Nephrol 15:2012-2022.
15. Iwai N, Mino Y, Hosoyamada M, Tago N, Kokubo Y, and Endou H (2004) A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. Kidney Int 66:935-944.
16. Kikuchi R, Kusuhara H, Hattori N, Shiota K, Kim I, Gonzalez FJ, and Sugiyama Y (2006) Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1α/β and DNA methylation. Mol Pharmacol 70:887-896.
17. Lazzaro D, De Simone V, De Magistris L, Lehtonen E, and Cortese R (1992) LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development. Development 114:469-479.
18. Ledermann HM (1995) Is maturity onset diabetes at young age (MODY) more common in Europe than previously assumed? Lancet 345:648.
19. Lee YH, Sauer B, and Gonzalez FJ (1998) Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol 18:3059-3068.
20. Li T, Walsh JR, Ghishan FK, and Bai L (2004) Molecular cloning and characterization of a human urate transporter (hURAT1) gene promoter. Biochim Biophys Acta 1681:53-58.
21. Magoula I, Tsapas G, Paletas K, and Mavromatidis K (1991) Insulin-dependent diabetes and renal hypouricemia. Nephron 59:21-26.
22. Maher JM, Slitt AL, Callaghan TN, Cheng X, Cheung C, Gonzalez FJ, and Klaassen CD (2006) Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha. Biochem Pharmacol 72:512-522.
23. Mendel DB and Crabtree GR (1991) HNF-1, a member of a novel class of dimerizing homeodomain proteins. J Biol Chem 266:677-680.
24. Pontoglio M, Barra J, Hadchouel M, Doyen A, Kress C, Bach JP, Babinet C, and Yaniv M (1996) Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 84:575-585.
25. Pontoglio M, Prie D, Cheret C, Doyen A, Leroy C, Froguel P, Velho G, Yaniv M, and Friedlander G (2000) HNF1alpha controls renal glucose reabsorption in mouse and man. EMBO Rep 1:359-365.
26. Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, et al. (1998) Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest 101:2215-2222.
27. Rafey MA, Lipkowitz MS, Leal-Pinto E, and Abramson RG (2003) Uric acid transport. Curr Opin Nephrol Hypertens 12:511-516.
28. Rey-Campos J, Chouard T, Yaniv M, and Cereghini S (1991) vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J 10:1445-1457.
29. Ryffel GU (2001) Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences. J Mol Endocrinol 27:11-29.
30. Shichiri M, Iwamoto H, and Shiigai T (1987) Diabetic renal hypouricemia. Arch Intern Med 147:225-228.
31. Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL, Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL, et al. (2001) Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet 27:375-382.
32. Shiota K (2004) DNA methylation profiles of CpG islands for cellular differentiation and development in mammals. Cytogenet Genome Res 105:325-334.
33. Tronche F and Yaniv M (1992) HNF1, a homeoprotein member of the hepatic transcription regulatory network. Bioessays 14:579-587.
34. Winter WE and Silverstein JH (2000) Molecular and genetic bases for maturity onset diabetes of youth. Curr Opin Pediatr 12:388-393.
35. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, et al. (1996) Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3). Nature 384:455-458.