Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3

Journal of the American Society of Nephrology

Volumn 17, Issue 1, 2006, Pages 46-53

  Sauvant, Christoph ^a   Holzinger, Hildegard ^a   Gekle, Michael ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCEIN; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PROSTAGLANDIN E2; RECOMBINANT PROTEIN; ORGANIC ANION TRANSPORTER; SLC22A6 PROTEIN, RAT;

ANIMAL CELL; ANION TRANSPORT; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DOWN REGULATION; FEVER; HORMONE ACTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; URIC ACID BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; CELL LINE; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; KIDNEY TUBULES, PROXIMAL; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS;

EID: 33645457811     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2005070727     Document Type: Article

References (49)

1. Wright SH, Dantzler WH: Molecular and cellular physiology of renal organic cation and anion transport. Physiol Rev 84: 987-1049, 2004
2. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274: 13675-13680, 1999
3. Bakhiya A, Bahn A, Burckhardt G, Wolff N: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem 13: 249-256, 2003
4. Sweet DH, Chan LM, Walden R, Yang XP, Miller DS, Pritchard JB: Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. Am J Physiol Renal Physiol 284: F763-F769, 2003
5. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429: 179-182, 1998
6. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 275: 4507-4512, 2000
7. Youngblood GL, Sweet DH: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol 287: F236-F244, 2004
8. Monte JC, Nagle MA, Eraly SA, Nigam SK: Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 323: 429-436, 2004
9. Terlouw SA, Masereeuw R, Russel FG: Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport. Biochem Pharmacol 65: 1393-1405, 2003
10. Reyes JL, Melendez E, Alegria A, Jaramillo-Juarez F: Influence of sex differences on the renal secretion of organic anions. Endocrinology 139: 1581-1587, 1998
11. Ljubojevic M, Herak-Kramberger CM, Hagos Y, Bahn A, Endou H, Burckhardt G, Sabolic I: Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am J Physiol Renal Physiol 287: F124-F138, 2004
12. Buist SC, Cherrington NJ, Klaassen CD: Endocrine regulation of rat organic anion transporters. Drug Metab Dispos 31: 559-564, 2003
13. Habu Y, Yano I, Okuda M, Fukatsu A, Inui K: Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney. Biochem Pharmacol 69: 993-999, 2005
14. Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther 301: 293-298, 2002
15. Dinarello CA: Infection, fever, and exogenous and endogenous pyrogens: Some concepts have changed. J Endotoxin Res 10: 201-222, 2004
16. Blatteis CM, Sehic E, Li S: Pyrogen sensing and signaling: Old views and new concepts. Clin Infect Dis 31[Suppl 5]: S168-S177, 2000
17. Davidson J, Abul H, Milton A, Rotondo D: Cytokines and cytokine inducers stimulate prostaglandin E2 entry into the brain. Pflugers Arch Eur J Phys 442: 526-533, 2001
18. Romanovsky AA, Ivanov AI, Karman EK: Blood-borne, albumin-bound prostaglandin E2 may be involved in fever. Am J Physiol Regul Integr Comp Physiol 276: R1840-R1844, 1999
19. Ivanov AI, Romanovsky AA: Prostaglandin E2 as a mediator of fever: Synthesis and catabolism. Front Biosci 9: 1977-1993, 2004
20. Ivanov AI, Pero RS, Scheck AC, Romanovsky AA: Prostaglandin E(2)-synthesizing enzymes in fever: Differential transcriptional regulation. Am J Physiol Regul Integr Comp Physiol 283: R1104-R1117, 2002
21. Samuelsson B: Prostaglandins and related factors. 27. Synthesis of tritium-labeled prostaglandin El and studies on its distribution and excretion in the rat. J Biol Chem 239: 4091-4096, 1964
22. Haylor J, Lote C, Towers J: Tubular mechanisms determining the urinary excretion of tritiated prostaglandin E2 in the anaesthetized rat. J Physiol (Lond) 403: 1-14, 1988
23. Sauvant C, Holzinger H, Gekle M: Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA(2), and COX1. J Am Soc Nephrol 13: 1981-1991, 2002
24. Sauvant C, Hesse D, Holzinger H, Evans KK, Dantzler WH, Gekle M: Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells. Am J Physiol Renal Physiol 286: F774-F783, 2004
25. Sauvant C, Holzinger H, Gekle M: Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: Prostaglandin E2 acts via receptor mediated activation of PKA. J Am Soc Nephrol 14: 3017-3026, 2003
26. Lungkaphin A, Chatsudthipong V, Evans KK, Groves CE, Wright SH, Dantzler WH: Interaction of the metal chelator, DMPS, with OAT1 and OAT3 in intact isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol 286: F68-F76, 2003
27. Dantzler WH, Wright SH: The molecular and cellular physiology of basolateral organic anion transport in mammalian renal tubules. Biochim Biophys Acta 1618: 185-193, 2003
28. Sauvant C, Silbernagl S, Gekle M: Exposure to ochratoxin A impairs organic anion transport in proximal-tubule-derived opossum kidney cells. J Pharmacol Exp Ther 287: 13-20, 1998
29. Hesse D, Sauvant C, Holzinger H, Gekle M: Apical expression or expression in a nonpolarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1. Cell Physiol Biochem 14: 177-186, 2004
30. Sauvant C, Holzinger H, Gekle M: Modulation of the basolateral and apical step of transepithelial organic anion secretion in proximal tubular OK cells: Acute effects of EGF and MAPK. J Biol Chem 276: 14695-14703, 2001
31. DeLean A, Munson PJ, Rodbard D: Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235: E97-E102, 1978
32. Ziemann C, Schafer D, Rudell G, Kahl GF, Hirsch-Ernst KI: The cyclooxygenase system participates in functional mdr1b overexpression in primary rat hepatocyte cultures. Hepatology 35: 579-588, 2002
33. Van Montfoort JE, Hagenbuch B, Groothuis GM, Koepsell H, Meier PJ, Meijer DK: Drug uptake systems in liver and kidney. Curr Drug Metab 4: 185-211, 2003
34. Dantzler WH: Comparative aspects of renal organic anion transport. Cell Physiol Biochem 6: 28-38, 1996
35. Verrey F, Ristic Z, Romeo E, Ramadam T, Makrides V, Dave MH, Wagner CA, Camargo SMR: Novel renal amino acid transporters. Annu Rev Physiol 67: 557-572, 2005
36. Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C. Am J Physiol 276: F295-F303, 1999
37. Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276: F122-F128, 1999
38. Kojima R, Sekine T, Kawachi M, Cha SH, Suzuki Y, Endou H: Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol 13: 848-857, 2002
39. Sanchez-Moreno C, Dashe JF, Scott T, Thaler D, Folstein MF, Martin A: Decreased levels of plasma vitamin C and increased concentrations of inflammatory and oxidative stress markers after stroke. Stroke 35: 163-168, 2004
40. Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe J-M, Saha S, Roach ML, Carter D, Thomas NA, Durtschi BA, McNeish JD, Hambor JE, Jakobsson P-J, Carty TJ, Perez JR, Audoly LP: Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Nat Acad Sci U S A 100: 9044-9049, 2003
41. Sakaguchi Y, Shirahase H, Ichikawa A, Kanda M, Nozaki Y, Uehara Y: Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice. Life Sci 75: 2257-2267, 2004
42. Seyberth HW, Koniger SJ, Rascher W, Kuhl PG, Schweer H: Role of prostaglandins in hyperprostaglandin E syndrome and in selected renal tubular disorders. Pediatr Nephrol 1: 491-497, 1987
43. Rafey MA, Lipkowitz MS, Leal-Pinto E, Abramson RG: Uric acid transport. Curr Opin Nephrol Hypertens 12: 511-516, 2003
44. Breyer MD, Breyer RM: Prostaglandin E receptors and the kidney. Am J Physiol Renal Physiol 279: F12-F23, 2000
45. Kam PC, See AU: Cyclo-oxygenase isoenzymes: Physiological and pharmacological role. Anaesthesia 55: 442-449, 2000
46. Alavi N, Lianos EA, Bentzel CJ: Prostaglandin and thromboxane synthesis by highly enriched rabbit proximal tubular cells in culture. J Lab Clin Med 110: 338-345, 1987
47. Hartner A, Pahl A, Brune K, Goppelt-Struebe M: Upregulation of cyclooxygenase-1 and the PGE2 receptor EP2 in rat and human mesangioproliferative glomerulonephritis. Inflamm Res 49: 345-354, 2000
48. Tokuyama H, Hayashi K, Matsuda H, Kubota E, Honda M, Okubo K, Takamatsu I, Ozawa Y, Saruta T: Role of nitric oxide and prostaglandin E2 in acute renal hypoperfusion. Nephrology (Carlton) 8: 65-71, 2003
49. Takenaka T, Okada H, Kanno Y, Inoue T, Ryuzaki M, Nakamoto H, Kawachi H, Shimizu F, Suzuki H: Exogenous 5′-nucleotidase improves glomerular autoregulation in Thy-1 nephritic rats. Am J Physiol Renal Physiol Sept 27, 2005 [epub ahead of print]