Characterization of methotrexate transport and its drug interactions with human organic anion transporters

Journal of Pharmacology and Experimental Therapeutics

Volumn 302, Issue 2, 2002, Pages 666-671

  Takeda, Michio ^a   Khamdang, Suparat ^a   Narikawa, Shinichi ^a   Kimura, Hiroaki ^a   Coceani, Flavio ^a,b,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Department of Cardiovascular Therapeutics ^*  (Italy)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; HUMAN ORGANIC ANION TRANSPORTER 1; HUMAN ORGANIC ANION TRANSPORTER 3; HUMAN ORGANIC ANION TRANSPORTER 4; IBUPROFEN; INDOMETACIN; KETOPROFEN; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PENICILLIN G; PHENYLBUTAZONE; PIROXICAM; PROBENECID; SALICYLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; DRUG TRANSPORT; DRUG UPTAKE; KIDNEY PROXIMAL TUBULE; KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL TRANSPORT; CELLS, CULTURED; HUMANS; INDOMETHACIN; KINETICS; METHOTREXATE; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; PHENYLBUTAZONE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROBENECID;

EID: 0036076780     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.034330     Document Type: Article

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