Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)- induced nephrotoxicity

Kidney International

Volumn 56, Issue 6, 1999, Pages 2128-2136

  Takeda, Michio ^a   Tojo, Akihiro ^a   Sekine, Takashi ^a   Hosoyamada, Makoto ^a   Kanai, Yoshikatsu ^a   Endou, Hitoshi ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell line; Cephalosporin; Lipid peroxidation; PAH; Proximal tubule; SV40

Indexed keywords

4 AMINOHIPPURIC ACID; CARRIER PROTEIN; CEFADROXIL; CEFALEXIN; CEFALORIDINE; CEFALOTIN; CEFAMANDOLE; CEFAZOLIN; CEFOPERAZONE; CEFOTAXIME; CEFTRIAXONE; ORGANIC ANION TRANSPORTER 1; PROBENECID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANION TRANSPORT; ARTICLE; CELL VIABILITY; DRUG UPTAKE; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; LIPID PEROXIDATION; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0033458777     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.00789.x     Document Type: Article

References (38)

1. 1. Atkinson RM, Currie JP, Davis B, Pratt Dah, Sharpe HM, Tomich EG: Acute toxicity of cephaloridine, an antibiotic derived from cephalosporin C. Toxicol Appl Pharmacol 8:398-406, 1966
2. 2. Foord RD: Cephaloridine, cephalothin and the kidney. J Antimicrob Chemother (Suppl 1): 119-133, 1975
3. 3. Tune BM, Fernholt M: Relationship between cephaloridine and p-aminohippurate transport in the kidney. Am J Physiol 225:1114-1117, 1973
4. 4. Wold JS, Turnispeed SA, Miller BL: The effect of renal cation transport on cephaloridine nephrotoxicity. Toxicol Appl Pharmacol 45:115-122, 1979
5. 5. Kuo CH, Hook JB: Depletion of renal GSH content and nephrotoxicity of cephaloridine in rabbits, rats and mice. Toxicol Appl Pharmacol 63:292-302, 1982
6. 6. Tune M, Hsu CY: Toxicity of cephaloridine to carnitine transport and fatty acid metabolism in rabbit renal cortical mitochondria: Structure-activity relationship. J Pharmacol Exp Ther 270:873-880, 1994
7. 1-receptor antagonist, on cephaloridine-induced acute renal failure in rats. Jpn J Pharmacol 64:9-17, 1994
8. 8. Pritchard JB, Miller DS: Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 73:765-796, 1993
9. 9. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529, 1997
10. 10. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver, FEBS Lett 429:179-182, 1998
11. +-independent organic anion transporter. Proc Natl Acad Sci USA 91:133-137, 1994
12. 12. Noe B, Hagenbuch B, Stieger B, Meier PJ: Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA 94:10346-10350, 1997
13. 13. Saito H, Masuda S, Inui K: Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J Biol Chem 271:20719-20275, 1996
14. 14. Hosoyamada M, Obinata M, Suzuki M, Endou H: Cisplatin-induced toxicity in immortalized renal cell lines established from transgenic mice harboring temperature sensitive SV40 large T-antigen gene. Arch Toxicol 70:284-292, 1996
15. 15. Takano M, Kato M, Takayama A, Yasuhara M, Inui K, Hori R: Transport of procainamide in a kidney epithelial cell line LLC-PK, Biochem Biophys Acta 1108:133-139, 1992
16. 16. Walker PD, Shah SV: Hydrogen peroxide cytotoxicity in LLC-PK, cells: A role for iron. Kidney Int 40:891-898, 1991
17. 17. Ohkawa H, Ohoshi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. J Biol Chem 262:1098-1104, 1987
18. 18. Sheridan AM, Fitzpatrick S, Wang C, Wheeler DC, Lieberthal W: Lipid peroxidation contributes to hydrogen peroxide induced cytotoxicity in renal epithelial cells. Kidney Int 49:88-93, 1996
19. 19. Goldstein BS, Pasino DA, Hewitt WR, Hook JB: Biochemical mechanisms of cephaloridine nephrotoxicity: Time and concentration dependence of peroxidative injury. Toxicol Appl Pharmacol 83:261-270, 1986
20. 20. Rush GF, Ponsler GD: Cephaloridine-induced biochemical changes and cytotoxicity in suspensions of rabbit isolated proximal tubules. Toxicol Appl Pharmacol 109:314-326, 1991
21. 21. Bolon C, Gauthier C, Simonnet H, Baverel G: Advantages of a two-chamber culture system to test drug nephrotoxicity: The example of cephaloridine. Kidney Blood Press Res 20:264-270, 1997.
22. 1. Jpn J Pharmacol 72:67-70, 1996
23. 1). Antimicrob Agents Chemother 32:314-318, 1988
24. 1 epithelia as a model for in vitro assessment of proximal tubular nephrotoxicity. In Vitro Cell Dev Biol 31:94-106, 1995
25. 25. Rush GF, Heim A, Ponsler D, Engelhardt J: Cephaloridine-induced renal pathological and biochemical changes in female rabbits and isolated proximal tubules in suspension. Toxicol Pathol 20:155-168, 1992
26. 26. Wold JS: Cephalosporin nephrotoxicity, in Toxicology of the Kidney, edited by Hook JB, New York, Raven Press, 1988. pp 251-266
27. +-dicarboxylate transporter. Am J Physiol 275:F298-F305, 1998
28. 28. Bergwerk AJ, Shi X, Ford AC, Kanai N, Jacquemin E, Burk RD, Bai S, Novikoff PM, Stieger B, Meier PJ, Schuster VL, Wolkoff AW: Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am J Physiol 271:G231-G238, 1996
29. 29. Masuda S, Saito H, Nonoguchi H, Tomita K, Inui K: mRNA distribution and membrane localization of the OAT-K1 organic anion transporter ion rat renal tubules. FEBS Lett 407:127-131, 1997
30. 30. Tune BM: Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention. Pediatr Nephrol 11:768-772, 1997
31. 31. Grundemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372:549-552, 1994
32. 32. Tune BM, Wu KY, Kempson RL: Inhibition of transport and prevention of toxicity of cephaloridine in the kidney. Dose-responsiveness of the rabbit and guinea pig to probenecid. J Pharmacol Exp Ther 202:466-471, 1977
33. 33. Cojocel C, Laeschke KH, Inselmann G, Baumann K: Inhibition of cephaloridine-induced lipid peroxidation. Toxicology 35:295-305, 1985
34. 34. Suzuki Y, Sudo J: Changes in lipid peroxidation and activities of xanthine oxidase, superoxide dismutase and catalyse in kidneys of cephaloridine-administered rats. Jpn J Pharmacol 49:43-51, 1989
35. 35. Suzuki Y, Sudo J: Lipid peroxidation and generations of oxygen radicals induced by cephaloridine in renal cortical microsomes of rats. Jpn J Pharmacol 52:233-243, 1990
36. 36. Tune BM: Renal tubular transport and nephrotoxicity of beta lactam antibiotics: Structure-activity relationships. Miner Electrolyte Metab 20:221-231, 1994
37. +/organic cation antiport system. J Pharmacol Exp Ther 233:181-185, 1985
38. 38. Hosoyamada M, Sekine T, Kanai Y, Endou H: Molecular cloning and functional characterization of a novel multispecific organic transporter from human kidney. Am J Physiol 276:F122-F128, 1999