Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A)

European Journal of Pharmacology

Volumn 503, Issue 1-3, 2004, Pages 25-30

  Motohashi, Hideyuki ^a   Uwai, Yuichi ^a   Hiramoto, Kiyo ^a   Okuda, Masahiro ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cimetidine; Famotidine; Organic anion transporter; Organic cation transporter; Renal tubular secretion

Indexed keywords

4 AMINOHIPPURIC ACID; CARBON 14; CIMETIDINE; ESTRONE; FAMOTIDINE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 3; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 2; TETRYLAMMONIUM; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TRANSPORT; DRUG UPTAKE; FEMALE; KIDNEY TUBULE EXCRETION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS LAEVIS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIMETIDINE; FAMOTIDINE; HISTAMINE H2 ANTAGONISTS; HUMANS; KIDNEY; KINETICS; OOCYTES; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANIC CATION TRANSPORT PROTEINS; P-AMINOHIPPURIC ACID; XENOPUS LAEVIS;

EID: 7444254904     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.09.032     Document Type: Article

References (30)

1. P. Arndt, C. Volk, V. Gorboulev, T. Budiman, C. Popp, I. Ulzheimer-Teuber, A. Akhoundova, S. Koppatz, E. Bamberg, G. Nagel, and H. Koepsell Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1 Am. J. Physiol., Renal. Physiol. 281 2001 F454 F468
2. P.A. Boom, S. Hoet, and F.G.M. Russel Saturable urinary excretion kinetics of famotidine in the dog J. Pharm. Pharmacol. 49 1996 288 292
3. B.C. Burckhardt, S. Brai, S. Wallis, W. Krick, N.A. Wolff, and G. Burckhardt Transport of cimetidine by flounder and human renal organic anion transporter 1 Am. J. Physiol., Renal. Physiol. 284 2003 F503 F509
4. S.H. Cha, T. Sekine, J. Fukushima, Y. Kanai, Y. Kobayashi, T. Goya, and H. Endou Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney Mol. Pharmacol. 59 2001 1277 1286
5. C.D. Christian Jr., C.G. Meredith, and K.V. Speeg Jr. Cimetidine inhibits renal procainamide clearance Clin. Pharmacol. Ther. 36 1984 221 227
6. T.C. Dowling, R.F. Frye, D.S. Fraley, and G.R. Matzke Characterization of tubular functional capacity in humans using para-aminohippurate and famotidine Kidney Int. 59 2001 295 303
7. M.J. Dresser, M.K. Leabman, and K.M. Giacomini Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters J. Pharm. Sci. 90 2001 397 421
8. L.G. Gisclon, R.A. Boyd, R.L. Williams, and K.M. Giacomini The effect of probenecid on the renal elimination of cimetidine Clin. Pharmacol. Ther. 45 1989 444 452
9. Y. Habu, I. Yano, A. Takeuchi, H. Saito, M. Okuda, A. Fukatsu, and K. Inui Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2 Biochem. Pharmacol. 66 2003 1107 1114
10. 2-receptor antagonist: comparison with cimetidine and ranitidine in the treatment of Zollinger-Ellison syndrome Gastroenterology 88 1985 1026 1033
11. T.J. Humphries Famotidine: a notable lack of drug interactions Scand. J. Gastroenterol. 22 1987 55 60
12. N. Inotsume, M. Nishimura, M. Nakano, S. Fujiyama, and T. Sato The inhibitory effect of probenecid on renal excretion of famotidine in young, healthy volunteers J. Clin. Pharmacol. 30 1990 50 56
13. K. Inui, S. Masuda, and H. Saito Cellular and molecular aspects of drug transport in the kidney Kidney Int. 58 2000 944 958
14. L. Ji, S. Masuda, H. Saito, and K. Inui Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy Kidney Int. 62 2002 514 524
15. 2-receptor antagonist, does not affect hepatic elimination of diazepam or tubular secretion of procainamide Eur. J. Clin. Pharmacol. 28 1985 671 675
16. H. Kusuhara, T. Sekine, N. Utsunomiya-Tate, M. Tsuda, R. Kojima, S.H. Cha, Y. Sugiyama, Y. Kanai, and H. Endou Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain J. Biol. Chem. 274 1999 13675 13680
17. K. Lee, C. Ng, K.L. Brouwer, and D.R. Thakker Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers J. Pharmacol. Exp. Ther. 303 2002 574 580
18. J.H. Lin, A.N. Chremos, K.C. Yeh, J. Antonello, and G.A. Hessey II Effects of age and chronic renal failure on the urinary excretion kinetics of famotidine in man Eur. J. Clin. Pharmacol. 34 1988 41 46
19. H. Motohashi, Y. Sakurai, H. Saito, S. Masuda, Y. Urakami, M. Goto, A. Fukatsu, O. Ogawa, and K. Inui Gene expression levels and immunolocalization of organic ion transporters in the human kidney J. Am. Soc. Nephrol. 13 2002 866 874
20. 1 Am. J. Physiol. 262 1992 C59 C66
21. Y. Sakurai, H. Motohashi, H. Ueo, S. Masuda, H. Saito, M. Okuda, N. Mori, M. Matsuura, T. Doi, A. Fukatsu, O. Ogawa, and K. Inui Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases Pharm. Res. 21 2004 61 67
22. T. Sekine, S.H. Cha, and H. Endou The multispecific organic anion transporter (OAT) family Pflügers Arch. 440 2000 337 350
23. A. Somogyi, A. McLean, and B. Heinzow Cimetidine-procainamide pharmacokinetic interaction in man: evidence of competition for tubular secretion of basic drugs Eur. J. Clin. Pharmacol. 25 1983 339 345
24. 2-receptor antagonist, in relation to renal function Eur. J. Clin. Pharmacol. 28 1985 327 331
25. Y. Urakami, M. Okuda, S. Masuda, M. Akazawa, H. Saito, and K. Inui Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules Pharm. Res. 18 2001 1528 1534
26. Y. Urakami, M. Akazawa, H. Saito, M. Okuda, and K. Inui cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney J. Am. Soc. Nephrol. 13 2002 1703 1710
27. Y. Uwai, H. Saito, Y. Hashimoto, and K. Inui Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1 J. Pharmacol. Exp. Ther. 295 2000 261 265
28. J. van Crugten, F. Bochner, J. Keal, and A. Somogyi Selectivity of the cimetidine-induced alterations in the renal handling of organic substrates in humans. Studies with anionic, cationic and zwitterionic drugs J. Pharmacol. Exp. Ther. 236 1986 481 487
29. 2 antagonist-induced thrombocytopenia: is this a real phenomenon? Intensive Care Med. 28 2002 459 465
30. K. Yoshimoto, S. Saima, H. Echizen, Y. Nakamura, T. Kondo, Y. Yagishita, and T. Ishizaki Famotidine-associated central nervous system reactions and plasma and cerebrospinal drug concentrations in neurosurgical patients with renal failure Clin. Pharmacol. Ther. 55 1994 693 700