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Volumn 97, Issue 11, 2006, Pages 1260-1266

Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BREAST CANCER RESISTANCE PROTEIN; CONSTITUTIVE ANDROSTANE RECEPTOR; CREATININE; CYTOCHROME P450 2B6; CYTOCHROME P450 3A1; FARNESOID X RECEPTOR; FOLINATE CALCIUM; FOLINIC ACID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 3; PREGNANE X RECEPTOR; PROTEIN; RETINOID X RECEPTOR ALPHA;

EID: 33748942990     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2006.00304.x     Document Type: Article
Times cited : (44)

References (38)
  • 1
    • 0023503165 scopus 로고
    • High-dose methotrexate: A critical reappraisal
    • Ackland SP, Schilsky RL. High-dose methotrexate: A critical reappraisal. J Clin Oncol 1987; 5: 2017-31.
    • (1987) J Clin Oncol , vol.5 , pp. 2017-2031
    • Ackland, S.P.1    Schilsky, R.L.2
  • 2
    • 0011760333 scopus 로고
    • Physicians' desk reference. New Jersey: Thomson Healthcare
    • Physicians' desk reference. Physicians'desk reference. New Jersey: Thomson Healthcare, 1992.
    • (1992) Physicians' Desk Reference
  • 3
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 2000; 92: 1295-302.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 5
    • 17544368685 scopus 로고    scopus 로고
    • Coleb Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie EM, Deeley RG, Cole SP. Coleb Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appli Pharmacol 2005; 204: 216-37.
    • (2005) Toxicol Appli Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 6
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • König J, Nies AT, Cui Y, Leier I, Keppler D. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta 1999; 1461: 377-94.
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 377-394
    • König, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 7
    • 0030753176 scopus 로고    scopus 로고
    • Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats
    • Masuda M, Iizuka Y, Yamazaki M et al. Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats. Cancer Res 1997; 57: 3506-10.
    • (1997) Cancer Res , vol.57 , pp. 3506-3510
    • Masuda, M.1    Iizuka, Y.2    Yamazaki, M.3
  • 8
    • 0036070539 scopus 로고    scopus 로고
    • Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition
    • Gerk PM, Vore M. Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J Pharmacol Exp Ther 2002; 302: 407-15.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 407-415
    • Gerk, P.M.1    Vore, M.2
  • 9
    • 0032745443 scopus 로고    scopus 로고
    • The human multidrug resistance protein 2 gene: Functional characterization of the 5′-flanking region and expression in hepatic cells
    • Tanaka T, Uchiumi T, Hinoshita E, Inokuchi A, Toh S wada M, Takano H, Kohno K, Kuwano M. The human multidrug resistance protein 2 gene: functional characterization of the 5′-flanking region and expression in hepatic cells. Hepatology 1999; 30: 1507-12.
    • (1999) Hepatology , vol.30 , pp. 1507-1512
    • Tanaka, T.1    Uchiumi, T.2    Hinoshita, E.3    Inokuchi, A.4    Toh, S.5    Wada, M.6    Takano, H.7    Kohno, K.8    Kuwano, M.9
  • 10
    • 17744375160 scopus 로고    scopus 로고
    • The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
    • Jones SA, Moore LB, Shenk JL et al. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 2000; 14: 27-39.
    • (2000) Mol Endocrinol , vol.14 , pp. 27-39
    • Jones, S.A.1    Moore, L.B.2    Shenk, J.L.3
  • 11
    • 0034793718 scopus 로고    scopus 로고
    • Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism
    • Willson TM, Jones SA, Moore JT, Kliewer SA. Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism. Med Res Rev 2001; 21: 513-22.
    • (2001) Med Res Rev , vol.21 , pp. 513-522
    • Willson, T.M.1    Jones, S.A.2    Moore, J.T.3    Kliewer, S.A.4
  • 12
    • 0344665555 scopus 로고    scopus 로고
    • ABC of oral bioavailability: Transporters as gatekeepers in the gut
    • Dietrich CG, Geier A, Oude Elferink RP. ABC of oral bioavailability: transporters as gatekeepers in the gut. Gut 2003; 12: 1788-95.
    • (2003) Gut , vol.12 , pp. 1788-1795
    • Dietrich, C.G.1    Geier, A.2    Oude Elferink, R.P.3
  • 13
    • 0033938669 scopus 로고    scopus 로고
    • The multispecific organic anion transporter (Oat) family
    • Sekine T, Cha SH, Endou H. The multispecific organic anion transporter (Oat) family. Pflügers Arch 2000; 440: 337-50.
    • (2000) Pflügers Arch , vol.440 , pp. 337-350
    • Sekine, T.1    Cha, S.H.2    Endou, H.3
  • 14
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H. Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 1997; 272: 18526-9.
    • (1997) J Biol Chem , vol.272 , pp. 18526-18529
    • Sekine, T.1    Watanabe, N.2    Hosoyamada, M.3    Kanai, Y.4    Endou, H.5
  • 15
    • 0034817065 scopus 로고    scopus 로고
    • Isolation of a family of organic anion transporters from human liver and kidney
    • Sun W, Wu RR, van Poelje PD, Erion MD. Isolation of a family of organic anion transporters from human liver and kidney. Biochem Biophys Res Commun 2001; 283: 417-22.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 417-422
    • Sun, W.1    Wu, R.R.2    van Poelje, P.D.3    Erion, M.D.4
  • 16
    • 4544322271 scopus 로고    scopus 로고
    • Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa
    • Monte JC, Nagle MA, Eraly SA, Nigam SK. Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 2004; 323: 429-36.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 429-436
    • Monte, J.C.1    Nagle, M.A.2    Eraly, S.A.3    Nigam, S.K.4
  • 17
    • 0031768564 scopus 로고    scopus 로고
    • Functional characterization of the rat multispecific organic anion transporter 1 mediating basolateral uptake of anionic drugs in the kidney
    • Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K. Functional characterization of the rat multispecific organic anion transporter 1 mediating basolateral uptake of anionic drugs in the kidney. FEBS Lett 1998; 438: 321-4.
    • (1998) FEBS Lett , vol.438 , pp. 321-324
    • Uwai, Y.1    Okuda, M.2    Takami, K.3    Hashimoto, Y.4    Inui, K.5
  • 18
    • 0036084956 scopus 로고    scopus 로고
    • Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice
    • Kobayashi Y, Ohshiro N, Shibusawa A et al. Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol 2002; 62: 7-14.
    • (2002) Mol Pharmacol , vol.62 , pp. 7-14
    • Kobayashi, Y.1    Ohshiro, N.2    Shibusawa, A.3
  • 19
    • 2442720194 scopus 로고    scopus 로고
    • Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier
    • Ohtsuki S, Kikkawa T, Mori S et al. Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther 2004; 309: 1273-81.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 1273-1281
    • Ohtsuki, S.1    Kikkawa, T.2    Mori, S.3
  • 20
    • 0032432662 scopus 로고    scopus 로고
    • Induction of hepatic mrp2 (cmrp/cmoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen
    • Kauffmann HM, Keppler D, Gant TW, Schrenk D. Induction of hepatic mrp2 (cmrp/cmoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen. Arch Toxicol 1998; 72: 763-8.
    • (1998) Arch Toxicol , vol.72 , pp. 763-768
    • Kauffmann, H.M.1    Keppler, D.2    Gant, T.W.3    Schrenk, D.4
  • 21
    • 0032933142 scopus 로고    scopus 로고
    • Dexamethasone modulation of multidrug transporters in normal tissues
    • Demeule M, Jodoin J, Beaulieu É, Brossard M, Béliveau R. Dexamethasone modulation of multidrug transporters in normal tissues. FEBS Lett 1999; 442: 208-14.
    • (1999) FEBS Lett , vol.442 , pp. 208-214
    • Demeule, M.1    Jodoin, J.2    Beaulieu, É.3    Brossard, M.4    Béliveau, R.5
  • 22
    • 0032944048 scopus 로고    scopus 로고
    • Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone
    • Kubitz R, Wettstein M, Warskulat U, Haussinger D. Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 1999; 116: 401-10.
    • (1999) Gastroenterology , vol.116 , pp. 401-410
    • Kubitz, R.1    Wettstein, M.2    Warskulat, U.3    Haussinger, D.4
  • 23
    • 1942425487 scopus 로고    scopus 로고
    • St John's Wort (Hypericum perforatum) induces overexpression of multidrug resistance protein 2 (MRP2) in rats: A 30-day ingestion study
    • Shibayama Y, Ikeda R, Motoya T, Yamada K. St John's Wort (Hypericum perforatum) induces overexpression of multidrug resistance protein 2 (MRP2) in rats: A 30-day ingestion study. Food Chem Toxcol 2004; 42: 995-1002.
    • (2004) Food Chem Toxcol , vol.42 , pp. 995-1002
    • Shibayama, Y.1    Ikeda, R.2    Motoya, T.3    Yamada, K.4
  • 24
    • 3042599451 scopus 로고    scopus 로고
    • Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats
    • Cherrington NJ, Slitt AL, Li N, Klaassen CD. Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos 2004; 32: 734-41.
    • (2004) Drug Metab Dispos , vol.32 , pp. 734-741
    • Cherrington, N.J.1    Slitt, A.L.2    Li, N.3    Klaassen, C.D.4
  • 25
    • 0033373863 scopus 로고    scopus 로고
    • Cisplatin induces renal expression of P-glycoprotein and canalicular multispecific organic anion transporter
    • Demeule M, Brossard M, Beliveau R. Cisplatin induces renal expression of P-glycoprotein and canalicular multispecific organic anion transporter. Am J Physiol 1999; 277: F832-40.
    • (1999) Am J Physiol , vol.277
    • Demeule, M.1    Brossard, M.2    Beliveau, R.3
  • 26
    • 0022423216 scopus 로고
    • Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
    • Fort P, Marty L, Piechaczyk M et al. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucl Acids Res 1985; 13: 1431-42.
    • (1985) Nucl Acids Res , vol.13 , pp. 1431-1442
    • Fort, P.1    Marty, L.2    Piechaczyk, M.3
  • 27
    • 0029981430 scopus 로고    scopus 로고
    • Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
    • Paulusma CC, Bosma PJ, Zaman GJ et al. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 1996; 271: 1126-8.
    • (1996) Science , vol.271 , pp. 1126-1128
    • Paulusma, C.C.1    Bosma, P.J.2    Zaman, G.J.3
  • 28
    • 14844365200 scopus 로고    scopus 로고
    • CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs
    • Chirulli V, Longo V, Marini S, Mazzaccaro A, Fiorio R, Gervasi PG. CAR and PXR expression and inducibility of CYP2B and CYP3A activities in rat and rabbit lungs. Life Sci 2005; 76: 2535-46.
    • (2005) Life Sci , vol.76 , pp. 2535-2546
    • Chirulli, V.1    Longo, V.2    Marini, S.3    Mazzaccaro, A.4    Fiorio, R.5    Gervasi, P.G.6
  • 29
    • 1542375424 scopus 로고    scopus 로고
    • Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure
    • Fang C, Yoon S, Tindberg N, Jarvelainen HA, Lindros KO, Ingelman-Sundberg M. Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure. Biochem Pharmacol 2004; 67: 1389-97.
    • (2004) Biochem Pharmacol , vol.67 , pp. 1389-1397
    • Fang, C.1    Yoon, S.2    Tindberg, N.3    Jarvelainen, H.A.4    Lindros, K.O.5    Ingelman-Sundberg, M.6
  • 30
    • 0034655747 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 (CYP) genes by nuclear receptors
    • Honkakoski P, Negishi M. Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 2000; 347: 321-37.
    • (2000) Biochem J , vol.347 , pp. 321-337
    • Honkakoski, P.1    Negishi, M.2
  • 31
    • 0037260573 scopus 로고    scopus 로고
    • Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats
    • Chen C, Scott D, Hanson E et al. Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats. Pharm Res 2003; 20: 31-7.
    • (2003) Pharm Res , vol.20 , pp. 31-37
    • Chen, C.1    Scott, D.2    Hanson, E.3
  • 32
    • 16644364657 scopus 로고    scopus 로고
    • Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions
    • Naba H, Kuwayama C, Kakinuma C, Ohnishi S, Ogihara T. Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions. Drug Metab Pharmacokinet 2004; 19: 339-51.
    • (2004) Drug Metab Pharmacokinet , vol.19 , pp. 339-351
    • Naba, H.1    Kuwayama, C.2    Kakinuma, C.3    Ohnishi, S.4    Ogihara, T.5
  • 34
    • 0033532065 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
    • Kusuhara H, Sekine T, Utsunomiya-Tate N et al. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 1999; 274: 13675-80.
    • (1999) J Biol Chem , vol.274 , pp. 13675-13680
    • Kusuhara, H.1    Sekine, T.2    Utsunomiya-Tate, N.3
  • 35
    • 0036761059 scopus 로고    scopus 로고
    • Down-regulation of organic anion transporter 2 mRNA expression by nitric oxide in primary cultured rat hepatocytes
    • Cha SH, Kim HP, Jung NH, Lee WK, Kim JY, Cha YN. Down-regulation of organic anion transporter 2 mRNA expression by nitric oxide in primary cultured rat hepatocytes. IUBMB Life 2002; 54: 129-35.
    • (2002) IUBMB Life , vol.54 , pp. 129-135
    • Cha, S.H.1    Kim, H.P.2    Jung, N.H.3    Lee, W.K.4    Kim, J.Y.5    Cha, Y.N.6
  • 36
    • 0034731355 scopus 로고    scopus 로고
    • Hydrogen peroxide downregulates human organic anion transporters in the basolateral membrane of the proximal tubule
    • Takeda M, Hosoyamada M, Cha SH, Sekine T, Endou H. Hydrogen peroxide downregulates human organic anion transporters in the basolateral membrane of the proximal tubule. Life Sci 2000; 68: 679-87.
    • (2000) Life Sci , vol.68 , pp. 679-687
    • Takeda, M.1    Hosoyamada, M.2    Cha, S.H.3    Sekine, T.4    Endou, H.5
  • 38
    • 0030963906 scopus 로고    scopus 로고
    • The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
    • Trauner M, Arrese M, Soroka CJ et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997; 113: 255-64.
    • (1997) Gastroenterology , vol.113 , pp. 255-264
    • Trauner, M.1    Arrese, M.2    Soroka, C.J.3


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