-
1
-
-
24644487045
-
Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants
-
DOI 10.1016/j.bbrc.2005.07.201, PII S0006291X05016967
-
MM Abd El Mohsen MM Iravani JP Spencer S Rose AT Fahim TM Motawi NA Ismail P Jenner 2005 Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants Biochem Biophys Res Commun 336 386 391 16139799 1:CAS:528:DC%2BD2MXhtVWns7nO (Pubitemid 41268663)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.336
, Issue.2
, pp. 386-391
-
-
Abd El Mohsen, M.M.1
Iravani, M.M.2
Spencer, J.P.E.3
Rose, S.4
Fahim, A.T.5
Motawi, T.M.K.6
Ismail, N.A.F.7
Jenner, P.8
-
2
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
DOI 10.1016/S0197-4580(00)00124-X, PII S019745800000124X
-
H Akiyama S Barger S Barnum B Bradt J Bauer GM Cole NR Cooper P Eikelenboom M Emmerling BL Fiebich CE Finch S Frautschy WS Griffin H Hampel M Hull G Landreth L Lue R Mrak IR Mackenzie PL McGeer MK O'Banion J Pachter G Pasinetti C Plata-Salaman J Rogers R Rydel Y Shen W Streit R Strohmeyer I Tooyoma FL Van Muiswinkel R Veerhuis D Walker S Webster B Wegrzyniak G Wenk T Wyss-Coray 2000 Inflammation and Alzheimer's disease Neurobiol Aging 21 383 421 10858586 1:CAS:528:DC%2BD3cXktVSmt74%3D (Pubitemid 30349107)
-
(2000)
Neurobiology of Aging
, vol.21
, Issue.3
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.M.6
Cooper, N.R.7
Eikelenboom, P.8
Emmerling, M.9
Fiebich, B.L.10
Finch, C.E.11
Frautschy, S.12
Griffin, W.S.T.13
Hampel, H.14
Hull, M.15
Landreth, G.16
Lue, L.-F.17
Mrak, R.18
MacKenzie, I.R.19
McGeer, P.L.20
O'Banion, M.K.21
Pachter, J.22
Pasinetti, G.23
Plata-Salaman, C.24
Rogers, J.25
Rydel, R.26
Shen, Y.27
Streit, W.28
Strohmeyer, R.29
Tooyoma, I.30
Van Muiswinkel, F.L.31
Veerhuis, R.32
Walker, D.33
Webster, S.34
Wegrzyniak, B.35
Wenk, G.36
Wyss-Coray, T.37
more..
-
3
-
-
33646534207
-
Beta-amyloid mediated nitration of manganese superoxide dismutase: Implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease
-
16651627 1:CAS:528:DC%2BD28XkvF2ntLo%3D
-
M Anantharaman J Tangpong JN Keller MP Murphy WR Markesbery KK Kiningham DK St Clair 2006 Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease Am J Pathol 168 1608 1618 16651627 1:CAS:528:DC%2BD28XkvF2ntLo%3D
-
(2006)
Am J Pathol
, vol.168
, pp. 1608-1618
-
-
Anantharaman, M.1
Tangpong, J.2
Keller, J.N.3
Murphy, M.P.4
Markesbery, W.R.5
Kiningham, K.K.6
St Clair, D.K.7
-
4
-
-
0033546729
-
JNK-SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-γ and the phosphatidylinositol 3-kinase signaling pathways of the receptor
-
DOI 10.1006/bbrc.1999.1090
-
Z Assefa M Valius T Vántus P Agostinis W Merlevede JR Vandenheede 1999 JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-gamma and the phosphatidylinositol 3-kinase signaling pathways of the receptor Biochem Biophys Res Commun 261 641 645 10441479 1:CAS:528:DyaK1MXltVags7k%3D (Pubitemid 29408111)
-
(1999)
Biochemical and Biophysical Research Communications
, vol.261
, Issue.3
, pp. 641-645
-
-
Assefa, Z.1
Valius, M.2
Vantus, T.3
Agostinis, P.4
Merlevede, W.5
Vandenheede, J.R.6
-
5
-
-
0037436022
-
Cerebral hemorrhage and amyloid-beta
-
12586924 1:CAS:528:DC%2BD3sXht1Kjs7w%3D
-
CS Atwood G Perry MA Smith 2003 Cerebral hemorrhage and amyloid-beta Science 299 1014 12586924 1:CAS:528:DC%2BD3sXht1Kjs7w%3D
-
(2003)
Science
, vol.299
, pp. 1014
-
-
Atwood, C.S.1
Perry, G.2
Smith, M.A.3
-
6
-
-
0027457545
-
Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study
-
DL Bachman PA Wolf RT Linn JE Knoefel JL Cobb AJ Belanger LR White RB D'Agostino 1993 Incidence of dementia and probable Alzheimer's disease in a general population: the Framingham Study Neurology 43 515 519 8450993 1:STN:280:DyaK3s7ps1yrsA%3D%3D (Pubitemid 23088484)
-
(1993)
Neurology
, vol.43
, Issue.3
, pp. 515-519
-
-
Bachman, D.L.1
Wolf, P.A.2
Linn, R.T.3
Knoefel, J.E.4
Cobb, J.L.5
Belanger, A.J.6
White, L.R.7
D'Agostino, R.B.8
-
7
-
-
4544322045
-
Free radicals and aging
-
DOI 10.1016/j.tins.2004.07.005, PII S0166223604002334
-
G Barja 2004 Free radicals and aging Trends Neurosci 27 595 600 15374670 1:CAS:528:DC%2BD2cXnslOjtrk%3D (Pubitemid 39221395)
-
(2004)
Trends in Neurosciences
, vol.27
, Issue.10
, pp. 595-600
-
-
Barja, G.1
-
8
-
-
9444284334
-
Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β-amyloid
-
DOI 10.1096/fj.04-1890fje
-
KJ Barnham F Haeffner GD Ciccotosto CC Curtain D Tew C Mavros K Beyreuther D Carrington CL Masters RA Cherny R Cappai AI Bush 2004 Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid FASEB J 18 1427 1429 15231727 1:CAS:528:DC%2BD2cXntlKlu7g%3D (Pubitemid 39561603)
-
(2004)
FASEB Journal
, vol.18
, Issue.12
, pp. 1427-1429
-
-
Barnham, K.J.1
Haeffner, F.2
Ciccotosto, G.D.3
Curtain, C.C.4
Tew, D.5
Mavros, C.6
Beyreuther, K.7
Carrington, D.8
Masters, C.L.9
Cherny, R.A.10
Cappai, R.11
Bush, A.I.12
-
9
-
-
15944364190
-
Oxidative stress in Alzheimer's disease: Implications for prevention and therapy
-
15709473 1:CAS:528:DC%2BD2MXotFaksbY%3D
-
C Behl 2005 Oxidative stress in Alzheimer's disease: implications for prevention and therapy Subcell Biochem 38 65 78 15709473 1:CAS:528: DC%2BD2MXotFaksbY%3D
-
(2005)
Subcell Biochem
, vol.38
, pp. 65-78
-
-
Behl, C.1
-
10
-
-
0037098866
-
Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach
-
DOI 10.1016/S0891-5849(02)00883-3, PII S0891584902008833
-
C Behl B Moosmann 2002 Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach Free Radic Biol Med 33 182 191 12106814 1:CAS:528:DC%2BD38XmsVekt7s%3D (Pubitemid 34775190)
-
(2002)
Free Radical Biology and Medicine
, vol.33
, Issue.2
, pp. 182-191
-
-
Behl, C.1
Moosmann, B.2
-
11
-
-
34250745912
-
o site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
-
DOI 10.1083/jcb.200609074
-
EL Bell TA Klimova J Eisenbart CT Moraes MP Murphy GR Budinger NS Chandel 2007 The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production J Cell Biol 177 1029 1036 17562787 1:CAS:528:DC%2BD2sXmvF2ru7o%3D (Pubitemid 46955707)
-
(2007)
Journal of Cell Biology
, vol.177
, Issue.6
, pp. 1029-1036
-
-
Bell, E.L.1
Klimova, T.A.2
Eisenbart, J.3
Moraes, C.T.4
Murphy, M.P.5
Budinger, G.R.S.6
Chandel, N.S.7
-
12
-
-
34247363219
-
The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease
-
DOI 10.1016/j.neurobiolaging.2006.05.004, PII S019745800600145X
-
R Borghi S Patriarca N Traverso A Piccini D Storace A Garuti G Cirmena P Odetti M Tabaton 2007 The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease Neurobiol Aging 28 1009 1014 16769154 1:CAS:528:DC%2BD2sXkslegurs%3D (Pubitemid 46635907)
-
(2007)
Neurobiology of Aging
, vol.28
, Issue.7
, pp. 1009-1014
-
-
Borghi, R.1
Patriarca, S.2
Traverso, N.3
Piccini, A.4
Storace, D.5
Garuti, A.6
Cirmena, G.7
Odetti, P.8
Tabaton, M.9
-
13
-
-
34248178463
-
Differential regulation of BACE1 promoter activity by nuclear factor-κB in neurons and glia upon exposure to β-amyloid peptides
-
DOI 10.1002/jnr.21252
-
KZ Bourne DC Ferrari C Lange-Dohna S Rossner TG Wood JR Perez-Polo 2007 Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides J Neurosci Res 85 1194 1204 17385716 1:CAS:528:DC%2BD2sXlsV2rs7s%3D (Pubitemid 46724363)
-
(2007)
Journal of Neuroscience Research
, vol.85
, Issue.6
, pp. 1194-1204
-
-
Bourne, K.Z.1
Ferrari, D.C.2
Lange-Dohna, C.3
Rossner, S.4
Wood, T.G.5
Perez-Polo, J.R.6
-
14
-
-
0023803371
-
Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease
-
2850143 1:STN:280:DyaL1M%2FptVOqtQ%3D%3D
-
M Brownlee A Cerami H Vlassara 1988 Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease Diabetes Metab Rev 4 437 451 2850143 1:STN:280:DyaL1M%2FptVOqtQ%3D%3D
-
(1988)
Diabetes Metab Rev
, vol.4
, pp. 437-451
-
-
Brownlee, M.1
Cerami, A.2
Vlassara, H.3
-
15
-
-
34250811784
-
LRP in amyloid-beta production and metabolism
-
17185504 1:CAS:528:DC%2BD2sXhtVWhtL4%3D
-
G Bu J Cam C Zerbinatti 2006 LRP in amyloid-beta production and metabolism Ann N Y Acad Sci 1086 35 53 17185504 1:CAS:528:DC%2BD2sXhtVWhtL4%3D
-
(2006)
Ann N y Acad Sci
, vol.1086
, pp. 35-53
-
-
Bu, G.1
Cam, J.2
Zerbinatti, C.3
-
16
-
-
0026482265
-
Advanced glycosylation: Chemistry, biology, and implications for diabetes and aging
-
1540533 1:CAS:528:DyaK38Xks1Oms7o%3D
-
R Bucala A Cerami 1992 Advanced glycosylation: chemistry, biology, and implications for diabetes and aging Adv Pharmacol 23 1 34 1540533 1:CAS:528:DyaK38Xks1Oms7o%3D
-
(1992)
Adv Pharmacol
, vol.23
, pp. 1-34
-
-
Bucala, R.1
Cerami, A.2
-
17
-
-
44349140124
-
NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42
-
18263584 1:CAS:528:DC%2BD1cXkt1alurk%3D
-
V Buggia-Prevot J Sevalle S Rossner F Checler 2008 NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42 J Biol Chem 283 10037 10047 18263584 1:CAS:528:DC%2BD1cXkt1alurk%3D
-
(2008)
J Biol Chem
, vol.283
, pp. 10037-10047
-
-
Buggia-Prevot, V.1
Sevalle, J.2
Rossner, S.3
Checler, F.4
-
18
-
-
0035194145
-
Evidence of oxidative damage in Alzheimer's disease brain: Central role for amyloid β-peptide
-
DOI 10.1016/S1471-4914(01)02173-6, PII S1471491401021736
-
DA Butterfield J Drake C Pocernich A Castegna 2001 Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide Trends Mol Med 7 548 554 11733217 1:CAS:528:DC%2BD3MXovVCnu7o%3D (Pubitemid 33127140)
-
(2001)
Trends in Molecular Medicine
, vol.7
, Issue.12
, pp. 548-554
-
-
Butterfield, D.A.1
Drake, J.2
Pocernich, C.3
Castegna, A.4
-
21
-
-
0345276649
-
The induction of amyloid precursor protein and α-synuclein in rat hippocampal astrocytes by diethyldithiocarbamate and copper with or without glutathione
-
DOI 10.1016/j.toxlet.2003.09.009
-
SY Cheng LD Trombetta 2004 The induction of amyloid precursor protein and alpha-synuclein in rat hippocampal astrocytes by diethyldithiocarbamate and copper with or without glutathione Toxicol Lett 146 139 149 14643966 1:CAS:528:DC%2BD3sXpt1Witbg%3D (Pubitemid 37487828)
-
(2004)
Toxicology Letters
, vol.146
, Issue.2
, pp. 139-149
-
-
Cheng, S.Y.1
Trombetta, L.D.2
-
22
-
-
40549129366
-
Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling
-
DOI 10.1111/j.1474-9726.2007.00360.x
-
HJ Cho SM Jin HD Youn K Huh I Mook-Jung 2008 Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling Aging Cell 7 137 147 18081741 1:CAS:528: DC%2BD1cXksFeiurk%3D (Pubitemid 351359647)
-
(2008)
Aging Cell
, vol.7
, Issue.2
, pp. 137-147
-
-
Cho, H.-J.1
Jin, S.M.2
Youn, H.D.3
Huh, K.4
Mook-Jung, I.5
-
23
-
-
68849129707
-
RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model
-
19332646 1:CAS:528:DC%2BD1MXpvFOltL0%3D
-
HJ Cho SM Son SM Jin HS Hong DH Shin SJ Kim K Huh I Mook-Jung 2009 RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model FASEB J 23 2639 2649 19332646 1:CAS:528:DC%2BD1MXpvFOltL0%3D
-
(2009)
FASEB J
, vol.23
, pp. 2639-2649
-
-
Cho, H.J.1
Son, S.M.2
Jin, S.M.3
Hong, H.S.4
Shin, D.H.5
Kim, S.J.6
Huh, K.7
Mook-Jung, I.8
-
24
-
-
0347356360
-
Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1
-
DOI 10.1128/MCB.24.2.865-874.2004
-
MA Christensen W Zhou H Qing A Lehman S Philipsen W Song 2004 Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1 Mol Cell Biol 24 865 874 14701757 1:CAS:528: DC%2BD2cXktVyrsw%3D%3D (Pubitemid 38057936)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.2
, pp. 865-874
-
-
Christensen, M.A.1
Zhou, W.2
Qing, H.3
Lehman, A.4
Philipsen, S.5
Song, W.6
-
25
-
-
0032895651
-
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
-
DOI 10.1038/8438
-
DH Chui H Tanahashi K Ozawa S Ikeda F Checler O Ueda H Suzuki W Araki H Inoue K Shirotani K Takahashi F Gallyas T Tabira 1999 Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation Nat Med 5 560 564 10229234 1:CAS:528:DyaK1MXivVKrs7c%3D (Pubitemid 29220216)
-
(1999)
Nature Medicine
, vol.5
, Issue.5
, pp. 560-564
-
-
Chui, D.-H.1
Tanahashi, H.2
Ozawa, K.3
Ikeda, S.4
Checler, F.5
Ueda, O.6
Suzuki, H.7
Araki, W.8
Inoue, H.9
Shirotani, K.10
Takahashi, K.11
Gallyas, F.12
Tabira, T.13
-
26
-
-
0026745610
-
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
-
DOI 10.1038/360672a0
-
M Citron T Oltersdorf C Haass L McConlogue AY Hung P Seubert C Vigo-Pelfrey I Lieberburg DJ Selkoe 1992 Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production Nature 360 672 674 1465129 1:CAS:528:DyaK3sXnvVGnuw%3D%3D (Pubitemid 23007680)
-
(1992)
Nature
, vol.360
, Issue.6405
, pp. 672-674
-
-
Citron, M.1
Oltersdorf, T.2
Haass, C.3
McConlogue, L.4
Hung, A.Y.5
Seubert, P.6
Vigo-Pelfrey, C.7
Lieberburg, I.8
Selkoe, D.J.9
-
27
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
DOI 10.1038/nm0197-67
-
M Citron D Westaway W Xia G Carlson T Diehl G Levesque K Johnson-Wood M Lee P Seubert A Davis D Kholodenko R Motter R Sherrington B Perry H Yao R Strome I Lieberburg J Rommens S Kim D Schenk P Fraser P St George Hyslop DJ Selkoe 1997 Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice Nat Med 3 67 72 8986743 1:CAS:528:DyaK2sXitFOrtg%3D%3D (Pubitemid 27019143)
-
(1997)
Nature Medicine
, vol.3
, Issue.1
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St. George Hyslop, P.22
Selkoe, D.J.23
more..
-
28
-
-
34548736635
-
The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability [4]
-
DOI 10.1038/sj.cdd.4402202, PII 4402202
-
A Colombo M Repici M Pesaresi S Santambrogio G Forloni T Borsello 2007 The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability Cell Death Differ 14 1845 1848 17641679 1:CAS:528:DC%2BD2sXhtVCisbrP (Pubitemid 47423652)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.10
, pp. 1845-1848
-
-
Colombo, A.1
Repici, M.2
Pesaresi, M.3
Santambrogio, S.4
Forloni, G.5
Borsello, T.6
-
29
-
-
60849105665
-
JNK regulates APP cleavage and degradation in a model of Alzheimer's disease
-
19166938 1:CAS:528:DC%2BD1MXitVSjt74%3D
-
A Colombo A Bastone C Ploia A Sclip M Salmona G Forloni T Borsello 2009 JNK regulates APP cleavage and degradation in a model of Alzheimer's disease Neurobiol Dis 33 518 525 19166938 1:CAS:528:DC%2BD1MXitVSjt74%3D
-
(2009)
Neurobiol Dis
, vol.33
, pp. 518-525
-
-
Colombo, A.1
Bastone, A.2
Ploia, C.3
Sclip, A.4
Salmona, M.5
Forloni, G.6
Borsello, T.7
-
30
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
EH Corder AM Saunders WJ Strittmatter DE Schmechel PC Gaskell GW Small AD Roses JL Haines MA Pericak-Vance 1993 Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 921 923 8346443 1:CAS:528:DyaK3sXmtVWjur8%3D (Pubitemid 23275809)
-
(1993)
Science
, vol.261
, Issue.5123
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
Roses, A.D.7
Haines, J.L.8
Pericak-Vance, M.A.9
-
32
-
-
0027017232
-
Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age
-
1303288 1:CAS:528:DyaK3sXnvVGntQ%3D%3D
-
M Corral-Debrinski T Horton MT Lott JM Shoffner MF Beal DC Wallace 1992 Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age Nat Genet 2 324 329 1303288 1:CAS:528:DyaK3sXnvVGntQ%3D%3D
-
(1992)
Nat Genet
, vol.2
, pp. 324-329
-
-
Corral-Debrinski, M.1
Horton, T.2
Lott, M.T.3
Shoffner, J.M.4
Beal, M.F.5
Wallace, D.C.6
-
33
-
-
27344441077
-
The expression of p75 neurotrophin receptor protects against the neurotoxicity of soluble oligomers of β-amyloid
-
DOI 10.1016/j.yexcr.2005.09.004, PII S0014482705004179
-
C Costantini V Della-Bianca E Formaggio C Chiamulera A Montresor F Rossi 2005 The expression of p75 neurotrophin receptor protects against the neurotoxicity of soluble oligomers of beta-amyloid Exp Cell Res 311 126 134 16223482 1:CAS:528:DC%2BD2MXhtFKmtbzF (Pubitemid 41527181)
-
(2005)
Experimental Cell Research
, vol.311
, Issue.1
, pp. 126-134
-
-
Costantini, C.1
Della-Bianca, V.2
Formaggio, E.3
Chiamulera, C.4
Montresor, A.5
Rossi, F.6
-
34
-
-
1242338183
-
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
-
DOI 10.1073/pnas.0305799101
-
RG Cutler J Kelly K Storie WA Pedersen A Tammara K Hatanpaa JC Troncoso MP Mattson 2004 Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease Proc Natl Acad Sci USA 101 2070 2075 14970312 1:CAS:528:DC%2BD2cXhs1Srsrw%3D (Pubitemid 38229016)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.7
, pp. 2070-2075
-
-
Cutler, R.G.1
Kelly, J.2
Storie, K.3
Pedersen, W.A.4
Tammara, A.5
Hatanpaa, K.6
Troncoso, J.C.7
Mattson, M.P.8
-
35
-
-
77951251848
-
Calcium signaling and amyloid toxicity in Alzheimer disease
-
20212036 1:CAS:528:DC%2BC3cXkvVGjt7s%3D
-
A Demuro I Parker GE Stutzmann 2010 Calcium signaling and amyloid toxicity in Alzheimer disease J Biol Chem 285 12463 12468 20212036 1:CAS:528:DC%2BC3cXkvVGjt7s%3D
-
(2010)
J Biol Chem
, vol.285
, pp. 12463-12468
-
-
Demuro, A.1
Parker, I.2
Stutzmann, G.E.3
-
36
-
-
77953123687
-
L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway
-
20416364 1:CAS:528:DC%2BC3cXmsVeltr8%3D
-
X Di J Yan Y Zhao J Zhang Z Shi Y Chang B Zhao 2010 L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway Neuroscience 168 778 786 20416364 1:CAS:528:DC%2BC3cXmsVeltr8%3D
-
(2010)
Neuroscience
, vol.168
, pp. 778-786
-
-
Di, X.1
Yan, J.2
Zhao, Y.3
Zhang, J.4
Shi, Z.5
Chang, Y.6
Zhao, B.7
-
37
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
-
DOI 10.1038/nn842
-
JC Dodart KR Bales KS Gannon SJ Greene RB DeMattos C Mathis CA DeLong S Wu X Wu DM Holtzman SM Paul 2002 Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model Nat Neurosci 5 452 457 11941374 1:CAS:528:DC%2BD38XjtFykurY%3D (Pubitemid 34454251)
-
(2002)
Nature Neuroscience
, vol.5
, Issue.5
, pp. 452-457
-
-
Dodart, J.-C.1
Bales, K.R.2
Gannon, K.S.3
Greene, S.J.4
DeMattos, R.B.5
Mathis, C.6
DeLong, C.A.7
Wu, S.8
Wu, X.9
Holtzman, D.M.10
Paul, S.M.11
-
39
-
-
16044366039
-
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
-
DOI 10.1038/383710a0
-
K Duff C Eckman C Zehr X Yu CM Prada J Perez-tur M Hutton L Buee Y Harigaya D Yager D Morgan MN Gordon L Holcomb L Refolo B Zenk J Hardy S Younkin 1996 Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1 Nature 383 710 713 8878479 1:CAS:528:DyaK28XmsVGnsrs%3D (Pubitemid 26360645)
-
(1996)
Nature
, vol.383
, Issue.6602
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.-M.5
Perez-Tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
40
-
-
2442684094
-
Cholesterol and APOE genotype interact to influence alzheimer disease progression
-
RM Evans S Hui A Perkins DK Lahiri J Poirier MR Farlow 2004 Cholesterol and APOE genotype interact to influence Alzheimer disease progression Neurology 62 1869 1871 15159498 1:CAS:528:DC%2BD2cXjs1yltLk%3D (Pubitemid 38661755)
-
(2004)
Neurology
, vol.62
, Issue.10
, pp. 1869-1871
-
-
Evans, R.M.1
Hui, S.2
Perkins, A.3
Lahiri, D.K.4
Poirier, J.5
Farlow, M.R.6
-
41
-
-
0036228106
-
FAD mutant PS-1 gene-targeted mice: Increased Aβ42 and Aβ deposition without APP overproduction
-
DOI 10.1016/S0197-4580(01)00330-X, PII S019745800100330X
-
DG Flood AG Reaume KS Dorfman YG Lin DM Lang SP Trusko MJ Savage WG Annaert B De Strooper R Siman RW Scott 2002 FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction Neurobiol Aging 23 335 348 11959395 1:CAS:528:DC%2BD38XivVShu7k%3D (Pubitemid 34312016)
-
(2002)
Neurobiology of Aging
, vol.23
, Issue.3
, pp. 335-348
-
-
Flood, D.G.1
Reaume, A.G.2
Dorfman, K.S.3
Lin, Y.-G.4
Lang, D.M.5
Trusko, S.P.6
Savage, M.J.7
Annaert, W.G.8
De Strooper, B.9
Siman, R.10
Scott, R.W.11
-
42
-
-
0036751954
-
Oxidative stress in brain aging: Implications for therapeutics of neurodegenerative diseases
-
DOI 10.1016/S0197-4580(02)00019-2, PII S0197458002000192
-
RA Floyd K Hensley 2002 Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases Neurobiol Aging 23 795 807 12392783 1:CAS:528:DC%2BD38XotVCiurk%3D (Pubitemid 35217704)
-
(2002)
Neurobiology of Aging
, vol.23
, Issue.5
, pp. 795-807
-
-
Floyd, R.A.1
Hensley, K.2
-
43
-
-
0029985732
-
Oxidative stress increases production of β-amyloid precursor protein and β-amyloid (Aβ) in mammalian lenses, and Aβ has toxic effects on lens epithelial cells
-
DOI 10.1074/jbc.271.17.10169
-
PH Frederikse D Garland JS Zigler Jr J Piatigorsky 1996 Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells J Biol Chem 271 10169 10174 8626578 1:CAS:528:DyaK28XisFKjsro%3D (Pubitemid 26131580)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.17
, pp. 10169-10174
-
-
Frederikse, P.H.1
Garland, D.2
Zigler Jr., J.S.3
Piatigorsky, J.4
-
44
-
-
33645937614
-
Presenilin-dependent gamma-secretase on plasma membrane and endosome is functionally distinct
-
16605258 1:CAS:528:DC%2BD28XivVChtLY%3D
-
A Fukumori M Okochi S Tagami J Jiang N Itoh T Nakayama K Yanagida Y Ishizuka-Katsura T Morihara K Kamino T Tanaka T Kudo H Tanii A Ikuta C Haass M Takeda 2006 Presenilin-dependent gamma-secretase on plasma membrane and endosome is functionally distinct Biochemistry 45 4907 4914 16605258 1:CAS:528:DC%2BD28XivVChtLY%3D
-
(2006)
Biochemistry
, vol.45
, pp. 4907-4914
-
-
Fukumori, A.1
Okochi, M.2
Tagami, S.3
Jiang, J.4
Itoh, N.5
Nakayama, T.6
Yanagida, K.7
Ishizuka-Katsura, Y.8
Morihara, T.9
Kamino, K.10
Tanaka, T.11
Kudo, T.12
Tanii, H.13
Ikuta, A.14
Haass, C.15
Takeda, M.16
-
45
-
-
0036718272
-
β-secretase protein and activity are increased in the neocortex in Alzheimer disease
-
DOI 10.1001/archneur.59.9.1381
-
H Fukumoto BS Cheung BT Hyman MC Irizarry 2002 Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease Arch Neurol 59 1381 1389 12223024 (Pubitemid 35014802)
-
(2002)
Archives of Neurology
, vol.59
, Issue.9
, pp. 1381-1389
-
-
Fukumoto, H.1
Cheung, B.S.2
Hyman, B.T.3
Irizarry, M.C.4
-
46
-
-
79955955895
-
Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: Three partners in crime
-
21272192 1:CAS:528:DC%2BC3MXnsF2jsL4%3D
-
P Gamba G Leonarduzzi E Tamagno M Guglielmotto G Testa B Sottero S Gargiulo F Biasi A Mauro J Viña G Poli 2011 Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime Aging Cell 10 403 417 21272192 1:CAS:528:DC%2BC3MXnsF2jsL4%3D
-
(2011)
Aging Cell
, vol.10
, pp. 403-417
-
-
Gamba, P.1
Leonarduzzi, G.2
Tamagno, E.3
Guglielmotto, M.4
Testa, G.5
Sottero, B.6
Gargiulo, S.7
Biasi, F.8
Mauro, A.9
Viña, J.10
Poli, G.11
-
47
-
-
66149127297
-
Mutant presenilin 1 increases the expression and activity of BACE1
-
19196715 1:CAS:528:DC%2BD1MXjs1ynur0%3D
-
L Giliberto R Borghi A Piccini R Mangerini S Sorbi G Cirmena A Garuti B Ghetti F Tagliavini MR Mughal MP Mattson X Zhu X Wang M Guglielmotto E Tamagno M Tabaton 2009 Mutant presenilin 1 increases the expression and activity of BACE1 J Biol Chem 284 9027 9038 19196715 1:CAS:528:DC%2BD1MXjs1ynur0%3D
-
(2009)
J Biol Chem
, vol.284
, pp. 9027-9038
-
-
Giliberto, L.1
Borghi, R.2
Piccini, A.3
Mangerini, R.4
Sorbi, S.5
Cirmena, G.6
Garuti, A.7
Ghetti, B.8
Tagliavini, F.9
Mughal, M.R.10
Mattson, M.P.11
Zhu, X.12
Wang, X.13
Guglielmotto, M.14
Tamagno, E.15
Tabaton, M.16
-
48
-
-
0042838303
-
Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss
-
DOI 10.1073/pnas.1834302100
-
Y Gong L Chang KL Viola PN Lacor MP Lambert CE Finch GA Krafft WL Klein 2003 Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss Proc Natl Acad Sci USA 100 10417 10422 12925731 1:CAS:528:DC%2BD3sXntFyns78%3D (Pubitemid 37071893)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.18
, pp. 10417-10422
-
-
Gong, Y.1
Chang, L.2
Viola, K.L.3
Lacor, P.N.4
Lambert, M.P.5
Finch, C.E.6
Krafft, G.A.7
Klein, W.L.8
-
50
-
-
58549119790
-
The up-regulation of BACE1 mediated by hypoxia and ischemic injury: Role of oxidative stress and HIF1alpha
-
19196431 1:CAS:528:DC%2BD1MXisV2htLg%3D
-
M Guglielmotto M Aragno R Autelli L Giliberto E Novo S Colombatto O Danni M Parola MA Smith G Perry E Tamagno M Tabaton 2009 The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha J Neurochem 108 1045 1056 19196431 1:CAS:528:DC%2BD1MXisV2htLg%3D
-
(2009)
J Neurochem
, vol.108
, pp. 1045-1056
-
-
Guglielmotto, M.1
Aragno, M.2
Autelli, R.3
Giliberto, L.4
Novo, E.5
Colombatto, S.6
Danni, O.7
Parola, M.8
Smith, M.A.9
Perry, G.10
Tamagno, E.11
Tabaton, M.12
-
51
-
-
79952859933
-
AGEs/RAGE complex upregulates BACE1 via NF-kappaB pathway activation
-
[Epub ahead of print]
-
Guglielmotto M, Aragno M, Tamagno E, Vercellinatto I, Visentin S, Medana C, Catalano MG, Smith MA, Perry G, Danni O, Boccuzzi G, Tabaton M (2010) AGEs/RAGE complex upregulates BACE1 via NF-kappaB pathway activation. Neurobiol Aging [Epub ahead of print]
-
(2010)
Neurobiol Aging
-
-
Guglielmotto, M.1
Aragno, M.2
Tamagno, E.3
Vercellinatto, I.4
Visentin, S.5
Medana, C.6
Catalano, M.G.7
Ma, S.8
Perry, G.9
Danni, O.10
Boccuzzi, G.11
Tabaton, M.12
-
52
-
-
84455193364
-
Amyloid-β42 activates the expression of BACE1 through the JNK pathway
-
[Epub ahead of print]
-
Guglielmotto M, Monteleone D, Giliberto L, Fornaro M, Borghi R, Tamagno E,Tabaton M (2011) Amyloid-β42 Activates the Expression of BACE1 Through the JNK Pathway. J Alzheimers Dis [Epub ahead of print]
-
(2011)
J Alzheimers Dis
-
-
Guglielmotto, M.1
Monteleone, D.2
Giliberto, L.3
Fornaro, M.4
Borghi, R.5
Tamagno, E.6
Tabaton, M.7
-
53
-
-
29844435497
-
Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease
-
DOI 10.1016/j.neurobiolaging.2005.01.001, PII S0197458005000163
-
I Guidi D Galimberti S Lonati C Novembrino F Bamonti M Tiriticco C Fenoglio E Venturelli P Baron N Bresolin E Scarpini 2006 Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease Neurobiol Aging 27 262 269 16399211 1:CAS:528:DC%2BD28XitFClug%3D%3D (Pubitemid 43038550)
-
(2006)
Neurobiology of Aging
, vol.27
, Issue.2
, pp. 262-269
-
-
Guidi, I.1
Galimberti, D.2
Lonati, S.3
Novembrino, C.4
Bamonti, F.5
Tiriticco, M.6
Fenoglio, C.7
Venturelli, E.8
Baron, P.9
Bresolin, N.10
Scarpini, E.11
-
54
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
1763432 1:CAS:528:DyaK3MXmslKktr8%3D
-
J Hardy D Allsop 1991 Amyloid deposition as the central event in the aetiology of Alzheimer's disease Trends Pharmacol Sci 12 383 388 1763432 1:CAS:528:DyaK3MXmslKktr8%3D
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
55
-
-
0026775958
-
Free radical theory of aging
-
1383768 1:CAS:528:DyaK38XmsVyqtr0%3D
-
D Harman 1992 Free radical theory of aging Mutat Res 275 257 266 1383768 1:CAS:528:DyaK38XmsVyqtr0%3D
-
(1992)
Mutat Res
, vol.275
, pp. 257-266
-
-
Harman, D.1
-
56
-
-
20244361899
-
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death
-
DOI 10.1046/j.1471-4159.2003.01585.x
-
Y Hashimoto O Tsuji T Niikura Y Yamagishi M Ishizaka M Kawasumi T Chiba K Kanekura M Yamada E Tsukamoto K Kouyama K Terashita S Aiso A Lin I Nishimoto 2003 Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death J Neurochem 84 864 877 12562529 1:CAS:528:DC%2BD3sXht1amtrc%3D (Pubitemid 36176943)
-
(2003)
Journal of Neurochemistry
, vol.84
, Issue.4
, pp. 864-877
-
-
Hashimoto, Y.1
Tsuji, O.2
Niikura, T.3
Yamagishi, Y.4
Ishizaka, M.5
Kawasumi, M.6
Chiba, T.7
Kanekura, K.8
Yamada, M.9
Tsukamoto, E.10
Kouyama, K.11
Terashita, K.12
Aiso, S.13
Lint, A.14
Nishimoto, I.15
-
57
-
-
0028180518
-
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
-
8159737 1:CAS:528:DyaK2cXivFGrt7s%3D
-
K Hensley JM Carney MP Mattson M Aksenova M Harris JF Wu RA Floyd DA Butterfield 1994 A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease Proc Natl Acad Sci USA 91 3270 3274 8159737 1:CAS:528:DyaK2cXivFGrt7s%3D
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3270-3274
-
-
Hensley, K.1
Carney, J.M.2
Mattson, M.P.3
Aksenova, M.4
Harris, M.5
Wu, J.F.6
Floyd, R.A.7
Butterfield, D.A.8
-
58
-
-
0036260892
-
Increased expression of the amyloid precursor β-secretase in Alzheimer's disease
-
DOI 10.1002/ana.10208
-
RM Holsinger CA McLean K Beyreuther CL Masters G Evin 2002 Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease Ann Neurol 51 783 786 12112088 1:CAS:528:DC%2BD3sXhsFygsbc%3D (Pubitemid 34568861)
-
(2002)
Annals of Neurology
, vol.51
, Issue.6
, pp. 783-786
-
-
Holsinger, R.M.D.1
McLean, C.A.2
Beyreuther, K.3
Masters, C.L.4
Evin, G.5
-
59
-
-
0033601338
-
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction
-
10601271 1:CAS:528:DC%2BD3cXpsFSi
-
X Huang MP Cuajungco CS Atwood MA Hartshorn JD Tyndall GR Hanson KC Stokes M Leopold G Multhaup LE Goldstein RC Scarpa AJ Saunders J Lim RD Moir C Glabe EF Bowden CL Masters DP Fairlie RE Tanzi AI Bush 1999 Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction J Biol Chem 274 37111 37116 10601271 1:CAS:528:DC%2BD3cXpsFSi
-
(1999)
J Biol Chem
, vol.274
, pp. 37111-37116
-
-
Huang, X.1
Cuajungco, M.P.2
Atwood, C.S.3
Hartshorn, M.A.4
Tyndall, J.D.5
Hanson, G.R.6
Stokes, K.C.7
Leopold, M.8
Multhaup, G.9
Goldstein, L.E.10
Scarpa, R.C.11
Saunders, A.J.12
Lim, J.13
Moir, R.D.14
Glabe, C.15
Bowden, E.F.16
Masters, C.L.17
Fairlie, D.P.18
Tanzi, R.E.19
Bush, A.I.20
more..
-
60
-
-
0141783612
-
Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-β (Aβ) 40 or Aβ 42 in humans
-
DOI 10.1016/S0304-3940(03)00895-4
-
K Ishii T Tokuda T Matsushima F Miya S Shoji S Ikeda A Tamaoka 2003 Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-beta (Abeta) 40 or Abeta 42 in humans Neurosci Lett 350 161 164 14550919 1:CAS:528:DC%2BD3sXnvVOjsL8%3D (Pubitemid 37205190)
-
(2003)
Neuroscience Letters
, vol.350
, Issue.3
, pp. 161-164
-
-
Ishii, K.1
Tokuda, T.2
Matsushima, T.3
Miya, F.4
Shoji, S.5
Ikeda, S.-I.6
Tamaoka, A.7
-
61
-
-
42149122012
-
Functional role of lipoprotein receptors in Alzheimer's disease
-
DOI 10.2174/156720508783884675
-
S Jaeger CU Pietrzik 2008 Functional role of lipoprotein receptors in Alzheimer's disease Curr Alzheimer Res 5 15 25 18288927 1:CAS:528: DC%2BD1cXitF2ktbs%3D (Pubitemid 351536350)
-
(2008)
Current Alzheimer Research
, vol.5
, Issue.1
, pp. 15-25
-
-
Jaeger, S.1
Pietrzik, C.U.2
-
62
-
-
0037111135
-
The pathology of ischemic-vascular dementia: An update
-
DOI 10.1016/S0022-510X(02)00282-4, PII S0022510X02002824
-
Jellinger KA (2002) The pathology of ischemic-vascular dementia: an update. J Neurol Sci 203-204:153-157 (Pubitemid 35287392)
-
(2002)
Journal of the Neurological Sciences
, vol.203-204
, pp. 153-157
-
-
Jellinger, K.A.1
-
64
-
-
77951975308
-
Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease
-
18687504 1:CAS:528:DC%2BC3cXkvFKmt7c%3D
-
DG Jo TV Arumugam HN Woo JS Park SC Tang M Mughal DH Hyun JH Park YH Choi AR Gwon S Camandola A Cheng H Cai W Song WR Markesbery MP Mattson 2010 Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease Neurobiol Aging 31 917 925 18687504 1:CAS:528:DC%2BC3cXkvFKmt7c%3D
-
(2010)
Neurobiol Aging
, vol.31
, pp. 917-925
-
-
Jo, D.G.1
Arumugam, T.V.2
Woo, H.N.3
Park, J.S.4
Tang, S.C.5
Mughal, M.6
Hyun, D.H.7
Park, J.H.8
Choi, Y.H.9
Gwon, A.R.10
Camandola, S.11
Cheng, A.12
Cai, H.13
Song, W.14
Markesbery, W.R.15
Mattson, M.P.16
-
65
-
-
67650128395
-
Therapeutic potential of statins in Alzheimer's disease
-
19321181 1:CAS:528:DC%2BD1MXoslSitro%3D
-
N Kandiah HH Feldman 2009 Therapeutic potential of statins in Alzheimer's disease J Neurol Sci 283 230 234 19321181 1:CAS:528:DC%2BD1MXoslSitro%3D
-
(2009)
J Neurol Sci
, vol.283
, pp. 230-234
-
-
Kandiah, N.1
Feldman, H.H.2
-
66
-
-
0345826094
-
BACE1 suppression by RNA interference in primary cortical neurons
-
DOI 10.1074/jbc.M309219200
-
SC Kao AM Krichevsky KS Kosik LH Tsai 2004 BACE1 suppression by RNA interference in primary cortical neurons J Biol Chem 279 1942 1949 14600149 1:CAS:528:DC%2BD2cXisF2rsQ%3D%3D (Pubitemid 38084465)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.3
, pp. 1942-1949
-
-
Kao, S.-C.1
Krichevsky, A.M.2
Kosik, K.S.3
Tsai, L.-H.4
-
67
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
DOI 10.1126/science.1079469
-
R Kayed E Head JL Thompson TM McIntire SC Milton CW Cotman CG Glabe 2003 Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis Science 300 486 489 12702875 1:CAS:528:DC%2BD3sXivFyms7k%3D (Pubitemid 36444329)
-
(2003)
Science
, vol.300
, Issue.5618
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabel, C.G.7
-
68
-
-
0031840571
-
Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system
-
JN Keller MP Mattson 1998 Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system Rev Neurosci 9 105 116 9711902 1:STN:280:DyaK1cznsFOhsg%3D%3D (Pubitemid 28386642)
-
(1998)
Reviews in the Neurosciences
, vol.9
, Issue.2
, pp. 105-116
-
-
Keller, J.N.1
Mattson, M.P.2
-
70
-
-
69949107465
-
The unsolved relationship of brain aging and late-onset Alzheimer disease
-
19632303 1:CAS:528:DC%2BD1MXhtFamsr3I
-
A Kern C Behl 2009 The unsolved relationship of brain aging and late-onset Alzheimer disease Biochim Biophys Acta 1790 1124 1132 19632303 1:CAS:528:DC%2BD1MXhtFamsr3I
-
(2009)
Biochim Biophys Acta
, vol.1790
, pp. 1124-1132
-
-
Kern, A.1
Behl, C.2
-
71
-
-
23644459835
-
Molecular mechanisms initiating amyloid β-fibril formation in Alzheimer's disease
-
MD Kirkitadze A Kowalska 2005 Molecular mechanisms initiating amyloid beta-fibril formation in Alzheimer's disease Acta Biochim Pol 52 417 423 15933761 1:CAS:528:DC%2BD2MXhtFWisbbK (Pubitemid 41133776)
-
(2005)
Acta Biochimica Polonica
, vol.52
, Issue.2
, pp. 417-423
-
-
Kirkitadze, M.D.1
Kowalska, A.2
-
72
-
-
40949126440
-
Mitochondrial complex III regulates hypoxic activation of HIF
-
DOI 10.1038/sj.cdd.4402307, PII 4402307, The biology of Hypoxia-inducible factors
-
T Klimova NS Chandel 2008 Mitochondrial complex III regulates hypoxic activation of HIF Cell Death Differ 15 660 666 18219320 1:CAS:528: DC%2BD1cXjtl2is74%3D (Pubitemid 351405069)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.4
, pp. 660-666
-
-
Klimova, T.1
Chandel, N.S.2
-
73
-
-
0035807829
-
Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques
-
DOI 10.1073/pnas.261562998
-
M Koistinaho M Ort JM Cimadevilla R Vondrous B Cordell J Koistinaho J Bures LS Higgins 2001 Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques Proc Natl Acad Sci USA 98 14675 14680 11724968 1:CAS:528:DC%2BD3MXptFCksbs%3D (Pubitemid 33121450)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.25
, pp. 14675-14680
-
-
Koistinaho, M.1
Ort, M.2
Cimadevilla, J.M.3
Vondrous, R.4
Cordell, B.5
Koistinaho, J.6
Bures, J.7
Higgins, L.S.8
-
75
-
-
0028065142
-
Analysis of microtubule-associated protein tau glycation in paired helical filaments
-
MD Ledesma P Bonay C Colaço J Avila 1994 Analysis of microtubule-associated protein tau glycation in paired helical filaments J Biol Chem 269 21614 21619 8063802 1:CAS:528:DyaK2cXlsFCrsr4%3D (Pubitemid 24274797)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.34
, pp. 21614-21619
-
-
Ledesma, M.D.1
Bonay, P.2
Colaco, C.3
Avila, J.4
-
76
-
-
16044365171
-
The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
-
DOI 10.1038/nm1096-1146
-
CA Lemere F Lopera KS Kosik CL Lendon J Ossa TC Saido H Yamaguchi A Ruiz A Martinez L Madrigal L Hincapie JC Arango DC Anthony EH Koo AM Goate DJ Selkoe JC Arango 1996 The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology Nat Med 2 1146 1150 8837617 1:CAS:528:DyaK28Xmt1Wmsrg%3D (Pubitemid 26338637)
-
(1996)
Nature Medicine
, vol.2
, Issue.10
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
Lendon, C.L.4
Ossa, J.5
Saido, T.C.6
Yamaguchi, H.7
Ruiz, A.8
Martinez, A.9
Madrigal, L.10
Hincapie, L.11
Arango, L.J.C.12
Anthony, D.C.13
Koo, E.H.14
Goate, A.M.15
Selkoe, D.J.16
Arango, V.J.C.17
-
77
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
16541076
-
S Lesné MT Koh L Kotilinek R Kayed CG Glabe A Yang M Gallagher KH Ashe 2006 A specific amyloid-beta protein assembly in the brain impairs memory Nature 440 352 357 16541076
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesné, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
78
-
-
0035105715
-
Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid
-
MA Lovell WR Markesbery 2001 Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid Arch Neurol 58 392 396 11255442 1:STN:280: DC%2BD3M7pvVCisw%3D%3D (Pubitemid 32217455)
-
(2001)
Archives of Neurology
, vol.58
, Issue.3
, pp. 392-396
-
-
Lovell, M.A.1
Markesbery, W.R.2
-
79
-
-
0029835410
-
Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
-
DOI 10.1073/pnas.93.18.9799
-
D Lütjohann O Breuer G Ahlborg I Nennesmo A Sidén U Diczfalusy I Björkhem 1996 Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation Proc Natl Acad Sci USA 93 9799 9804 8790411 (Pubitemid 26296689)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.18
, pp. 9799-9804
-
-
Lutjohann, D.1
Breuer, O.2
Ahlborg, G.3
Nennesmo, I.4
Siden, A.5
Diczfalusy, U.6
Bjorkhem, I.7
-
80
-
-
0031020476
-
A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β- peptide
-
RJ Mark MA Lovell WR Markesbery K Uchida MP Mattson 1997 A role for 4 hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide J Neurochem 68 255 264 8978733 1:CAS:528:DyaK2sXhsFyltA%3D%3D (Pubitemid 26427315)
-
(1997)
Journal of Neurochemistry
, vol.68
, Issue.1
, pp. 255-264
-
-
Mark, R.J.1
Lovell, M.A.2
Markesbery, W.R.3
Uchida, K.4
Mattson, M.P.5
-
81
-
-
0032902974
-
Oxidative alterations in Alzheimer's disease
-
WR Markesbery JM Carney 1999 Oxidative alterations in Alzheimer's disease Brain Pathol 9 133 146 9989456 1:CAS:528:DyaK1MXht1Cmsbw%3D (Pubitemid 29056524)
-
(1999)
Brain Pathology
, vol.9
, Issue.1
, pp. 133-146
-
-
Markesbery, W.R.1
Carney, J.M.2
-
82
-
-
0031980065
-
Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease
-
DOI 10.1016/S0197-4580(98)00009-8, PII S0197458098000098
-
WR Markesbery MA Lovell 1998 Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease Neurobiol Aging 19 33 36 9562500 1:CAS:528:DyaK1cXisFyrtLg%3D (Pubitemid 28167792)
-
(1998)
Neurobiology of Aging
, vol.19
, Issue.1
, pp. 33-36
-
-
Markesbery, W.R.1
Lovell, M.A.2
-
83
-
-
27644446857
-
Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment
-
DOI 10.1002/ana.20629
-
WR Markesbery RJ Kryscio MA Lovell JD Morrow 2005 Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment Ann Neurol 58 730 735 16240347 1:CAS:528:DC%2BD2MXht1Cgu73F (Pubitemid 41552548)
-
(2005)
Annals of Neurology
, vol.58
, Issue.5
, pp. 730-735
-
-
Markesbery, W.R.1
Kryscio, R.J.2
Lovell, M.A.3
Morrow, J.D.4
-
84
-
-
79961126043
-
Dysregulation of SREBP2 induces BACE1 expression
-
21726644 1:CAS:528:DC%2BC3MXpvFyhtb4%3D
-
R Mastrocola M Guglielmotto C Medana MG Catalano S Cutrupi R Borghi E Tamagno G Boccuzzi M Aragno 2011 Dysregulation of SREBP2 induces BACE1 expression Neurobiol Dis 44 116 124 21726644 1:CAS:528:DC%2BC3MXpvFyhtb4%3D
-
(2011)
Neurobiol Dis
, vol.44
, pp. 116-124
-
-
Mastrocola, R.1
Guglielmotto, M.2
Medana, C.3
Catalano, M.G.4
Cutrupi, S.5
Borghi, R.6
Tamagno, E.7
Boccuzzi, G.8
Aragno, M.9
-
85
-
-
33646934160
-
Lipids and the pathogenesis of Alzheimer's disease: Is there a link?
-
DOI 10.1080/09540260600583007, PII L679574534254
-
MM Mielke CG Lyketsos 2006 Lipids and the pathogenesis of Alzheimer's disease: is there a link? Int Rev Psychiatry 18 173 186 16777671 (Pubitemid 43791680)
-
(2006)
International Review of Psychiatry
, vol.18
, Issue.2
, pp. 173-186
-
-
Mielke, M.M.1
Lyketsos, C.G.2
-
86
-
-
33847714347
-
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage
-
DOI 10.1074/jbc.C600276200
-
G Minopoli M Stante F Napolitano F Telese L Aloia M De Felice R Di Lauro R Pacelli A Brunetti N Zambrano T Russo 2007 Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage J Biol Chem 282 831 835 17121854 1:CAS:528:DC%2BD2sXit1Ojtg%3D%3D (Pubitemid 47076515)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.2
, pp. 831-835
-
-
Minopoli, G.1
Stante, M.2
Napolitano, F.3
Telese, F.4
Aloia, L.5
De Felice, M.6
Di Lauro, R.7
Pacelli, R.8
Brunetti, A.9
Zambrano, N.10
Russo, T.11
-
87
-
-
0034643895
-
Oxidative stress induces intracellular accumulation of amyloid β- protein (Aβ) in human neuroblastoma cells
-
DOI 10.1021/bi000169p
-
H Misonou M Morishima-Kawashima Y Ihara 2000 Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells Biochemistry 39 6951 6959 10841777 1:CAS:528: DC%2BD3cXjt1emsLk%3D (Pubitemid 30390389)
-
(2000)
Biochemistry
, vol.39
, Issue.23
, pp. 6951-6959
-
-
Misonou, H.1
Morishima-Kawashima, M.2
Ihara, Y.3
-
88
-
-
0036799799
-
Antioxidants as treatment for neurodegenerative disorders
-
DOI 10.1517/13543784.11.10.1407
-
B Moosmann C Behl 2002 Antioxidants as treatment for neurodegenerative disorders Expert Opin Investig Drugs 11 1407 1435 12387703 1:CAS:528: DC%2BD38XosFGhsL4%3D (Pubitemid 35174938)
-
(2002)
Expert Opinion on Investigational Drugs
, vol.11
, Issue.10
, pp. 1407-1435
-
-
Moosmann, B.1
Behl, C.2
-
89
-
-
27544511750
-
Formation and stabilization model of the 42-mer Aβ radical: Implications for the long-lasting oxidative stress in Alzheimer's disease
-
DOI 10.1021/ja054041c
-
K Murakami K Irie H Ohigashi H Hara M Nagao T Shimizu T Shirasawa 2005 Formation stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease J Am Chem Soc 127 15168 15174 16248658 1:CAS:528:DC%2BD2MXhtVylsr%2FE (Pubitemid 41547384)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.43
, pp. 15168-15174
-
-
Murakami, K.1
Irie, K.2
Ohigashi, H.3
Hara, H.4
Nagao, M.5
Shimizu, T.6
Shirasawa, T.7
-
90
-
-
34248219460
-
Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid β proteins
-
DOI 10.1074/jbc.M608589200
-
IV Murray L Liu H Komatsu K Uryu G Xiao JA Lawson PH Axelsen 2007 Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins J Biol Chem 282 9335 9345 17255094 1:CAS:528: DC%2BD2sXjtlCisbY%3D (Pubitemid 47104603)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.13
, pp. 9335-9345
-
-
Murray, I.V.J.1
Liu, L.2
Komatsu, H.3
Uryu, K.4
Xiao, G.5
Lawson, J.A.6
Axelsen, P.H.7
-
92
-
-
0026659883
-
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
-
1378843 1:CAS:528:DyaK3sXktVGnt7w%3D
-
M Neeper AM Schmidt J Brett SD Yan F Wang YC Pan K Elliston D Stern A Shaw 1992 Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins J Biol Chem 267 14998 15004 1378843 1:CAS:528:DyaK3sXktVGnt7w%3D
-
(1992)
J Biol Chem
, vol.267
, pp. 14998-15004
-
-
Neeper, M.1
Schmidt, A.M.2
Brett, J.3
Yan, S.D.4
Wang, F.5
Pan, Y.C.6
Elliston, K.7
Stern, D.8
Shaw, A.9
-
94
-
-
0034923434
-
Oxidative damage is the earliest event in Alzheimer disease
-
A Nunomura G Perry G Aliev K Hirai A Takeda EK Balraj PK Jones H Ghanbari T Wataya S Shimohama S Chiba CS Atwood RB Petersen MA Smith 2001 Oxidative damage is the earliest event in Alzheimer disease J Neuropathol Exp Neurol 60 759 767 11487050 1:CAS:528:DC%2BD3MXmtVGmsr0%3D (Pubitemid 32678256)
-
(2001)
Journal of Neuropathology and Experimental Neurology
, vol.60
, Issue.8
, pp. 759-767
-
-
Nunomura, A.1
Perry, G.2
Aliev, G.3
Hirai, K.4
Takeda, A.5
Balraj, E.K.6
Jones, P.K.7
Ghanbari, H.8
Wataya, T.9
Shimohama, S.10
Chiba, S.11
Atwood, C.S.12
Petersen, R.B.13
Smith, M.A.14
-
95
-
-
20144383657
-
C-Jun N-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain
-
DOI 10.1074/jbc.M501898200
-
I Ortega-Pérez E Cano F Were M Villar J Vázquez JM Redondo 2005 c-Jun N-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain J Biol Chem 280 20867 20878 15743762 (Pubitemid 40776792)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20867-20878
-
-
Ortega-Perez, I.1
Cano, E.2
Were, F.3
Villar, M.4
Vazquez, J.5
Redondo, J.M.6
-
96
-
-
33845983646
-
Total cholesterol levels and the risk of mild cognitive impairment and Alzheimer's disease [5]
-
DOI 10.1111/j.1532-5415.2006.01003.x
-
F Panza C Capurso A D'Introno AM Colacicco D De Candia A Capurso V Solfrizzi 2007 Total cholesterol levels and the risk of mild cognitive impairment and Alzheimer's disease J Am Geriatr Soc 55 133 135 17233704 (Pubitemid 46046247)
-
(2007)
Journal of the American Geriatrics Society
, vol.55
, Issue.1
, pp. 133-135
-
-
Panza, F.1
Capurso, C.2
D'Introno, A.3
Colacicco, A.M.4
De Candia, D.5
Capurso, A.6
Solfrizzi, V.7
-
97
-
-
0034673209
-
Oxidative stress induces increase in intracellular amyloid β-protein production and selective activation of βI and βII PKCs in NT2 cells
-
DOI 10.1006/bbrc.2000.2164
-
D Paola C Domenicotti M Nitti A Vitali R Borghi D Cottalasso D Zaccheo P Odetti P Strocchi UM Marinari M Tabaton MA Pronzato 2000 Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells Biochem Biophys Res Commun 268 642 646 10679257 1:CAS:528:DC%2BD3cXhtFGjtLw%3D (Pubitemid 30119675)
-
(2000)
Biochemical and Biophysical Research Communications
, vol.268
, Issue.2
, pp. 642-646
-
-
Paola, D.1
Domenicotti, C.2
Nitti, M.3
Vitali, A.4
Borghi, R.5
Cottalasso, D.6
Zaccheo, D.7
Odetti, P.8
Strocchi, P.9
Marinari, U.M.10
Tabaton, M.11
Pronzato, M.A.12
-
98
-
-
0026823074
-
Immunohistochemical evidence of oxidative stress in Alzheimer's disease
-
MA Pappolla RA Omar KS Kim NK Robakis 1992 Immunohistochemical evidence of oxidative stress in Alzheimer's disease Am J Pathol 14 621 628
-
(1992)
Am J Pathol
, vol.14
, pp. 621-628
-
-
Pappolla, M.A.1
Omar, R.A.2
Kim, K.S.3
Robakis, N.K.4
-
99
-
-
0034488295
-
Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid β protein precursor
-
B Passer L Pellegrini C Russo RM Siegel MJ Lenardo G Schettini M Bachmann M Tabaton L D'Adamio 2000 Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor J Alzheimers Dis 2 289 301 12214090 1:CAS:528:DC%2BD3MXps1Wmuw%3D%3D (Pubitemid 32095613)
-
(2000)
Journal of Alzheimer's Disease
, vol.2
, Issue.3-4
, pp. 289-301
-
-
Passer, B.1
Pellegrini, L.2
Russo, C.3
Siegel, R.M.4
Lenardo, M.J.5
Schettini, G.6
Bachmann, M.7
Tabaton, M.8
D'Adamio, L.9
-
100
-
-
33747760007
-
Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons
-
DOI 10.1016/j.neulet.2006.07.015, PII S0304394006007087
-
S Patil L Sheng A Masserang C Chan 2006 Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons Neurosci Lett 406 55 59 16904262 1:CAS:528: DC%2BD28XoslOht7w%3D (Pubitemid 44278378)
-
(2006)
Neuroscience Letters
, vol.406
, Issue.1-2
, pp. 55-59
-
-
Patil, S.1
Sheng, L.2
Masserang, A.3
Chan, C.4
-
101
-
-
0034237121
-
Oxidative damage in Alzheimer's disease: The metabolic dimension
-
DOI 10.1016/S0736-5748(00)00006-X, PII S073657480000006X
-
G Perry A Nunomura K Hirai A Takeda G Aliev MA Smith 2000 Oxidative damage in Alzheimer's disease: the metabolic dimension Int J Dev Neurosci 18 417 421 10817925 1:CAS:528:DC%2BD3cXks1Sqs74%3D (Pubitemid 30243071)
-
(2000)
International Journal of Developmental Neuroscience
, vol.18
, Issue.4-5
, pp. 417-421
-
-
Perry, G.1
Nunomura, A.2
Hirai, K.3
Takeda, A.4
Aliev, G.5
Smith, M.A.6
-
102
-
-
56349145099
-
Oxidative stress hypothesis in Alzheimer's disease: A reappraisal
-
18838179
-
D Praticò 2008 Oxidative stress hypothesis in Alzheimer's disease: a reappraisal Trends Pharmacol Sci 29 609 615 18838179
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 609-615
-
-
Praticò, D.1
-
103
-
-
0345669752
-
Alzheimer's disease: The cholesterol connection
-
DOI 10.1038/nn0403-345
-
L Puglielli RE Tanzi DM Kovacs 2003 Alzheimer's disease: the cholesterol connection Nat Neurosci 6 345 351 12658281 1:CAS:528:DC%2BD3sXitlequrY%3D (Pubitemid 36373979)
-
(2003)
Nature Neuroscience
, vol.6
, Issue.4
, pp. 345-351
-
-
Puglielli, L.1
Tanzi, R.E.2
Kovacs, D.M.3
-
104
-
-
7044284920
-
Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding βA plaques in APP Tg2576 mice
-
DOI 10.1111/j.1365-2990.2004.00569.x
-
B Puig T Gómez-Isla E Ribé M Cuadrado B Torrejón-Escribano E Dalfó I Ferrer 2004 Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP Tg2576 mice Neuropathol Appl Neurobiol 30 491 502 15488025 1:CAS:528:DC%2BD2cXhtVektLbI (Pubitemid 39423036)
-
(2004)
Neuropathology and Applied Neurobiology
, vol.30
, Issue.5
, pp. 491-502
-
-
Puig, B.1
Gomez-Isla, T.2
Ribe, E.3
Cuadrado, M.4
Torrejon-Escribano, B.5
Dalfo, E.6
Ferrer, I.7
-
105
-
-
49349084487
-
Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress
-
18438937 1:CAS:528:DC%2BD1cXpvFKqtbY%3D
-
J Qin R Goswami S Dawson G Dawson 2008 Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress J Neurosci Res 86 2414 2422 18438937 1:CAS:528:DC%2BD1cXpvFKqtbY%3D
-
(2008)
J Neurosci Res
, vol.86
, pp. 2414-2422
-
-
Qin, J.1
Goswami, R.2
Dawson, S.3
Dawson, G.4
-
106
-
-
49249118742
-
Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death
-
18621106 1:CAS:528:DC%2BD1cXhtVSgtbbN
-
R Resende E Ferreiro C Pereira C Resende de Oliveira 2008 Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death Neuroscience 155 725 737 18621106 1:CAS:528:DC%2BD1cXhtVSgtbbN
-
(2008)
Neuroscience
, vol.155
, pp. 725-737
-
-
Resende, R.1
Ferreiro, E.2
Pereira, C.3
Resende De Oliveira, C.4
-
107
-
-
67149139988
-
The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects
-
19519304 1:CAS:528:DC%2BD1MXnsFWktbw%3D
-
A Rocchi D Orsucci G Tognoni R Ceravolo G Siciliano 2009 The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects Curr Alzheimer Res 6 224 237 19519304 1:CAS:528: DC%2BD1MXnsFWktbw%3D
-
(2009)
Curr Alzheimer Res
, vol.6
, pp. 224-237
-
-
Rocchi, A.1
Orsucci, D.2
Tognoni, G.3
Ceravolo, R.4
Siciliano, G.5
-
108
-
-
27644596252
-
Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats
-
DOI 10.1016/j.lfs.2005.04.044, PII S0024320505006909
-
I Rodrigues Siqueira C Fochesatto IL da Silva Torres C Dalmaz C Alexandre Netto 2005 Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats Life Sci 78 271 278 16112138 1:CAS:528: DC%2BD2MXhtFOgtr%2FO (Pubitemid 41570197)
-
(2005)
Life Sciences
, vol.78
, Issue.3
, pp. 271-278
-
-
Rodrigues Siqueira, I.1
Fochesatto, C.2
Da Silva Torres, I.L.3
Dalmaz, C.4
Netto, C.A.5
-
109
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
-
JT Rogers JD Randall CM Cahill PS Eder X Huang H Gunshin L Leiter J McPhee SS Sarang T Utsuki NH Greig DK Lahiri RE Tanzi AI Bush T Giordano SR Gullans 2002 An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript J Biol Chem 277 24558 45518
-
(2002)
J Biol Chem
, vol.277
, pp. 24558-45518
-
-
Rogers, J.T.1
Randall, J.D.2
Cahill, C.M.3
Eder, P.S.4
Huang, X.5
Gunshin, H.6
Leiter, L.7
McPhee, J.8
Sarang, S.S.9
Utsuki, T.10
Greig, N.H.11
Lahiri, D.K.12
Tanzi, R.E.13
Bush, A.I.14
Giordano, T.15
Gullans, S.R.16
-
110
-
-
6944231363
-
Gene structure and organization of the human β-secretase (BACE) promoter
-
DOI 10.1096/fj.03-1378fje
-
K Sambamurti R Kinsey B Maloney YW Ge DK Lahiri 2004 Gene structure and organization of the human beta-secretase (BACE) promoter FASEB J 18 1034 1036 15059975 1:CAS:528:DC%2BD2cXkslWiur0%3D (Pubitemid 39561516)
-
(2004)
FASEB Journal
, vol.18
, Issue.9
, pp. 1034-1036
-
-
Sambamurti, K.1
Kinsey, R.2
Maloney, B.3
Ge, Y.-W.4
Lahiri, D.K.5
-
111
-
-
31044445398
-
Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ
-
DOI 10.1073/pnas.0503839103
-
M Sastre I Dewachter S Rossner N Bogdanovic E Rosen P Borghgraef BO Evert L Dumitrescu-Ozimek DR Thal G Landreth J Walter T Klockgether F van Leuven MT Heneka 2006 Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma Proc Natl Acad Sci USA 103 443 448 16407166 1:CAS:528:DC%2BD28XpsVSluw%3D%3D (Pubitemid 43122420)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.2
, pp. 443-448
-
-
Sastre, M.1
Dewachter, I.2
Rossner, S.3
Bogdanovic, N.4
Rosen, E.5
Borghgraef, P.6
Evert, B.O.7
Dumitrescu-Ozimek, L.8
Thal, D.R.9
Landreth, G.10
Walter, J.11
Klockgether, T.12
Van Leuven, F.13
Heneka, M.T.14
-
112
-
-
0030983405
-
Mechanisms of neurotoxicity associated with amyloid β deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: A critical appraisal
-
DOI 10.1021/tx970009n
-
LM Sayre MG Zagorski WK Surewicz GA Krafft G Perry 1997 Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal Chem Res Toxicol 10 518 526 9168248 1:CAS:528:DyaK2sXjs1Wgur4%3D (Pubitemid 27217207)
-
(1997)
Chemical Research in Toxicology
, vol.10
, Issue.5
, pp. 518-526
-
-
Sayre, L.M.1
Zagorski, M.G.2
Surewicz, W.K.3
Krafft, G.A.4
Perry, G.5
-
113
-
-
0037426416
-
Relation of cerebral infarctions to dementia and cognitive function in older persons
-
JA Schneider RS Wilson EJ Cochran JL Bienias SE Arnold DA Evans DA Bennett 2003 Relation of cerebral infarctions to dementia and cognitive function in older persons Neurology 60 1082 1088 12682310 1:STN:280: DC%2BD3s7msFSisQ%3D%3D (Pubitemid 36418764)
-
(2003)
Neurology
, vol.60
, Issue.7
, pp. 1082-1088
-
-
Schneider, J.A.1
Wilson, R.S.2
Cochran, E.J.3
Bienias, J.L.4
Arnold, S.E.5
Evans, D.A.6
Bennett, D.A.7
-
114
-
-
77956411745
-
Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers
-
20473136 1:CAS:528:DC%2BC3cXhtVOhsrvE
-
A Serrano-Pozo GL Vega D Lütjohann JJ Locascio MK Tennis A Deng A Atri BT Hyman MC Irizarry JH Growdon 2010 Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers Alzheimer Dis Assoc Disord 24 220 226 20473136 1:CAS:528:DC%2BC3cXhtVOhsrvE
-
(2010)
Alzheimer Dis Assoc Disord
, vol.24
, pp. 220-226
-
-
Serrano-Pozo, A.1
Vega, G.L.2
Lütjohann, D.3
Locascio, J.J.4
Tennis, M.K.5
Deng, A.6
Atri, A.7
Hyman, B.T.8
Irizarry, M.C.9
Growdon, J.H.10
-
115
-
-
77957256030
-
Role of by-products of lipid oxidation in Alzheimer's disease brain: A focus on acrolein
-
20634576 1:CAS:528:DC%2BC3cXhtFKmurnO
-
M Singh DT Nam M Arseneault C Ramassamy 2010 Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein J Alzheimers Dis 21 741 756 20634576 1:CAS:528:DC%2BC3cXhtFKmurnO
-
(2010)
J Alzheimers Dis
, vol.21
, pp. 741-756
-
-
Singh, M.1
Nam, D.T.2
Arseneault, M.3
Ramassamy, C.4
-
116
-
-
0028233977
-
Advanced Maillard reaction end products are associated with Alzheimer disease pathology
-
DOI 10.1073/pnas.91.12.5710
-
MA Smith S Taneda PL Richey S Miyata SD Yan D Stern LM Sayre VM Monnier G Perry 1994 Advanced Maillard reaction end products are associated with Alzheimer disease pathology Proc Natl Acad Sci USA 91 5710 5714 8202552 1:CAS:528:DyaK2cXksFGisb4%3D (Pubitemid 24174398)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.12
, pp. 5710-5714
-
-
Smith, M.A.1
Taneda, S.2
Richey, P.L.3
Miyata, S.4
Yan, S.-D.5
Stern, D.6
Sayre, L.M.7
Monnier, V.M.8
Perry, G.9
-
117
-
-
0029007478
-
Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease
-
7539057 1:CAS:528:DyaK2MXlsl2ltrw%3D
-
MA Smith M Rudnicka-Nawrot PL Richey D Praprotnik P Mulvihill CA Miller LM Sayre G Perry 1995 Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease J Neurochem 64 2660 2666 7539057 1:CAS:528:DyaK2MXlsl2ltrw%3D
-
(1995)
J Neurochem
, vol.64
, pp. 2660-2666
-
-
Smith, M.A.1
Rudnicka-Nawrot, M.2
Richey, P.L.3
Praprotnik, D.4
Mulvihill, P.5
Miller, C.A.6
Sayre, L.M.7
Perry, G.8
-
118
-
-
70349499185
-
Plasma biomarkers for mild cognitive impairment and Alzheimer's disease
-
19464319 1:CAS:528:DC%2BD1MXht1WntbvK
-
F Song A Poljak GA Smythe P Sachdev 2009 Plasma biomarkers for mild cognitive impairment and Alzheimer's disease Brain Res Rev 61 69 80 19464319 1:CAS:528:DC%2BD1MXht1WntbvK
-
(2009)
Brain Res Rev
, vol.61
, pp. 69-80
-
-
Song, F.1
Poljak, A.2
Smythe, G.A.3
Sachdev, P.4
-
119
-
-
67349253085
-
Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: Role of Abeta in pathogenesis
-
19288120 1:CAS:528:DC%2BD1MXmt1ahu7s%3D
-
R Sultana M Perluigi DA Butterfield 2009 Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis Acta Neuropathol 118 131 150 19288120 1:CAS:528:DC%2BD1MXmt1ahu7s%3D
-
(2009)
Acta Neuropathol
, vol.118
, pp. 131-150
-
-
Sultana, R.1
Perluigi, M.2
Butterfield, D.A.3
-
120
-
-
33845505233
-
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expession
-
DOI 10.1073/pnas.0606298103
-
X Sun G He H Qing W Zhou F Dobie F Cai M Staufenbiel LE Huang W Song 2006 Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression Proc Natl Acad Sci USA 103 18727 18732 17121991 1:CAS:528:DC%2BD28Xhtlaht7jJ (Pubitemid 44913478)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.49
, pp. 18727-18732
-
-
Sun, X.1
He, G.2
Qing, H.3
Zhou, W.4
Dobie, F.5
Cai, F.6
Staufenbiel, M.7
Huang, L.E.8
Song, W.9
-
121
-
-
27744542593
-
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia
-
DOI 10.1074/jbc.C500238200
-
BJ Tabner OM El-Agnaf S Turnbull MJ German KE Paleologou Y Hayashi LJ Cooper NJ Fullwood D Allsop 2005 Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia J Biol Chem 280 35789 35792 16141213 1:CAS:528:DC%2BD2MXhtFCjsbbO (Pubitemid 41633844)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.43
, pp. 35789-35792
-
-
Tabner, B.J.1
El-Agnaf, O.M.A.2
Turnbull, S.3
German, M.J.4
Paleologou, K.E.5
Hayashi, Y.6
Cooper, L.J.7
Fullwood, N.J.8
Allsop, D.9
-
122
-
-
40449113201
-
Processes of β-amyloid and intracellular cytoplasmic domain generation by presenilin/γ-secretase
-
DOI 10.1159/000113690
-
S Tagami M Okochi A Fukumori J Jiang K Yanagida T Nakayama T Morihara T Tanaka T Kudo M Takeda 2008 Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase Neurodegener Dis 5 160 162 18322378 1:CAS:528:DC%2BD1cXjs1Wht7o%3D (Pubitemid 351347838)
-
(2008)
Neurodegenerative Diseases
, vol.5
, Issue.3-4
, pp. 160-162
-
-
Tagami, S.1
Okochi, M.2
Fukumori, A.3
Jiang, J.4
Yanagida, K.5
Nakayama, T.6
Morihara, T.7
Tanaka, T.8
Kudo, T.9
Takeda, M.10
-
123
-
-
0035412127
-
Alternative routes for the formation of immunochemically distinct advanced glycation end-products in vivo
-
M Takeuchi Z Makita 2001 Alternative routes for the formation of immunochemically distinct advanced glycation end-products in vivo Curr Mol Med 1 305 315 11899079 1:CAS:528:DC%2BD3MXltFGlurg%3D (Pubitemid 33772959)
-
(2001)
Current Molecular Medicine
, vol.1
, Issue.3
, pp. 305-315
-
-
Takeuchi, M.1
Makita, Z.2
-
124
-
-
0036403838
-
2 neurons
-
DOI 10.1006/nbdi.2002.0515
-
E Tamagno P Bardini A Obbili A Vitali R Borghi D Zaccheo MA Pronzato O Danni MA Smith G Perry M Tabaton 2002 Oxidative stress increases expression and
-
(2002)
Neurobiology of Disease
, vol.10
, Issue.3
, pp. 279-288
-
-
Tamagno, E.1
Bardini, P.2
Obbili, A.3
Vitali, A.4
Borghi, R.5
Zaccheo, D.6
Pronzato, M.A.7
Danni, O.8
Smith, M.A.9
Perry, G.10
Tabaton, M.11
-
125
-
-
0142219838
-
2 neurons exposed to oxidative stress
-
DOI 10.1016/S0969-9961(03)00131-1
-
E Tamagno M Guglielmotto P Bardini G Santoro A Davit D Di Simone O Danni M Tabaton 2003 Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress Neurobiol Dis 14 291 301 14572450 1:CAS:528:DC%2BD3sXot1Grt70%3D (Pubitemid 37311292)
-
(2003)
Neurobiology of Disease
, vol.14
, Issue.2
, pp. 291-301
-
-
Tamagno, E.1
Guglielmotto, M.2
Bardini, P.3
Santoro, G.4
Davit, A.5
Di Simone, D.6
Danni, O.7
Tabaton, M.8
-
126
-
-
19944433845
-
β-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways
-
DOI 10.1111/j.1471-4159.2004.02895.x
-
E Tamagno M Parola P Bardini A Piccini R Borghi M Guglielmotto G Santoro A Davit O Danni MA Smith G Perry M Tabaton 2005 Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways J Neurochem 92 628 636 15659232 1:CAS:528: DC%2BD2MXht12msb8%3D (Pubitemid 40189465)
-
(2005)
Journal of Neurochemistry
, vol.92
, Issue.3
, pp. 628-636
-
-
Tamagno, E.1
Parola, M.2
Bardini, P.3
Piccini, A.4
Borghi, R.5
Guglielmotto, M.6
Santoro, G.7
Davit, A.8
Danni, O.9
Smith, M.A.10
Perry, G.11
Tabaton, M.12
-
127
-
-
33745228920
-
The various aggregation states of β-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression
-
DOI 10.1016/j.freeradbiomed.2006.01.021, PII S0891584906000645
-
E Tamagno P Bardini M Guglielmotto O Danni M Tabaton 2006 The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression Free Radic Biol Med 41 202 212 16814100 1:CAS:528:DC%2BD28Xmt1OrsLY%3D (Pubitemid 43928492)
-
(2006)
Free Radical Biology and Medicine
, vol.41
, Issue.2
, pp. 202-212
-
-
Tamagno, E.1
Bardini, P.2
Guglielmotto, M.3
Danni, O.4
Tabaton, M.5
-
128
-
-
38049098793
-
Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein
-
18005001 1:CAS:528:DC%2BD1cXhvF2rs70%3D
-
E Tamagno M Guglielmotto M Aragno R Borghi R Autelli L Giliberto G Muraca O Danni X Zhu MA Smith G Perry DG Jo MP Mattson M Tabaton 2008 Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein J Neurochem 104 683 695 18005001 1:CAS:528:DC%2BD1cXhvF2rs70%3D
-
(2008)
J Neurochem
, vol.104
, pp. 683-695
-
-
Tamagno, E.1
Guglielmotto, M.2
Aragno, M.3
Borghi, R.4
Autelli, R.5
Giliberto, L.6
Muraca, G.7
Danni, O.8
Zhu, X.9
Smith, M.A.10
Perry, G.11
Jo, D.G.12
Mattson, M.P.13
Tabaton, M.14
-
129
-
-
20944444768
-
Oxidative stress potentiates BACE1 gene expression and Aβ generation
-
DOI 10.1007/s00702-004-0255-3
-
Y Tong W Zhou V Fung MA Christensen H Qing X Sun W Song 2005 Oxidative stress potentiates BACE1 gene expression and Abeta generation J Neural Transm 112 455 469 15614428 1:CAS:528:DC%2BD2MXhsVOmtrY%3D (Pubitemid 40868054)
-
(2005)
Journal of Neural Transmission
, vol.112
, Issue.3
, pp. 455-469
-
-
Tong, Y.1
Zhou, W.2
Fung, V.3
Christensen, M.A.4
Qing, H.5
Sun, X.6
Song, W.7
-
130
-
-
0142150051
-
Mitochondrial formation of reactive oxygen species
-
DOI 10.1113/jphysiol.2003.049478
-
JF Turrens 2003 Mitochondrial formation of reactive oxygen species J Physiol 552 335 344 14561818 1:CAS:528:DC%2BD3sXps1ehtLc%3D (Pubitemid 37321833)
-
(2003)
Journal of Physiology
, vol.552
, Issue.2
, pp. 335-344
-
-
Turrens, J.F.1
-
132
-
-
77957795389
-
Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation
-
20708684 1:CAS:528:DC%2BC3cXhtlSnurjL
-
M Vieira J Fernandes A Burgeiro GM Thomas RL Huganir CB Duarte AL Carvalho AE Santos 2010 Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation Neurobiol Dis 40 645 655 20708684 1:CAS:528:DC%2BC3cXhtlSnurjL
-
(2010)
Neurobiol Dis
, vol.40
, pp. 645-655
-
-
Vieira, M.1
Fernandes, J.2
Burgeiro, A.3
Thomas, G.M.4
Huganir, R.L.5
Duarte, C.B.6
Carvalho, A.L.7
Santos, A.E.8
-
133
-
-
0028363366
-
Advanced glycation end products contribute to amyloidosis in Alzheimer disease
-
8197133 1:CAS:528:DyaK2cXktlansbs%3D
-
MP Vitek K Bhattacharya JM Glendening E Stopa H Vlassara R Bucala K Manogue A Cerami 1994 Advanced glycation end products contribute to amyloidosis in Alzheimer disease Proc Natl Acad Sci USA 91 4766 47670 8197133 1:CAS:528:DyaK2cXktlansbs%3D
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4766-47670
-
-
Vitek, M.P.1
Bhattacharya, K.2
Glendening, J.M.3
Stopa, E.4
Vlassara, H.5
Bucala, R.6
Manogue, K.7
Cerami, A.8
-
134
-
-
18844462415
-
Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease
-
DOI 10.1111/j.1471-4159.2005.03053.x
-
J Wang S Xiong C Xie WR Markesbery MA Lovell 2005 Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease J Neurochem 93 953 962 15857398 1:CAS:528:DC%2BD2MXksFKgu7o%3D (Pubitemid 40695754)
-
(2005)
Journal of Neurochemistry
, vol.93
, Issue.4
, pp. 953-962
-
-
Wang, J.1
Xiong, S.2
Xie, C.3
Markesbery, W.R.4
Lovell, M.A.5
-
135
-
-
40249114794
-
Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing
-
DOI 10.1016/j.neuron.2008.02.024, PII S0896627308001785
-
Y Wen WH Yu B Maloney J Bailey J Ma I Marié T Maurin L Wang H Figueroa M Herman P Krishnamurthy L Liu E Planel LF Lau DK Lahiri K Duff 2008 Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing Neuron 57 680 690 18341989 1:CAS:528: DC%2BD1cXjslegt7k%3D (Pubitemid 351335351)
-
(2008)
Neuron
, vol.57
, Issue.5
, pp. 680-690
-
-
Wen, Y.1
Yu, W.H.2
Maloney, B.3
Bailey, J.4
Ma, J.5
Marie, I.6
Maurin, T.7
Wang, L.8
Figueroa, H.9
Herman, M.10
Krishnamurthy, P.11
Liu, L.12
Planel, E.13
Lau, L.-F.14
Lahiri, D.K.15
Duff, K.16
-
136
-
-
0347318065
-
Cholesterol and the Biology of Alzheimer's Disease
-
DOI 10.1016/S0896-6273(03)00840-7
-
B Wolozin 2004 Cholesterol and the biology of Alzheimer's disease Neuron 41 7 10 14715130 1:CAS:528:DC%2BD2cXnt12msA%3D%3D (Pubitemid 38068431)
-
(2004)
Neuron
, vol.41
, Issue.1
, pp. 7-10
-
-
Wolozin, B.1
-
137
-
-
71249161927
-
IL-1beta induces MMP-9 expression via a Ca2+-dependent CaMKII/JNK/c-JUN cascade in rat brain astrocytes
-
19455716
-
CY Wu HL Hsieh CC Sun CM Yang 2009 IL-1beta induces MMP-9 expression via a Ca2+-dependent CaMKII/JNK/c-JUN cascade in rat brain astrocytes Glia 57 1775 1789 19455716
-
(2009)
Glia
, vol.57
, pp. 1775-1789
-
-
Wu, C.Y.1
Hsieh, H.L.2
Sun, C.C.3
Yang, C.M.4
-
138
-
-
34548563973
-
NTR protects neurones from beta amyloid (1-40)-induced cell death
-
DOI 10.1111/j.1365-2990.2007.00844.x
-
M Yaar S Zhai I Panova RE Fine PB Eisenhauer JK Blusztajn I Lopez-Coviella BA Gilchrest 2007 A cyclic peptide that binds p75(NTR) protects neurones from beta amyloid(1-40)-induced cell death Neuropathol Appl Neurobiol 33 533 543 17596181 1:CAS:528:DC%2BD2sXhtF2qsrzN (Pubitemid 47390079)
-
(2007)
Neuropathology and Applied Neurobiology
, vol.33
, Issue.5
, pp. 533-543
-
-
Yaar, M.1
Zhai, S.2
Panova, I.3
Fine, R.E.4
Eisenhauer, P.B.5
Blusztajn, J.K.6
Lopez-Coviella, I.7
Gilchrest, B.A.8
-
139
-
-
0028023944
-
Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress
-
DOI 10.1073/pnas.91.16.7787
-
SD Yan X Chen AM Schmidt J Brett G Godman YS Zou CW Scott C Caputo T Frappier MA Smith 1994 Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress Proc Natl Acad Sci USA 91 7787 7791 8052661 1:CAS:528:DyaK2cXltlWmt7k%3D (Pubitemid 24238270)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.16
, pp. 7787-7791
-
-
Yan, S.-D.1
Chen, X.2
Schmidt, A.-M.3
Brett, J.4
Godman, G.5
Zou, Y.-S.6
Scott, C.W.7
Caputo, C.8
Frappier, T.9
Smith, M.A.10
Perry, G.11
Yen, S.-H.12
Stern, D.13
-
140
-
-
0029076397
-
Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide
-
7585153 1:CAS:528:DyaK2MXms1Kgtr8%3D
-
SD Yan SF Yan X Chen J Fu M Chen P Kuppusamy MA Smith G Perry GC Godman P Nawroth 1995 Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide Nat Med 1 693 699 7585153 1:CAS:528:DyaK2MXms1Kgtr8%3D
-
(1995)
Nat Med
, vol.1
, pp. 693-699
-
-
Yan, S.D.1
Yan, S.F.2
Chen, X.3
Fu, J.4
Chen, M.5
Kuppusamy, P.6
Smith, M.A.7
Perry, G.8
Godman, G.C.9
Nawroth, P.10
-
141
-
-
0013615899
-
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
-
DOI 10.1038/382685a0
-
SD Yan X Chen J Fu M Chen H Zhu A Roher T Slattery L Zhao M Nagashima J Morser A Migheli P Nawroth D Stern AM Schmidt 1996 RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease Nature 382 685 691 8751438 1:CAS:528:DyaK28Xlt1yltr0%3D (Pubitemid 26282167)
-
(1996)
Nature
, vol.382
, Issue.6593
, pp. 685-691
-
-
Yan, S.D.1
Chen, X.2
Fu, J.3
Chen, M.4
Zhu, H.5
Roher, A.6
Slattery, T.7
Zhao, L.8
Nagashima, M.9
Morser, J.10
Migheli, A.11
Nawroth, P.12
Stern, D.13
Schmidt, A.M.14
-
142
-
-
0037236622
-
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease [1]
-
DOI 10.1038/nm0103-3
-
LB Yang K Lindholm R Yan M Citron W Xia XL Yang T Beach L Sue P Wong D Price R Li Y Shen 2003 Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease Nat Med 9 3 4 12514700 1:CAS:528:DC%2BD3sXivFyk (Pubitemid 36098241)
-
(2003)
Nature Medicine
, vol.9
, Issue.1
, pp. 3-4
-
-
Yang, L.-B.1
Lindholm, K.2
Yan, R.3
Citron, M.4
Xia, W.5
Yang, X.-L.6
Beach, T.7
Sue, L.8
Wong, P.9
Price, D.10
Li, R.11
Shen, Y.12
-
143
-
-
0029896354
-
Mechanisms of neuronal degeneration in Alzheimer's disease
-
DOI 10.1016/S0896-6273(00)80115-4
-
BA Yankner 1996 Mechanisms of neuronal degeneration in Alzheimer's disease Neuron 16 921 932 8630250 1:CAS:528:DyaK28XjsVKgs7o%3D (Pubitemid 26171198)
-
(1996)
Neuron
, vol.16
, Issue.5
, pp. 921-932
-
-
Yankner, B.A.1
-
144
-
-
0033133579
-
In vitro and in vivo oxidative stress associated with Alzheimer's amyloid β-peptide (1-42)
-
DOI 10.1016/S0197-4580(99)00056-1, PII S0197458099000561
-
SM Yatin S Varadarajan CD Link DA Butterfield 1999 In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42) Neurobiol Aging 20 325 330 10588580 1:STN:280:DC%2BD3c%2Fltlyjsw%3D%3D (Pubitemid 29525418)
-
(1999)
Neurobiology of Aging
, vol.20
, Issue.3
, pp. 325-330
-
-
Yatin, S.M.1
Varadarajan, S.2
Link, C.D.3
Butterfield, D.A.4
-
145
-
-
3142712947
-
Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK)
-
DOI 10.1111/j.1471-4159.2004.02479.x
-
H Yoshida CJ Hastie H McLauchlan P Cohen M Goedert 2004 Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK) J Neurochem 90 352 358 15228592 1:CAS:528:DC%2BD2cXmtVyrtrg%3D (Pubitemid 38938221)
-
(2004)
Journal of Neurochemistry
, vol.90
, Issue.2
, pp. 352-358
-
-
Yoshida, H.1
Hastie, C.J.2
McLauchlan, H.3
Cohen, P.4
Goedert, M.5
-
146
-
-
34249727115
-
Hypoxia-inducible factor 1α (HIF-1α)-mediated hypoxia increases BACE1 expression and β-amyloid generation
-
DOI 10.1074/jbc.M608856200
-
X Zhang K Zhou R Wang J Cui SA Lipton FF Liao H Xu YW Zhang 2007 Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation J Biol Chem 282 10873 10880 17303576 1:CAS:528:DC%2BD2sXjvFagsrs%3D (Pubitemid 47100783)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.15
, pp. 10873-10880
-
-
Zhang, X.1
Zhou, K.2
Wang, R.3
Cui, J.4
Lipton, S.A.5
Liao, F.-F.6
Xu, H.7
Zhang, Y.-W.8
-
147
-
-
34147120073
-
β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis
-
DOI 10.1523/JNEUROSCI.4396-06.2007
-
J Zhao Y Fu M Yasvoina P Shao B Hitt T O'Connor S Logan E Maus M Citron R Berry L Binder R Vassar 2007 Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis J Neurosci 27 3639 3649 17409228 1:CAS:528:DC%2BD2sXksFSlu7Y%3D (Pubitemid 46557686)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.14
, pp. 3639-3649
-
-
Zhao, J.1
Fu, Y.2
Yasvoina, M.3
Shao, P.4
Hitt, B.5
O'Connor, T.6
Logan, S.7
Maus, E.8
Citron, M.9
Berry, R.10
Binder, L.11
Vassar, R.12
-
148
-
-
0037380952
-
JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease
-
X Zhu O Ogawa Y Wang G Perry MA Smith 2003 JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease J Neurochem 85 87 93 12641730 1:CAS:528:DC%2BD3sXislOltbo%3D (Pubitemid 36389698)
-
(2003)
Journal of Neurochemistry
, vol.85
, Issue.1
, pp. 87-93
-
-
Zhu, X.1
Ogawa, O.2
Wang, Y.3
Perry, G.4
Smith, M.A.5
-
149
-
-
0142139355
-
Oxidative stress and neuronal adaptation in alzheimer disease: The role of SAPK pathways
-
X Zhu AK Raina HG Lee M Chao A Nunomura M Tabaton RB Petersen G Perry MA Smith 2003 Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways Antioxid Redox Signal 5 571 576 14580312 1:CAS:528:DC%2BD3sXosVert70%3D (Pubitemid 37315144)
-
(2003)
Antioxidants and Redox Signaling
, vol.5
, Issue.5
, pp. 571-576
-
-
Zhu, X.1
Raina, A.K.2
Lee, H.-G.3
Chao, M.4
Nunomura, A.5
Tabaton, M.6
Petersen, R.B.7
Perry, G.8
Smith, M.A.9
-
150
-
-
33744525840
-
Age-related changes in glutathione and glutathione-related enzymes in rat brain
-
DOI 10.1016/j.brainres.2006.03.063, PII S0006899306008481
-
Y Zhu PM Carvey Z Ling 2006 Age-related changes in glutathione and glutathione-related enzymes in rat brain Brain Res 1090 35 44 16647047 1:CAS:528:DC%2BD28Xltl2nu74%3D (Pubitemid 43817938)
-
(2006)
Brain Research
, vol.1090
, Issue.1
, pp. 35-44
-
-
Zhu, Y.1
Carvey, P.M.2
Ling, Z.3
|