Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 18, 1996, Pages 9799-9804

  Lütjohann, Dieter ^a   Breuer, Olof ^a   Ahlborg, Gunvor ^a   Nennesmo, Inger ^a   Sidén, Åke ^a   Diczfalusy, Ulf ^a   Björkhem, Ingemar ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

cerebrospinal fluid; oxysterols; plasma; stable isotopes

Indexed keywords

CHOLESTEROL; CHOLESTEROL DERIVATIVE;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CIRCULATION; CHILD; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CIRCADIAN RHYTHM; DRUG ELIMINATION; FEMALE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROXYLATION; INFANT; MALE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT; STEREOISOMERISM;

ADOLESCENT; ADULT; AGED; AGING; ANIMALS; BRAIN; CHILD; CHILD, PRESCHOOL; CIRCADIAN RHYTHM; FEMALE; HOMEOSTASIS; HUMANS; HYDROXYCHOLESTEROLS; INFANT; MALE; MIDDLE AGED; OXYGEN; RATS; REFERENCE VALUES; STEREOISOMERISM; TISSUE DISTRIBUTION;

EID: 0029835410     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.18.9799     Document Type: Article

References (35)

1. Dietschy, J. M., Turley, S. D. & Spady, D. K. (1993) J Lipid Res. 34, 1637-1659.
2. Spady, D. K. & Dietschy, J. M. (1983) J. Lipid Res. 24, 303-315.
3. Andersson, M., Elmberger, P. G., Edlund, C., Kristensson, K. & Dallner, G. (1990) FEBS Lett. 269, 15-18.
4. Björkhem, I., Andersson, O., Diczfalusy, U., Sevastik, B., Duan, C., Xiu, R. & Lund, E. (1994) Proc. Natl. Acad. Sci. USA 91, 8592-8596.
5. Lund, E., Andersson, O., Zhang, J., Babiker, A., Ahlborg, G., Diczfalusy, U., Einarsson, K., Sjövall, J. & Björkhem, I. (1996) Arteriosclerosis (Dallas) 16, 208-212.
6. Pedersen, J. I., Oftebro, H. & Björkhem, I. (1989) Biochem. Int. 18, 615-622.
7. Dzeletovic, S., Breuer, O., Lund, E. & Diczfalusy, U. (1995) Anal. Biochem. 225, 73-80.
8. Czubayko, F., Beumers, B., Lammsfuss, S., Lütjohann, D. & von Bergmann, K. (1991). J. Lipid Res. 32, 1861-1867.
9. Vihko, R. (1966) Acta Endocrinol. Suppl. 109, 29.
10. Breuer, O. & Björkhem, I. (1995) J. Biol. Chem. 270, 20278-20284.
11. Ercoli, A. & De Ruggieri, P. (1953) Gazz. Chim. Ital. 83, 78-86.
12. Di Frisco, S., De Ruggieri, P. & Ercoli, A. (1953) Boll. Soc. Ital. Biol. Sper. 29, 1351-1352.
13. Lin, Y. & Smith, L. L. (1974) Biochim. Biophys. Acta 348, 189-196.
14. Dhar, A. K., Teng, J. I. & Smith, L. L. (1973) J. Neurochem. 21, 51-60.
15. Prasad, V. V., Ponticorvo, L. & Lieberman, S. (1984) J. Steroid Biochem. 21, 733-736.
16. Schöning, M., Walter, J. & Scheel, P. (1994) Stroke 25, 1524-1525.
17. Smith, L. L., Ray, D. R., Moody, J. A., Wells, J. D. & van Lier, J. E. (1972) J. Neurochem. 19, 899-904.
18. Kudo, K., Emmons, G. T., Casserly, E. W., Vìa, D. P., Smith, L. C., Pyrek, J. & Schroepfer, G. J., Jr. (1989) J. Lipid Res. 30, 1097-1111.
19. Lin, Y. & Smith, L. L. (1975) J. Neurochem. 25, 659-665.
20. Lange, Y., Ye, J. & Strebel, F. (1995) J. Lipid Res. 36, 1092-1097.
21. Gordión, E. L., Danielsson, P. E., Ngvyen, T. S. & Winn, H. R. (1991) In Vitro Cell Dev. Biol. 27A, 312-326.
22. DeVries, H. (1995) Thesis (Costar Europe Ltd., Badhoevedorp, The Netherlands).
23. Björkhem, I. (1992) J. Lipid Res. 33, 455-471.
24. Ramsey, R. B. & Nichols, H. J. (1982) Lipids 17, 263-267.
25. Teng, J. I. & Smith, L. L. (1975) Tex. Rep. Biol. Med. 33, 293-301.
26. Aringer, L., Eneroth, P. & Nordström, L. (1976) J. Steroid Biochem. 17, 263-267.
27. Lund, E., Breuer, O. & Björkhem, I. (1992) J. Biol. Chem. 267, 25092-25097.
28. Lund, E., Björkhem, I., Furster, C. & Wikvall, K. (1993) Biochim. Biophys. Acta 1166, 177-182.
29. Björkhem, I. & Muri-Boberg, K. (1994) in The Metabolic Basis of Inherited Diseases, eds. Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D. (McGraw-Hill, New York), pp. 2073-2100.
30. Zhang, J., Akwa, Y., Baulieu, E. E. & Sjövall, J. (1995) Compt. Rend. 318, 345-349.
31. Mellon, S. H. & Deschepper, C. F. (1993) Brain Res. 629, 283-292.
32. Jung-Testas, I., Hu, Z. Y., Baulieu, E. E. & Robel, P. (1989) Endocrinology 125, 2083-2091.
33. Stapleton, G., Steel, M., Richardson, M., Mason, J. O., Rose, K. A., Morris, R. G. M. & Lathe, R. (1996) J. Biol. Chem. 270, 29739-29745.
34. Gustafsson, J.-Å. & Sjövall, J. (1969) Eur. J. Biochem. 8, 467-472.
35. Saucier, S. E., Kandutsch, A. A., Gayen, A. K., Swaha, D. K. & Spencer, T. A. (1989) J Biol. Chem. 264, 6863-6869.