Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death

Journal of Neurochemistry

Volumn 84, Issue 4, 2003, Pages 864-877

  Hashimoto, Yuichi ^a   Tsuji, Osahiko ^a   Niikura, Takako ^a   Yamagishi, Yohichi ^a   Ishizaka, Miho ^a   Kawasumi, Masaoki ^a   Chiba, Tomohiro ^a   Kanekura, Kohsuke ^a   Yamada, Marina ^a   Tsukamoto, Emi ^a   Kouyama, Keisuke ^a   Terashita, Kenzo ^a   Aiso, Sadakazu ^a   Lint, Anning ^b   Nishimoto, Ikuo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Alzheimer's amyloid precursor protein; Antiamyloid precursor protein antibody; C Jun N terminal kinase; G protein; Humanin; Neuronal death

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CELL SURFACE RECEPTOR; PERTUSSIS TOXIN; PROTEIN ANTIBODY; PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL CYCLE G0 PHASE; CONTROLLED STUDY; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTHRACENES; ANTIBODIES; CARRIER PROTEINS; CELL DEATH; CELLS, CULTURED; ENZYME INHIBITORS; GENES, DOMINANT; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HETEROTRIMERIC GTP-BINDING PROTEINS; HYBRID CELLS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPROTECTIVE AGENTS; PERTUSSIS TOXIN; PROTEINS;

ANIMALIA;

EID: 20244361899     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01585.x     Document Type: Article

References (47)

1. Bennett B. L., Sasaki D. T., Murray B. W., O'Leary E. C., Sakata S. T., Xu W., Leisten J. C., Motiwala A., Pierce S., Satoh Y. et al. (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl Acad. Sci. USA 98, 13681-13686.
2. Bozyczko-Coyne D., O'Kane T. M., Wu Z. L., Dobrzanski P., Murthy S., Vaught J. L. and Scott R. W. (2001) CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ-induced cortical neuron apoptosis. J. Neurochem. 77, 849-863.
3. o heterotrimeric protein within a cell compartment specialized in signal transduction. J. Neurosci, 19, 1717-1727.
4. Caricasole A., Bruno V., Cappuccio I., Melchiorri D., Copani A. and Nicoletti F. (2002) A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity. FASEB J. 16, 1331-1333.
5. Coso O. A., Teramoto H., Simonds W. F. and Gutkind J. S. (1996) Signaling from G protein-coupled receptors to c-Jun kinase involves βy subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J. Biol. Chem. 271, 3963-3966.
6. De Strooper B. and Annaert W. (2000) Proteolytic processing and cell biological functions of the amyloid precursor protein. J. Cell. Sci. 113, 1857-1870.
7. Dickens M., Rogers J. S., Cavanagh J., Raitano A., Xia Z., Halpern J. R., Greenberg M. E., Sawyers C. L. and Davis R. J. (1997) A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277, 693-696.
8. Giambarella U., Yamatsuji T., Okamoto T., Matsui T., Ikezu T., Murayama Y., Levine M. A., Katz A., Gautam N. and Nishimoto I. (1997) G protein βy complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J. 16, 4897-4907.
9. Gillardon F., Spranger M., Tiesler C. and Hossmann K. A. (1999) Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia. Brain Res. Mol. Brain Res. 73, 138-143.
10. Han Z., Boyle D. L., Chang L., Bennett B., Karin M., Yang L., Manning A. M. and Firestein G. S. (2001) c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Invest. 108, 73-81. Erratum in J. Clin. Invest. 108, 1883.
11. t'Hart B. A. and Simons J. M. (1992) Metabolic activation of phenols by stimulated neutrophils: a concept for a selective type of antiinflammatory drug. Biotechnol. Ther 3, 119-135.
12. Hashimoto Y., Niikura T., Ito Y. and Nishimoto I. (2000a) Multiple mechanisms underlie neurotoxicity by different type Alzheimer's disease mutations of amyloid precursor protein. J. Biol. Chem. 275, 34 541-34 551.
13. Hashimoto Y., Jiang H., Niikura T., Ito Y., Hagiwara A., Umezawa K., Abe Y, Murayama Y. and Nishimoto I. (2000b) Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. J. Neurosci. 20, 8401-8409.
14. Hashimoto Y., Niikura T., Tajima H., Yasukawa Y., Sudo H., Ito Y., Kita Y., Kawasumi M., Kouyama K., Doyu M. et al. (2001a) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proc. Natl Acad. Sci. USA 98, 6336-6341. Correction in Proc. Natl Acad. Sci. USA 98, 12 854.
15. Hashimoto Y., Ito Y., Niikura T., Shao Z., Hata M., Oyama F. and Nishimoto I. (2001b) Mechanisms of neuroprotection by a novel rescue factor Humanin from Swedish mutant amyloid precursor protein. Biochem. Biophys. Res. Commun. 283, 460-468.
16. Hashimoto Y., Niikura T., Ito Y., Sudo H., Hata M., Arakawa E., Abe Y., Kita Y. and Nishimoto I. (2001c) Detailed characterization of neuroprotection by a rescue factor Humanin against various Alzheimer's disease-relevant insults. J. Neurosci. 21, 9235-9245.
17. Hashimoto Y., Niikura T., Ito Y., Kita Y., Terashita K. and Nishimoto I. (2002a) Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2. J. Pharmacol. Exp. Ther. 300, 736-745.
18. Hashimoto Y., Ito Y., Arakawa E., Kita Y., Terashita K., Niikura T. and Nishimoto I. (2002b) Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target. J. Neurochem. 80, 426-437.
19. Jung S. S., Nalbantoglu J. and Cashman N. R. (1996) Alzheimer's β-amyloid precursor protein is expressed on the surface of immediately ex vivo brain cells: a flow cytometric study. J. Neurosci. Res. 46, 336-348.
20. Kang J., Lemaire H.-G., Unterback A., Salbaum J. M., Masters C. L., Grezeschik K. H., Multhaup G., Beyreuther K. and Müller-Hill B. (1987) The precursor of Alzheimer disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
21. Kyriakis J. M., Banerjee P., Nikolakaki E., Dai T., Rubie E. A., Ahmad M. F., Avruch J. and Woodgett J. R. (1994) The stress-activated protein kinase subfamily of c-jun kinases. Nature 369, 156-160.
22. Matsuda S., Yasukawa T., Homma Y., Shao Z., Ito Y., Niikura T., Hiraki T., Hirai S., Ohno S., Kita Y. et al. (2001) c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J. Neurosci. 21, 6597-6607.
23. Mbebi C., See V., Mercken L., Pradier L., Muller U. and Loeffler J. P. (2002) Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. J. Biol. Chem. 277, 20979-20990.
24. Morishima Y., Gotoh Y., Zieg J., Barrett T., Takano H., Flavell R., Davis R. J., Shirasaki Y. and Greenberg M. E. (2001) β-Amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J. Neurosci. 21, 7551-7560.
25. Namgung U. and Xia Z. (2000) Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J. Neurosci. 20, 6442-6451.
26. Niikura T., Hashimoto Y., Tajima H. and Nishimoto I. (2002) Death and survival of neuronal cells exposed to Alzheimer's insults. J. Neurosci. Res. 70, 380-391.
27. o. Nature 362, 75-79.
28. Noh K.-M. and Koh J.-Y. (2000) Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J. Neurosci. 20, RC111.
29. O'Donnell B. V., Tew D. G., Jones O. T. and England P. J. (1993) Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem. J. 290, 41-49.
30. Platika D., Boulos M. H., Baizer L. and Fishman M. C. (1985) Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells. Proc. Natl Acad. Sci. USA 82, 3499-3503.
31. Rohn T. T., Ivins K. J., Bahr B. A., Cotman C. W. and Cribbs D. H. (2000) A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J. Neurochem. 74, 2331-2342.
32. Saporito M. S., Thomas B. A. and Scott R. W. (2000) MPTP activates c-Jun NH (2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo. J. Neurochem. 75, 1200-1208.
33. Scheinfeld M. H., Roncarati R., Vito P., Lopez P. A., Abdallah M. and D'Adamio L. (2002) Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's β-amyloid precursor protein (APP). J. Biol. Chem. 277, 3767-3775.
34. Schubert W., Prior R., Weidemann A., Dircksen H., Multhaup G., Masters C. L. and Beyreuther K. (1991) Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites. Brain Res. 563, 184-194.
35. Sudo H., Jiang H., Yasukawa T., Hashimoto Y., Niikura T., Kawasumi M., Matsuda S., Takeuchi Y., Aiso S., Matsuoka M. et al. (2000) Antibody-regulated neurotoxic function of cell surface β-amyloid precursor protein. Mol. Cell. Neurosci. 16, 708-723.
36. Sudo H., Hashimoto Y., Niikura T, Shao Z., Yasukawa T., Ito Y., Yamada M., Hata M., Hiraki T., Kawasumi M. et al. (2001) Secreted Aβ does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein. Biochem. Biophys. Res. Commun. 282, 548-556.
37. Taussig R., Sanchez S., Rifo M., Gilman A. G. and Belardetti F. (1992) Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins. Neuron 8, 799-809.
38. Tian X. Y., Sha Y. S., Zhang S. M., Chen Y. B., Miao S. Y., Wang L. F. and Koide S. S. (2001) Extracellular domain of YWK-II, a human sperm transmembrane protein, interacts with rat Mullerian-inhibiting substance. Reproduction 121, 873-880.
39. Troy C. M., Rabacchi S. A., Xu Z., Maroney A. C., Connors T. J., Shelanski M. L. and Greene L. A. (2001) β-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J. Neurochem. 77, 157-164.
40. Wei W., Wang X. and Kusiak J. W. (2002) Signaling events in amyloid β-peptide-induced neuronal death and IGF-I protection. J. Biol. Chem. 277, 17 649-17 656.
41. Xia Z., Dickens M., Raingeaud J., Davis R. J. and Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
42. Yamatsuji T., Okamoto T., Takeda S., Fukumoto H., Iwatsubo T., Suzuki N., Asami-Odaka A., Ireland S., Kinane T. B. and Nishimoto I. (1996a) G-protein-mediated neuronal DNA fragmentation by familial Alzheimer's disease-associated V642 mutants of APP. Science 272, 1349-1352.
43. Yamatsuji T., Okamoto T., Takeda S., Murayama Y., Tanaka N. and Nishimoto I. (1996b) Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype. EMBO J. 15, 498-509.
44. Yasuda S., Inoue K., Hirabayashi M., Higashiyama H., Yamamoto Y., Fuyuhiro H., Komure O., Tanaka F., Sobue G., Tsuchiya K. et al. (1999) Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies. Genes Cells 4, 743-756.
45. Zheng C., Xiang J., Hunter T. and Lin A. (1999) The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity. J. Biol. Chem. 274, 28 966-28 971.
46. Zhu X., Castellani R. J., Takeda A., Nunomura A., Atwood C. S., Perry G. and Smith M. A. (2001a) Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mech. Ageing 123, 39-46.
47. Zhu X., Raina A. K., Rottkamp C. A., Aliev G., Perry G., Boux H. and Smith M. A. (2001b) Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J. Neurochem. 76, 435-441.