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Volumn 283, Issue 1-2, 2009, Pages 230-234

Therapeutic potential of statins in Alzheimer's disease

Author keywords

Alzheimer's disease; Cholesterol; Statins

Indexed keywords

APOLIPOPROTEIN E; ATORVASTATIN; CERIVASTATIN; CHOLESTEROL; CHOLINESTERASE INHIBITOR; DONEPEZIL; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PITAVASTATIN; PLACEBO; PRAVASTATIN; SIMVASTATIN;

EID: 67650128395     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2009.02.352     Document Type: Article
Times cited : (92)

References (54)
  • 1
    • 0025717816 scopus 로고
    • The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
    • Arnold S.E., Hyman B.T., Flory J., Damasio A.R., and Van Hoesen G.W. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex 1 1 (Jan 1991) 103-116
    • (1991) Cereb Cortex , vol.1 , Issue.1 , pp. 103-116
    • Arnold, S.E.1    Hyman, B.T.2    Flory, J.3    Damasio, A.R.4    Van Hoesen, G.W.5
  • 2
    • 34547315810 scopus 로고    scopus 로고
    • Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins
    • Reid P.C., Urano Y., Kodama T., and Hamakubo T. Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med 11 3 (May 2007) 383-392
    • (2007) J Cell Mol Med , vol.11 , Issue.3 , pp. 383-392
    • Reid, P.C.1    Urano, Y.2    Kodama, T.3    Hamakubo, T.4
  • 5
    • 0036305918 scopus 로고    scopus 로고
    • The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment
    • Hajjar I., Schumpert J., Hirth V., Wieland D., and Eleazer G.P. The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment. J Gerontol A Biol Sci Med Sci 57 7 (Jul 2002) M414-M418
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57 , Issue.7
    • Hajjar, I.1    Schumpert, J.2    Hirth, V.3    Wieland, D.4    Eleazer, G.P.5
  • 6
    • 0036126850 scopus 로고    scopus 로고
    • Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    • Rockwood K., Kirkland S., Hogan D.B., MacKnight C., Merry H., Verreault R., et al. Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people. Arch Neurol 59 2 (Feb 2002) 223-227
    • (2002) Arch Neurol , vol.59 , Issue.2 , pp. 223-227
    • Rockwood, K.1    Kirkland, S.2    Hogan, D.B.3    MacKnight, C.4    Merry, H.5    Verreault, R.6
  • 8
    • 22844431778 scopus 로고    scopus 로고
    • Statin use and the risk of incident dementia: the Cardiovascular Health Study
    • Rea T.D., Breitner J.C., Psaty B.M., Fitzpatrick A.L., Lopez O.K., Newman A.B., et al. Statin use and the risk of incident dementia: the Cardiovascular Health Study. Arch Neurol 62 7 (Jul 2005) 1047-1051
    • (2005) Arch Neurol , vol.62 , Issue.7 , pp. 1047-1051
    • Rea, T.D.1    Breitner, J.C.2    Psaty, B.M.3    Fitzpatrick, A.L.4    Lopez, O.K.5    Newman, A.B.6
  • 9
    • 8644239495 scopus 로고    scopus 로고
    • Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study
    • Li G., Higdon R., Kukull W.A., Peskind E., Van Valen Moore K., Tsuang D., et al. Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study. Neurology 63 9 (Nov 9 2004) 1624-1628
    • (2004) Neurology , vol.63 , Issue.9 , pp. 1624-1628
    • Li, G.1    Higdon, R.2    Kukull, W.A.3    Peskind, E.4    Van Valen Moore, K.5    Tsuang, D.6
  • 10
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360 (Jul 6 2002) 7-22
    • (2002) Lancet , vol.360 , pp. 7-22
    • Heart Protection Study Collaborative Group1
  • 11
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
    • Shepherd J., Blauw G.J., Murphy M.B., Bollen E.L., Buckley B.M., Cobbe S.M., et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 360 9346 (Nov 23 2002) 1623-1630
    • (2002) Lancet , vol.360 , Issue.9346 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3    Bollen, E.L.4    Buckley, B.M.5    Cobbe, S.M.6
  • 12
    • 0036186663 scopus 로고    scopus 로고
    • Serum lipoprotein levels, statin use, and cognitive function in older women
    • Yaffe K., Barrett-Connor E., Lin F., and Grady D. Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol 59 (2002) 378-384
    • (2002) Arch Neurol , vol.59 , pp. 378-384
    • Yaffe, K.1    Barrett-Connor, E.2    Lin, F.3    Grady, D.4
  • 13
    • 20844440894 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results
    • Sparks D.L., Sabbagh M.N., Connor D.J., Lopez J., Launer L.J., Browne P., et al. Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. Arch Neurol 62 5 (May 2005) 753-757
    • (2005) Arch Neurol , vol.62 , Issue.5 , pp. 753-757
    • Sparks, D.L.1    Sabbagh, M.N.2    Connor, D.J.3    Lopez, J.4    Launer, L.J.5    Browne, P.6
  • 14
    • 0037710127 scopus 로고    scopus 로고
    • Cholesterol homeostasis and function in neurons of the central nervous system
    • Pfrieger F.W. Cholesterol homeostasis and function in neurons of the central nervous system. Cell Mol Life Sci 60 6 (Jun 2003) 1158-1171
    • (2003) Cell Mol Life Sci , vol.60 , Issue.6 , pp. 1158-1171
    • Pfrieger, F.W.1
  • 15
    • 0842303768 scopus 로고    scopus 로고
    • Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
    • Heverin M., Bogdanovic N., Lutjohann D., Bayer T., Pikuleva I., Bretillon L., et al. Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J Lipid Res 45 1 (Jan 2004) 186-193
    • (2004) J Lipid Res , vol.45 , Issue.1 , pp. 186-193
    • Heverin, M.1    Bogdanovic, N.2    Lutjohann, D.3    Bayer, T.4    Pikuleva, I.5    Bretillon, L.6
  • 16
    • 0141700567 scopus 로고    scopus 로고
    • Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
    • Leoni V., Masterman T., Patel P., Meaney S., Diczfalusy U., and Bjorkhem I. Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. J Lipid Res 44 4 (Apr 2003) 793-799
    • (2003) J Lipid Res , vol.44 , Issue.4 , pp. 793-799
    • Leoni, V.1    Masterman, T.2    Patel, P.3    Meaney, S.4    Diczfalusy, U.5    Bjorkhem, I.6
  • 18
    • 0028801536 scopus 로고
    • Cholesterol for synthesis of myelin is made locally, not imported into brain
    • Jurevics H., and Morell P. Cholesterol for synthesis of myelin is made locally, not imported into brain. J Neurochem 64 2 (Feb 1995) 895-901
    • (1995) J Neurochem , vol.64 , Issue.2 , pp. 895-901
    • Jurevics, H.1    Morell, P.2
  • 19
    • 0037359765 scopus 로고    scopus 로고
    • Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease
    • Poirier J. Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. Trends Mol Med 9 3 (Mar 2003) 94-101
    • (2003) Trends Mol Med , vol.9 , Issue.3 , pp. 94-101
    • Poirier, J.1
  • 20
    • 0035856407 scopus 로고    scopus 로고
    • On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
    • Bogdanovic N., Bretillon L., Lund E.G., Diczfalusy U., Lannfelt L., Winblad B., et al. On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neurosci Lett 314 1-2 (Nov 13 2001) 45-48
    • (2001) Neurosci Lett , vol.314 , Issue.1-2 , pp. 45-48
    • Bogdanovic, N.1    Bretillon, L.2    Lund, E.G.3    Diczfalusy, U.4    Lannfelt, L.5    Winblad, B.6
  • 22
    • 4544282709 scopus 로고    scopus 로고
    • Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients
    • Kolsch H., Heun R., Kerksiek A., Bergmann K.V., Maier W., and Lutjohann D. Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. Neurosci Lett 368 3 (Sep 30 2004) 303-308
    • (2004) Neurosci Lett , vol.368 , Issue.3 , pp. 303-308
    • Kolsch, H.1    Heun, R.2    Kerksiek, A.3    Bergmann, K.V.4    Maier, W.5    Lutjohann, D.6
  • 23
    • 0242384924 scopus 로고    scopus 로고
    • Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles
    • Liu L., Bortnick A.E., Nickel M., Dhanasekaran P., Subbaiah P.V., Lund-Katz S., et al. Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles. J Biol Chem 278 44 (Oct 31 2003) 42976-42984
    • (2003) J Biol Chem , vol.278 , Issue.44 , pp. 42976-42984
    • Liu, L.1    Bortnick, A.E.2    Nickel, M.3    Dhanasekaran, P.4    Subbaiah, P.V.5    Lund-Katz, S.6
  • 24
    • 0037969631 scopus 로고    scopus 로고
    • 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion
    • Koldamova R.P., Lefterov I.M., Ikonomovic M.D., Skoko J., Lefterov P.I., Isanski B.A., et al. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. J Biol Chem 278 15 (Apr 11 2003) 13244-13256
    • (2003) J Biol Chem , vol.278 , Issue.15 , pp. 13244-13256
    • Koldamova, R.P.1    Lefterov, I.M.2    Ikonomovic, M.D.3    Skoko, J.4    Lefterov, P.I.5    Isanski, B.A.6
  • 25
    • 0028329090 scopus 로고
    • The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis
    • Moya K.L., Benowitz L.I., Schneider G.E., and Allinquant B. The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis. Dev Biol 161 2 (Feb 1994) 597-603
    • (1994) Dev Biol , vol.161 , Issue.2 , pp. 597-603
    • Moya, K.L.1    Benowitz, L.I.2    Schneider, G.E.3    Allinquant, B.4
  • 26
    • 33847724188 scopus 로고    scopus 로고
    • The amyloid precursor protein: beyond amyloid
    • Zheng H., and Koo E.H. The amyloid precursor protein: beyond amyloid. Mol Neurodegener 1 (2006) 5
    • (2006) Mol Neurodegener , vol.1 , pp. 5
    • Zheng, H.1    Koo, E.H.2
  • 27
    • 0036180950 scopus 로고    scopus 로고
    • Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains
    • Wahrle S., Das P., Nyborg A.C., McLendon C., Shoji M., Kawarabayashi T., et al. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 9 1 (Feb 2002) 11-23
    • (2002) Neurobiol Dis , vol.9 , Issue.1 , pp. 11-23
    • Wahrle, S.1    Das, P.2    Nyborg, A.C.3    McLendon, C.4    Shoji, M.5    Kawarabayashi, T.6
  • 28
    • 0029671454 scopus 로고    scopus 로고
    • Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein
    • Bodovitz S., and Klein W.L. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J Biol Chem 271 8 (Feb 23 1996) 4436-4440
    • (1996) J Biol Chem , vol.271 , Issue.8 , pp. 4436-4440
    • Bodovitz, S.1    Klein, W.L.2
  • 29
    • 0035826909 scopus 로고    scopus 로고
    • Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
    • Kojro E., Gimpl G., Lammich S., Marz W., and Fahrenholz F. Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc Natl Acad Sci U S A 98 10 (May 8 2001) 5815-5820
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.10 , pp. 5815-5820
    • Kojro, E.1    Gimpl, G.2    Lammich, S.3    Marz, W.4    Fahrenholz, F.5
  • 30
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: the cholesterol connection
    • Puglielli L., Tanzi R.E., and Kovacs D.M. Alzheimer's disease: the cholesterol connection. Nat Neurosci 6 4 (Apr 2003) 345-351
    • (2003) Nat Neurosci , vol.6 , Issue.4 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 31
    • 0242383360 scopus 로고    scopus 로고
    • Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis
    • McLaurin J., Darabie A.A., and Morrison M.R. Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis. Pharmacopsychiatry 36 Suppl 2 (Sep 2003) S130-S135
    • (2003) Pharmacopsychiatry , vol.36 , Issue.SUPPL. 2
    • McLaurin, J.1    Darabie, A.A.2    Morrison, M.R.3
  • 33
    • 0029835410 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
    • Lutjohann D., Breuer O., Ahlborg G., Nennesmo I., Siden A., Diczfalusy U., et al. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci U S A 93 18 (Sep 3 1996) 9799-9804
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.18 , pp. 9799-9804
    • Lutjohann, D.1    Breuer, O.2    Ahlborg, G.3    Nennesmo, I.4    Siden, A.5    Diczfalusy, U.6
  • 34
    • 34249828178 scopus 로고    scopus 로고
    • Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway
    • Famer D., Meaney S., Mousavi M., Nordberg A., Bjorkhem I., and Crisby M. Regulation of alpha- and beta-secretase activity by oxysterols: cerebrosterol stimulates processing of APP via the alpha-secretase pathway. Biochem Biophys Res Commun 359 1 (Jul 20 2007) 46-50
    • (2007) Biochem Biophys Res Commun , vol.359 , Issue.1 , pp. 46-50
    • Famer, D.1    Meaney, S.2    Mousavi, M.3    Nordberg, A.4    Bjorkhem, I.5    Crisby, M.6
  • 36
    • 0034021375 scopus 로고    scopus 로고
    • Vascular involvement in cognitive decline and dementia. Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study
    • Breteler M.M. Vascular involvement in cognitive decline and dementia. Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study. Ann N Y Acad Sci 903 (Apr 2000) 457-465
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 457-465
    • Breteler, M.M.1
  • 37
    • 0034123538 scopus 로고    scopus 로고
    • Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model
    • Holtzman D.M., Fagan A.M., Mackey B., Tenkova T., Sartorius L., Paul S.M., et al. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol 47 6 (Jun 2000) 739-747
    • (2000) Ann Neurol , vol.47 , Issue.6 , pp. 739-747
    • Holtzman, D.M.1    Fagan, A.M.2    Mackey, B.3    Tenkova, T.4    Sartorius, L.5    Paul, S.M.6
  • 38
    • 34548291482 scopus 로고    scopus 로고
    • Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    • Li G., Larson E.B., Sonnen J.A., Shofer J.B., Petrie E.C., Schantz A., et al. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 69 9 (Aug 28 2007) 878-885
    • (2007) Neurology , vol.69 , Issue.9 , pp. 878-885
    • Li, G.1    Larson, E.B.2    Sonnen, J.A.3    Shofer, J.B.4    Petrie, E.C.5    Schantz, A.6
  • 39
    • 0034990260 scopus 로고    scopus 로고
    • Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide
    • Buxbaum J.D., Geoghagen N.S., and Friedhoff L.T. Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide. J Alzheimers Dis 3 2 (Apr 2001) 221-229
    • (2001) J Alzheimers Dis , vol.3 , Issue.2 , pp. 221-229
    • Buxbaum, J.D.1    Geoghagen, N.S.2    Friedhoff, L.T.3
  • 40
    • 0037333737 scopus 로고    scopus 로고
    • Statin effects on cholesterol micro-domains in brain plasma membranes
    • Kirsch C., Eckert G.P., and Mueller W.E. Statin effects on cholesterol micro-domains in brain plasma membranes. Biochem Pharmacol 65 5 (Mar 1 2003) 843-856
    • (2003) Biochem Pharmacol , vol.65 , Issue.5 , pp. 843-856
    • Kirsch, C.1    Eckert, G.P.2    Mueller, W.E.3
  • 41
    • 0036128358 scopus 로고    scopus 로고
    • Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain
    • Locatelli S., Lutjohann D., Schmidt H.H., Otto C., Beisiegel U., and von Bergmann K. Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain. Arch Neurol 59 2 (Feb 2002) 213-216
    • (2002) Arch Neurol , vol.59 , Issue.2 , pp. 213-216
    • Locatelli, S.1    Lutjohann, D.2    Schmidt, H.H.3    Otto, C.4    Beisiegel, U.5    von Bergmann, K.6
  • 42
    • 0037388527 scopus 로고    scopus 로고
    • Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease
    • Vega G.L., Weiner M.F., Lipton A.M., von Bergmann K., Lutjohann D., Moore C., et al. Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. Arch Neurol 60 4 (Apr 2003) 510-515
    • (2003) Arch Neurol , vol.60 , Issue.4 , pp. 510-515
    • Vega, G.L.1    Weiner, M.F.2    Lipton, A.M.3    von Bergmann, K.4    Lutjohann, D.5    Moore, C.6
  • 43
    • 0034701033 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins): a promising approach to stroke prevention
    • Hess D.C., Demchuk A.M., Brass L.M., and Yatsu F.M. HMG-CoA reductase inhibitors (statins): a promising approach to stroke prevention. Neurology 54 4 (Feb 22 2000) 790-796
    • (2000) Neurology , vol.54 , Issue.4 , pp. 790-796
    • Hess, D.C.1    Demchuk, A.M.2    Brass, L.M.3    Yatsu, F.M.4
  • 44
    • 0032896636 scopus 로고    scopus 로고
    • Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions
    • Kaesemeyer W.H., Caldwell R.B., Huang J., and Caldwell R.W. Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions. J Am Coll Cardiol 33 1 (Jan 1999) 234-241
    • (1999) J Am Coll Cardiol , vol.33 , Issue.1 , pp. 234-241
    • Kaesemeyer, W.H.1    Caldwell, R.B.2    Huang, J.3    Caldwell, R.W.4
  • 45
    • 0033393022 scopus 로고    scopus 로고
    • Low-density lipoprotein-independent effects of statins
    • Davignon J., and Laaksonen R. Low-density lipoprotein-independent effects of statins. Curr Opin Lipidol 10 6 (Dec 1999) 543-559
    • (1999) Curr Opin Lipidol , vol.10 , Issue.6 , pp. 543-559
    • Davignon, J.1    Laaksonen, R.2
  • 49
    • 27744602604 scopus 로고    scopus 로고
    • Cholesterol in Alzheimer's disease
    • Shobab L.A., Hsiung G.Y., and Feldman H.H. Cholesterol in Alzheimer's disease. Lancet Neurol 4 12 (Dec 2005) 841-852
    • (2005) Lancet Neurol , vol.4 , Issue.12 , pp. 841-852
    • Shobab, L.A.1    Hsiung, G.Y.2    Feldman, H.H.3
  • 50
    • 39349084356 scopus 로고    scopus 로고
    • Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovascular disease
    • Vergouwen M.D., de Hann R.J., Vermeulen M., and Roos Y.B. Statin treatment and the occurrence of hemorrhagic stroke in patients with a history of cerebrovascular disease. Stroke 39 2 (2008) 497-502
    • (2008) Stroke , vol.39 , Issue.2 , pp. 497-502
    • Vergouwen, M.D.1    de Hann, R.J.2    Vermeulen, M.3    Roos, Y.B.4
  • 52
    • 33644857332 scopus 로고    scopus 로고
    • Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls
    • Sudlow C., Martinez Gonzalez N.A., Kim J., and Clark C. Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls. Stroke 37 2 (Feb 2006) 364-370
    • (2006) Stroke , vol.37 , Issue.2 , pp. 364-370
    • Sudlow, C.1    Martinez Gonzalez, N.A.2    Kim, J.3    Clark, C.4
  • 53
    • 0032189866 scopus 로고    scopus 로고
    • Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis
    • Michikawa M., and Yanagisawa K. Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. J Neurosci Res 54 1 (Oct 1 1998) 58-67
    • (1998) J Neurosci Res , vol.54 , Issue.1 , pp. 58-67
    • Michikawa, M.1    Yanagisawa, K.2
  • 54
    • 0037235059 scopus 로고    scopus 로고
    • Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease
    • Meske V., Albert F., Richter D., Schwarze J., and Ohm T.G. Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein tau via suppression of geranylgeranylpyrophosphate formation: implications for Alzheimer's disease. Eur J Neurosci 17 1 (Jan 2003) 93-102
    • (2003) Eur J Neurosci , vol.17 , Issue.1 , pp. 93-102
    • Meske, V.1    Albert, F.2    Richter, D.3    Schwarze, J.4    Ohm, T.G.5


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