FAD mutant PS-1 gene-targeted mice: Increased Aβ42 and Aβ deposition without APP overproduction

Neurobiology of Aging

Volumn 23, Issue 3, 2002, Pages 335-348

  Flood, Dorothy G ^a   Reaume, Andrew G ^a   Dorfman, Karen S ^a   Lin, Yin Guo ^a   Lang, Diane M ^a   Trusko, Stephen P ^a   Savage, Mary J ^a   Annaert, Wim G ^b   De Strooper, Bart ^b   Siman, Robert ^a   Scott, Richard W ^a  

^a CEPHALON INC   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

A deposition; Alzheimer's disease; Amyloid; Animal model; Gene targeting; Mouse; Presenilin; Transgenic

Indexed keywords

AMYLOID BETA PROTEIN; MESSENGER RNA; PRESENILIN 1; PROTEIN; PROTEIN ABETA42; PROTEIN APP; UNCLASSIFIED DRUG;

AGE; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SPINAL CORD; TRANSGENIC MOUSE; WILD TYPE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL LINE; FEMALE; GENE TARGETING; GENOTYPE; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; NEOCORTEX; PEPTIDE FRAGMENTS; PREGNANCY; PRESENILIN-1; RNA, MESSENGER;

EID: 0036228106     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(01)00330-X     Document Type: Article

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