-
1
-
-
0035066332
-
Alzheimer's disease: genes, proteins, and therapy
-
Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
2
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82 (1991) 239-259
-
(1991)
Acta Neuropathol.
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
3
-
-
15944369995
-
The interaction of amyloid-beta with ApoE
-
Carter D.B. The interaction of amyloid-beta with ApoE. Subcell. Biochem. 38 (2005) 255-272
-
(2005)
Subcell. Biochem.
, vol.38
, pp. 255-272
-
-
Carter, D.B.1
-
4
-
-
38949104188
-
The coming acceleration of global population ageing
-
Lutz W., Sanderson W., and Scherbov S. The coming acceleration of global population ageing. Nature 451 (2008) 716-719
-
(2008)
Nature
, vol.451
, pp. 716-719
-
-
Lutz, W.1
Sanderson, W.2
Scherbov, S.3
-
5
-
-
29144508843
-
Global prevalence of dementia: A Delphi consensus study
-
C.P. Ferri, M. Prince, C. Brayne et al., Global prevalence of dementia: a Delphi consensus study, Lancet 366 2112-2117.
-
Lancet
, vol.366
, pp. 2112-2117
-
-
Ferri, C.P.1
Prince, M.2
Brayne, C.3
-
6
-
-
0035724698
-
National estimates of the quantity and cost of informal caregiving for the elderly with dementia
-
Langa K.M., Chernew M.E., Kabeto M.U., et al. National estimates of the quantity and cost of informal caregiving for the elderly with dementia. J. Gen. Intern. Med. 16 (2001) 770-778
-
(2001)
J. Gen. Intern. Med.
, vol.16
, pp. 770-778
-
-
Langa, K.M.1
Chernew, M.E.2
Kabeto, M.U.3
-
7
-
-
0034643928
-
Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts
-
Lobo A., Launer L.J., Fratiglioni L., et al. Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurology 54 (2000) S4-9
-
(2000)
Neurology
, vol.54
-
-
Lobo, A.1
Launer, L.J.2
Fratiglioni, L.3
-
8
-
-
49049122193
-
Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors
-
Kalaria R.N., Maestre G.E., Arizaga R., et al. Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurology 7 (2008) 812-826
-
(2008)
Lancet Neurology
, vol.7
, pp. 812-826
-
-
Kalaria, R.N.1
Maestre, G.E.2
Arizaga, R.3
-
9
-
-
35948958128
-
Cognitive-behavioral profiles of neurodegenerative dementias: beyond Alzheimer's disease
-
Levy J.A., and Chelune G.J. Cognitive-behavioral profiles of neurodegenerative dementias: beyond Alzheimer's disease. J. Geriatr. Psychiatry Neurol. 20 (2007) 227-238
-
(2007)
J. Geriatr. Psychiatry Neurol.
, vol.20
, pp. 227-238
-
-
Levy, J.A.1
Chelune, G.J.2
-
10
-
-
0032988610
-
Mild cognitive impairment: clinical characterization and outcome
-
Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Tangalos E.G., and Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol. 56 (1999) 303-308
-
(1999)
Arch. Neurol.
, vol.56
, pp. 303-308
-
-
Petersen, R.C.1
Smith, G.E.2
Waring, S.C.3
Ivnik, R.J.4
Tangalos, E.G.5
Kokmen, E.6
-
11
-
-
0035826925
-
Practice parameter: Early detection of dementia: mild cognitive impairment (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology
-
Petersen R.C., Stevens J.C., Ganguli M., Tangalos E.G., Cummings J.L., and DeKosky S.T. Practice parameter: Early detection of dementia: mild cognitive impairment (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56 (2001) 1133-1142
-
(2001)
Neurology
, vol.56
, pp. 1133-1142
-
-
Petersen, R.C.1
Stevens, J.C.2
Ganguli, M.3
Tangalos, E.G.4
Cummings, J.L.5
DeKosky, S.T.6
-
12
-
-
0030909279
-
Prevalence and severity of cognitive impairment with and without dementia in an elderly population
-
Graham J.E., Rockwood K., Beattie B.L., et al. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet 349 (1997) 1793-1796
-
(1997)
Lancet
, vol.349
, pp. 1793-1796
-
-
Graham, J.E.1
Rockwood, K.2
Beattie, B.L.3
-
13
-
-
0016823810
-
"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
-
Folstein M.F., Folstein S.E., and McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 (1975) 189-198
-
(1975)
J. Psychiatr. Res.
, vol.12
, pp. 189-198
-
-
Folstein, M.F.1
Folstein, S.E.2
McHugh, P.R.3
-
14
-
-
0020040238
-
A new clinical scale for the staging of dementia
-
Hughes C.P., Berg L., Danziger W.L., Coben L.A., and Martin R.L. A new clinical scale for the staging of dementia. Br. J. Psychiatry 140 (1982) 566-572
-
(1982)
Br. J. Psychiatry
, vol.140
, pp. 566-572
-
-
Hughes, C.P.1
Berg, L.2
Danziger, W.L.3
Coben, L.A.4
Martin, R.L.5
-
15
-
-
0019967975
-
The Global Deterioration Scale for assessment of primary degenerative dementia
-
Reisberg B., Ferris S.H., de Leon M.J., and Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am. J. Psychiatry 139 (1982) 1136-1139
-
(1982)
Am. J. Psychiatry
, vol.139
, pp. 1136-1139
-
-
Reisberg, B.1
Ferris, S.H.2
de Leon, M.J.3
Crook, T.4
-
16
-
-
29244439038
-
Neural plasticity in the ageing brain
-
Burke S.N., and Barnes C.A. Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 7 (2006) 30-40
-
(2006)
Nat. Rev. Neurosci.
, vol.7
, pp. 30-40
-
-
Burke, S.N.1
Barnes, C.A.2
-
17
-
-
0037007045
-
Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI
-
Scahill R.I., Schott J.M., Stevens J.M., Rossor M.N., and Fox N.C. Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 4703-4707
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 4703-4707
-
-
Scahill, R.I.1
Schott, J.M.2
Stevens, J.M.3
Rossor, M.N.4
Fox, N.C.5
-
18
-
-
10744231722
-
Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD
-
Jack Jr. C.R., Shiung M.M., Gunter J.L., et al. Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology 62 (2004) 591-600
-
(2004)
Neurology
, vol.62
, pp. 591-600
-
-
Jack Jr., C.R.1
Shiung, M.M.2
Gunter, J.L.3
-
19
-
-
0028794544
-
Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes
-
Ohm T.G., Muller H., Braak H., and Bohl J. Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes. Neuroscience 64 (1995) 209-217
-
(1995)
Neuroscience
, vol.64
, pp. 209-217
-
-
Ohm, T.G.1
Muller, H.2
Braak, H.3
Bohl, J.4
-
20
-
-
37349096335
-
Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity
-
Nelson P.T., Jicha G.A., Schmitt F.A., et al. Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J. Neuropathol. Exp. Neurol. 66 (2007) 1136-1146
-
(2007)
J. Neuropathol. Exp. Neurol.
, vol.66
, pp. 1136-1146
-
-
Nelson, P.T.1
Jicha, G.A.2
Schmitt, F.A.3
-
21
-
-
0038708285
-
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
-
Giannakopoulos P., Herrmann F.R., Bussiere T., et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology 60 (2003) 1495-1500
-
(2003)
Neurology
, vol.60
, pp. 1495-1500
-
-
Giannakopoulos, P.1
Herrmann, F.R.2
Bussiere, T.3
-
22
-
-
2942561028
-
The importance of neuritic plaques and tangles to the development and evolution of AD
-
Tiraboschi P., Hansen L.A., Thal L.J., and Corey-Bloom J. The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology 62 (2004) 1984-1989
-
(2004)
Neurology
, vol.62
, pp. 1984-1989
-
-
Tiraboschi, P.1
Hansen, L.A.2
Thal, L.J.3
Corey-Bloom, J.4
-
23
-
-
47549094635
-
Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium
-
Alafuzoff I., Arzberger T., Al-Sarraj S., et al. Staging of neurofibrillary pathology in Alzheimer's disease: a study of the BrainNet Europe Consortium. Brain Pathol. 18 (2008) 484-496
-
(2008)
Brain Pathol.
, vol.18
, pp. 484-496
-
-
Alafuzoff, I.1
Arzberger, T.2
Al-Sarraj, S.3
-
24
-
-
54049152421
-
MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study
-
Whitwell J.L., Josephs K.A., Murray M.E., et al. MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study. Neurology 71 (2008) 743-749
-
(2008)
Neurology
, vol.71
, pp. 743-749
-
-
Whitwell, J.L.1
Josephs, K.A.2
Murray, M.E.3
-
25
-
-
33745700402
-
Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study
-
Archer H.A., Edison P., Brooks D.J., et al. Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. Ann. Neurol. 60 (2006) 145-147
-
(2006)
Ann. Neurol.
, vol.60
, pp. 145-147
-
-
Archer, H.A.1
Edison, P.2
Brooks, D.J.3
-
26
-
-
0042932776
-
Changes in premorbid brain volume predict Alzheimer's disease pathology
-
Silbert L.C., Quinn J.F., Moore M.M., et al. Changes in premorbid brain volume predict Alzheimer's disease pathology. Neurology 61 (2003) 487-492
-
(2003)
Neurology
, vol.61
, pp. 487-492
-
-
Silbert, L.C.1
Quinn, J.F.2
Moore, M.M.3
-
27
-
-
40449135167
-
Beta-amyloid burden is not associated with rates of brain atrophy
-
Josephs K.A., Whitwell J.L., Ahmed Z., et al. Beta-amyloid burden is not associated with rates of brain atrophy. Ann. Neurol. 63 (2008) 204-212
-
(2008)
Ann. Neurol.
, vol.63
, pp. 204-212
-
-
Josephs, K.A.1
Whitwell, J.L.2
Ahmed, Z.3
-
28
-
-
0006325405
-
Alzheimer's disease: a re-examination of the amyloid hypothesis
-
Neve R.L., and Robakis N.K. Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends Neurosci. 21 (1998) 15-19
-
(1998)
Trends Neurosci.
, vol.21
, pp. 15-19
-
-
Neve, R.L.1
Robakis, N.K.2
-
29
-
-
0038117796
-
Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
-
Naslund J., Haroutunian V., Mohs R., et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. Jama 283 (2000) 1571-1577
-
(2000)
Jama
, vol.283
, pp. 1571-1577
-
-
Naslund, J.1
Haroutunian, V.2
Mohs, R.3
-
30
-
-
52949118083
-
Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease
-
Schupf N., Tang M.X., Fukuyama H., et al. Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 14052-14057
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 14052-14057
-
-
Schupf, N.1
Tang, M.X.2
Fukuyama, H.3
-
32
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D., Adams D., Alessandrini R., et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373 (1995) 523-527
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
-
33
-
-
0030611097
-
Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
-
Irizarry M.C., Soriano F., McNamara M., et al. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 17 (1997) 7053-7059
-
(1997)
J. Neurosci.
, vol.17
, pp. 7053-7059
-
-
Irizarry, M.C.1
Soriano, F.2
McNamara, M.3
-
34
-
-
26844449402
-
Transgenic models of Alzheimer's disease: learning from animals
-
Spires T.L., and Hyman B.T. Transgenic models of Alzheimer's disease: learning from animals. NeuroRx 2 (2005) 423-437
-
(2005)
NeuroRx
, vol.2
, pp. 423-437
-
-
Spires, T.L.1
Hyman, B.T.2
-
35
-
-
0036583275
-
A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat
-
Clayton D.A., Mesches M.H., Alvarez E., Bickford P.C., and Browning M.D. A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. J. Neurosci. 22 (2002) 3628-3637
-
(2002)
J. Neurosci.
, vol.22
, pp. 3628-3637
-
-
Clayton, D.A.1
Mesches, M.H.2
Alvarez, E.3
Bickford, P.C.4
Browning, M.D.5
-
36
-
-
0032737984
-
Involvement of hippocampal synaptic plasticity in age-related memory decline
-
Foster T.C. Involvement of hippocampal synaptic plasticity in age-related memory decline. Brain Res. Rev. 30 (1999) 236-249
-
(1999)
Brain Res. Rev.
, vol.30
, pp. 236-249
-
-
Foster, T.C.1
-
37
-
-
0037936789
-
Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
-
Rosenzweig E.S., and Barnes C.A. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog. Neurobiol. 69 (2003) 143-179
-
(2003)
Prog. Neurobiol.
, vol.69
, pp. 143-179
-
-
Rosenzweig, E.S.1
Barnes, C.A.2
-
38
-
-
0033529082
-
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
-
Engert F., and Bonhoeffer T. Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 399 (1999) 66-70
-
(1999)
Nature
, vol.399
, pp. 66-70
-
-
Engert, F.1
Bonhoeffer, T.2
-
39
-
-
0031824046
-
Layer-specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex
-
de Brabander J.M., Kramers R.J., and Uylings H.B. Layer-specific dendritic regression of pyramidal cells with ageing in the human prefrontal cortex. Eur. J. Neurosci. 10 (1998) 1261-1269
-
(1998)
Eur. J. Neurosci.
, vol.10
, pp. 1261-1269
-
-
de Brabander, J.M.1
Kramers, R.J.2
Uylings, H.B.3
-
40
-
-
0021994846
-
Age-related changes of pyramidal cell basal dendrites in layers III and V of human motor cortex: a quantitative Golgi study
-
Nakamura S., Akiguchi I., Kameyama M., and Mizuno N. Age-related changes of pyramidal cell basal dendrites in layers III and V of human motor cortex: a quantitative Golgi study. Acta Neuropathol. 65 (1985) 281-284
-
(1985)
Acta Neuropathol.
, vol.65
, pp. 281-284
-
-
Nakamura, S.1
Akiguchi, I.2
Kameyama, M.3
Mizuno, N.4
-
41
-
-
30444453661
-
The glutamate story
-
Watkins J.C., and Jane D.E. The glutamate story. Br. J. Pharmacol 147 Suppl. 1 (2006) S100-S108
-
(2006)
Br. J. Pharmacol
, vol.147
, Issue.SUPPL. 1
-
-
Watkins, J.C.1
Jane, D.E.2
-
42
-
-
0027476024
-
A synaptic model of memory: long-term potentiation in the hippocampus
-
Bliss T.V., and Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361 (1993) 31-39
-
(1993)
Nature
, vol.361
, pp. 31-39
-
-
Bliss, T.V.1
Collingridge, G.L.2
-
44
-
-
49249094142
-
Glutamate receptor subunits expression in memory-associated brain structures: regional variations and effects of aging
-
Liu P., Smith P.F., and Darlington C.L. Glutamate receptor subunits expression in memory-associated brain structures: regional variations and effects of aging. Synapse 62 (2008) 834-841
-
(2008)
Synapse
, vol.62
, pp. 834-841
-
-
Liu, P.1
Smith, P.F.2
Darlington, C.L.3
-
45
-
-
0032507530
-
The aging of the NMDA receptor complex
-
Magnusson K.R. The aging of the NMDA receptor complex. Front. Biosci. 3 (1998) e70-80
-
(1998)
Front. Biosci.
, vol.3
-
-
Magnusson, K.R.1
-
46
-
-
0027085867
-
Mechanisms of excitotoxicity in neurologic diseases
-
Beal M.F. Mechanisms of excitotoxicity in neurologic diseases. FASEB J. 6 (1992) 3338-3344
-
(1992)
FASEB J.
, vol.6
, pp. 3338-3344
-
-
Beal, M.F.1
-
47
-
-
13444291406
-
Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders
-
Lipton S.A. Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders. J. Alzheimers Dis. 6 (2004) S61-74
-
(2004)
J. Alzheimers Dis.
, vol.6
-
-
Lipton, S.A.1
-
48
-
-
0029414737
-
Memantine prevents progressive functional neurodegeneration in rats
-
Heim C., and Sontag K.H. Memantine prevents progressive functional neurodegeneration in rats. J. Neural. Transm. Suppl. 46 (1995) 117-130
-
(1995)
J. Neural. Transm. Suppl.
, vol.46
, pp. 117-130
-
-
Heim, C.1
Sontag, K.H.2
-
49
-
-
0027246262
-
NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine
-
Weller M., Finiels-Marlier F., and Paul S.M. NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine. Brain Res. 613 (1993) 143-148
-
(1993)
Brain Res.
, vol.613
, pp. 143-148
-
-
Weller, M.1
Finiels-Marlier, F.2
Paul, S.M.3
-
50
-
-
40549106116
-
Memantine treatment in patients with mild to moderate Alzheimer's disease: results of a randomised, double-blind, placebo-controlled 6-month study
-
Bakchine S., and Loft H. Memantine treatment in patients with mild to moderate Alzheimer's disease: results of a randomised, double-blind, placebo-controlled 6-month study. J. Alzheimers Dis. 13 (2008) 97-107
-
(2008)
J. Alzheimers Dis.
, vol.13
, pp. 97-107
-
-
Bakchine, S.1
Loft, H.2
-
51
-
-
0037417238
-
Memantine in moderate-to-severe Alzheimer's disease
-
Reisberg B., Doody R., Stoffler A., Schmitt F., Ferris S., and Mobius H.J. Memantine in moderate-to-severe Alzheimer's disease. N. Engl. J. Med. 348 (2003) 1333-1341
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1333-1341
-
-
Reisberg, B.1
Doody, R.2
Stoffler, A.3
Schmitt, F.4
Ferris, S.5
Mobius, H.J.6
-
52
-
-
0345872128
-
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial
-
Tariot P.N., Farlow M.R., Grossberg G.T., Graham S.M., McDonald S., and Gergel I. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. Jama 291 (2004) 317-324
-
(2004)
Jama
, vol.291
, pp. 317-324
-
-
Tariot, P.N.1
Farlow, M.R.2
Grossberg, G.T.3
Graham, S.M.4
McDonald, S.5
Gergel, I.6
-
53
-
-
6344247564
-
Memantine Improves Spatial Learning in a Transgenic Mouse Model of Alzheimer's disease
-
Minkeviciene R., Banerjee P., and Tanila H. Memantine Improves Spatial Learning in a Transgenic Mouse Model of Alzheimer's disease. J. Pharmacol. Exp. Ther. 311 (2004) 677-682
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.311
, pp. 677-682
-
-
Minkeviciene, R.1
Banerjee, P.2
Tanila, H.3
-
54
-
-
57049085109
-
Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging
-
Scholtzova H., Wadghiri Y.Z., Douadi M., et al. Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging. J. Neurosci. Res. 86 (2008) 2784-2791
-
(2008)
J. Neurosci. Res.
, vol.86
, pp. 2784-2791
-
-
Scholtzova, H.1
Wadghiri, Y.Z.2
Douadi, M.3
-
55
-
-
41949104908
-
Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease
-
Geula C., Nagykery N., Nicholas A., and Wu C.K. Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer disease. J. Neuropathol. Exp. Neurol. 67 (2008) 309-318
-
(2008)
J. Neuropathol. Exp. Neurol.
, vol.67
, pp. 309-318
-
-
Geula, C.1
Nagykery, N.2
Nicholas, A.3
Wu, C.K.4
-
56
-
-
30344460006
-
Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation-a pharmacological fMRI study
-
Goekoop R., Scheltens P., Barkhof F., and Rombouts S.A. Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation-a pharmacological fMRI study. Brain 129 (2006) 141-157
-
(2006)
Brain
, vol.129
, pp. 141-157
-
-
Goekoop, R.1
Scheltens, P.2
Barkhof, F.3
Rombouts, S.A.4
-
57
-
-
27744443298
-
Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis
-
Gron G., Brandenburg I., Wunderlich A.P., and Riepe M.W. Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis. Neurobiol. Aging 27 (2006) 78-87
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 78-87
-
-
Gron, G.1
Brandenburg, I.2
Wunderlich, A.P.3
Riepe, M.W.4
-
58
-
-
0034125843
-
On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis
-
Bartus R.T. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 163 (2000) 495-529
-
(2000)
Exp. Neurol.
, vol.163
, pp. 495-529
-
-
Bartus, R.T.1
-
59
-
-
0020072221
-
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain
-
Whitehouse P.J., Price D.L., Struble R.G., Clark A.W., Coyle J.T., and Delon M.R. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215 (1982) 1237-1239
-
(1982)
Science
, vol.215
, pp. 1237-1239
-
-
Whitehouse, P.J.1
Price, D.L.2
Struble, R.G.3
Clark, A.W.4
Coyle, J.T.5
Delon, M.R.6
-
60
-
-
0028873975
-
Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits
-
Bierer L.M., Haroutunian V., Gabriel S., et al. Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J. Neurochem. 64 (1995) 749-760
-
(1995)
J. Neurochem.
, vol.64
, pp. 749-760
-
-
Bierer, L.M.1
Haroutunian, V.2
Gabriel, S.3
-
61
-
-
14844311990
-
Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's disease
-
Ikonomovic M.D., Mufson E.J., Wuu J., Bennett D.A., and DeKosky S.T. Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's disease. Arch. Neurol. 62 (2005) 425-430
-
(2005)
Arch. Neurol.
, vol.62
, pp. 425-430
-
-
Ikonomovic, M.D.1
Mufson, E.J.2
Wuu, J.3
Bennett, D.A.4
DeKosky, S.T.5
-
62
-
-
35548935721
-
Donepezil for Alzheimer's disease
-
Benjamin B., and Burns A. Donepezil for Alzheimer's disease. Expert Rev. Neurother. 7 (2007) 1243-1249
-
(2007)
Expert Rev. Neurother.
, vol.7
, pp. 1243-1249
-
-
Benjamin, B.1
Burns, A.2
-
64
-
-
18544400908
-
Donepezil therapy in clinical practice: a randomized crossover study
-
Greenberg S.M., Tennis M.K., Brown L.B., et al. Donepezil therapy in clinical practice: a randomized crossover study. Arch. Neurol. 57 (2000) 94-99
-
(2000)
Arch. Neurol.
, vol.57
, pp. 94-99
-
-
Greenberg, S.M.1
Tennis, M.K.2
Brown, L.B.3
-
65
-
-
47849119964
-
Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis
-
Hansen R.A., Gartlehner G., Webb A.P., Morgan L.C., Moore C.G., and Jonas D.E. Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis. Clin. Interv. Aging 3 (2008) 211-225
-
(2008)
Clin. Interv. Aging
, vol.3
, pp. 211-225
-
-
Hansen, R.A.1
Gartlehner, G.2
Webb, A.P.3
Morgan, L.C.4
Moore, C.G.5
Jonas, D.E.6
-
66
-
-
0035830396
-
Cardiovascular risk factors and cognitive decline in middle-aged adults
-
Knopman D., Boland L.L., Mosley T., et al. Cardiovascular risk factors and cognitive decline in middle-aged adults. Neurology 56 (2001) 42-48
-
(2001)
Neurology
, vol.56
, pp. 42-48
-
-
Knopman, D.1
Boland, L.L.2
Mosley, T.3
-
67
-
-
0030603535
-
15-year longitudinal study of blood pressure and dementia
-
Skoog I., Lernfelt B., Landahl S., et al. 15-year longitudinal study of blood pressure and dementia. Lancet 347 (1996) 1141-1145
-
(1996)
Lancet
, vol.347
, pp. 1141-1145
-
-
Skoog, I.1
Lernfelt, B.2
Landahl, S.3
-
68
-
-
12744273863
-
Midlife cardiovascular risk factors and risk of dementia in late life
-
Whitmer R.A., Sidney S., Selby J., Johnston S.C., and Yaffe K. Midlife cardiovascular risk factors and risk of dementia in late life. Neurology 64 (2005) 277-281
-
(2005)
Neurology
, vol.64
, pp. 277-281
-
-
Whitmer, R.A.1
Sidney, S.2
Selby, J.3
Johnston, S.C.4
Yaffe, K.5
-
69
-
-
0346103691
-
Low blood pressure and the risk of dementia in very old individuals
-
Verghese J., Lipton R.B., Hall C.B., Kuslansky G., and Katz M.J. Low blood pressure and the risk of dementia in very old individuals. Neurology 61 (2003) 1667-1672
-
(2003)
Neurology
, vol.61
, pp. 1667-1672
-
-
Verghese, J.1
Lipton, R.B.2
Hall, C.B.3
Kuslansky, G.4
Katz, M.J.5
-
70
-
-
16444367153
-
Evolution of blood pressure in patients with Alzheimer's disease: a one year survey of a French Cohort (REAL.FR)
-
Hanon O., Latour F., Seux M.L., Lenoir H., Forette F., and Rigaud A.S. Evolution of blood pressure in patients with Alzheimer's disease: a one year survey of a French Cohort (REAL.FR). J. Nutr. Health Aging 9 (2005) 106-111
-
(2005)
J. Nutr. Health Aging
, vol.9
, pp. 106-111
-
-
Hanon, O.1
Latour, F.2
Seux, M.L.3
Lenoir, H.4
Forette, F.5
Rigaud, A.S.6
-
71
-
-
2142769752
-
Interaction between hypertension, apoE, and cerebral white matter lesions
-
de Leeuw F.E., Richard F., de Groot J.C., et al. Interaction between hypertension, apoE, and cerebral white matter lesions. Stroke 35 (2004) 1057-1060
-
(2004)
Stroke
, vol.35
, pp. 1057-1060
-
-
de Leeuw, F.E.1
Richard, F.2
de Groot, J.C.3
-
72
-
-
0037078312
-
The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study
-
Forette F., Seux M.L., Staessen J.A., et al. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch. Intern. Med. 162 (2002) 2046-2052
-
(2002)
Arch. Intern. Med.
, vol.162
, pp. 2046-2052
-
-
Forette, F.1
Seux, M.L.2
Staessen, J.A.3
-
73
-
-
0038669268
-
Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease
-
Tzourio C., Anderson C., Chapman N., et al. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch. Intern. Med. 163 (2003) 1069-1075
-
(2003)
Arch. Intern. Med.
, vol.163
, pp. 1069-1075
-
-
Tzourio, C.1
Anderson, C.2
Chapman, N.3
-
74
-
-
0028006802
-
Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program
-
Applegate W.B., Pressel S., Wittes J., et al. Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program. Arch. Intern. Med. 154 (1994) 2154-2160
-
(1994)
Arch. Intern. Med.
, vol.154
, pp. 2154-2160
-
-
Applegate, W.B.1
Pressel, S.2
Wittes, J.3
-
75
-
-
3843078519
-
The Study on COgnition and Prognosis in the Elderly (SCOPE); outcomes in patients not receiving add-on therapy after randomization
-
Lithell H., Hansson L., Skoog I., et al. The Study on COgnition and Prognosis in the Elderly (SCOPE); outcomes in patients not receiving add-on therapy after randomization. J. Hypertens. 22 (2004) 1605-1612
-
(2004)
J. Hypertens.
, vol.22
, pp. 1605-1612
-
-
Lithell, H.1
Hansson, L.2
Skoog, I.3
-
76
-
-
0029988543
-
Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's trial of hypertension in older adults
-
Prince M.J., Bird A.S., Blizard R.A., and Mann A.H. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's trial of hypertension in older adults. Bmj 312 (1996) 801-805
-
(1996)
Bmj
, vol.312
, pp. 801-805
-
-
Prince, M.J.1
Bird, A.S.2
Blizard, R.A.3
Mann, A.H.4
-
77
-
-
33748698462
-
Association of metabolic syndrome with Alzheimer disease: a population-based study
-
Vanhanen M., Koivisto K., Moilanen L., et al. Association of metabolic syndrome with Alzheimer disease: a population-based study. Neurology 67 (2006) 843-847
-
(2006)
Neurology
, vol.67
, pp. 843-847
-
-
Vanhanen, M.1
Koivisto, K.2
Moilanen, L.3
-
78
-
-
0033786473
-
Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study
-
Kalmijn S., Foley D., White L., et al. Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 2255-2260
-
(2000)
Arterioscler. Thromb. Vasc. Biol.
, vol.20
, pp. 2255-2260
-
-
Kalmijn, S.1
Foley, D.2
White, L.3
-
79
-
-
33644516288
-
Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms
-
Sastre M., Klockgether T., and Heneka M.T. Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. Int. J. Dev. Neurosci. 24 (2006) 167-176
-
(2006)
Int. J. Dev. Neurosci.
, vol.24
, pp. 167-176
-
-
Sastre, M.1
Klockgether, T.2
Heneka, M.T.3
-
80
-
-
34247367165
-
Astrocytes aged in vitro show a decreased neuroprotective capacity
-
Pertusa M., Garcia-Matas S., Rodriguez-Farre E., Sanfeliu C., and Cristofol R. Astrocytes aged in vitro show a decreased neuroprotective capacity. J. Neurochem. 101 (2007) 794-805
-
(2007)
J. Neurochem.
, vol.101
, pp. 794-805
-
-
Pertusa, M.1
Garcia-Matas, S.2
Rodriguez-Farre, E.3
Sanfeliu, C.4
Cristofol, R.5
-
81
-
-
77049085956
-
Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain
-
in press, doi:10.1016/j.neurobiolaging.2008.05.015
-
J.E. Simpson, P.G. Ince, G. Lace, et al., Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain, Neurobiol. Aging (in press). doi:10.1016/j.neurobiolaging.2008.05.015.
-
Neurobiol. Aging
-
-
Simpson, J.E.1
Ince, P.G.2
Lace, G.3
-
82
-
-
2542481651
-
Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease
-
Nagele R.G., Wegiel J., Venkataraman V., Imaki H., Wang K.C., and Wegiel J. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease. Neurobiol. Aging 25 (2004) 663-674
-
(2004)
Neurobiol. Aging
, vol.25
, pp. 663-674
-
-
Nagele, R.G.1
Wegiel, J.2
Venkataraman, V.3
Imaki, H.4
Wang, K.C.5
Wegiel, J.6
-
83
-
-
0024824922
-
Patterns of gliosis in Alzheimer's disease and aging cerebrum
-
Beach R.W.T.G., and McGeer E.G. Patterns of gliosis in Alzheimer's disease and aging cerebrum. Glia 2 (1989) 420-436
-
(1989)
Glia
, vol.2
, pp. 420-436
-
-
Beach, R.W.T.G.1
McGeer, E.G.2
-
84
-
-
0037333633
-
Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease
-
Vehmas A.K., Kawas C.H., Stewart W.F., and Troncoso J.C. Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiol. Aging 24 (2003) 321-331
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 321-331
-
-
Vehmas, A.K.1
Kawas, C.H.2
Stewart, W.F.3
Troncoso, J.C.4
-
85
-
-
0035146889
-
Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function
-
Barger S.W., and Basile A.S. Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J. Neurochem. 76 (2001) 846-854
-
(2001)
J. Neurochem.
, vol.76
, pp. 846-854
-
-
Barger, S.W.1
Basile, A.S.2
-
86
-
-
33746354022
-
Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
-
Takeuchi H., Jin S., Wang J., et al. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 281 (2006) 21362-21368
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 21362-21368
-
-
Takeuchi, H.1
Jin, S.2
Wang, J.3
-
87
-
-
50849098818
-
Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases
-
Timothy I.F.A., Harrigan J., David Jourd'heuil, and Mongin A.A. Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases. J. Neurochem. 106 (2008) 2449-2462
-
(2008)
J. Neurochem.
, vol.106
, pp. 2449-2462
-
-
Timothy, I.F.A.1
Harrigan, J.2
David Jourd'heuil3
Mongin, A.A.4
-
88
-
-
14944385354
-
Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors
-
Floden A.M., Li S., and Combs C.K. Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J. Neurosci. 25 (2005) 2566-2575
-
(2005)
J. Neurosci.
, vol.25
, pp. 2566-2575
-
-
Floden, A.M.1
Li, S.2
Combs, C.K.3
-
89
-
-
0029021217
-
Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study
-
Andersen K., Launer L.J., Ott A., Hoes A.W., Breteler M.M., and Hofman A. Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam Study. Neurology 45 (1995) 1441-1445
-
(1995)
Neurology
, vol.45
, pp. 1441-1445
-
-
Andersen, K.1
Launer, L.J.2
Ott, A.3
Hoes, A.W.4
Breteler, M.M.5
Hofman, A.6
-
90
-
-
0028289083
-
Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study
-
Breitner J.C., Gau B.A., Welsh K.A., et al. Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology 44 (1994) 227-232
-
(1994)
Neurology
, vol.44
, pp. 227-232
-
-
Breitner, J.C.1
Gau, B.A.2
Welsh, K.A.3
-
91
-
-
0032450999
-
NSAIDs and incident Alzheimer's disease. The Rotterdam Study
-
in't Veld B.A., Launer L.J., Hoes A.W., et al. NSAIDs and incident Alzheimer's disease. The Rotterdam Study. Neurobiol. Aging 19 (1998) 607-611
-
(1998)
Neurobiol. Aging
, vol.19
, pp. 607-611
-
-
in't Veld, B.A.1
Launer, L.J.2
Hoes, A.W.3
-
92
-
-
47549107705
-
Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib
-
Martin B.K., Szekely C., Brandt J., et al. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch. Neurol. 65 (2008) 896-905
-
(2008)
Arch. Neurol.
, vol.65
, pp. 896-905
-
-
Martin, B.K.1
Szekely, C.2
Brandt, J.3
-
93
-
-
0015319592
-
The biologic clock: the mitochondria?
-
Harman D. The biologic clock: the mitochondria?. J. Am. Geriatr. Soc. 20 (1972) 145-147
-
(1972)
J. Am. Geriatr. Soc.
, vol.20
, pp. 145-147
-
-
Harman, D.1
-
94
-
-
38349126762
-
Mitochondrially encoded cysteine predicts animal lifespan
-
Moosmann B., and Behl C. Mitochondrially encoded cysteine predicts animal lifespan. Aging Cell 7 (2008) 32-46
-
(2008)
Aging Cell
, vol.7
, pp. 32-46
-
-
Moosmann, B.1
Behl, C.2
-
95
-
-
0029055175
-
Oxidative processes and antioxidative defence mechanisms in the aging brain
-
Reiter R.J. Oxidative processes and antioxidative defence mechanisms in the aging brain. FASEB J. 9 (1995) 526-533
-
(1995)
FASEB J.
, vol.9
, pp. 526-533
-
-
Reiter, R.J.1
-
96
-
-
0037098866
-
Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach
-
Behl C., and Moosmann B. Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach. Free Radic. Biol. Med. 33 (2002) 182-191
-
(2002)
Free Radic. Biol. Med.
, vol.33
, pp. 182-191
-
-
Behl, C.1
Moosmann, B.2
-
97
-
-
0036799799
-
Antioxidants as treatment for neurodegenerative disorders
-
Moosmann B., and Behl C. Antioxidants as treatment for neurodegenerative disorders. Expert. Opin. Investig. Drugs 11 (2002) 1407-1435
-
(2002)
Expert. Opin. Investig. Drugs
, vol.11
, pp. 1407-1435
-
-
Moosmann, B.1
Behl, C.2
-
98
-
-
33744525840
-
Age-related changes in glutathione and glutathione-related enzymes in rat brain
-
Zhu Y., Carvey P.M., and Ling Z. Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res. 1090 (2006) 35-44
-
(2006)
Brain Res.
, vol.1090
, pp. 35-44
-
-
Zhu, Y.1
Carvey, P.M.2
Ling, Z.3
-
99
-
-
0028854465
-
Studies on lipid peroxidation and protein oxidation in the aging brain
-
Cini M., and Moretti A. Studies on lipid peroxidation and protein oxidation in the aging brain. Neurobiol. Aging 16 (1995) 53-57
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 53-57
-
-
Cini, M.1
Moretti, A.2
-
100
-
-
0032412522
-
Dietary antioxidant supplementation reverses age-related neuronal changes
-
O'Donnell E., and Lynch M.A. Dietary antioxidant supplementation reverses age-related neuronal changes. Neurobiol. Aging 19 (1998) 461-467
-
(1998)
Neurobiol. Aging
, vol.19
, pp. 461-467
-
-
O'Donnell, E.1
Lynch, M.A.2
-
101
-
-
0032780281
-
Lipid peroxidation and tissue damage
-
Mylonas C., and Kouretas D. Lipid peroxidation and tissue damage. In Vivo 13 (1999) 295-309
-
(1999)
In Vivo
, vol.13
, pp. 295-309
-
-
Mylonas, C.1
Kouretas, D.2
-
102
-
-
0031840571
-
Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system
-
Keller J.N., and Mattson M.P. Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system. Rev. Neurosci. 9 (1998) 105-116
-
(1998)
Rev. Neurosci.
, vol.9
, pp. 105-116
-
-
Keller, J.N.1
Mattson, M.P.2
-
103
-
-
34447279020
-
Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment
-
Markesbery W.R., and Lovell M.A. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch. Neurol. 64 (2007) 954-956
-
(2007)
Arch. Neurol.
, vol.64
, pp. 954-956
-
-
Markesbery, W.R.1
Lovell, M.A.2
-
104
-
-
33646934160
-
Lipids and the pathogenesis of Alzheimer's disease: Is there a link?
-
Mielke M.M., and Lyketsos C.G. Lipids and the pathogenesis of Alzheimer's disease: Is there a link?. Int. Rev. Psychiatry 18 (2006) 173-186
-
(2006)
Int. Rev. Psychiatry
, vol.18
, pp. 173-186
-
-
Mielke, M.M.1
Lyketsos, C.G.2
-
105
-
-
24644487045
-
Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants
-
Abd El Mohsen M.M., Iravani M.M., et al. Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants. Biochem. Biophys. Res. Commun. 336 (2005) 386-391
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.336
, pp. 386-391
-
-
Abd El Mohsen, M.M.1
Iravani, M.M.2
-
106
-
-
33646708957
-
Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis
-
Poon H.F., Shepherd H.M., Reed T.T., et al. Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis. Neurobiol. Aging 27 (2006) 1020-1034
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 1020-1034
-
-
Poon, H.F.1
Shepherd, H.M.2
Reed, T.T.3
-
107
-
-
27644596252
-
Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats
-
Rodrigues Siqueira I., Fochesatto C., da Silva Torres I.L., Dalmaz C., and Alexandre Netto C. Aging affects oxidative state in hippocampus, hypothalamus and adrenal glands of Wistar rats. Life Sci. 78 (2005) 271-278
-
(2005)
Life Sci.
, vol.78
, pp. 271-278
-
-
Rodrigues Siqueira, I.1
Fochesatto, C.2
da Silva Torres, I.L.3
Dalmaz, C.4
Alexandre Netto, C.5
-
108
-
-
48449092905
-
Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease
-
Greilberger J., Koidl C., Greilberger M., et al. Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease. Free Radic. Res. 42 (2008) 633-638
-
(2008)
Free Radic. Res.
, vol.42
, pp. 633-638
-
-
Greilberger, J.1
Koidl, C.2
Greilberger, M.3
-
109
-
-
16844382331
-
Evidence of increased oxidative damage in subjects with mild cognitive impairment
-
Keller J.N., Schmitt F.A., Scheff S.W., et al. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology 64 (2005) 1152-1156
-
(2005)
Neurology
, vol.64
, pp. 1152-1156
-
-
Keller, J.N.1
Schmitt, F.A.2
Scheff, S.W.3
-
110
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
Bender A., Krishnan K.J., Morris C.M., et al. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat. Genet. 38 (2006) 515-517
-
(2006)
Nat. Genet.
, vol.38
, pp. 515-517
-
-
Bender, A.1
Krishnan, K.J.2
Morris, C.M.3
-
111
-
-
0027017232
-
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
-
Corral-Debrinski M., Horton T., Lott M.T., Shoffner J.M., Beal M.F., and Wallace D.C. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat. Genet. 2 (1992) 324-329
-
(1992)
Nat. Genet.
, vol.2
, pp. 324-329
-
-
Corral-Debrinski, M.1
Horton, T.2
Lott, M.T.3
Shoffner, J.M.4
Beal, M.F.5
Wallace, D.C.6
-
112
-
-
33645106680
-
Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment
-
Wang J., Markesbery W.R., and Lovell M.A. Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment. J. Neurochem. 96 (2006) 825-832
-
(2006)
J. Neurochem.
, vol.96
, pp. 825-832
-
-
Wang, J.1
Markesbery, W.R.2
Lovell, M.A.3
-
113
-
-
18844462415
-
Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease
-
Wang J., Xiong S., Xie C., Markesbery W.R., and Lovell M.A. Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J. Neurochem. 93 (2005) 953-962
-
(2005)
J. Neurochem.
, vol.93
, pp. 953-962
-
-
Wang, J.1
Xiong, S.2
Xie, C.3
Markesbery, W.R.4
Lovell, M.A.5
-
114
-
-
33645299343
-
Antioxidants as a potential therapy against age-related neurodegenerative diseases: amyloid Beta toxicity and Alzheimer's disease
-
Hajieva P., and Behl C. Antioxidants as a potential therapy against age-related neurodegenerative diseases: amyloid Beta toxicity and Alzheimer's disease. Curr. Pharm. Des. 12 (2006) 699-704
-
(2006)
Curr. Pharm. Des.
, vol.12
, pp. 699-704
-
-
Hajieva, P.1
Behl, C.2
-
115
-
-
34249978381
-
Antioxidant intake and cognitive function of elderly men and women: the Cache County Study
-
Wengreen H.J., Munger R.G., Corcoran C.D., et al. Antioxidant intake and cognitive function of elderly men and women: the Cache County Study. J. Nutr. Health Aging 11 (2007) 230-237
-
(2007)
J. Nutr. Health Aging
, vol.11
, pp. 230-237
-
-
Wengreen, H.J.1
Munger, R.G.2
Corcoran, C.D.3
-
116
-
-
36149001299
-
A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II
-
Grodstein F., Kang J.H., Glynn R.J., Cook N.R., and Gaziano J.M. A randomized trial of beta carotene supplementation and cognitive function in men: the Physicians' Health Study II. Arch. Intern. Med. 167 (2007) 2184-2190
-
(2007)
Arch. Intern. Med.
, vol.167
, pp. 2184-2190
-
-
Grodstein, F.1
Kang, J.H.2
Glynn, R.J.3
Cook, N.R.4
Gaziano, J.M.5
-
117
-
-
0030967165
-
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
-
Sano M., Ernesto C., Thomas R.G., et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N. Engl. J. Med. 336 (1997) 1216-1222
-
(1997)
N. Engl. J. Med.
, vol.336
, pp. 1216-1222
-
-
Sano, M.1
Ernesto, C.2
Thomas, R.G.3
-
119
-
-
56649112752
-
Ginkgo biloba for prevention of dementia: a randomized controlled trial
-
Dekosky S.T., Williamson J.D., Fitzpatrick A.L., et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. Jama 300 (2008) 2253-2262
-
(2008)
Jama
, vol.300
, pp. 2253-2262
-
-
Dekosky, S.T.1
Williamson, J.D.2
Fitzpatrick, A.L.3
-
120
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner G.G., and Wong C.W. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 122 (1984) 1131-1135
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
121
-
-
0022156464
-
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
-
Masters C.L., Multhaup G., Simms G., Pottgiesser J., Martins R.N., and Beyreuther K. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J. 4 (1985) 2757-2763
-
(1985)
EMBO J.
, vol.4
, pp. 2757-2763
-
-
Masters, C.L.1
Multhaup, G.2
Simms, G.3
Pottgiesser, J.4
Martins, R.N.5
Beyreuther, K.6
-
122
-
-
0026325645
-
Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
-
Haass C., Hung A.Y., and Selkoe D.J. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. J. Neurosci. 11 (1991) 3783-3793
-
(1991)
J. Neurosci.
, vol.11
, pp. 3783-3793
-
-
Haass, C.1
Hung, A.Y.2
Selkoe, D.J.3
-
123
-
-
1442264828
-
Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
-
Haass C. Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. EMBO J. 23 (2004) 483-488
-
(2004)
EMBO J.
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
124
-
-
0033616716
-
Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
-
Lammich S., Kojro E., Postina R., et al. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 3922-3927
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 3922-3927
-
-
Lammich, S.1
Kojro, E.2
Postina, R.3
-
125
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R., Bennett B.D., Babu-Khan S., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 (1999) 735-741
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
-
126
-
-
2642582435
-
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation
-
Cao X., and Sudhof T.C. Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J. Biol. Chem. 279 (2004) 24601-24611
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 24601-24611
-
-
Cao, X.1
Sudhof, T.C.2
-
127
-
-
36349024875
-
Active gamma-secretase complexes contain only one of each component
-
Sato T., Diehl T.S., Narayanan S., Funamoto S., Ihara Y., De Strooper B., Steiner H., Haass C., and Wolfe M.S. Active gamma-secretase complexes contain only one of each component. J. Biol. Chem. 282 (2007) 33985-33993
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 33985-33993
-
-
Sato, T.1
Diehl, T.S.2
Narayanan, S.3
Funamoto, S.4
Ihara, Y.5
De Strooper, B.6
Steiner, H.7
Haass, C.8
Wolfe, M.S.9
-
128
-
-
0035929554
-
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch
-
Gu Y., Misonou H., Sato T., Dohmae N., Takio K., and Ihara Y. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. J. Biol. Chem. 276 (2001) 35235-35238
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35235-35238
-
-
Gu, Y.1
Misonou, H.2
Sato, T.3
Dohmae, N.4
Takio, K.5
Ihara, Y.6
-
129
-
-
19944430034
-
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase
-
Qi-Takahara Y., Morishima-Kawashima M., Tanimura Y., et al. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J. Neurosci. 25 (2005) 436-445
-
(2005)
J. Neurosci.
, vol.25
, pp. 436-445
-
-
Qi-Takahara, Y.1
Morishima-Kawashima, M.2
Tanimura, Y.3
-
130
-
-
0026597063
-
Alzheimer's disease: the amyloid cascade hypothesis
-
Hardy J.A., and Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science 256 (1992) 184-185
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
131
-
-
45749130981
-
A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk
-
Dreses-Werringloer U., Lambert J.C., Vingtdeux V., et al. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell 133 (2008) 1149-1161
-
(2008)
Cell
, vol.133
, pp. 1149-1161
-
-
Dreses-Werringloer, U.1
Lambert, J.C.2
Vingtdeux, V.3
-
132
-
-
34248574203
-
Fifteen-year follow-up of 92 hospitalized adults with Down's syndrome: incidence of cognitive decline, its relationship to age and neuropathology
-
Margallo-Lana M.L., Moore P.B., Kay D.W., et al. Fifteen-year follow-up of 92 hospitalized adults with Down's syndrome: incidence of cognitive decline, its relationship to age and neuropathology. J. Intellect. Disabil. Res. 51 (2007) 463-477
-
(2007)
J. Intellect. Disabil. Res.
, vol.51
, pp. 463-477
-
-
Margallo-Lana, M.L.1
Moore, P.B.2
Kay, D.W.3
-
133
-
-
0024472693
-
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
-
Yankner B.A., Dawes L.R., Fisher S., Villa-Komaroff L., Oster-Granite M.L., and Neve R.L. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245 (1989) 417-420
-
(1989)
Science
, vol.245
, pp. 417-420
-
-
Yankner, B.A.1
Dawes, L.R.2
Fisher, S.3
Villa-Komaroff, L.4
Oster-Granite, M.L.5
Neve, R.L.6
-
134
-
-
0028322017
-
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
-
Suzuki N., Cheung T.T., Cai X.D., et al. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 264 (1994) 1336-1340
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
-
135
-
-
0028172886
-
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red
-
Lorenzo A., and Yankner B.A. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 12243-12247
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.A.2
-
136
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
Lambert M.P., Barlow A.K., Chromy B.A., et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 6448-6453
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
-
138
-
-
0028832354
-
Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells
-
Gitter B.D., Cox L.M., Rydel R.E., and May P.C. Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 10738-10741
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 10738-10741
-
-
Gitter, B.D.1
Cox, L.M.2
Rydel, R.E.3
May, P.C.4
-
139
-
-
0028178458
-
beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain
-
Jiang H., Burdick D., Glabe C.G., Cotman C.W., and Tenner A.J. beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J. Immunol. 152 (1994) 5050-5059
-
(1994)
J. Immunol.
, vol.152
, pp. 5050-5059
-
-
Jiang, H.1
Burdick, D.2
Glabe, C.G.3
Cotman, C.W.4
Tenner, A.J.5
-
140
-
-
1642499152
-
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
-
Abramov A.Y., Canevari L., and Duchen M.R. Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J. Neurosci. 24 (2004) 565-575
-
(2004)
J. Neurosci.
, vol.24
, pp. 565-575
-
-
Abramov, A.Y.1
Canevari, L.2
Duchen, M.R.3
-
141
-
-
33646152108
-
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression
-
Manczak M., Anekonda T.S., Henson E., Park B.S., Quinn J., and Reddy P.H. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum. Mol. Genet. 15 (2006) 1437-1449
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1437-1449
-
-
Manczak, M.1
Anekonda, T.S.2
Henson, E.3
Park, B.S.4
Quinn, J.5
Reddy, P.H.6
-
142
-
-
0027490362
-
Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes
-
Arispe N., Pollard H.B., and Rojas E. Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 10573-10577
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 10573-10577
-
-
Arispe, N.1
Pollard, H.B.2
Rojas, E.3
-
143
-
-
0030966536
-
Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons
-
Kawahara M., Arispe N., Kuroda Y., and Rojas E. Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons. Biophys. J. 73 (1997) 67-75
-
(1997)
Biophys. J.
, vol.73
, pp. 67-75
-
-
Kawahara, M.1
Arispe, N.2
Kuroda, Y.3
Rojas, E.4
-
144
-
-
0026570528
-
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
-
Mattson M.P., Cheng B., Davis D., Bryant K., Lieberburg I., and Rydel R.E. beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12 (1992) 376-389
-
(1992)
J. Neurosci.
, vol.12
, pp. 376-389
-
-
Mattson, M.P.1
Cheng, B.2
Davis, D.3
Bryant, K.4
Lieberburg, I.5
Rydel, R.E.6
-
145
-
-
0001282871
-
Amyloid beta protein-(1-42) forms calcium-permeable, Zn2+-sensitive channel
-
Rhee S.K., Quist A.P., and Lal R. Amyloid beta protein-(1-42) forms calcium-permeable, Zn2+-sensitive channel. J. Biol. Chem. 273 (1998) 13379-13382
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13379-13382
-
-
Rhee, S.K.1
Quist, A.P.2
Lal, R.3
-
146
-
-
0028233494
-
Hydrogen peroxide mediates amyloid beta protein toxicity
-
Behl C., Davis J.B., Lesley R., and Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77 (1994) 817-827
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
147
-
-
0035194145
-
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide
-
Butterfield D.A., Drake J., Pocernich C., and Castegna A. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol. Med. 7 (2001) 548-554
-
(2001)
Trends Mol. Med.
, vol.7
, pp. 548-554
-
-
Butterfield, D.A.1
Drake, J.2
Pocernich, C.3
Castegna, A.4
-
148
-
-
52649131924
-
Oxidative stress increases levels of endogenous amyloid-beta peptides secreted from primary chick brain neurons
-
Goldsbury C., Whiteman I.T., Jeong E.V., and Lim Y.A. Oxidative stress increases levels of endogenous amyloid-beta peptides secreted from primary chick brain neurons. Aging Cell 7 (2008) 771-775
-
(2008)
Aging Cell
, vol.7
, pp. 771-775
-
-
Goldsbury, C.1
Whiteman, I.T.2
Jeong, E.V.3
Lim, Y.A.4
-
149
-
-
20944444768
-
Oxidative stress potentiates BACE1 gene expression and Abeta generation
-
Tong Y., Zhou W., Fung V., et al. Oxidative stress potentiates BACE1 gene expression and Abeta generation. J. Neural. Transm. 112 (2005) 455-469
-
(2005)
J. Neural. Transm.
, vol.112
, pp. 455-469
-
-
Tong, Y.1
Zhou, W.2
Fung, V.3
-
150
-
-
56249097900
-
Neuroscience: the plaque plan
-
Abbott A. Neuroscience: the plaque plan. Nature 456 (2008) 161-164
-
(2008)
Nature
, vol.456
, pp. 161-164
-
-
Abbott, A.1
-
151
-
-
33745897301
-
The amyloid code
-
Mandavilli A. The amyloid code. Nat. Med. 12 (2006) 747-751
-
(2006)
Nat. Med.
, vol.12
, pp. 747-751
-
-
Mandavilli, A.1
-
152
-
-
0030809128
-
Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments
-
Cullen W.K., Suh Y.H., Anwyl R., and Rowan M.J. Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments. Neuroreport 8 (1997) 3213-3217
-
(1997)
Neuroreport
, vol.8
, pp. 3213-3217
-
-
Cullen, W.K.1
Suh, Y.H.2
Anwyl, R.3
Rowan, M.J.4
-
153
-
-
0035128734
-
Blockade of long-term potentiation by beta-amyloid peptides in the CA1 region of the rat hippocampus in vivo
-
Freir D.B., Holscher C., and Herron C.E. Blockade of long-term potentiation by beta-amyloid peptides in the CA1 region of the rat hippocampus in vivo. J. Neurophysiol. 85 (2001) 708-713
-
(2001)
J. Neurophysiol.
, vol.85
, pp. 708-713
-
-
Freir, D.B.1
Holscher, C.2
Herron, C.E.3
-
154
-
-
0035425615
-
Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits
-
Stephan A., Laroche S., and Davis S. Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits. J. Neurosci. 21 (2001) 5703-5714
-
(2001)
J. Neurosci.
, vol.21
, pp. 5703-5714
-
-
Stephan, A.1
Laroche, S.2
Davis, S.3
-
155
-
-
0033360356
-
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
-
Chapman P.F., White G.L., Jones M.W., et al. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat. Neurosci. 2 (1999) 271-276
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 271-276
-
-
Chapman, P.F.1
White, G.L.2
Jones, M.W.3
-
156
-
-
0036489445
-
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease
-
Westerman M.A., Cooper-Blacketer D., Mariash A., et al. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 22 (2002) 1858-1867
-
(2002)
J. Neurosci.
, vol.22
, pp. 1858-1867
-
-
Westerman, M.A.1
Cooper-Blacketer, D.2
Mariash, A.3
-
157
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz F., Tomita T., Hsieh H., et al. APP processing and synaptic function. Neuron 37 (2003) 925-937
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
-
158
-
-
29144487182
-
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo
-
Cirrito J.R., Yamada K.A., Finn M.B., et al. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 48 (2005) 913-922
-
(2005)
Neuron
, vol.48
, pp. 913-922
-
-
Cirrito, J.R.1
Yamada, K.A.2
Finn, M.B.3
-
159
-
-
33746233383
-
Synapse formation and function is modulated by the amyloid precursor protein
-
Priller C., Bauer T., Mitteregger G., Krebs B., Kretzschmar H.A., and Herms J. Synapse formation and function is modulated by the amyloid precursor protein. J. Neurosci. 26 (2006) 7212-7221
-
(2006)
J. Neurosci.
, vol.26
, pp. 7212-7221
-
-
Priller, C.1
Bauer, T.2
Mitteregger, G.3
Krebs, B.4
Kretzschmar, H.A.5
Herms, J.6
-
160
-
-
33846068084
-
Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms
-
Ting J.T., Kelley B.G., Lambert T.J., Cook D.G., and Sullivan J.M. Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 353-358
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 353-358
-
-
Ting, J.T.1
Kelley, B.G.2
Lambert, T.J.3
Cook, D.G.4
Sullivan, J.M.5
-
161
-
-
33845411954
-
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
-
Hsieh H., Boehm J., Sato C., et al. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 52 (2006) 831-843
-
(2006)
Neuron
, vol.52
, pp. 831-843
-
-
Hsieh, H.1
Boehm, J.2
Sato, C.3
-
162
-
-
0032167980
-
Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus
-
Nusser Z., Lujan R., Laube G., Roberts J.D., Molnar E., and Somogyi P. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21 (1998) 545-559
-
(1998)
Neuron
, vol.21
, pp. 545-559
-
-
Nusser, Z.1
Lujan, R.2
Laube, G.3
Roberts, J.D.4
Molnar, E.5
Somogyi, P.6
-
163
-
-
0342375000
-
Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
-
Takumi Y., Ramirez-Leon V., Laake P., Rinvik E., and Ottersen O.P. Different modes of expression of AMPA and NMDA receptors in hippocampal synapses. Nat. Neurosci. 2 (1999) 618-624
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 618-624
-
-
Takumi, Y.1
Ramirez-Leon, V.2
Laake, P.3
Rinvik, E.4
Ottersen, O.P.5
-
164
-
-
67449084098
-
{beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution
-
Gu Z., Liu W., and Yan Z. {beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution. J. Biol. Chem. 284 (2009) 10639-10649
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 10639-10649
-
-
Gu, Z.1
Liu, W.2
Yan, Z.3
-
165
-
-
58149385218
-
Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
-
Puzzo D., Privitera L., Leznik E., et al. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28 (2008) 14537-14545
-
(2008)
J. Neurosci.
, vol.28
, pp. 14537-14545
-
-
Puzzo, D.1
Privitera, L.2
Leznik, E.3
-
166
-
-
63449094785
-
Amyloid beta mediates memory formation
-
Garcia-Osta A., and Alberini C.M. Amyloid beta mediates memory formation. Learn. Mem. 16 (2009) 267-272
-
(2009)
Learn. Mem.
, vol.16
, pp. 267-272
-
-
Garcia-Osta, A.1
Alberini, C.M.2
-
167
-
-
36048982129
-
Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine
-
Blasko I., Jellinger K., Kemmler G., et al. Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine. Neurobiol. Aging 29 (2008) 1-11
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 1-11
-
-
Blasko, I.1
Jellinger, K.2
Kemmler, G.3
-
168
-
-
0242412140
-
Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk
-
Mayeux R., Honig L.S., Tang M.X., et al. Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk. Neurology 61 (2003) 1185-1190
-
(2003)
Neurology
, vol.61
, pp. 1185-1190
-
-
Mayeux, R.1
Honig, L.S.2
Tang, M.X.3
-
169
-
-
33646383889
-
Down-regulation of endogenous amyloid precursor protein processing due to cellular aging
-
Kern A., Roempp B., Prager K., Walter J., and Behl C. Down-regulation of endogenous amyloid precursor protein processing due to cellular aging. J. Biol. Chem. 281 (2006) 2405-2413
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 2405-2413
-
-
Kern, A.1
Roempp, B.2
Prager, K.3
Walter, J.4
Behl, C.5
-
170
-
-
34548847452
-
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice
-
McConlogue L., Buttini M., Anderson J.P., et al. Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice. J. Biol. Chem. 282 (2007) 26326-26334
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26326-26334
-
-
McConlogue, L.1
Buttini, M.2
Anderson, J.P.3
-
171
-
-
1542349913
-
Beta-secretase activity increases with aging in human, monkey, and mouse brain
-
Fukumoto H., Rosene D.L., Moss M.B., Raju S., Hyman B.T., and Irizarry M.C. Beta-secretase activity increases with aging in human, monkey, and mouse brain. Am. J. Pathol. 164 (2004) 719-725
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 719-725
-
-
Fukumoto, H.1
Rosene, D.L.2
Moss, M.B.3
Raju, S.4
Hyman, B.T.5
Irizarry, M.C.6
-
173
-
-
34250864717
-
Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain
-
Stockley J.H., Ravid R., and O'Neill C. Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain. FEBS Lett. 580 (2006) 6550-6560
-
(2006)
FEBS Lett.
, vol.580
, pp. 6550-6560
-
-
Stockley, J.H.1
Ravid, R.2
O'Neill, C.3
-
174
-
-
0030035294
-
Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries
-
Ghersi-Egea J.F., Gorevic P.D., Ghiso J., Frangione B., Patlak C.S., and Fenstermacher J.D. Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. J. Neurochem. 67 (1996) 880-883
-
(1996)
J. Neurochem.
, vol.67
, pp. 880-883
-
-
Ghersi-Egea, J.F.1
Gorevic, P.D.2
Ghiso, J.3
Frangione, B.4
Patlak, C.S.5
Fenstermacher, J.D.6
-
175
-
-
0034521392
-
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
Shibata M., Yamada S., Kumar S.R., et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106 (2000) 1489-1499
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.R.3
-
176
-
-
34948888151
-
Clearance of amyloid-beta by circulating lipoprotein receptors
-
Sagare A., Deane R., Bell R.D., et al. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat. Med. 13 (2007) 1029-1031
-
(2007)
Nat. Med.
, vol.13
, pp. 1029-1031
-
-
Sagare, A.1
Deane, R.2
Bell, R.D.3
-
177
-
-
0036797713
-
Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
-
Vogelgesang S., Cascorbi I., Schroeder E., et al. Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12 (2002) 535-541
-
(2002)
Pharmacogenetics
, vol.12
, pp. 535-541
-
-
Vogelgesang, S.1
Cascorbi, I.2
Schroeder, E.3
-
178
-
-
0037703255
-
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
-
Deane R., Yan S.D., Submamaryan R.K., et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9 (2003) 907-913
-
(2003)
Nat. Med.
, vol.9
, pp. 907-913
-
-
Deane, R.1
Yan, S.D.2
Submamaryan, R.K.3
-
179
-
-
0346101885
-
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
Leissring M.A., Farris W., Chang A.Y., et al. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40 (2003) 1087-1093
-
(2003)
Neuron
, vol.40
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
-
180
-
-
33750841488
-
Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit
-
Poirier R., Wolfer D.P., Welzl H., et al. Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit. Neurobiol. Dis. 24 (2006) 475-483
-
(2006)
Neurobiol. Dis.
, vol.24
, pp. 475-483
-
-
Poirier, R.1
Wolfer, D.P.2
Welzl, H.3
-
181
-
-
37549012213
-
Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels
-
Hellstrom-Lindahl E., Ravid R., and Nordberg A. Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels. Neurobiol. Aging 29 (2008) 210-221
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 210-221
-
-
Hellstrom-Lindahl, E.1
Ravid, R.2
Nordberg, A.3
-
182
-
-
27544432457
-
Neprylisin decreases uniformly in Alzheimer's disease and in normal aging
-
Russo R., Borghi R., Markesbery W., Tabaton M., and Piccini A. Neprylisin decreases uniformly in Alzheimer's disease and in normal aging. FEBS Lett. 579 (2005) 6027-6030
-
(2005)
FEBS Lett.
, vol.579
, pp. 6027-6030
-
-
Russo, R.1
Borghi, R.2
Markesbery, W.3
Tabaton, M.4
Piccini, A.5
-
183
-
-
33749475139
-
Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy
-
Miners J.S., Van Helmond Z., Chalmers K., Wilcock G., Love S., and Kehoe P.G. Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy. J. Neuropathol. Exp. Neurol. 65 (2006) 1012-1021
-
(2006)
J. Neuropathol. Exp. Neurol.
, vol.65
, pp. 1012-1021
-
-
Miners, J.S.1
Van Helmond, Z.2
Chalmers, K.3
Wilcock, G.4
Love, S.5
Kehoe, P.G.6
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