Oxidative damage in Alzheimer's disease: The metabolic dimension

International Journal of Developmental Neuroscience

Volumn 18, Issue 4-5, 2000, Pages 417-421

  Perry, George ^a   Nunomura, Akihiko ^a,c   Hirai, Keisuke ^b   Takeda, Atsushi ^a   Aliev, Gjumrakch ^a   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Alzheimer disease; Amyloid ; Lipid peroxidation; Mitochondria; Neurofibrillary tangle; Oxidative damage

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CARBONYL DERIVATIVE; NUCLEIC ACID; REACTIVE OXYGEN METABOLITE;

AGING; ALZHEIMER DISEASE; ARTICLE; BREATHING; HUMAN; LIPID PEROXIDATION; METABOLIC DISORDER; NERVE INJURY; NEUROFIBRILLARY TANGLE; NITRATION; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL;

ALZHEIMER DISEASE; HUMANS; NEURONS; OXIDATIVE STRESS;

EID: 0034237121     PISSN: 07365748     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-5748(00)00006-X     Document Type: Article

References (28)

1. Smith M.A., Sayre L.M., Monnier V.M., Perry G. Radical AGEing in Alzheimer's disease. Trends Neurosci. 18:1995;172-176.
2. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic. Biol. Med. 23:1997;134-147.
3. Perry G., Castellani R.J., Hirai K., Smith M.A. Reactive oxygen species mediate cellular damage in Alzheimer disease. J. Alzheimer's Disease. 1:1998;45-55.
4. Smith M.A., Taneda S., Richey P.L., Miyata S., Yan S.-D., Stern D., Sayre L.M., Monnier V.M., Perry G. Advanced Maillard reaction products are associated with Alzheimer disease pathology. Proc. Natl. Acad. Sci. USA. 91:1994;5710-5714.
5. Vitek M.P., Bhattacharya K., Glendening J.M., Stopa E., Vlassara H., Bucala R., Manogue K., Cerami A. Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc. Natl. Acad. Sci. USA. 91:1994;4766-4770.
6. Mattson M.P., Carney J.W., Butterfield D.A. A tombstone in Alzheimer's? Nature. 373:1995;481.
7. Hensley K., Carney J.M., Mattson M.P., Aksenova M., Harris M., Wu J.F., Floyd R.A., Butterfield D.A. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc. Natl. Acad. Sci. USA. 91:1994;3270-3274.
8. Nunomura A., Perry G., Pappolla M.A., Wade R., Hirai K., Chiba S., Smith M.A. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J. Neurosci. 19:1999;1959-1964.
9. Smith M.A., Harris P.L.R., Sayre L.M., Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl. Acad. Sci. USA. 94:1997;9866-9868.
10. Perez M., Valpuesta J.M., de Garcini E.M., Quintana C., Arrasate M., Lopez Carrascosa J.L., Rabano A., Garcia de Yebenes J., Avila J. Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy. Am. J. Pathol. 152:1998;1531-1539.
11. Smith M.A., Perry G. Protein modifications and interactions in Alzheimer's disease. Turner J.D., Beyreuther K., Theuring F. Alzheimer's Disease: Etiological Mechanisms and Therapeutic Possibilities. 1996;169-182 Springer-Verlag, Berlin.
12. Han S.H., Hulette C., Saunders A.M., Einstein G., Pericak-Vance M., Strittmatter W.J., Roses A.D., Schmechel D.E. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Exp. Neurol. 128:1994;13-26.
13. Perry G., Smith M.A., McCann C.E., Siedlak S.L., Jones P.K., Friedland R.P. Cerebrovascular muscle atrophy is a feature of Alzheimer's disease. Brain Res. 791:1998;63-66.
14. Perry G., Smith M.A. The case for vascular abnormalities in Alzheimer's disease. Current Research in Alzheimer's Disease. 3:1998;181-186.
15. Sparks D.L. Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? Ann. NY Acad. Sci. 826:1997;128-146.
16. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:1991;109-142.
17. Stueher D.J. Structure-function aspects in the nitric oxide synthases. Annu. Rev. Pharmacol. Toxicol. 37:1997;339-359.
18. Ignarro L.J. Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu. Rev. Pharmacol. Toxicol. 30:1990;535-560.
19. Dawson V.L., Dawson T.M. Nitric oxide in neuronal degeneration. Proc. Soc. Exp. Biol. 211:1996;33-40.
20. Xia Y., Dawson V.L., Dawson T.M., Snyder S.H., Zweier J.L. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cell leading to peroxynitrite-mediated cellular injury. Proc. Natl. Acad. Sci., USA. 93:1996;6770-6774.
21. Smith M.A., Harris P.L.R., Sayre L.M., Beckman J.S., Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17:1997;2653-2657.
22. Wink D.A., Mitchell J.B. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free Radic. Biol. Med. 25:1998;434-456.
23. Multhaup G., Ruppert T., Schlicksupp A., Hesse L., Bill E., Pipkorn R., Masters C.L., Beyreuther K. Copper-binding amyloid precursor undergoes a site-specific fragmentation in the reduction of hydrogen peroxide. Biochemistry. 37:1998;7224-7230.
24. Raina, A. K., Templeton, D. J., Deak, J. C., Perry, G. and Smith, M. A., NQO1, a sensitive redox indicator, is increased in Alzheimer disease. Redox Report, 1999, 4, 23-27.
25. Perry G., Nunomura A., Smith M.A. A suicide note from Alzheimer disease neurons? (News and Views). Nature Med. 4:1998;897-898.
26. Perry G., Nunomura A., Lucassen P., Lassmann H., Smith M.A. Apoptosis and Alzheimer's disease. Science. 282:1998;1268-1269.
27. Cras P., Smith M.A., Richey P.L., Siedlak S.L., Mulvihill P., Perry G. Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease. Acta Neuropathol. 89:1995;291-295.
28. Sayre L.M., Perry G., Harris P.L.R., Lin Y., Schubert K., Smith M.A. In situ redox catalysis by neurofibrillary tangles and senile plaques in Alzheimer Disease: a central role for bound transition metals. J. Neurochem. 74:2000;270-279.