Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome

Annals of the New York Academy of Sciences

Volumn 893, Issue , 1999, Pages 362-364

  Nunomura, Akihiko ^a,b   Perry, George ^a   Hirai, Keisuke ^a,c   Aliev, Gjumrakch ^a   Takeda, Atsushi ^a   Chiba, Shigeru ^b   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; GUANOSINE DERIVATIVE; RNA;

ADULT; AGED; ALZHEIMER DISEASE; BRAIN NERVE CELL; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DOWN SYNDROME; HUMAN; HUMAN TISSUE; OXIDATION; OXIDATIVE STRESS;

EID: 0033397009     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07855.x     Document Type: Conference Paper

References (7)

1. 1. Nunomura, A. et al. 1999. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J. Neurosci. 19: 1959-1964.
2. 2. Hyman, B.T., K. Marzloff & P.V. Arriagada. 1993. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J. Neuropathol. Exp. Neurol. 52: 594-600.
3. 3. Smith, M.A. et al. 1996. Oxidative damage in Alzheimer's. Nature 382: 120-121.
4. 4. Sayre, L.M. et al. 1997. 4-Hydroxynonenal-derived advance lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68: 2092-2097.
5. 5. Busciglio, J. & B.A. Yankner. 1995. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378: 776-779.
6. 6. Jovanovic, S.V., D. Clements & K. MacLeod. 1998. Biomarkers of oxidative stress are significantly elevated in Down syndrome. Free Radic. Biol. Med. 25: 1044-1048.
7. 7. Odetti, P. et al. 1998. Early glycoxidation damage in brains from Down's syndrome. Biochem. Biophys. Res. Commun. 243: 849-851.