-
1
-
-
0024362809
-
Human telomeres contain at least three types of G-rich repeat distributed non-randomly
-
Allshire RC, Dempster M et al (1989) Human telomeres contain at least three types of G-rich repeat distributed non-randomly. Nucleic Acids Res 17(12):4611-4627
-
(1989)
Nucleic Acids Res
, vol.17
, Issue.12
, pp. 4611-4627
-
-
Allshire, R.C.1
Dempster, M.2
-
2
-
-
0035851090
-
Nuclear retention of ATM at sites of DNA double strand breaks
-
Andegeko Y, Moyal L et al (2001) Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem 276(41):38224-38230
-
(2001)
J Biol Chem
, vol.276
, Issue.41
, pp. 38224-38230
-
-
Andegeko, Y.1
Moyal, L.2
-
3
-
-
0035813227
-
Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy
-
Anderson DE, Trujillo KM et al (2001) Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. J Biol Chem 276(40):37027-37033
-
(2001)
J Biol Chem
, vol.276
, Issue.40
, pp. 37027-37033
-
-
Anderson, D.E.1
Trujillo, K.M.2
-
4
-
-
0037040990
-
Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity
-
Arai K, Masutomi K et al (2002) Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity. J Biol Chem 277(10):8538-8544
-
(2002)
J Biol Chem
, vol.277
, Issue.10
, pp. 8538-8544
-
-
Arai, K.1
Masutomi, K.2
-
5
-
-
0012142942
-
Telomeric associations of gametic and somatic chromsomes in Diploid and autotetraploid Ornithogalum virens
-
Ashley T, Wagenaar EB (1974) Telomeric associations of gametic and somatic chromsomes in Diploid and autotetraploid Ornithogalum virens. Can J Genet Cytol 16:61-76
-
(1974)
Can J Genet Cytol
, vol.16
, pp. 61-76
-
-
Ashley, T.1
Wagenaar, E.B.2
-
6
-
-
0029111404
-
Increased activity of p53 in senescing fibroblasts
-
Atadja P, Wong H et al (1995) Increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sci USA 92(18):8348-8352
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.18
, pp. 8348-8352
-
-
Atadja, P.1
Wong, H.2
-
7
-
-
84983711696
-
Studies on the chemical nature of the substance inducing transformation of pneumococcal types: Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III
-
Avery OT, MacLeod CM et al (1944) Studies on the chemical nature of the substance inducing transformation of pneumococcal types: Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J Exp Med 79:137-158
-
(1944)
J Exp Med
, vol.79
, pp. 137-158
-
-
Avery, O.T.1
MacLeod, C.M.2
-
8
-
-
11244269445
-
The CDK regulates repair of double-strand breaks by homologous recombination During the cell cycle
-
Aylon Y, Liefshitz B et al (2004) The CDK regulates repair of double-strand breaks by homologous recombination During the cell cycle. EMBO J 23(24):4868-4875
-
(2004)
EMBO J
, vol.23
, Issue.24
, pp. 4868-4875
-
-
Aylon, Y.1
Liefshitz, B.2
-
9
-
-
37349043972
-
Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends
-
Azzalin CM, Reichenbach P et al (2007) Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 318(5851):798-801
-
(2007)
Science
, vol.318
, Issue.5851
, pp. 798-801
-
-
Azzalin, C.M.1
Reichenbach, P.2
-
10
-
-
0842303305
-
The kinase activity of DNA-PK is required to protect mammalian telomeres
-
Bailey SM, Brenneman MA et al (2004) The kinase activity of DNA-PK is required to protect mammalian telomeres. DNA Repair (Amst) 3(3):225-233
-
(2004)
DNA Repair (Amst
, vol.3
, Issue.3
, pp. 225-233
-
-
Bailey, S.M.1
Brenneman, M.A.2
-
11
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist CJ, Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421(6922):499-506
-
(2003)
Nature
, vol.421
, Issue.6922
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
12
-
-
0035844082
-
Pot1, the putative telomere end-binding protein in fission yeast and humans
-
Baumann P, Cech TR (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292(5519):1171-1175
-
(2001)
Science
, vol.292
, Issue.5519
, pp. 1171-1175
-
-
Baumann, P.1
Cech, T.R.2
-
13
-
-
0035874977
-
Telomere position effect in human cells
-
Baur JA, Zou Y et al (2001) Telomere position effect in human cells. Science 292(5524):2075-2077
-
(2001)
Science
, vol.292
, Issue.5524
, pp. 2075-2077
-
-
Baur, J.A.1
Zou, Y.2
-
14
-
-
0032576733
-
Reconstitution of human telomerase activity in vitro
-
Beattie TL, Zhou W et al (1998) Reconstitution of human telomerase activity in vitro. Curr Biol 8(3):177-180
-
(1998)
Curr Biol
, vol.8
, Issue.3
, pp. 177-180
-
-
Beattie, T.L.1
Zhou, W.2
-
15
-
-
0035723994
-
Functional multimerization of the human telomerase reverse transcriptase
-
Beattie TL, Zhou W et al (2001) Functional multimerization of the human telomerase reverse transcriptase. Mol Cell Biol 21(18):6151-6160
-
(2001)
Mol Cell Biol
, vol.21
, Issue.18
, pp. 6151-6160
-
-
Beattie, T.L.1
Zhou, W.2
-
16
-
-
33846590977
-
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
-
Benetti R, Garcia-Cao M et al (2007) Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet 39(2):243-250
-
(2007)
Nat Genet
, vol.39
, Issue.2
, pp. 243-250
-
-
Benetti, R.1
Garcia-Cao, M.2
-
17
-
-
40949100837
-
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases
-
Benetti R, Gonzalo S et al (2008) A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol 15(3):268-279
-
(2008)
Nat Struct Mol Biol
, vol.15
, Issue.3
, pp. 268-279
-
-
Benetti, R.1
Gonzalo, S.2
-
18
-
-
0141868298
-
The Ku heterodimer performs separable activities at doublestrand breaks and chromosome termini
-
Bertuch AA, Lundblad V (2003) The Ku heterodimer performs separable activities at doublestrand breaks and chromosome termini. Mol Cell Biol 23(22):8202-8215
-
(2003)
Mol Cell Biol
, vol.23
, Issue.22
, pp. 8202-8215
-
-
Bertuch, A.A.1
Lundblad, V.2
-
19
-
-
47549086947
-
How telomerase reaches its end: Mechanism of telomerase regulation by the telomeric complex
-
Bianchi A, Shore D (2008) How telomerase reaches its end: Mechanism of telomerase regulation by the telomeric complex. Mol Cell 31(2):153-165
-
(2008)
Mol Cell
, vol.31
, Issue.2
, pp. 153-165
-
-
Bianchi, A.1
Shore, D.2
-
20
-
-
0033570177
-
TRF1 binds a bipartite telomeric site with extreme spatial flexibility
-
Bianchi A, Stansel RM et al (1999) TRF1 binds a bipartite telomeric site with extreme spatial flexibility. EMBO J 18(20):5735-5744
-
(1999)
EMBO J
, vol.18
, Issue.20
, pp. 5735-5744
-
-
Bianchi, A.1
Stansel, R.M.2
-
21
-
-
0025574887
-
Telomeres and their synthesis
-
Blackburn EH (1990) Telomeres and their synthesis. Harvey Lect 86:1-18
-
(1990)
Harvey Lect
, vol.86
, pp. 1-18
-
-
Blackburn, E.H.1
-
22
-
-
0017833637
-
A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena
-
Blackburn EH, Gall JG (1978) A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J Mol Biol 120(1):33-53
-
(1978)
J Mol Biol
, vol.120
, Issue.1
, pp. 33-53
-
-
Blackburn, E.H.1
Gall, J.G.2
-
23
-
-
0029154735
-
Functional characterization and developmental regulation of mouse telomerase RNA
-
Blasco MA, Funk W et al (1995) Functional characterization and developmental regulation of mouse telomerase RNA. Science 269(5228):1267-1270
-
(1995)
Science
, vol.269
, Issue.5228
, pp. 1267-1270
-
-
Blasco, M.A.1
Funk, W.2
-
24
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M et al (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279(5349):349-352
-
(1998)
Science
, vol.279
, Issue.5349
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
-
25
-
-
0029843408
-
Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance
-
Boulton SJ, Jackson SP (1996a) Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res 24(23):4639-4648
-
(1996)
Nucleic Acids Res
, vol.24
, Issue.23
, pp. 4639-4648
-
-
Boulton, S.J.1
Jackson, S.P.2
-
26
-
-
0029791694
-
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways
-
Boulton SJ, Jackson SP (1996b) Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J 15(18):5093-5103
-
(1996)
EMBO J
, vol.15
, Issue.18
, pp. 5093-5103
-
-
Boulton, S.J.1
Jackson, S.P.2
-
27
-
-
0032536861
-
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
-
Boulton SJ, Jackson SP (1998) Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 17(6):1819-1828
-
(1998)
EMBO J
, vol.17
, Issue.6
, pp. 1819-1828
-
-
Boulton, S.J.1
Jackson, S.P.2
-
28
-
-
0032721091
-
The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
-
Bressan DA, Baxter BK et al (1999) The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol Cell Biol 19(11):7681-7687
-
(1999)
Mol Cell Biol
, vol.19
, Issue.11
, pp. 7681-7687
-
-
Bressan, D.A.1
Baxter, B.K.2
-
29
-
-
84984775429
-
Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
-
Broccoli DSA, Chong L, de Lange T (1997) Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 997(2):231-235
-
(1997)
Nat Genet
, vol.997
, Issue.2
, pp. 231-235
-
-
Broccoli, D.S.A.1
Chong, L.2
De Lange, T.3
-
30
-
-
0032714089
-
Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes
-
Brock GJ, Charlton J et al (1999) Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes. Gene 240(2):269-277
-
(1999)
Gene
, vol.240
, Issue.2
, pp. 269-277
-
-
Brock, G.J.1
Charlton, J.2
-
31
-
-
0030990049
-
Telomere dynamics and telomerase activity in in vitro immortalised human cells
-
Bryan TM, Reddel RR (1997) Telomere dynamics and telomerase activity in in vitro immortalised human cells. Eur J Cancer 33(5):767-773
-
(1997)
Eur J Cancer
, vol.33
, Issue.5
, pp. 767-773
-
-
Bryan, T.M.1
Reddel, R.R.2
-
32
-
-
0029162563
-
Telomere elongation in immortal human cells without detectable telomerase activity
-
Bryan TM, Englezou A et al (1995) Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14(17):4240-4248
-
(1995)
EMBO J
, vol.14
, Issue.17
, pp. 4240-4248
-
-
Bryan, T.M.1
Englezou, A.2
-
33
-
-
0030697342
-
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
-
Bryan TM, Englezou A et al (1997a) Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 3(11):1271-1274
-
(1997)
Nat Med
, vol.3
, Issue.11
, pp. 1271-1274
-
-
Bryan, T.M.1
Englezou, A.2
-
34
-
-
0030916582
-
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
-
Bryan TM, Marusic L et al (1997b) The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum Mol Genet 6(6):921-926
-
(1997)
Hum Mol Genet
, vol.6
, Issue.6
, pp. 921-926
-
-
Bryan, T.M.1
Marusic, L.2
-
35
-
-
0033636319
-
Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase
-
Bryan TM, Goodrich KJ et al (2000) Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol Cell 6(2):493-499
-
(2000)
Mol Cell
, vol.6
, Issue.2
, pp. 493-499
-
-
Bryan, T.M.1
Goodrich, K.J.2
-
36
-
-
0344875514
-
Tetrahymena telomerase is active as a monomer
-
Bryan TM, Goodrich KJ et al (2003) Tetrahymena telomerase is active as a monomer. Mol Biol Cell 14(12):4794-4804
-
(2003)
Mol Biol Cell
, vol.14
, Issue.12
, pp. 4794-4804
-
-
Bryan, T.M.1
Goodrich, K.J.2
-
37
-
-
35848962284
-
Transcription and RNAi in heterochromatic gene silencing
-
Buhler M, Moazed D (2007) Transcription and RNAi in heterochromatic gene silencing. Nat Struct Mol Biol 14(11):1041-1048
-
(2007)
Nat Struct Mol Biol
, vol.14
, Issue.11
, pp. 1041-1048
-
-
Buhler, M.1
Moazed, D.2
-
38
-
-
34948816005
-
The nature of telomere fusion and a definition of the critical telomere length in human cells
-
Capper R, Britt-Compton B et al (2007) The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev 21(19):2495-2508
-
(2007)
Genes Dev
, vol.21
, Issue.19
, pp. 2495-2508
-
-
Capper, R.1
Britt-Compton, B.2
-
40
-
-
0037033062
-
Human Ku70/80 associates physically with telomerase through interaction with hTERT
-
Chai W, Ford LP et al (2002) Human Ku70/80 associates physically with telomerase through interaction with hTERT. J Biol Chem 277(49):47242-47247
-
(2002)
J Biol Chem
, vol.277
, Issue.49
, pp. 47242-47247
-
-
Chai, W.1
Ford, L.P.2
-
41
-
-
33645800789
-
The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres
-
Chai W, Sfeir AJ et al (2006) The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep 7(2):225-230
-
(2006)
EMBO Rep
, vol.7
, Issue.2
, pp. 225-230
-
-
Chai, W.1
Sfeir, A.J.2
-
42
-
-
41749119869
-
Cell signaling Tel2 finally tells one story
-
Chang M, Lingner J (2008) Cell signaling. Tel2 finally tells one story. Science 320(5872):60-61
-
(2008)
Science
, vol.320
, Issue.5872
, pp. 60-61
-
-
Chang, M.1
Lingner, J.2
-
43
-
-
0037439107
-
Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility
-
Chen JL, Greider CW (2003a) Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J 22(2):304-314
-
(2003)
EMBO J
, vol.22
, Issue.2
, pp. 304-314
-
-
Chen, J.L.1
Greider, C.W.2
-
44
-
-
0344011566
-
Template boundary definition in mammalian telomerase
-
Chen JL, Greider CW (2003b) Template boundary definition in mammalian telomerase. Genes Dev 17(22):2747-2752
-
(2003)
Genes Dev
, vol.17
, Issue.22
, pp. 2747-2752
-
-
Chen, J.L.1
Greider, C.W.2
-
45
-
-
1842813934
-
Telomerase RNA structure and function: Implications for dyskeratosis congenita
-
Chen JL, Greider CW (2004) Telomerase RNA structure and function: Implications for dyskeratosis congenita. Trends Biochem Sci 29(4):183-192
-
(2004)
Trends Biochem Sci
, vol.29
, Issue.4
, pp. 183-192
-
-
Chen, J.L.1
Greider, C.W.2
-
46
-
-
20444374113
-
Functional analysis of the pseudoknot structure in human telomerase RNA
-
8080-8085 discussion
-
Chen JL, Greider CW (2005) Functional analysis of the pseudoknot structure in human telomerase RNA. Proc Natl Acad Sci USA 102(23):8080-8085 discussion 8077-8079
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.23
, pp. 8077-8079
-
-
Chen, J.L.1
Greider, C.W.2
-
47
-
-
0034598919
-
Secondary structure of vertebrate telomerase RNA
-
Chen JL, Blasco MA et al (2000) Secondary structure of vertebrate telomerase RNA. Cell 100(5):503-514
-
(2000)
Cell
, vol.100
, Issue.5
, pp. 503-514
-
-
Chen, J.L.1
Blasco, M.A.2
-
48
-
-
33746136947
-
Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma
-
Chen YJ, Hakin-Smith V et al (2006) Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Res 66(13):6473-6476
-
(2006)
Cancer Res
, vol.66
, Issue.13
, pp. 6473-6476
-
-
Chen, Y.J.1
Hakin-Smith, V.2
-
49
-
-
39749134753
-
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins
-
Chen Y, Yang Y et al (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319(5866):1092-1096
-
(2008)
Science
, vol.319
, Issue.5866
, pp. 1092-1096
-
-
Chen, Y.1
Yang, Y.2
-
50
-
-
0029586089
-
A human telomeric protein
-
Chong L, van Steensel B et al (1995) A human telomeric protein. Science 270(5242):1663-1667
-
(1995)
Science
, vol.270
, Issue.5242
, pp. 1663-1667
-
-
Chong, L.1
Van Steensel, B.2
-
51
-
-
0035861983
-
Crystal structure of the N-Terminal domain of Oxytricha nova telomere end-binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA
-
Classen S, Ruggles JA et al (2001) Crystal structure of the N-Terminal domain of Oxytricha nova telomere end-binding protein alpha subunit both uncomplexed and complexed with telomeric ssDNA. J Mol Biol 314(5):1113-1125
-
(2001)
J Mol Biol
, vol.314
, Issue.5
, pp. 1113-1125
-
-
Classen, S.1
Ruggles, J.A.2
-
52
-
-
34147095342
-
Protein composition of catalytically active human telomerase from immortal cells
-
Cohen SB, Graham ME et al (2007) Protein composition of catalytically active human telomerase from immortal cells. Science 315(5820):1850-1853
-
(2007)
Science
, vol.315
, Issue.5820
, pp. 1850-1853
-
-
Cohen, S.B.1
Graham, M.E.2
-
53
-
-
0038413786
-
Human POT1 facilitates telomere elongation by telomerase
-
Colgin LM, Baran K et al (2003) Human POT1 facilitates telomere elongation by telomerase. Curr Biol 13(11):942-946
-
(2003)
Curr Biol
, vol.13
, Issue.11
, pp. 942-946
-
-
Colgin, L.M.1
Baran, K.2
-
54
-
-
0032834328
-
Ciliate telomerase biochemistry
-
Collins K (1999) Ciliate telomerase biochemistry. Annu Rev Biochem 68:187-218
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 187-218
-
-
Collins, K.1
-
55
-
-
33745862398
-
The biogenesis and regulation of telomerase holoenzymes
-
Collins K (2006) The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol 7(7):484-494
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, Issue.7
, pp. 484-494
-
-
Collins, K.1
-
56
-
-
38849191137
-
Physiological assembly and activity of human telomerase complexes
-
Collins K (2008) Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev 129(1-2):91-98
-
(2008)
Mech Ageing Dev
, vol.129
, Issue.1-2
, pp. 91-98
-
-
Collins, K.1
-
57
-
-
0027275438
-
Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation
-
Collins K, Greider CW (1993) Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev 7(7B):1364-1376
-
(1993)
Genes Dev
, vol.7 B7
, pp. 1364-1376
-
-
Collins, K.1
Greider, C.W.2
-
58
-
-
33847726179
-
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells
-
Compton SA, Choi JH et al (2007) Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells. Cancer Res 67(4):1513-1519
-
(2007)
Cancer Res
, vol.67
, Issue.4
, pp. 1513-1519
-
-
Compton, S.A.1
Choi, J.H.2
-
59
-
-
0032440891
-
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
-
Counter CM, Hahn WC et al (1998) Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci USA 95(25):14723-14728
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.25
, pp. 14723-14728
-
-
Counter, C.M.1
Hahn, W.C.2
-
60
-
-
21444444520
-
How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: A view from high-resolution crystal structures
-
Court R, Chapman L et al (2005) How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: A view from high-resolution crystal structures. EMBO Rep 6(1):39-45
-
(2005)
EMBO Rep
, vol.6
, Issue.1
, pp. 39-45
-
-
Court, R.1
Chapman, L.2
-
61
-
-
45849099050
-
Living on a break: Cellular senescence as a DNA-damage response
-
d'Adda di Fagagna F (2008) Living on a break: Cellular senescence as a DNA-damage response. Nat Rev Cancer 8(7):512-522
-
(2008)
Nat Rev Cancer
, vol.8
, Issue.7
, pp. 512-522
-
-
D'Addadi Fagagna, F.1
-
62
-
-
0035822641
-
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
-
d'Adda di Fagagna F, Hande MP et al. 2001 Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol 11 15 1192-1196
-
(2001)
Curr Biol
, vol.11
, Issue.15
, pp. 1192-1196
-
-
D'Adda Di Fagagna, F.1
Hande, M.P.2
-
63
-
-
0344441890
-
A DNA damage checkpoint response in telomereinitiated senescence
-
d'Adda di Fagagna F, Reaper PM et al. 2003 A DNA damage checkpoint response in telomereinitiated senescence. Nature 426 6963 194-198
-
(2003)
Nature
, vol.426
, Issue.6963
, pp. 194-198
-
-
D'Adda Di Fagagna, F.1
Reaper, P.M.2
-
64
-
-
0036276388
-
The Mre11 complex: At the crossroads of dna repair and checkpoint signalling
-
D'Amours D, Jackson SP (2002) The Mre11 complex: At the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol 3(5):317-327
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, Issue.5
, pp. 317-327
-
-
D'Amours, D.1
Jackson, S.P.2
-
65
-
-
0018769599
-
Telomere replication and fusion in eukaryotes
-
Dancis BM, Holmquist GP (1979) Telomere replication and fusion in eukaryotes. J Theor Biol 78(2):211-224
-
(1979)
J Theor Biol
, vol.78
, Issue.2
, pp. 211-224
-
-
Dancis, B.M.1
Holmquist, G.P.2
-
66
-
-
3142532677
-
A phylogenetically based secondary structure for the yeast telomerase RNA
-
Dandjinou AT, Levesque N et al (2004) A phylogenetically based secondary structure for the yeast telomerase RNA. Curr Biol 14(13):1148-1158
-
(2004)
Curr Biol
, vol.14
, Issue.13
, pp. 1148-1158
-
-
Dandjinou, A.T.1
Levesque, N.2
-
67
-
-
24944460598
-
Shelterin: The protein complex that shapes and safeguards human telomeres
-
de Lange T (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev 19(18):2100-2110
-
(2005)
Genes Dev
, vol.19
, Issue.18
, pp. 2100-2110
-
-
De Lange, T.1
-
68
-
-
0025115349
-
Structure and variability of human chromosome ends
-
de Lange T, Shiue L et al (1990) Structure and variability of human chromosome ends. Mol Cell Biol 10(2):518-527
-
(1990)
Mol Cell Biol
, vol.10
, Issue.2
, pp. 518-527
-
-
De Lange, T.1
Shiue, L.2
-
69
-
-
34548317418
-
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
-
Denchi EL, de Lange T (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448(7157):1068-1071
-
(2007)
Nature
, vol.448
, Issue.7157
, pp. 1068-1071
-
-
Denchi, E.L.1
De Lange, T.2
-
70
-
-
0027970713
-
DNA damage triggers a prolonged p53-dependent G1 arrest and long-Term induction of Cip1 in normal human fibroblasts
-
Di Leonardo A, Linke SP et al (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-Term induction of Cip1 in normal human fibroblasts. Genes Dev 8(21):2540-2551
-
(1994)
Genes Dev
, vol.8
, Issue.21
, pp. 2540-2551
-
-
Di Leonardo, A.1
Linke, S.P.2
-
71
-
-
0033598944
-
Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
-
Diede SJ, Gottschling DE (1999) Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell 99(7):723-733
-
(1999)
Cell
, vol.99
, Issue.7
, pp. 723-733
-
-
Diede, S.J.1
Gottschling, D.E.2
-
72
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92(20):9363-9367
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.20
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
-
73
-
-
0037102196
-
The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells
-
Dimri GP, Martinez JL et al (2002) The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 62(16):4736-4745
-
(2002)
Cancer Res
, vol.62
, Issue.16
, pp. 4736-4745
-
-
Dimri, G.P.1
Martinez, J.L.2
-
74
-
-
0033214013
-
Est1 and Cdc13 as comediators of telomerase access
-
Evans SK, Lundblad V (1999) Est1 and Cdc13 as comediators of telomerase access. Science 286(5437):117-120
-
(1999)
Science
, vol.286
, Issue.5437
, pp. 117-120
-
-
Evans, S.K.1
Lundblad, V.2
-
75
-
-
0030807761
-
Coordinate regulation of G- And C strand length during new telomere synthesis
-
Fan X, Price CM (1997) Coordinate regulation of G- And C strand length during new telomere synthesis. Mol Biol Cell 8(11):2145-2155
-
(1997)
Mol Biol Cell
, vol.8
, Issue.11
, pp. 2145-2155
-
-
Fan, X.1
Price, C.M.2
-
76
-
-
0029096515
-
The RNA component of human telomerase
-
Feng J, Funk WD et al (1995) The RNA component of human telomerase. Science 269(5228):1236-1241
-
(1995)
Science
, vol.269
, Issue.5228
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
-
77
-
-
0036237039
-
Oncogenic ras and p53 cooperate to induce cellular senescence
-
Ferbeyre G, de Stanchina E et al (2002) Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol 22(10):3497-3508
-
(2002)
Mol Cell Biol
, vol.22
, Issue.10
, pp. 3497-3508
-
-
Ferbeyre, G.1
De Stanchina, E.2
-
78
-
-
16544390953
-
Cell cycle-dependent regulation of yeast telomerase by Ku
-
Fisher TS, Taggart AK et al (2004) Cell cycle-dependent regulation of yeast telomerase by Ku. Nat Struct Mol Biol 11(12):1198-1205
-
(2004)
Nat Struct Mol Biol
, vol.11
, Issue.12
, pp. 1198-1205
-
-
Fisher, T.S.1
Taggart, A.K.2
-
79
-
-
0032554620
-
Effect of DNA secondary structure on human telomerase activity
-
Fletcher TM, Sun D et al (1998) Effect of DNA secondary structure on human telomerase activity. Biochemistry 37(16):5536-5541
-
(1998)
Biochemistry
, vol.37
, Issue.16
, pp. 5536-5541
-
-
Fletcher, T.M.1
Sun, D.2
-
80
-
-
17644372030
-
Telomerase limits the extent of base pairing between template RNA and telomeric DNA
-
Forstemann K, Lingner J (2005) Telomerase limits the extent of base pairing between template RNA and telomeric DNA. EMBO Rep 6(4):361-366
-
(2005)
EMBO Rep
, vol.6
, Issue.4
, pp. 361-366
-
-
Forstemann, K.1
Lingner, J.2
-
81
-
-
0032699279
-
Essential functions of amino-Terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants
-
Friedman KL, Cech TR (1999) Essential functions of amino-Terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev 13(21):2863-2874
-
(1999)
Genes Dev
, vol.13
, Issue.21
, pp. 2863-2874
-
-
Friedman, K.L.1
Cech, T.R.2
-
82
-
-
36749010238
-
Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
-
Fu D, Collins K (2007) Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell 28(5):773-785
-
(2007)
Mol Cell
, vol.28
, Issue.5
, pp. 773-785
-
-
Fu, D.1
Collins, K.2
-
83
-
-
0036843088
-
A role for the Rb family of proteins in controlling telomere length
-
Garcia-Cao M, Gonzalo S et al (2002) A role for the Rb family of proteins in controlling telomere length. Nat Genet 32(3):415-419
-
(2002)
Nat Genet
, vol.32
, Issue.3
, pp. 415-419
-
-
Garcia-Cao, M.1
Gonzalo, S.2
-
84
-
-
0034106722
-
ATM-dependent phosphorylation of nibrin in response to radiation exposure
-
Gatei M, Young D et al (2000) ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 25(1):115-119
-
(2000)
Nat Genet
, vol.25
, Issue.1
, pp. 115-119
-
-
Gatei, M.1
Young, D.2
-
85
-
-
33750695316
-
Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling
-
Gavory G, Symmons MF et al (2006) Structural analysis of the catalytic core of human telomerase RNA by FRET and molecular modeling. Biochemistry 45(44):13304-13311
-
(2006)
Biochemistry
, vol.45
, Issue.44
, pp. 13304-13311
-
-
Gavory, G.1
Symmons, M.F.2
-
86
-
-
53349161932
-
Structure of the Tribolium castaneum telomerase catalytic subunit TERT
-
Gillis AJ, Schuller AP et al (2008) Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature 455(7213):633-637
-
(2008)
Nature
, vol.455
, Issue.7213
, pp. 633-637
-
-
Gillis, A.J.1
Schuller, A.P.2
-
87
-
-
0028246339
-
The yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA quadruplexes in telomeric DNA
-
Giraldo R, Rhodes D (1994) The yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA quadruplexes in telomeric DNA. EMBO J 13(10):2411-2420
-
(1994)
EMBO J
, vol.13
, Issue.10
, pp. 2411-2420
-
-
Giraldo, R.1
Rhodes, D.2
-
88
-
-
25144491542
-
Role of Rb family in the epigenetic definition of chromatin
-
Gonzalo S, Blasco MA (2005) Role of Rb family in the epigenetic definition of chromatin. Cell Cycle 4(6):752-755
-
(2005)
Cell Cycle
, vol.4
, Issue.6
, pp. 752-755
-
-
Gonzalo, S.1
Blasco, M.A.2
-
89
-
-
20244376464
-
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
-
Gonzalo S, Garcia-Cao M et al (2005) Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol 7(4):420-428
-
(2005)
Nat Cell Biol
, vol.7
, Issue.4
, pp. 420-428
-
-
Gonzalo, S.1
Garcia-Cao, M.2
-
90
-
-
33645702660
-
DNA methyltransferases control telomere length and telomere recombination in mammalian cells
-
Gonzalo S, Jaco I et al (2006) DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol 8(4):416-424
-
(2006)
Nat Cell Biol
, vol.8
, Issue.4
, pp. 416-424
-
-
Gonzalo, S.1
Jaco, I.2
-
91
-
-
0032076127
-
Yeast Ku as a regulator of chromosomal DNA end structure
-
Gravel S, Larrivée M, Labrecque P, Wellinger R (1998) Yeast Ku as a regulator of chromosomal DNA end structure. Science 280(5364):741-744
-
(1998)
Science
, vol.280
, Issue.5364
, pp. 741-744
-
-
Gravel, S.1
Larrivée, M.2
Labrecque, P.3
Wellinger, R.4
-
92
-
-
0025914141
-
Telomerase is processive
-
Greider CW (1991) Telomerase is processive. Mol Cell Biol 11(9):4572-4580
-
(1991)
Mol Cell Biol
, vol.11
, Issue.9
, pp. 4572-4580
-
-
Greider, C.W.1
-
93
-
-
0031939872
-
Telomerase activity, cell proliferation, and cancer
-
Greider CW (1998) Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci USA 95(1):90-92
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.1
, pp. 90-92
-
-
Greider, C.W.1
-
94
-
-
0022402513
-
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
-
Greider CW, Blackburn EH (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43(2 Pt 1):405-413
-
(1985)
Cell 43
, vol.2
, Issue.PART 1
, pp. 405-413
-
-
Greider, C.W.1
Blackburn, E.H.2
-
95
-
-
0023663881
-
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
-
Greider CW, Blackburn EH (1987) The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51(6):887-898
-
(1987)
Cell
, vol.51
, Issue.6
, pp. 887-898
-
-
Greider, C.W.1
Blackburn, E.H.2
-
96
-
-
0024978857
-
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
-
Greider CW, Blackburn EH (1989) A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337(6205):331-337
-
(1989)
Nature
, vol.337
, Issue.6205
, pp. 331-337
-
-
Greider, C.W.1
Blackburn, E.H.2
-
97
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith JD, Comeau L et al (1999) Mammalian telomeres end in a large duplex loop. Cell 97(4):503-514
-
(1999)
Cell
, vol.97
, Issue.4
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
-
98
-
-
48249112529
-
A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice
-
Gu BW, Bessler M et al (2008) A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice. Proc Natl Acad Sci USA 105(29):10173-10178
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.29
, pp. 10173-10178
-
-
Gu, B.W.1
Bessler, M.2
-
99
-
-
36248952723
-
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
-
Guo X, Deng Y et al (2007) Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J 26(22):4709-4719
-
(2007)
EMBO J
, vol.26
, Issue.22
, pp. 4709-4719
-
-
Guo, X.1
Deng, Y.2
-
100
-
-
0035823233
-
NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains
-
Hanaoka S, Nagadoi A et al (2001) NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains. J Mol Biol 312(1):167-175
-
(2001)
J Mol Biol
, vol.312
, Issue.1
, pp. 167-175
-
-
Hanaoka, S.1
Nagadoi, A.2
-
101
-
-
0025279931
-
Telomeres shorten During ageing of human fibroblasts
-
Harley CB, Futcher AB et al (1990) Telomeres shorten During ageing of human fibroblasts. Nature 345(6274):458-460
-
(1990)
Nature
, vol.345
, Issue.6274
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
-
102
-
-
0026628668
-
The telomere hypothesis of cellular aging
-
Harley CB, Vaziri H et al (1992) The telomere hypothesis of cellular aging. Exp Gerontol 27(4):375-382
-
(1992)
Exp Gerontol
, vol.27
, Issue.4
, pp. 375-382
-
-
Harley, C.B.1
Vaziri, H.2
-
103
-
-
5444247905
-
Does the reservoir for self-renewal stem from the ends?
-
Harrington L (2004) Does the reservoir for self-renewal stem from the ends?. Oncogene 23(43):7283-7289
-
(2004)
Oncogene
, vol.23
, Issue.43
, pp. 7283-7289
-
-
Harrington, L.1
-
104
-
-
0025743438
-
Telomerase primer specificity and chromosome healing
-
Harrington LA, Greider CW (1991) Telomerase primer specificity and chromosome healing. Nature 353(6343):451-454
-
(1991)
Nature
, vol.353
, Issue.6343
, pp. 451-454
-
-
Harrington, L.A.1
Greider, C.W.2
-
105
-
-
0028917465
-
Gel shift and UV cross-linking analysis of Tetrahymena telomerase
-
Harrington L, Hull C et al (1995) Gel shift and UV cross-linking analysis of Tetrahymena telomerase. J Biol Chem 270(15):8893-8901
-
(1995)
J Biol Chem
, vol.270
, Issue.15
, pp. 8893-8901
-
-
Harrington, L.1
Hull, C.2
-
106
-
-
0030668722
-
Human telomerase contains evolutionarily conserved catalytic and structural subunits
-
Harrington L, Zhou W et al (1997) Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev 11(23):3109-3115
-
(1997)
Genes Dev
, vol.11
, Issue.23
, pp. 3109-3115
-
-
Harrington, L.1
Zhou, W.2
-
107
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie ND, Dempster M et al (1990) Telomere reduction in human colorectal carcinoma and with ageing. Nature 346(6287):866-868
-
(1990)
Nature
, vol.346
, Issue.6287
, pp. 866-868
-
-
Hastie, N.D.1
Dempster, M.2
-
108
-
-
0344622606
-
The serial cultivation of human Diploid cell strains
-
Hayflick L, Moorhead PS (1961) The serial cultivation of human Diploid cell strains. Exp Cell Res 25:585-621
-
(1961)
Exp Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
109
-
-
0031799895
-
X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions
-
Heiss NS, Knight SW et al (1998) X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet 19(1):32-38
-
(1998)
Nat Genet
, vol.19
, Issue.1
, pp. 32-38
-
-
Heiss, N.S.1
Knight, S.W.2
-
110
-
-
0034669532
-
Wild-derived inbred mouse strains have short telomeres
-
Hemann MT, Greider CW (2000) Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res 28(22):4474-4478
-
(2000)
Nucleic Acids Res
, vol.28
, Issue.22
, pp. 4474-4478
-
-
Hemann, M.T.1
Greider, C.W.2
-
111
-
-
0035812845
-
The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
-
Hemann MT, Strong MA et al (2001) The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107(1):67-77
-
(2001)
Cell
, vol.107
, Issue.1
, pp. 67-77
-
-
Hemann, M.T.1
Strong, M.A.2
-
112
-
-
0023663911
-
Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs
-
Henderson E, Hardin CC et al (1987) Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs. Cell 51(6):899-908
-
(1987)
Cell
, vol.51
, Issue.6
, pp. 899-908
-
-
Henderson, E.1
Hardin, C.C.2
-
113
-
-
0037148281
-
Alternative lengthening of telomeres in mammalian cells
-
Henson JD, Neumann AA et al (2002) Alternative lengthening of telomeres in mammalian cells. Oncogene 21(4):598-610
-
(2002)
Oncogene
, vol.21
, Issue.4
, pp. 598-610
-
-
Henson, J.D.1
Neumann, A.A.2
-
114
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a
-
Herbig U, Jobling WA et al (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14(4):501-513
-
(2004)
Mol Cell
, vol.14
, Issue.4
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
-
115
-
-
33745685066
-
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
-
Hockemeyer D, Daniels JP et al (2006) Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 126(1):63-77
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 63-77
-
-
Hockemeyer, D.1
Daniels, J.P.2
-
116
-
-
38849087253
-
Telomeric RNA enters the game
-
Horard B, Gilson E (2008) Telomeric RNA enters the game. Nat Cell Biol 10(2):113-115
-
(2008)
Nat Cell Biol
, vol.10
, Issue.2
, pp. 113-115
-
-
Horard, B.1
Gilson, E.2
-
117
-
-
4544258775
-
A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2
-
Houghtaling BR, Cuttonaro L et al (2004) A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2. Curr Biol 14(18):1621-1631
-
(2004)
Curr Biol
, vol.14
, Issue.18
, pp. 1621-1631
-
-
Houghtaling, B.R.1
Cuttonaro, L.2
-
118
-
-
37149034478
-
Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control
-
Houseley J, Kotovic K et al (2007) Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control. EMBO J 26(24):4996-5006
-
(2007)
EMBO J
, vol.26
, Issue.24
, pp. 4996-5006
-
-
Houseley, J.1
Kotovic, K.2
-
119
-
-
0033607160
-
Ku is associated with the telomere in mammals
-
Hsu HL, Gilley D et al (1999) Ku is associated with the telomere in mammals. Proc Natl Acad Sci USA 96(22):12454-12458
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, Issue.22
, pp. 12454-12458
-
-
Hsu, H.L.1
Gilley, D.2
-
120
-
-
0034669104
-
Ku acts in a unique way at the mammalian telomere to prevent end joining
-
Hsu HL, Gilley D et al (2000) Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev 14(22):2807-2812
-
(2000)
Genes Dev
, vol.14
, Issue.22
, pp. 2807-2812
-
-
Hsu, H.L.1
Gilley, D.2
-
121
-
-
33746211311
-
Telomere length homeostasis
-
Hug N, Lingner J (2006) Telomere length homeostasis. Chromosoma 115(6):413-425
-
(2006)
Chromosoma
, vol.115
, Issue.6
, pp. 413-425
-
-
Hug, N.1
Lingner, J.2
-
122
-
-
33646250688
-
The retinoblastoma protein regulates pericentric heterochromatin
-
Isaac CE, Francis SM et al (2006) The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol 26(9):3659-3671
-
(2006)
Mol Cell Biol
, vol.26
, Issue.9
, pp. 3659-3671
-
-
Isaac, C.E.1
Francis, S.M.2
-
123
-
-
0028791446
-
DNA double-strand break repair and V(D J recombination: Involvement of DNA-PK
-
Jackson SP, Jeggo PA (1995) DNA double-strand break repair and V(D)J recombination: Involvement of DNA-PK. Trends Biochem Sci 20(10):412-415
-
(1995)
Trends Biochem Sci
, vol.20
, Issue.10
, pp. 412-415
-
-
Jackson, S.P.1
Jeggo, P.A.2
-
124
-
-
0037623348
-
Generation of telomeric G strand overhangs involves both G and C strand cleavage
-
Jacob NK, Kirk KE et al (2003) Generation of telomeric G strand overhangs involves both G and C strand cleavage. Mol Cell 11(4):1021-1032
-
(2003)
Mol Cell
, vol.11
, Issue.4
, pp. 1021-1032
-
-
Jacob, N.K.1
Kirk, K.E.2
-
125
-
-
33644800744
-
Crystal structure of the essential N-Terminal domain of telomerase reverse transcriptase
-
Jacobs SA, Podell ER et al (2006) Crystal structure of the essential N-Terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol 13(3):218-225
-
(2006)
Nat Struct Mol Biol
, vol.13
, Issue.3
, pp. 218-225
-
-
Jacobs, S.A.1
Podell, E.R.2
-
126
-
-
0031773760
-
Identification of genes involved in repair of DNA double-strand breaks in mammalian cells
-
5 Suppl
-
Jeggo PA (1998) Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat Res 150(5 Suppl):S80-S91
-
(1998)
Radiat Res
, vol.150
-
-
Jeggo, P.A.1
-
127
-
-
34447559500
-
Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference
-
Jiang WQ, Zhong ZH et al (2007) Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference. Oncogene 26(32):4635-4647
-
(2007)
Oncogene
, vol.26
, Issue.32
, pp. 4635-4647
-
-
Jiang, W.Q.1
Zhong, Z.H.2
-
128
-
-
49649090009
-
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease
-
Jiang H, Schiffer E et al (2008) Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci USA 105(32):11299-11304
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.32
, pp. 11299-11304
-
-
Jiang, H.1
Schiffer, E.2
-
129
-
-
41149104371
-
Dyskerin is a component of the arabidopsis telomerase RNP required for telomere maintenance
-
Kannan K, Nelson AD et al (2008) Dyskerin is a component of the arabidopsis telomerase RNP required for telomere maintenance. Mol Cell Biol 28(7):2332-2341
-
(2008)
Mol Cell Biol
, vol.28
, Issue.7
, pp. 2332-2341
-
-
Kannan, K.1
Nelson, A.D.2
-
130
-
-
27144554038
-
Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres
-
Kanoh J, Sadaie M et al (2005) Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. Curr Biol 15(20):1808-1819
-
(2005)
Curr Biol
, vol.15
, Issue.20
, pp. 1808-1819
-
-
Kanoh, J.1
Sadaie, M.2
-
131
-
-
0038025489
-
Telomere repeat binding factors: Keeping the ends in check
-
Karlseder J (2003) Telomere repeat binding factors: Keeping the ends in check. Cancer Lett 194(2):189-197
-
(2003)
Cancer Lett
, vol.194
, Issue.2
, pp. 189-197
-
-
Karlseder, J.1
-
132
-
-
0033605145
-
P53- And ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder J, Broccoli D et al (1999) p53- And ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283(5406):1321-1325
-
(1999)
Science
, vol.283
, Issue.5406
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
-
133
-
-
0036850323
-
Telomerase: Biochemical considerations for enzyme and substrate
-
Kelleher C, Teixeira MT et al (2002) Telomerase: Biochemical considerations for enzyme and substrate. Trends Biochem Sci 27(11):572-579
-
(2002)
Trends Biochem Sci
, vol.27
, Issue.11
, pp. 572-579
-
-
Kelleher, C.1
Teixeira, M.T.2
-
134
-
-
11844280894
-
Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro
-
Kelleher C, Kurth I et al (2005) Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. Mol Cell Biol 25(2):808-818
-
(2005)
Mol Cell Biol
, vol.25
, Issue.2
, pp. 808-818
-
-
Kelleher, C.1
Kurth, I.2
-
135
-
-
0032727616
-
TIN2, a new regulator of telomere length in human cells
-
Kim SH, Kaminker P et al (1999) TIN2, a new regulator of telomere length in human cells. Nat Genet 23(4):405-412
-
(1999)
Nat Genet
, vol.23
, Issue.4
, pp. 405-412
-
-
Kim, S.H.1
Kaminker, P.2
-
136
-
-
6344289975
-
TIN2 mediates functions of TRF2 at human telomeres
-
Kim SH, Beausejour C et al (2004) TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem 279(42):43799-43804
-
(2004)
J Biol Chem
, vol.279
, Issue.42
, pp. 43799-43804
-
-
Kim, S.H.1
Beausejour, C.2
-
137
-
-
0031180154
-
Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae
-
Kironmai KM, Muniyappa K (1997) Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes Cells 2(7):443-455
-
(1997)
Genes Cells
, vol.2
, Issue.7
, pp. 443-455
-
-
Kironmai, K.M.1
Muniyappa, K.2
-
138
-
-
0035800767
-
Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks
-
Kishi S, Zhou XZ et al (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem 276(31):29282-29291
-
(2001)
J Biol Chem
, vol.276
, Issue.31
, pp. 29282-29291
-
-
Kishi, S.1
Zhou, X.Z.2
-
139
-
-
27544460718
-
Extended longevity and insulin signaling in adipose tissue
-
Kloting N, Bluher M (2005) Extended longevity and insulin signaling in adipose tissue. Exp Gerontol 40(11):878-883
-
(2005)
Exp Gerontol
, vol.40
, Issue.11
, pp. 878-883
-
-
Kloting, N.1
Bluher, M.2
-
140
-
-
2642653129
-
Sequence-specific DNA recognition by the myb-like domain of the human telomere binding protein TRF1: A model for the protein-DNA complex
-
Konig P, Fairall L et al (1998) Sequence-specific DNA recognition by the myb-like domain of the human telomere binding protein TRF1: A model for the protein-DNA complex. Nucleic Acids Res 26(7):1731-1740
-
(1998)
Nucleic Acids Res
, vol.26
, Issue.7
, pp. 1731-1740
-
-
Konig, P.1
Fairall, L.2
-
141
-
-
0028924516
-
Increased p53 protein associated with aging in human Diploid fibroblasts
-
Kulju KS, Lehman JM (1995) Increased p53 protein associated with aging in human Diploid fibroblasts. Exp Cell Res 217(2):336-345
-
(1995)
Exp Cell Res
, vol.217
, Issue.2
, pp. 336-345
-
-
Kulju, K.S.1
Lehman, J.M.2
-
142
-
-
0027326367
-
RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae
-
Kyrion G, Liu K et al (1993) RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev 7(7A):1146-1159
-
(1993)
Genes Dev
, vol.7 A7
, pp. 1146-1159
-
-
Kyrion, G.1
Liu, K.2
-
143
-
-
0035144580
-
RNA binding domain of telomerase reverse transcriptase
-
Lai CK, Mitchell JR et al (2001) RNA binding domain of telomerase reverse transcriptase. Mol Cell Biol 21(4):990-1000
-
(2001)
Mol Cell Biol
, vol.21
, Issue.4
, pp. 990-1000
-
-
Lai, C.K.1
Mitchell, J.R.2
-
144
-
-
0029776793
-
Determination of life-span in Caenorhabditis elegans by four clock genes
-
Lakowski B, Hekimi S (1996) Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272(5264):1010-1013
-
(1996)
Science
, vol.272
, Issue.5264
, pp. 1010-1013
-
-
Lakowski, B.1
Hekimi, S.2
-
145
-
-
2942644725
-
The generation of proper constitutive G-Tails on yeast telomeres is dependent on the MRX complex
-
Larrivee M, LeBel C et al (2004) The generation of proper constitutive G-Tails on yeast telomeres is dependent on the MRX complex. Genes Dev 18(12):1391-1396
-
(2004)
Genes Dev
, vol.18
, Issue.12
, pp. 1391-1396
-
-
Larrivee, M.1
LeBel, C.2
-
146
-
-
4544379480
-
DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase
-
Lee GE, Yu EY et al (2004) DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase. J Biol Chem 279(33):34750-34755
-
(2004)
J Biol Chem
, vol.279
, Issue.33
, pp. 34750-34755
-
-
Lee, G.E.1
Yu, E.Y.2
-
147
-
-
40549099084
-
Striking similarities in Diverse telomerase proteins revealed by combining structure prediction and machine learning approaches
-
Lee JH, Hamilton M et al (2008) Striking similarities in Diverse telomerase proteins revealed by combining structure prediction and machine learning approaches. Pac Symp Biocomput: 501-512
-
(2008)
Pac Symp Biocomput
, pp. 501-512
-
-
Lee, J.H.1
Hamilton, M.2
-
148
-
-
12844265975
-
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
-
Lei M, Podell ER et al (2004) Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol 11(12): 1223-1229
-
(2004)
Nat Struct Mol Biol
, vol.11
, Issue.12
, pp. 1223-1229
-
-
Lei, M.1
Podell, E.R.2
-
149
-
-
0030455861
-
Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
-
Lendvay TS, Morris DK et al (1996) Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144(4):1399-1412
-
(1996)
Genetics
, vol.144
, Issue.4
, pp. 1399-1412
-
-
Lendvay, T.S.1
Morris, D.K.2
-
150
-
-
0022351501
-
Effects of genomic position on the expression of transduced copies of the white gene of Drosophila
-
Levis R, Hazelrigg T et al (1985) Effects of genomic position on the expression of transduced copies of the white gene of Drosophila. Science 229(4713):558-561
-
(1985)
Science
, vol.229
, Issue.4713
, pp. 558-561
-
-
Levis, R.1
Hazelrigg, T.2
-
151
-
-
0035971076
-
Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex
-
Li B, Comai L (2001) Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. J Biol Chem 276(13):9896-9902
-
(2001)
J Biol Chem
, vol.276
, Issue.13
, pp. 9896-9902
-
-
Li, B.1
Comai, L.2
-
152
-
-
0036714151
-
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein
-
Li B, Comai L (2002) Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Nucleic Acids Res 30(17):3653-3661
-
(2002)
Nucleic Acids Res
, vol.30
, Issue.17
, pp. 3653-3661
-
-
Li, B.1
Comai, L.2
-
153
-
-
0034716904
-
Identification of human Rap1: Implications for telomere evolution
-
Li B, Oestreich S et al (2000) Identification of human Rap1: Implications for telomere evolution. Cell 101(5):471-483
-
(2000)
Cell
, vol.101
, Issue.5
, pp. 471-483
-
-
Li, B.1
Oestreich, S.2
-
154
-
-
0037154171
-
Ku86 is essential in human somatic cells
-
Li G, Nelsen C et al (2002) Ku86 is essential in human somatic cells. Proc Natl Acad Sci USA 99(2):832-837
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.2
, pp. 832-837
-
-
Li, G.1
Nelsen, C.2
-
155
-
-
0034611728
-
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
-
Lim DS, Kim ST et al (2000) ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404(6778):613-617
-
(2000)
Nature
, vol.404
, Issue.6778
, pp. 613-617
-
-
Lim, D.S.1
Kim, S.T.2
-
156
-
-
34948872046
-
Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
-
Limbo O, Chahwan C et al (2007) Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol Cell 28(1):134-146
-
(2007)
Mol Cell
, vol.28
, Issue.1
, pp. 134-146
-
-
Limbo, O.1
Chahwan, C.2
-
157
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin AW, Barradas M et al (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 12(19):3008-3019
-
(1998)
Genes Dev
, vol.12
, Issue.19
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
-
158
-
-
0029763191
-
Purification of telomerase from Euplotes aediculatus: Requirement of a primer 3c overhang
-
Lingner J, Cech TR (1996) Purification of telomerase from Euplotes aediculatus: Requirement of a primer 3c overhang. Proc Natl Acad Sci USA 93(20):10712-10717
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, Issue.20
, pp. 10712-10717
-
-
Lingner, J.1
Cech, T.R.2
-
159
-
-
0030938901
-
Reverse transcriptase motifs in the catalytic subunit of telomerase
-
Lingner J, Hughes TR et al (1997) Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276(5312):561-567
-
(1997)
Science
, vol.276
, Issue.5312
, pp. 561-567
-
-
Lingner, J.1
Hughes, T.R.2
-
160
-
-
10944240539
-
Telosome, a mammalian telomere-Associated complex formed by multiple telomeric proteins
-
Liu D, O'Connor MS et al (2004a) Telosome, a mammalian telomere-Associated complex formed by multiple telomeric proteins. J Biol Chem 279(49):51338-51342
-
(2004)
J Biol Chem
, vol.279
, Issue.49
, pp. 51338-51342
-
-
Liu, D.1
O'Connor, M.S.2
-
161
-
-
3242680818
-
PTOP interacts with POT1 and regulates its localization to telomeres
-
Liu D, Safari A et al (2004b) PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol 6(7):673-680
-
(2004)
Nat Cell Biol
, vol.6
, Issue.7
, pp. 673-680
-
-
Liu, D.1
Safari, A.2
-
162
-
-
36749034760
-
Telomere lengthening early in Development
-
Liu L, Bailey SM et al (2007) Telomere lengthening early in Development. Nat Cell Biol 9(12):1436-1441
-
(2007)
Nat Cell Biol
, vol.9
, Issue.12
, pp. 1436-1441
-
-
Liu, L.1
Bailey, S.M.2
-
164
-
-
4644354584
-
Adding to the ends: What makes telomerase processive and how important is it?
-
Lue NF (2004) Adding to the ends: What makes telomerase processive and how important is it?. Bioessays 26(9):955-962
-
(2004)
Bioessays
, vol.26
, Issue.9
, pp. 955-962
-
-
Lue, N.F.1
-
165
-
-
55949106494
-
The rat1p 5¢ to 3¢ exonuclease degrades telomeric repeat-containing rna and promotes telomere elongation in saccharomyces cerevisiae
-
Luke B, Panza A et al (2008) The Rat1p 5¢ to 3¢ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae. Mol Cell 32(4):465-477
-
(2008)
Mol Cell
, vol.32
, Issue.4
, pp. 465-477
-
-
Luke, B.1
Panza, A.2
-
166
-
-
0034705495
-
Molecular biology Telomeres keep on rappin
-
Lundblad V (2000) Molecular biology. Telomeres keep on rappin. Science 288(5474):2141-2142
-
(2000)
Science
, vol.288
, Issue.5474
, pp. 2141-2142
-
-
Lundblad, V.1
-
167
-
-
0038188748
-
Telomere replication: An Est fest
-
Lundblad V (2003) Telomere replication: An Est fest. Curr Biol 13(11):R439-R441
-
(2003)
Curr Biol
, vol.13
, Issue.11
-
-
Lundblad, V.1
-
168
-
-
0024973811
-
A mutant with a defect in telomere elongation leads to senescence in yeast
-
Lundblad V, Szostak JW (1989) A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57(4):633-643
-
(1989)
Cell
, vol.57
, Issue.4
, pp. 633-643
-
-
Lundblad, V.1
Szostak, J.W.2
-
169
-
-
9744241712
-
A biochemically defined system for mammalian nonhomologous DNA end joining
-
Ma Y, Lu H et al (2004) A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell 16(5):701-713
-
(2004)
Mol Cell
, vol.16
, Issue.5
, pp. 701-713
-
-
Ma, Y.1
Lu, H.2
-
170
-
-
41949120112
-
A dyskerin motif reactivates telomerase activity in X-linked dyskeratosis congenita and in telomerase-deficient human cells
-
Machado-Pinilla R, Sanchez-Perez I et al (2008) A dyskerin motif reactivates telomerase activity in X-linked dyskeratosis congenita and in telomerase-deficient human cells. Blood 111(5):2606-2614
-
(2008)
Blood
, vol.111
, Issue.5
, pp. 2606-2614
-
-
Machado-Pinilla, R.1
Sanchez-Perez, I.2
-
171
-
-
0029922114
-
Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination
-
Mages GJ, Feldmann HM et al (1996) Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination. J Biol Chem 271(14):7910-7915
-
(1996)
J Biol Chem
, vol.271
, Issue.14
, pp. 7910-7915
-
-
Mages, G.J.1
Feldmann, H.M.2
-
172
-
-
0027212790
-
Nucleosomal organization of telomere-specific chromatin in rat
-
Makarov VL, Lejnine S et al (1993) Nucleosomal organization of telomere-specific chromatin in rat. Cell 73(4):775-787
-
(1993)
Cell
, vol.73
, Issue.4
, pp. 775-787
-
-
Makarov, V.L.1
Lejnine, S.2
-
173
-
-
27244458940
-
A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation
-
Marie-Egyptienne DT, Cerone MA et al (2005) A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation. Nucleic Acids Res 33(17):5446-5457
-
(2005)
Nucleic Acids Res
, vol.33
, Issue.17
, pp. 5446-5457
-
-
Marie-Egyptienne, D.T.1
Cerone, M.A.2
-
174
-
-
19444383162
-
Dyskeratosis congenita: Telomerase, telomeres and anticipation
-
Marrone A, Walne A et al (2005) Dyskeratosis congenita: Telomerase, telomeres and anticipation. Curr Opin Genet Dev 15(3):249-257
-
(2005)
Curr Opin Genet Dev
, vol.15
, Issue.3
, pp. 249-257
-
-
Marrone, A.1
Walne, A.2
-
175
-
-
0033612287
-
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
-
Martin SG, Laroche T et al (1999) Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97(5):621-633
-
(1999)
Cell
, vol.97
, Issue.5
, pp. 621-633
-
-
Martin, S.G.1
Laroche, T.2
-
176
-
-
0035937133
-
Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system
-
Martin-Rivera L, Blasco MA (2001) Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system. J Biol Chem 276(8):5856-5865
-
(2001)
J Biol Chem
, vol.276
, Issue.8
, pp. 5856-5865
-
-
Martin-Rivera, L.1
Blasco, M.A.2
-
177
-
-
53749097353
-
A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans
-
Masse I, Molin L et al (2008) A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. PLoS ONE 3(10):e3354
-
(2008)
PLoS ONE
, vol.3
, Issue.10
-
-
Masse, I.1
Molin, L.2
-
178
-
-
0041925729
-
The order of the genes c, sh and wx in zea mays with reference to a cytologically known point in the chromosome
-
McClintock B (1931) The order of the genes C, Sh and Wx in Zea Mays with reference to a cytologically known point in the chromosome. Proc Natl Acad Sci USA 17(8):485-491
-
(1931)
Proc Natl Acad Sci USA
, vol.17
, Issue.8
, pp. 485-491
-
-
McClintock, B.1
-
179
-
-
0001294157
-
The stability of broken ends of chromosomes in Zea Mays
-
McClintock B (1941) The stability of broken ends of chromosomes in Zea Mays. Genetics 26(2):234-282
-
(1941)
Genetics
, vol.26
, Issue.2
, pp. 234-282
-
-
McClintock, B.1
-
180
-
-
0029895352
-
Processing of nontelomeric 3¢ ends by telomerase: Default template alignment and endonucleolytic cleavage
-
Melek M, Greene EC et al (1996) Processing of nontelomeric 3¢ ends by telomerase: Default template alignment and endonucleolytic cleavage. Mol Cell Biol 16(7):3437-3445
-
(1996)
Mol Cell Biol
, vol.16
, Issue.7
, pp. 3437-3445
-
-
Melek, M.1
Greene, E.C.2
-
181
-
-
40549127471
-
Drosophila lifespan control by dietary restriction independent of insulin-like signaling
-
Min KJ, Yamamoto R et al (2008) Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell 7(2):199-206
-
(2008)
Aging Cell
, vol.7
, Issue.2
, pp. 199-206
-
-
Min, K.J.1
Yamamoto, R.2
-
182
-
-
0033636897
-
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
-
Mitchell JR, Collins K (2000) Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol Cell 6(2):361-371
-
(2000)
Mol Cell
, vol.6
, Issue.2
, pp. 361-371
-
-
Mitchell, J.R.1
Collins, K.2
-
183
-
-
0032961170
-
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3¢ end
-
Mitchell JR, Cheng J et al (1999a) A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3¢ end. Mol Cell Biol 19(1):567-576
-
(1999)
Mol Cell Biol
, vol.19
, Issue.1
, pp. 567-576
-
-
Mitchell, J.R.1
Cheng, J.2
-
184
-
-
0033518188
-
A telomerase component is defective in the human Disease dyskeratosis congenita
-
Mitchell JR, Wood E et al (1999b) A telomerase component is defective in the human Disease dyskeratosis congenita. Nature 402(6761):551-555
-
(1999)
Nature
, vol.402
, Issue.6761
, pp. 551-555
-
-
Mitchell, J.R.1
Wood, E.2
-
185
-
-
3242656131
-
Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing
-
Mochizuki Y, He J et al (2004) Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing. Proc Natl Acad Sci USA 101(29):10756-10761
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.29
, pp. 10756-10761
-
-
Mochizuki, Y.1
He, J.2
-
186
-
-
0035158032
-
Multiple interactions in Sir protein recruitment by Rap1p at silencers and telomeres in yeast
-
Moretti P, Shore D (2001) Multiple interactions in Sir protein recruitment by Rap1p at silencers and telomeres in yeast. Mol Cell Biol 21(23):8082-8094
-
(2001)
Mol Cell Biol
, vol.21
, Issue.23
, pp. 8082-8094
-
-
Moretti, P.1
Shore, D.2
-
187
-
-
0024325562
-
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
-
Morin GB (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59(3):521-529
-
(1989)
Cell
, vol.59
, Issue.3
, pp. 521-529
-
-
Morin, G.B.1
-
188
-
-
0025808098
-
Recognition of a chromosome truncation site associated with alpha-Thalassaemia by human telomerase
-
Morin GB (1991) Recognition of a chromosome truncation site associated with alpha-Thalassaemia by human telomerase. Nature 353(6343):454-456
-
(1991)
Nature
, vol.353
, Issue.6343
, pp. 454-456
-
-
Morin, G.B.1
-
189
-
-
0013462065
-
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
-
Moyzis RK, Buckingham JM et al (1988) A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci USA 85(18):6622-6626
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, Issue.18
, pp. 6622-6626
-
-
Moyzis, R.K.1
Buckingham, J.M.2
-
190
-
-
0000049842
-
The remaking of chromosome
-
Muller HJ (1938) The remaking of chromosome. Collecting Net 13:181-198
-
(1938)
Collecting Net
, vol.13
, pp. 181-198
-
-
Muller, H.J.1
-
191
-
-
34547902154
-
Orchestration of chromatin-based processes: Mind the TRRAP
-
Murr R, Vaissiere T et al (2007) Orchestration of chromatin-based processes: Mind the TRRAP. Oncogene 26(37):5358-5372
-
(2007)
Oncogene
, vol.26
, Issue.37
, pp. 5358-5372
-
-
Murr, R.1
Vaissiere, T.2
-
192
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura TM, Morin GB et al (1997) Telomerase catalytic subunit homologs from fission yeast and human. Science 277(5328):955-959
-
(1997)
Science
, vol.277
, Issue.5328
, pp. 955-959
-
-
Nakamura, T.M.1
Morin, G.B.2
-
193
-
-
54949122449
-
Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging-what markers can we use?
-
Nalapareddy K, Jiang H et al (2008) Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging-what markers can we use?. Exp Gerontol 43(11):998-1004
-
(2008)
Exp Gerontol
, vol.43
, Issue.11
, pp. 998-1004
-
-
Nalapareddy, K.1
Jiang, H.2
-
194
-
-
0037040205
-
ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint
-
Nghiem P, Park PK et al (2002) ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J Biol Chem 277(6):4428-4434
-
(2002)
J Biol Chem
, vol.277
, Issue.6
, pp. 4428-4434
-
-
Nghiem, P.1
Park, P.K.2
-
195
-
-
0035936156
-
Innate antimicrobial peptide protects the skin from invasive bacterial infection
-
Nizet V, Ohtake T et al (2001) Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414(6862):454-457
-
(2001)
Nature
, vol.414
, Issue.6862
, pp. 454-457
-
-
Nizet, V.1
Ohtake, T.2
-
196
-
-
0015844590
-
A theory of marginotomy The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
-
Olovnikov AM (1973) A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 41(1):181-190
-
(1973)
J Theor Biol
, vol.41
, Issue.1
, pp. 181-190
-
-
Olovnikov, A.M.1
-
197
-
-
3042762532
-
A human telomerase-Associated nuclease
-
Oulton R, Harrington L (2004) A human telomerase-Associated nuclease. Mol Biol Cell 15(7):3244-3256
-
(2004)
Mol Biol Cell
, vol.15
, Issue.7
, pp. 3244-3256
-
-
Oulton, R.1
Harrington, L.2
-
198
-
-
27144451010
-
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
-
Paeschke K, Simonsson T et al (2005) Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo. Nat Struct Mol Biol 12(10):847-854
-
(2005)
Nat Struct Mol Biol
, vol.12
, Issue.10
, pp. 847-854
-
-
Paeschke, K.1
Simonsson, T.2
-
199
-
-
44849095213
-
Telomerase recruitment by the telomere end binding proteinbeta facilitates G-quadruplex DNA unfolding in ciliates
-
Paeschke K, Juranek S et al (2008) Telomerase recruitment by the telomere end binding proteinbeta facilitates G-quadruplex DNA unfolding in ciliates. Nat Struct Mol Biol 15(6):598-604
-
(2008)
Nat Struct Mol Biol
, vol.15
, Issue.6
, pp. 598-604
-
-
Paeschke, K.1
Juranek, S.2
-
200
-
-
0033288824
-
Drosophila telomeres: Two transposable elements with important roles in chromosomes
-
Pardue ML, DeBaryshe PG (1999) Drosophila telomeres: Two transposable elements with important roles in chromosomes. Genetica 107(1-3):189-196
-
(1999)
Genetica
, vol.107
, Issue.1-3
, pp. 189-196
-
-
Pardue, M.L.1
DeBaryshe, P.G.2
-
201
-
-
0346786214
-
Retrotransposons provide an evolutionarily robust non-Telomerase mechanism to maintain telomeres
-
Pardue ML, DeBaryshe PG (2003) Retrotransposons provide an evolutionarily robust non-Telomerase mechanism to maintain telomeres. Annu Rev Genet 37:485-511
-
(2003)
Annu Rev Genet
, vol.37
, pp. 485-511
-
-
Pardue, M.L.1
DeBaryshe, P.G.2
-
202
-
-
0032085295
-
The 3¢ to 5¢ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
-
Paull TT, Gellert M (1998) The 3¢ to 5¢ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell 1(7):969-979
-
(1998)
Mol Cell
, vol.1
, Issue.7
, pp. 969-979
-
-
Paull, T.T.1
Gellert, M.2
-
203
-
-
0033563229
-
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
-
Paull TT, Gellert M (1999) Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev 13(10):1276-1288
-
(1999)
Genes Dev
, vol.13
, Issue.10
, pp. 1276-1288
-
-
Paull, T.T.1
Gellert, M.2
-
204
-
-
0035830494
-
Cdc13 delivers separate complexes to the telomere for end protection and replication
-
Pennock E, Buckley K et al (2001) Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104(3):387-396
-
(2001)
Cell
, vol.104
, Issue.3
, pp. 387-396
-
-
Pennock, E.1
Buckley, K.2
-
205
-
-
0029919650
-
The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae
-
Porter SE, Greenwell PW et al (1996) The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res 24(4):582-585
-
(1996)
Nucleic Acids Res
, vol.24
, Issue.4
, pp. 582-585
-
-
Porter, S.E.1
Greenwell, P.W.2
-
206
-
-
0030781067
-
Functionally interacting telomerase RNAs in the yeast telomerase complex
-
Prescott J, Blackburn EH (1997) Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev 11(21):2790-2800
-
(1997)
Genes Dev
, vol.11
, Issue.21
, pp. 2790-2800
-
-
Prescott, J.1
Blackburn, E.H.2
-
207
-
-
0024551991
-
Properties of the telomeric DNA-binding protein from Oxytricha nova
-
Price CM, Cech TR (1989) Properties of the telomeric DNA-binding protein from Oxytricha nova. Biochemistry 28(2):769-774
-
(1989)
Biochemistry
, vol.28
, Issue.2
, pp. 769-774
-
-
Price, C.M.1
Cech, T.R.2
-
208
-
-
41549149451
-
Cellular senescence in vivo: A barrier to tumorigenesis
-
Prieur A, Peeper DS (2008) Cellular senescence in vivo: A barrier to tumorigenesis. Curr Opin Cell Biol 20(2):150-155
-
(2008)
Curr Opin Cell Biol
, vol.20
, Issue.2
, pp. 150-155
-
-
Prieur, A.1
Peeper, D.S.2
-
209
-
-
0032518680
-
Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks
-
Ramsden DA, Gellert M (1998) Ku protein stimulates DNA end joining by mammalian DNA ligases: A direct role for Ku in repair of DNA double-strand breaks. EMBO J 17(2):609-614
-
(1998)
EMBO J
, vol.17
, Issue.2
, pp. 609-614
-
-
Ramsden, D.A.1
Gellert, M.2
-
210
-
-
36749029313
-
Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase
-
Redon S, Reichenbach P et al (2007) Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Res 35(20):7011-7022
-
(2007)
Nucleic Acids Res
, vol.35
, Issue.20
, pp. 7011-7022
-
-
Redon, S.1
Reichenbach, P.2
-
211
-
-
0037381155
-
A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed
-
Reichenbach P, Hoss M et al (2003) A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr Biol 13(7):568-574
-
(2003)
Curr Biol
, vol.13
, Issue.7
, pp. 568-574
-
-
Reichenbach, P.1
Hoss, M.2
-
212
-
-
0030999605
-
Synthesis of the mammalian telomere lagging strand in vitro
-
Reveal PM, Henkels KM et al (1997) Synthesis of the mammalian telomere lagging strand in vitro. J Biol Chem 272(18):11678-11681
-
(1997)
J Biol Chem
, vol.272
, Issue.18
, pp. 11678-11681
-
-
Reveal, P.M.1
Henkels, K.M.2
-
213
-
-
33750033205
-
The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology
-
Riha K, Heacock ML et al (2006) The role of the nonhomologous end-joining DNA double-strand break repair pathway in telomere biology. Annu Rev Genet 40:237-277
-
(2006)
Annu Rev Genet
, vol.40
, pp. 237-277
-
-
Riha, K.1
Heacock, M.L.2
-
214
-
-
0034013797
-
The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast
-
Ritchie KB, Petes TD (2000) The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155(1):475-479
-
(2000)
Genetics
, vol.155
, Issue.1
, pp. 475-479
-
-
Ritchie, K.B.1
Petes, T.D.2
-
215
-
-
35748951600
-
Structure of the RNA-binding domain of telomerase: Implications for RNA recognition and binding
-
Rouda S, Skordalakes E (2007) Structure of the RNA-binding domain of telomerase: Implications for RNA recognition and binding. Structure 15(11):1403-1412
-
(2007)
Structure
, vol.15
, Issue.11
, pp. 1403-1412
-
-
Rouda, S.1
Skordalakes, E.2
-
216
-
-
16544382801
-
The role of stathmin in the regulation of the cell cycle
-
Rubin CI, Atweh GF (2004) The role of stathmin in the regulation of the cell cycle. J Cell Biochem 93(2):242-250
-
(2004)
J Cell Biochem
, vol.93
, Issue.2
, pp. 242-250
-
-
Rubin, C.I.1
Atweh, G.F.2
-
217
-
-
0029954325
-
TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae
-
Runge KW, Zakian VA (1996) TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 16(6):3094-3105
-
(1996)
Mol Cell Biol
, vol.16
, Issue.6
, pp. 3094-3105
-
-
Runge, K.W.1
Zakian, V.A.2
-
218
-
-
36049045013
-
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
-
Salvati E, Leonetti C et al (2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J Clin Invest 117(11):3236-3247
-
(2007)
J Clin Invest
, vol.117
, Issue.11
, pp. 3236-3247
-
-
Salvati, E.1
Leonetti, C.2
-
219
-
-
18744365757
-
Structures of HIV-1 reverse transcriptase with pre- And post-Translocation AZTMP-Terminated DNA
-
Sarafianos SG, Clark AD Jr et al (2002) Structures of HIV-1 reverse transcriptase with pre- And post-Translocation AZTMP-Terminated DNA. Embo J 21(23):6614-6624
-
(2002)
Embo J
, vol.21
, Issue.23
, pp. 6614-6624
-
-
Sarafianos, S.G.1
Clark Jr., A.D.2
-
220
-
-
0032125598
-
One-step affinity purification protocol for human telomerase
-
Schnapp G, Rodi HP et al (1998) One-step affinity purification protocol for human telomerase. Nucleic Acids Res 26(13):3311-3313
-
(1998)
Nucleic Acids Res
, vol.26
, Issue.13
, pp. 3311-3313
-
-
Schnapp, G.1
Rodi, H.P.2
-
221
-
-
38849111756
-
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
-
Schoeftner S, Blasco MA (2008) Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol 10(2):228-236
-
(2008)
Nat Cell Biol
, vol.10
, Issue.2
, pp. 228-236
-
-
Schoeftner, S.1
Blasco, M.A.2
-
222
-
-
15944368044
-
Telomere-end processing the terminal nucleotides of human chromosomes
-
Sfeir AJ, Chai W et al (2005a) Telomere-end processing the terminal nucleotides of human chromosomes. Mol Cell 18(1):131-138
-
(2005)
Mol Cell
, vol.18
, Issue.1
, pp. 131-138
-
-
Sfeir, A.J.1
Chai, W.2
-
223
-
-
27744458482
-
Fine-Tuning the chromosome ends: The last base of human telomeres
-
Sfeir AJ, Shay JW et al (2005b) Fine-Tuning the chromosome ends: The last base of human telomeres. Cell Cycle 4(11):1467-1470
-
(2005)
Cell Cycle
, vol.4
, Issue.11
, pp. 1467-1470
-
-
Sfeir, A.J.1
Shay, J.W.2
-
224
-
-
0023742169
-
Generation of telomere-length heterogeneity in Saccharomyces cerevisiae
-
Shampay J, Blackburn EH (1988) Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 85(2):534-538
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, Issue.2
, pp. 534-538
-
-
Shampay, J.1
Blackburn, E.H.2
-
225
-
-
0034601464
-
A chromatin remodelling complex involved in transcription and DNA processing
-
Shen X, Mizuguchi G et al (2000) A chromatin remodelling complex involved in transcription and DNA processing. Nature 406(6795):541-544
-
(2000)
Nature
, vol.406
, Issue.6795
, pp. 541-544
-
-
Shen, X.1
Mizuguchi, G.2
-
226
-
-
34247158238
-
Tel2 is required for activation of the Mrc1-mediated replication checkpoint
-
Shikata M, Ishikawa F et al (2007) Tel2 is required for activation of the Mrc1-mediated replication checkpoint. J Biol Chem 282(8):5346-5355
-
(2007)
J Biol Chem
, vol.282
, Issue.8
, pp. 5346-5355
-
-
Shikata, M.1
Ishikawa, F.2
-
227
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh Y (2003) ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer 3(3):155-168
-
(2003)
Nat Rev Cancer
, vol.3
, Issue.3
, pp. 155-168
-
-
Shiloh, Y.1
-
228
-
-
0025021235
-
Functional evidence for an RNA template in telomerase
-
Shippen-Lentz D, Blackburn EH (1990) Functional evidence for an RNA template in telomerase. Science 247(4942):546-552
-
(1990)
Science
, vol.247
, Issue.4942
, pp. 546-552
-
-
Shippen-Lentz, D.1
Blackburn, E.H.2
-
229
-
-
0030033061
-
The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination
-
Siede W, Friedl AA et al (1996) The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics 142(1):91-102
-
(1996)
Genetics
, vol.142
, Issue.1
, pp. 91-102
-
-
Siede, W.1
Friedl, A.A.2
-
230
-
-
0027944347
-
TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
-
Singer MS, Gottschling DE (1994) TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science 266(5184):404-409
-
(1994)
Science
, vol.266
, Issue.5184
, pp. 404-409
-
-
Singer, M.S.1
Gottschling, D.E.2
-
231
-
-
0032610295
-
DNA-dependent protein kinase and related proteins
-
Smith GC, Divecha N et al (1999) DNA-dependent protein kinase and related proteins. Biochem Soc Symp 64:91-104
-
(1999)
Biochem Soc Symp
, vol.64
, pp. 91-104
-
-
Smith, G.C.1
Divecha, N.2
-
232
-
-
0037102234
-
Different telomere damage signaling pathways in human and mouse cells
-
Smogorzewska A, de Lange T (2002) Different telomere damage signaling pathways in human and mouse cells. EMBO J 21(16):4338-4348
-
(2002)
EMBO J
, vol.21
, Issue.16
, pp. 4338-4348
-
-
Smogorzewska, A.1
De Lange, T.2
-
233
-
-
2042429168
-
Regulation of telomerase by telomeric proteins
-
Smogorzewska A, de Lange T (2004) Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73:177-208
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 177-208
-
-
Smogorzewska, A.1
De Lange, T.2
-
234
-
-
0033961281
-
Control of human telomere length by TRF1 and TRF2
-
Smogorzewska A, van Steensel B et al (2000) Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 20(5):1659-1668
-
(2000)
Mol Cell Biol
, vol.20
, Issue.5
, pp. 1659-1668
-
-
Smogorzewska, A.1
Van Steensel, B.2
-
235
-
-
0037447232
-
Functional conservation of the telomerase protein Est1p in humans
-
Snow BE, Erdmann N et al (2003) Functional conservation of the telomerase protein Est1p in humans. Curr Biol 13(8):698-704
-
(2003)
Curr Biol
, vol.13
, Issue.8
, pp. 698-704
-
-
Snow, B.E.1
Erdmann, N.2
-
236
-
-
0035476710
-
T-loop assembly in vitro involves binding of TRF2 near the 3¢ telomeric overhang
-
Stansel RM, de Lange T et al (2001) T-loop assembly in vitro involves binding of TRF2 near the 3¢ telomeric overhang. EMBO J 20(19):5532-5540
-
(2001)
EMBO J
, vol.20
, Issue.19
, pp. 5532-5540
-
-
Stansel, R.M.1
De Lange, T.2
-
237
-
-
2942617298
-
Modification of subtelomeric DNA
-
Steinert S, Shay JW et al (2004) Modification of subtelomeric DNA. Mol Cell Biol 24(10): 4571-4580
-
(2004)
Mol Cell Biol
, vol.24
, Issue.10
, pp. 4571-4580
-
-
Steinert, S.1
Shay, J.W.2
-
238
-
-
0141525391
-
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends
-
Stellwagen AE, Haimberger ZW et al (2003) Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev 17(19):2384-2395
-
(2003)
Genes Dev
, vol.17
, Issue.19
, pp. 2384-2395
-
-
Stellwagen, A.E.1
Haimberger, Z.W.2
-
239
-
-
0033544724
-
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-Telangiectasia-like disorder
-
Stewart GS, Maser RS et al (1999) The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-Telangiectasia-like disorder. Cell 99(6):577-587
-
(1999)
Cell
, vol.99
, Issue.6
, pp. 577-587
-
-
Stewart, G.S.1
Maser, R.S.2
-
240
-
-
37349014081
-
Tel2 regulates the stability of PI3K-related protein kinases
-
Takai H, Wang RC et al (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131(7):1248-1259
-
(2007)
Cell
, vol.131
, Issue.7
, pp. 1248-1259
-
-
Takai, H.1
Wang, R.C.2
-
241
-
-
13944265075
-
Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae
-
Takata H, Tanaka Y et al (2005) Late S phase-specific recruitment of Mre11 complex triggers hierarchical assembly of telomere replication proteins in Saccharomyces cerevisiae. Mol Cell 17(4):573-583
-
(2005)
Mol Cell
, vol.17
, Issue.4
, pp. 573-583
-
-
Takata, H.1
Tanaka, Y.2
-
242
-
-
33744799697
-
Structure and function of telomerase RNA
-
Theimer CA, Feigon J (2006) Structure and function of telomerase RNA. Curr Opin Struct Biol 16(3):307-318
-
(2006)
Curr Opin Struct Biol
, vol.16
, Issue.3
, pp. 307-318
-
-
Theimer, C.A.1
Feigon, J.2
-
243
-
-
0037457985
-
Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA
-
Theimer CA, Finger LD et al (2003) Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA. Proc Natl Acad Sci USA 100(2):449-454
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.2
, pp. 449-454
-
-
Theimer, C.A.1
Finger, L.D.2
-
244
-
-
0042972659
-
Homology among telomeric end-protection proteins
-
Theobald DL, Cervantes RB et al (2003a) Homology among telomeric end-protection proteins. Structure 11(9):1049-1050
-
(2003)
Structure
, vol.11
, Issue.9
, pp. 1049-1050
-
-
Theobald, D.L.1
Cervantes, R.B.2
-
246
-
-
17544363018
-
Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase
-
Ting NS, Yu Y et al (2005) Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase. Nucleic Acids Res 33(7):2090-2098
-
(2005)
Nucleic Acids Res
, vol.33
, Issue.7
, pp. 2090-2098
-
-
Ting, N.S.1
Yu, Y.2
-
247
-
-
0030963268
-
Function and synthesis of small nucleolar RNAs
-
Tollervey D, Kiss T (1997) Function and synthesis of small nucleolar RNAs. Curr Opin Cell Biol 9(3):337-342
-
(1997)
Curr Opin Cell Biol
, vol.9
, Issue.3
, pp. 337-342
-
-
Tollervey, D.1
Kiss, T.2
-
248
-
-
55449122193
-
Telomerase reverse transcriptase delays aging in cancerresistant mice
-
Tomas-Loba A, Flores I et al (2008) Telomerase reverse transcriptase delays aging in cancerresistant mice. Cell 135(4):609-622
-
(2008)
Cell
, vol.135
, Issue.4
, pp. 609-622
-
-
Tomas-Loba, A.1
Flores, I.2
-
249
-
-
0028101019
-
Unusual chromatin in human telomeres
-
Tommerup H, Dousmanis A et al (1994) Unusual chromatin in human telomeres. Mol Cell Biol 14(9):5777-5785
-
(1994)
Mol Cell Biol
, vol.14
, Issue.9
, pp. 5777-5785
-
-
Tommerup, H.1
Dousmanis, A.2
-
250
-
-
0034608073
-
Template boundary in a yeast telomerase specified by RNA structure
-
Tzfati Y, Fulton TB et al (2000) Template boundary in a yeast telomerase specified by RNA structure. Science 288(5467):863-867
-
(2000)
Science
, vol.288
, Issue.5467
, pp. 863-867
-
-
Tzfati, Y.1
Fulton, T.B.2
-
251
-
-
0037829618
-
A novel pseudoknot element is essential for the action of a yeast telomerase
-
Tzfati Y, Knight Z et al (2003) A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev 17(14):1779-1788
-
(2003)
Genes Dev
, vol.17
, Issue.14
, pp. 1779-1788
-
-
Tzfati, Y.1
Knight, Z.2
-
252
-
-
0031230933
-
Developmental regulation of telomerase activity in human fetal tissues during gestation
-
Ulaner GA, Giudice LC (1997) Developmental regulation of telomerase activity in human fetal tissues during gestation. Mol Hum Reprod 3(9):769-773
-
(1997)
Mol Hum Reprod
, vol.3
, Issue.9
, pp. 769-773
-
-
Ulaner, G.A.1
Giudice, L.C.2
-
253
-
-
33745652501
-
Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase
-
van Overbeek M, de Lange T (2006) Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase. Curr Biol 16(13):1295-1302
-
(2006)
Curr Biol
, vol.16
, Issue.13
, pp. 1295-1302
-
-
Van Overbeek, M.1
De Lange, T.2
-
254
-
-
0031027618
-
Control of telomere length by the human telomeric protein TRF1
-
van Steensel B, de Lange T (1997) Control of telomere length by the human telomeric protein TRF1. Nature 385(6618):740-743
-
(1997)
Nature
, vol.385
, Issue.6618
, pp. 740-743
-
-
Van Steensel, B.1
De Lange, T.2
-
255
-
-
0032489012
-
TRF2 protects human telomeres from end-To-end fusions
-
van Steensel B, Smogorzewska A et al (1998) TRF2 protects human telomeres from end-To-end fusions. Cell 92(3):401-413
-
(1998)
Cell
, vol.92
, Issue.3
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
-
256
-
-
0032076190
-
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
-
Varon R, Vissinga C et al (1998) Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93(3):467-476
-
(1998)
Cell
, vol.93
, Issue.3
, pp. 467-476
-
-
Varon, R.1
Vissinga, C.2
-
257
-
-
0032567967
-
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
-
Vaziri H, Benchimol S (1998) Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 8(5):279-282
-
(1998)
Curr Biol
, vol.8
, Issue.5
, pp. 279-282
-
-
Vaziri, H.1
Benchimol, S.2
-
258
-
-
11144277882
-
Loss of hPot1 function leads to telomere instability and a cut-like phenotype
-
Veldman T, Etheridge KT et al (2004) Loss of hPot1 function leads to telomere instability and a cut-like phenotype. Curr Biol 14(24):2264-2270
-
(2004)
Curr Biol
, vol.14
, Issue.24
, pp. 2264-2270
-
-
Veldman, T.1
Etheridge, K.T.2
-
259
-
-
40749135820
-
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly
-
Venteicher AS, Meng Z et al (2008) Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell 132(6):945-957
-
(2008)
Cell
, vol.132
, Issue.6
, pp. 945-957
-
-
Venteicher, A.S.1
Meng, Z.2
-
260
-
-
33750801681
-
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres
-
Verdun RE, Karlseder J (2006) The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 127(4):709-720
-
(2006)
Cell
, vol.127
, Issue.4
, pp. 709-720
-
-
Verdun, R.E.1
Karlseder, J.2
-
261
-
-
27944496124
-
Functional human telomeres are recognized as DNA damage in G2 of the cell cycle
-
Verdun RE, Crabbe L et al (2005) Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell 20(4):551-561
-
(2005)
Mol Cell
, vol.20
, Issue.4
, pp. 551-561
-
-
Verdun, R.E.1
Crabbe, L.2
-
262
-
-
0037072661
-
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
-
Volpe TA, Kidner C et al (2002) Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297(5588):1833-1837
-
(2002)
Science
, vol.297
, Issue.5588
, pp. 1833-1837
-
-
Volpe, T.A.1
Kidner, C.2
-
263
-
-
0036629255
-
Oxidative stress shortens telomeres
-
von Zglinicki T (2002) Oxidative stress shortens telomeres. Trends Biochem Sci 27(7):339-344
-
(2002)
Trends Biochem Sci
, vol.27
, Issue.7
, pp. 339-344
-
-
Von Zglinicki, T.1
-
264
-
-
10944257464
-
Human cell senescence as a DNA damage response
-
von Zglinicki T, Saretzki G et al (2005) Human cell senescence as a DNA damage response. Mech Ageing Dev 126(1):111-117
-
(2005)
Mech Ageing Dev
, vol.126
, Issue.1
, pp. 111-117
-
-
Von Zglinicki, T.1
Saretzki, G.2
-
265
-
-
0035833552
-
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
-
Walker JR, Corpina RA et al (2001) Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412(6847):607-614
-
(2001)
Nature
, vol.412
, Issue.6847
, pp. 607-614
-
-
Walker, J.R.1
Corpina, R.A.2
-
266
-
-
0031053530
-
De novo telomere addition by Tetrahymena telomerase in vitro
-
Wang H, Blackburn EH (1997) De novo telomere addition by Tetrahymena telomerase in vitro. EMBO J 16(4):866-879
-
(1997)
EMBO J
, vol.16
, Issue.4
, pp. 866-879
-
-
Wang, H.1
Blackburn, E.H.2
-
267
-
-
2442542173
-
Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins
-
Wang C, Meier UT (2004) Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. EMBO J 23(8):1857-1867
-
(2004)
EMBO J
, vol.23
, Issue.8
, pp. 1857-1867
-
-
Wang, C.1
Meier, U.T.2
-
268
-
-
0024331624
-
Cloning and molecular characterization of a cDNA clone to statin, a protein specifically expressed in nonproliferating quiescent and senescent fibroblasts
-
Wang E, Moutsatsos IK et al (1989) Cloning and molecular characterization of a cDNA clone to statin, a protein specifically expressed in nonproliferating quiescent and senescent fibroblasts. Exp Gerontol 24(5-6):485-499
-
(1989)
Exp Gerontol
, vol.24
, Issue.5-6
, pp. 485-499
-
-
Wang, E.1
Moutsatsos, I.K.2
-
269
-
-
0031587827
-
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69
-
Wang J, Sattar AK et al (1997) Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Cell 89(7):1087-1099
-
(1997)
Cell
, vol.89
, Issue.7
, pp. 1087-1099
-
-
Wang, J.1
Sattar, A.K.2
-
270
-
-
7044232011
-
Homologous recombination generates T-loop-sized deletions at human telomeres
-
Wang RC, Smogorzewska A et al (2004) Homologous recombination generates T-loop-sized deletions at human telomeres. Cell 119(3):355-368
-
(2004)
Cell
, vol.119
, Issue.3
, pp. 355-368
-
-
Wang, R.C.1
Smogorzewska, A.2
-
271
-
-
33846691378
-
The POT1-TPP1 telomere complex is a telomerase processivity factor
-
Wang F, Podell ER et al (2007) The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445(7127):506-510
-
(2007)
Nature
, vol.445
, Issue.7127
, pp. 506-510
-
-
Wang, F.1
Podell, E.R.2
-
272
-
-
9744222917
-
Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex
-
Watkins NJ, Lemm I et al (2004) Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. Mol Cell 16(5):789-798
-
(2004)
Mol Cell
, vol.16
, Issue.5
, pp. 789-798
-
-
Watkins, N.J.1
Lemm, I.2
-
273
-
-
0015515155
-
Origin of concatemeric T7 DNA
-
Watson JD (1972) Origin of concatemeric T7 DNA. Nat New Biol 239(94):197-201
-
(1972)
Nat New Biol
, vol.239
, Issue.94
, pp. 197-201
-
-
Watson, J.D.1
-
275
-
-
0030659644
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich SL, Pruzan R et al (1997) Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 17(4):498-502
-
(1997)
Nat Genet
, vol.17
, Issue.4
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
-
276
-
-
0035796403
-
Human telomerase contains two cooperating telomerase RNA molecules
-
Wenz C, Enenkel B et al (2001) Human telomerase contains two cooperating telomerase RNA molecules. EMBO J 20(13):3526-3534
-
(2001)
EMBO J
, vol.20
, Issue.13
, pp. 3526-3534
-
-
Wenz, C.1
Enenkel, B.2
-
277
-
-
34548492016
-
Mre11-rad50-nbs1 and atm function as co-mediators of trf1 in telomere length control
-
Wu Y, Xiao S et al (2007) MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat Struct Mol Biol 14(9):832-840
-
(2007)
Nat Struct Mol Biol
, vol.14
, Issue.9
, pp. 832-840
-
-
Wu, Y.1
Xiao, S.2
-
278
-
-
33846692105
-
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
-
Xin H, Liu D et al (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 445(7127):559-562
-
(2007)
Nature
, vol.445
, Issue.7127
, pp. 559-562
-
-
Xin, H.1
Liu, D.2
-
279
-
-
12844254472
-
POT1 and TRF2 cooperate to maintain telomeric integrity
-
Yang Q, Zheng YL et al (2005) POT1 and TRF2 cooperate to maintain telomeric integrity. Mol Cell Biol 25(3):1070-1080
-
(2005)
Mol Cell Biol
, vol.25
, Issue.3
, pp. 1070-1080
-
-
Yang, Q.1
Zheng, Y.L.2
-
280
-
-
3142679378
-
POT1-interacting protein PIP1: A telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
-
Ye JZ, Hockemeyer D et al (2004) POT1-interacting protein PIP1: A telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev 18(14):1649-1654
-
(2004)
Genes Dev
, vol.18
, Issue.14
, pp. 1649-1654
-
-
Ye, J.Z.1
Hockemeyer, D.2
-
281
-
-
0033199695
-
Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body
-
Yeager TR, Neumann AA et al (1999) Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res 59(17):4175-4179
-
(1999)
Cancer Res
, vol.59
, Issue.17
, pp. 4175-4179
-
-
Yeager, T.R.1
Neumann, A.A.2
-
282
-
-
0025279059
-
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
-
Yu GL, Bradley JD et al (1990) In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344(6262):126-132
-
(1990)
Nature 344
, vol.6262
, pp. 126-132
-
-
Yu, G.L.1
Bradley, J.D.2
-
283
-
-
3042798454
-
Yeast telomerase RNA: A flexible scaffold for protein subunits
-
Zappulla DC, Cech TR (2004) Yeast telomerase RNA: A flexible scaffold for protein subunits. Proc Natl Acad Sci USA 101(27):10024-10029
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.27
, pp. 10024-10029
-
-
Zappulla, D.C.1
Cech, T.R.2
-
284
-
-
28544450412
-
A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro
-
Zappulla DC, Goodrich K et al (2005) A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nat Struct Mol Biol 12(12):1072-1077
-
(2005)
Nat Struct Mol Biol
, vol.12
, Issue.12
, pp. 1072-1077
-
-
Zappulla, D.C.1
Goodrich, K.2
-
285
-
-
49449094794
-
Mutation in TERT separates processivity from anchor-site function
-
Zaug AJ, Podell ER et al (2008) Mutation in TERT separates processivity from anchor-site function. Nat Struct Mol Biol 15(8):870-872
-
(2008)
Nat Struct Mol Biol
, vol.15
, Issue.8
, pp. 870-872
-
-
Zaug, A.J.1
Podell, E.R.2
-
286
-
-
0026668731
-
A mammalian factor that binds telomeric TTAGGG repeats in vitro
-
Zhong Z, Shiue L et al (1992) A mammalian factor that binds telomeric TTAGGG repeats in vitro. Mol Cell Biol 12(11):4834-4843
-
(1992)
Mol Cell Biol
, vol.12
, Issue.11
, pp. 4834-4843
-
-
Zhong, Z.1
Shiue, L.2
-
287
-
-
0342561644
-
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
-
Zhu XD, Kuster B et al (2000) Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet 25(3):347-352
-
(2000)
Nat Genet
, vol.25
, Issue.3
, pp. 347-352
-
-
Zhu, X.D.1
Kuster, B.2
-
288
-
-
2942668626
-
Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation
-
Zhu Z, Zheng T et al (2004) Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 304(5677):1678-1682
-
(2004)
Science
, vol.304
, Issue.5677
, pp. 1678-1682
-
-
Zhu, Z.1
Zheng, T.2
-
289
-
-
0037567268
-
Sensing DNa damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L, Elledge SJ (2003) Sensing DNa damage through ATRIP recognition of RPA-ssDNA complexes. Science 300(5625):1542-1548
-
(2003)
Science
, vol.300
, Issue.5625
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
|