Role of Rb family in the epigenetic definition of chromatin

Cell Cycle

Volumn 4, Issue 6, 2005, Pages 752-755

  Gonzalo, Susana ^a   Blasco, María A ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

Centromeres; Euchromatin; Heterochromatin; Histone methylation; Retinoblastoma; Senescence; Telomeres

Indexed keywords

CELL CYCLE PROTEIN; HISTONE H4; HISTONE LYSINE METHYLTRANSFERASE; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN;

CANCER GENETICS; CENTROMERE; CHROMATIN; CHROMATIN STRUCTURE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME SEGREGATION; DISEASE ASSOCIATION; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; EUCHROMATIN; FREQUENCY ANALYSIS; GENE REPRESSION; GENOMIC INSTABILITY; HETEROCHROMATIN; MAMMAL; METHYLATION; NONHUMAN; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; REVIEW; TELOMERE; TUMOR SUPPRESSOR GENE;

EID: 25144491542     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.6.1720     Document Type: Review

References (30)

1. Weinberg RA. Tke retinoblastoma protein and cell cycle control. Cell 1995; 81:323-30.
2. Lipinski MM, Jacks T. The retinoblastoma gene family in differentiation and development. Oncogene 1999; 18:7873-82.
3. Classon M, Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer 2002; 2:910-7.
4. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev 1998; 12:2245-62.
5. Nevins JR. The Rb/E2F pathway and cancer. Hum Mol Genet 2001; 10:699-703.
6. Luo RX, Postigo AA, Dean DC. Rb interacts with histone deacetylase to repress transcription. Cell 1998; 92:463-73.
7. Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 2000; 25:338-42.
8. Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M, Crabtree GR, Goff SP. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 1994; 79:119-30.
9. Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O'Carroll D, Firestein R, Cleary M, Jenuwein T, Herrera RE, Kouzarides T. Rb targets histone H3 methylation and HP1 to promoters. Nature 2001; 412:561-5.
10. Vandel L, Nicolas E, Vaute O, Ferreira R, Ait-Si-Ali S, Trouche D. Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase. Mol Cell Biol 2001; 21:6484-94.
11. Weintraub SJ, Chow KN, Luo RX, Zhang SH, He S, Dean DC. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 1995; 375:812-5.
12. Brehm A, Kouzarides T. Retinoblastoma protein meets chromatin. Trends Biochem Sci 1999; 24:142-5.
13. Harbour JW, Dean DC. The Rb/E2F pathway: Expanding roles and emerging paradigms. Genes Dev 2000; 14:2393-409.
14. Harbour JW, Dean DC. Chromatin remodeling and Rb activity. Curr Opin Cell Biol 2000; 12:685-9.
15. Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 2003; 113:703-16.
16. Melcher M, Schmid M, Aagaard L, Selenko P, Laible G, Jenuwein T. Structurefunction analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression. Mol Cell Biol 2000; 20:3728-41.
17. Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SI. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 2001; 292:110-3.
18. Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 2001; 410:116-20.
19. Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 2001; 410:120-4.
20. Lachner M, O'Sullivan RJ, Jenuwein T. An epigenetic road map for histone lysine methylation. J Cell Sci 2003; 116:2117-24.
21. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev 2004; 18:1251-62.
22. Lehnertz B, Ueda Y, Derijck AA, Braunschweig U, Perez-Burgos L, Kubicek S, Chen T, Li E, Jenuwein T, Peters AH. Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol 2003; 13:1192-200.
23. Garcia-Cao M, O'Sullivan R, Peters AH, Jenuwein T, Blasco MA. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet 2004; 36:94-99-
24. Peters AH, O'Carroll D, Scherthan H, Mechtler K, Sauer S, Schofer C, Weipoltshammer K, Pagani M, Lachner M, Kohlmaier A, Opravil S, Doyle M, Sibilia M, Jenuwein T. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 2001; 107:323-37.
25. Aagaard L, Schmid M, Warburton P, Jenuwein T. Mitotic phosphorylation of SUV39H1, a novel component of active centromeres, coincides with transient accumulation at mammalian centromeres. J Cell Sci 2000; 113:817-29.
26. Gonzalo S, Garcia-Cao M, Fraga MF, Schotta G, Peters AH, Cotter SE, Eguia R, Dean DC, Esteller M, Jenuwein T, Blasco MA. Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol 2005; 7:420-8.
27. Garcia-Cao M, Gonzalo S, Dean D, Blasco MA. A role for the Rb family of proteins in controlling telomere length. Nat Genet 2002; 32:415-9.
28. Zheng L, Lee WH. Retinoblastoma tumor suppressor and genome stability. Adv Cancer Res 2002; 85:13-50.
29. Rowland BD, Denissov SG, Douma S, Stunnenberg HG, Bernards R, Peeper DS. E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest. Cancer Cell 2002; 2:55-65.
30. Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Perez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 2005; 37:391-400.