Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation

Science

Volumn 304, Issue 5677, 2004, Pages 1678-1682

  Zhu, Zhou ^a   Zheng, Tao ^a   Homer, Robert J ^a,b   Kim, Yoon Keun ^a   Chen, Ning Yuan ^a   Cohn, Lauren ^a   Hamid, Qutayba ^c   Elias, Jack A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; GENES; PULMONARY DISEASES;

INFLAMMATION; PARASITES;

ENZYMES;

CHITINASE; CYTOKINE; INTERLEUKIN 13;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNE RESPONSE; INFLAMMATION; LUNG DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; T LYMPHOCYTE; TH2 CELL;

ADULT; ALLERGENS; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; CHITIN; CHITINASE; EPITHELIAL CELLS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNE SERA; INTERLEUKIN-13; INTERLEUKINS; LUNG; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; OVALBUMIN; RESPIRATORY MUCOSA; TH2 CELLS; UP-REGULATION;

ANIMALIA; HEXAPODA; MAMMALIA;

EID: 2942668626     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1095336     Document Type: Article

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20. This work was supported by grants from NIH (R01-HL-61904, R01-HL-64242, R01-HL-66571, and P50-HL-56389) to J.A.E. and grants from NIH and American Lung Association (R01-HL-074095 and Research Grant, respectively) to Z.Z. We thank K. Bertier and S. Ardito for their excellent secretarial assistance and S. Chen for her technical assistance.